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Article ; Online: Watch-and-Wait is an Option in Rectal Cancer Patients: From Controversy to Common Clinical Practice.

Grotenhuis, B A / Beets, G L

Clinical oncology (Royal College of Radiologists (Great Britain))

2022 Volume 35, Issue 2, Page(s) 124–129

Abstract: Overview of the introduction of organ preservation in rectal cancer patients and future challenges. ...

Abstract	Overview of the introduction of organ preservation in rectal cancer patients and future challenges.
MeSH term(s)	Humans ; Chemoradiotherapy ; Neoplasm Recurrence, Local ; Organ Preservation ; Rectal Neoplasms/therapy ; Treatment Outcome ; Watchful Waiting
Language	English
Publishing date	2022-12-05
Publishing country	England
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	1036844-9
ISSN	1433-2981 ; 0936-6555
ISSN (online)	1433-2981
ISSN	0936-6555
DOI	10.1016/j.clon.2022.11.011
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Zs.A 2774: Show issues

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Article ; Online: Investigating locations of recurrences with MRI after CRS-HIPEC for colorectal peritoneal metastases.

Rijsemus, C J V / Kok, N F M / Aalbers, A G J / Grotenhuis, B A / Berardi, E / Snaebjornsson, P / Lambregts, D M J / Beets-Tan, R G H / Lahaye, M J

European journal of radiology

2024 Volume 175, Page(s) 111478

Abstract: Purpose: Patients with colorectal peritoneal metastases (PM) treated with cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) are at high risk of recurrent disease. Understanding where and why recurrences occur is the first ...

Abstract	Purpose: Patients with colorectal peritoneal metastases (PM) treated with cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) are at high risk of recurrent disease. Understanding where and why recurrences occur is the first step in finding solutions to reduce recurrence rates. Although diffusion-weighted (DW) MRI is not routinely used in the follow-up of CRC patients, it has a clear advantage over CT in detecting the location and spread of (recurrent) PM. This study aimed to identify common locations of recurrence in CRC patients after CRS-HIPEC with MRI. Method: This was a single-centre retrospective study of patients with recurrent PM after CRS-HIPEC performed between January 2016 and August 2020. Patients were eligible for inclusion if they had both an MRI preoperatively (MRI1) and at the time of recurrent disease (MRI2). Two abdominal radiologists reviewed in consensus and categorized recurrences according to their location on MRI2 and in correlation with previous disease location on prior imaging (MRI1) and the surgical report of the CRS-HIPEC. Results: Thirty patients were included, with a median surgical PCI of 7 (range 3-21) at the time of primary CRS-HIPEC. In total, 68 recurrent metastases were detected on MRI2, of which 14 were extra-peritoneal. Of the remaining 54 PM, 42 (78%) occurred where the peritoneum was damaged due to earlier resections or other surgical procedures (e.g. inserted surgical abdominal drains). Most recurrent metastases were found in the mesentery, lower abdomen/pelvis and abdominal wall (87%). Conclusions: Most recurrent PMs appeared in the mesentery, lower abdomen/pelvis and abdominal wall, especially where the peritoneum was previously damaged.
Language	English
Publishing date	2024-04-22
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	138815-0
ISSN	1872-7727 ; 0720-048X
ISSN (online)	1872-7727
ISSN	0720-048X
DOI	10.1016/j.ejrad.2024.111478
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Zs.A 1630: Show issues

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Article ; Online: Treatment outcome in breast cancer patients with ipsilateral supraclavicular lymph node metastasis at time of diagnosis: a review of the literature.

Grotenhuis, B A / Klem, T M A L / Vrijland, W W

European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology

2013 Volume 39, Issue 3, Page(s) 207–212

Abstract: Introduction: In the revised 6th edition of the AJCC-TNM staging system for breast cancer, metastasis in ipsilateral supraclavicular lymph node(s) is considered as a locoregional disease and classified as N3c rather than M1 distant disease. The aim of ... ...

Abstract	Introduction: In the revised 6th edition of the AJCC-TNM staging system for breast cancer, metastasis in ipsilateral supraclavicular lymph node(s) is considered as a locoregional disease and classified as N3c rather than M1 distant disease. The aim of this review was to search the recent literature in order to investigate whether the reported treatment outcome of patients with ipsilateral supraclavicular metastases in breast cancer patients justifies this revision. Methods: A review of the recent English-language literature (January 2001-June 2012) concerning breast cancer with supraclavicular involvement was performed. Results: A total number of six studies were included in the current review. All reported comparable data with regard to treatment outcome after multimodality treatment, despite considerable heterogeneity in study populations. Patients with ipsilateral supraclavicular lymph node involvement showed outcomes more similar to locally advanced breast cancer patients rather than patients with distant tumor spread. Conclusion: It seems that the 2002 revision of the AJCC-TNM staging system for breast cancer has appropriately reclassified patients with supraclavicular disease to a new category (N3c).
MeSH term(s)	Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Breast Neoplasms/pathology ; Breast Neoplasms/therapy ; Clavicle ; Confounding Factors (Epidemiology) ; Female ; Humans ; Lymph Nodes/pathology ; Lymphatic Metastasis ; Mastectomy, Segmental ; Neoplasm Staging ; Radiotherapy, Adjuvant ; Remission Induction ; Treatment Outcome
Language	English
Publishing date	2013-03
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	632519-1
ISSN	1532-2157 ; 0748-7983
ISSN (online)	1532-2157
ISSN	0748-7983
DOI	10.1016/j.ejso.2012.11.002
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Zs.A 1149: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 549: Show issues

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Article ; Online: Radiofrequency ablation for early-stage breast cancer: treatment outcomes and practical considerations.

Grotenhuis, B A / Vrijland, W W / Klem, T M A L

European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology

2013 Volume 39, Issue 12, Page(s) 1317–1324

Abstract: Background: Radiofrequency ablation (RFA) for early-stage breast cancer has the potential advantage of being a less invasive treatment associated with improved cosmetic outcome. The aim of this review was to summarise the reported treatment outcomes of ... ...

Abstract	Background: Radiofrequency ablation (RFA) for early-stage breast cancer has the potential advantage of being a less invasive treatment associated with improved cosmetic outcome. The aim of this review was to summarise the reported treatment outcomes of ultrasound-guided RFA for early-stage breast cancer and to highlight practical considerations with regard to this treatment. Methods: A search of the English-language literature concerning RFA for breast cancer treatment was performed. Results: RFA is a technique that can be safely applied in patients with early-stage breast cancer, which is restricted to cT1-T2N0 ductal carcinoma with radiologically defined borders without any signs of multifocality or multicentricity. However, before RFA can be adopted as local therapy for early-stage breast cancer, more research is needed to assess the post-treatment pathological complete response and margin status, the long-term oncologic outcome in comparison to current standard breast conserving therapy and the potential cosmetic superiority of percutaneous RFA. Conclusion: RFA appeared to be a feasible technique for the treatment of early-stage breast cancer, but considerable practical considerations form an obstacle to introduce RFA as a standard of care.
MeSH term(s)	Breast Neoplasms/pathology ; Breast Neoplasms/surgery ; Carcinoma, Ductal, Breast/pathology ; Carcinoma, Ductal, Breast/surgery ; Catheter Ablation/adverse effects ; Catheter Ablation/methods ; Esthetics ; Female ; Humans ; Patient Selection ; Treatment Outcome ; Ultrasonography, Interventional
Language	English
Publishing date	2013-12
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	632519-1
ISSN	1532-2157 ; 0748-7983
ISSN (online)	1532-2157
ISSN	0748-7983
DOI	10.1016/j.ejso.2013.09.007
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Zs.MO 549: Show issues

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Article ; Online: The HIPPO Trial, a Randomized Double-blind Trial Comparing Self-gripping Parietex Progrip Mesh and Sutured Parietex Mesh in Lichtenstein Hernioplasty: A Long-term Follow-up Study.

Molegraaf, Marijke J / Grotenhuis, Brechtje / Torensma, Bart / de Ridder, Victor / Lange, Johan F / Swank, Dingeman J

Annals of surgery

2017 Volume 266, Issue 6, Page(s) 939–945

Abstract: Objective: To evaluate the effect of a self-gripping mesh (Progrip) on the incidence of chronic postoperative inguinal pain (CPIP) and recurrence rate after Lichtenstein hernioplasty.: Background: Chronic pain is the most common complication of ... ...

Abstract	Objective: To evaluate the effect of a self-gripping mesh (Progrip) on the incidence of chronic postoperative inguinal pain (CPIP) and recurrence rate after Lichtenstein hernioplasty. Background: Chronic pain is the most common complication of inguinal hernioplasty. One of the causes may be the use of sutures to secure the mesh. Methods: Adult male patients undergoing Lichtenstein hernioplasty for a primary unilateral inguinal hernia were randomized to a self-gripping polyester mesh or a sutured polyester mesh. Follow-up took place after 2 weeks, 3, 12, and 24 months. Pain and quality of life were assessed using the Verbal Rating Scale, Visual Analog Scale, and Short Form 36. CPIP was defined as moderate pain lasting at least 3 months postoperatively. Results: There were 165 patients in the Progrip mesh group and 166 patients in the sutured mesh group. The incidence of CPIP was 7.3% at 3 months declining to 4.6% at 24 months and did not differ between both groups. Pain and quality of life scores were significantly improved after 2 years. Hernia recurrence rate after 24 months was 2.4% for the Progrip mesh and 1.8% for the sutured mesh (P = 0.213). The mean duration of surgery was significant shorter with the Progrip mesh (44 vs 53 minutes, P < 0.001). Conclusions: The self-gripping Progrip mesh does not reduce CPIP rates. Outcomes of the Progrip mesh are comparable to the Lichtenstein technique with the additional advantage of a reduced operation time. NCT01830452.
Keywords	covid19
Language	English
Publishing date	2017-12
Publishing country	United States
Document type	Journal Article
ZDB-ID	340-2
ISSN	1528-1140 ; 0003-4932
ISSN (online)	1528-1140
ISSN	0003-4932
DOI	10.1097/SLA.0000000000002169
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Article ; Online: Cancer stem cells and their potential implications for the treatment of solid tumors.

Grotenhuis, B A / Wijnhoven, B P L / van Lanschot, J J B

Journal of surgical oncology

2012 Volume 106, Issue 2, Page(s) 209–215

Abstract: Background and objectives: There is increasing evidence that a variety of human cancers is maintained by a subset of cells, cancer stem cells (CSCs), which sustain tumor growth, underlie its malignant behavior, and possibly initiate distant metastases. ... ...

Abstract	Background and objectives: There is increasing evidence that a variety of human cancers is maintained by a subset of cells, cancer stem cells (CSCs), which sustain tumor growth, underlie its malignant behavior, and possibly initiate distant metastases. The aim of this review is to evaluate the current evidence for the existence of CSCs and the implications on the present management and treatment of solid tumors. Methods: A retrospective review of the English-language literature (1997-2010) concerning CSCs and their therapeutic implications was performed. Results: CSCs are characterized by two main properties of normal stem cells: Self-renewal and differentiation, which are best assayed by serial transplantation experiments in immunodeficient mice. Cell-surface antigens that mark cell populations enriched for CSCs have been identified in various solid tumors. As such, the very existence of CSCs has vast clinical implications with regard to cancer treatment. The development of tailor-made CSC-targeted therapies (including therapies directed at these CSC-specific surface markers, and reversal of the intrinsic resistance of CSCs to chemo- and radiotherapy) entails great promises. However, normal stem cell toxicity and treatment resistance have been recognized as serious problems. Conclusion: The growing evidence indicating that CSCs drive and maintain various types of solid human malignancies has important implications for the treatment of patients. However, over the years the development of CSC-targeted therapies has faced a number of potential hurdles, which must be considered carefully in order to maximize the chance that such therapies will be successful.
MeSH term(s)	ADP-ribosyl Cyclase 1/metabolism ; Animals ; Antigens, CD34/metabolism ; Antineoplastic Agents/therapeutic use ; Apoptosis/immunology ; Cell Transformation, Neoplastic/metabolism ; Cell Transformation, Neoplastic/pathology ; Humans ; Interleukin-4/immunology ; Mice ; Molecular Targeted Therapy ; Neoplasms/drug therapy ; Neoplasms/immunology ; Neoplasms/metabolism ; Neoplasms/pathology ; Neoplastic Stem Cells/metabolism ; Neoplastic Stem Cells/pathology ; Wnt Signaling Pathway
Chemical Substances	Antigens, CD34 ; Antineoplastic Agents ; Interleukin-4 (207137-56-2) ; ADP-ribosyl Cyclase 1 (EC 3.2.2.6)
Language	English
Publishing date	2012-08-01
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	82063-5
ISSN	1096-9098 ; 0022-4790
ISSN (online)	1096-9098
ISSN	0022-4790
DOI	10.1002/jso.23069
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Zs.A 706: Show issues

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Article: The surgical treatment of stage III empyema: the effect on lung function.

Grotenhuis, B A / Janssen, P J H / Eerenberg, J P

Minerva chirurgica

2008 Volume 63, Issue 1, Page(s) 23–27

Abstract: Aim: The aim of this study was to evaluate the surgical treatment of stage III empyema.: Methods: Between 2002 and 2005, 30 patients underwent surgery for treatment of diagnosed stage III empyema preoperatively. Patients were referred for spirometry ... ...

Abstract	Aim: The aim of this study was to evaluate the surgical treatment of stage III empyema. Methods: Between 2002 and 2005, 30 patients underwent surgery for treatment of diagnosed stage III empyema preoperatively. Patients were referred for spirometry to evaluate lung function postoperatively. Results: Twenty nine patients underwent primary thoracotomy because of an extended stage III empyema, 1 patient video-assisted thoracoscopic surgery (VATS). Mean age was 62 years. Mean period from onset of symptoms until hospital admission was 29 days and mean time interval between admission and surgery was 11 days. Intraoperative complication happened in one patient (3%), in whom a phrenic nerve lesion was diagnosed. Overall mortality rate was 3%. In 17 patients postoperative spirometry was performed, showing normal vital capacity in 59% of the patients. Conclusion: There was no reluctance in performing primary thoracotomy in our population with a stage III empyema. Decortication by means of thoracotomy restored the complete expansion of the lung; the authors claim that vital capacity returned to normal values, as it was shown by the spirometry results postoperatively. Early referral to the respiratory department in case of a non-responding pneumonia and early surgical consultation in case of a parapneumonic effusion, will prevent progression to an extensive organized stage III empyema requiring decortication by thoracotomy.
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Data Interpretation, Statistical ; Empyema, Pleural/diagnosis ; Empyema, Pleural/diagnostic imaging ; Empyema, Pleural/mortality ; Empyema, Pleural/physiopathology ; Empyema, Pleural/surgery ; Female ; Follow-Up Studies ; Humans ; Male ; Middle Aged ; Radiography, Thoracic ; Spirometry ; Thoracic Surgery, Video-Assisted ; Thoracoscopy ; Time Factors ; Tomography, X-Ray Computed ; Vital Capacity
Language	English
Publishing date	2008-02
Publishing country	Italy
Document type	Comparative Study ; Evaluation Studies ; Journal Article
ZDB-ID	123603-9
ISSN	1827-1626 ; 0026-4733
ISSN (online)	1827-1626
ISSN	0026-4733
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Article: Fixed Size of Enlarged Calcified Lymph Nodes in Esophageal Adenocarcinoma despite Complete Remission

Grotenhuis, B.A. / Wijnhoven, B.P.L. / Hermans, J.J. / Biermann, K. / van Lanschot, J.J.B.

Case Reports in Gastroenterology

2009 Volume 3, Issue 2, Page(s) 182–186

Abstract: Untreated malignant lymph nodes that are calcified are rare. Publications on such calcifications are restricted to case reports. We present a case of calcified lymph nodes in a patient with adenocarcinoma of the gastroesophageal junction that seemed to ... ...

Institution	Departments of Surgery Radiology and Pathology, Erasmus Medical Center, Erasmus University, Rotterdam, The Netherlands
Abstract	Untreated malignant lymph nodes that are calcified are rare. Publications on such calcifications are restricted to case reports. We present a case of calcified lymph nodes in a patient with adenocarcinoma of the gastroesophageal junction that seemed to be nonresponsive to induction chemotherapy, as they did not decrease in size. However, on pathological examination of the resected lymph nodes no vital tumor cells could be detected anymore. Therefore, we hypothesize that a calcified lymph node is unable to shrink, even after adequate remission on induction chemotherapy. This should be taken into account when clinical decision-making depends on the change in size of an enlarged, calcified lymph node as a measure of treatment effect.
Keywords	Response evaluation ; Esophageal adenocarcinoma ; Calcification ; Lymph node
Language	English
Publishing date	2009-07-03
Publisher	S. Karger AG
Publishing place	Basel, Switzerland
Document type	Article
ZDB-ID	2440540-1
ISSN	1662-0631 ; 1662-0631
ISSN (online)	1662-0631
ISSN	1662-0631
DOI	10.1159/000226253
Database	Karger publisher's database

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Article ; Online: Benzopyrene serum concentration after endovenous laser ablation of the great saphenous vein.

Klem, T M A L / Stok, M / Grotenhuis, B A / Faber, M J / van Leeuwen, S P J / Janssen, H / Vrijland, W W

Vascular and endovascular surgery

2013 Volume 47, Issue 3, Page(s) 213–215

Abstract: Background: During endovenous laser ablation (EVLA) of the great saphenous vein, patients often involuntarily mention an uncomfortable "burnt" smell and taste. When applying intense heat to proteins and carbohydrates, it is inevitable that polycyclic ... ...

Abstract	Background: During endovenous laser ablation (EVLA) of the great saphenous vein, patients often involuntarily mention an uncomfortable "burnt" smell and taste. When applying intense heat to proteins and carbohydrates, it is inevitable that polycyclic aromatic hydrocarbons (PAHs) are formed. This group of PAH includes the human carcinogen benzo[a]pyrene (B[a]P). This study determined the serum concentration of B[a]P just before and after EVLA. Methods: A total of 20 patients were included. The B[a]P serum concentration was determined just before and directly after EVLA. Results: In 18 patients, B[a]P was determined before and after EVLA. In 2 patients, EVLA was not possible. In this study, no elevated serum concentration of B[a]P was found before and after EVLA. Conclusion: It remains to be established which heat products cause the burnt smell and taste sensation in patients during EVLA. Further research is needed to determine whether EVLA can be considered as a safe procedure.
MeSH term(s)	Adult ; Aged ; Benzo(a)pyrene/analysis ; Biomarkers/blood ; Endovascular Procedures/adverse effects ; Female ; Hot Temperature ; Humans ; Laser Therapy/adverse effects ; Male ; Middle Aged ; Odorants ; Saphenous Vein/surgery ; Smell ; Taste ; Treatment Outcome ; Varicose Veins/diagnosis ; Varicose Veins/surgery
Chemical Substances	Biomarkers ; Benzo(a)pyrene (3417WMA06D)
Language	English
Publishing date	2013-04
Publishing country	United States
Document type	Journal Article
ZDB-ID	2076272-0
ISSN	1938-9116 ; 1538-5744
ISSN (online)	1938-9116
ISSN	1538-5744
DOI	10.1177/1538574413479179
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Article: Fixed Size of Enlarged Calcified Lymph Nodes in Esophageal Adenocarcinoma despite Complete Remission.

Grotenhuis, B A / Wijnhoven, B P L / Hermans, J J / Biermann, K / van Lanschot, J J B

Case reports in gastroenterology

2009 Volume 3, Issue 2, Page(s) 182–186

Abstract	Untreated malignant lymph nodes that are calcified are rare. Publications on such calcifications are restricted to case reports. We present a case of calcified lymph nodes in a patient with adenocarcinoma of the gastroesophageal junction that seemed to be nonresponsive to induction chemotherapy, as they did not decrease in size. However, on pathological examination of the resected lymph nodes no vital tumor cells could be detected anymore. Therefore, we hypothesize that a calcified lymph node is unable to shrink, even after adequate remission on induction chemotherapy. This should be taken into account when clinical decision-making depends on the change in size of an enlarged, calcified lymph node as a measure of treatment effect.
Language	English
Publishing date	2009-07-03
Publishing country	Switzerland
Document type	Case Reports
ZDB-ID	2440540-1
ISSN	1662-0631
ISSN	1662-0631
DOI	10.1159/000226253
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