LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 181

Search options

  1. Article ; Online: [No title information]

    Grove, Erik Lerkevang

    Ugeskrift for laeger

    2022  Volume 184, Issue 20

    Title translation Perioperativ håndtering af orale antikoagulantia: altid omtanke, men sjældent heparin.
    MeSH term(s) Anticoagulants ; Heparin ; Heparin, Low-Molecular-Weight ; Humans
    Chemical Substances Anticoagulants ; Heparin, Low-Molecular-Weight ; Heparin (9005-49-6)
    Language Danish
    Publishing date 2022-05-17
    Publishing country Denmark
    Document type Journal Article ; Comment
    ZDB-ID 124102-3
    ISSN 1603-6824 ; 0041-5782
    ISSN (online) 1603-6824
    ISSN 0041-5782
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  2. Article ; Online: Large atrial mass in a patient with Crohn's disease: organised thrombus mimicking a myxoma.

    Grove, Erik Lerkevang

    BMJ case reports

    2017  Volume 2017

    MeSH term(s) Adult ; Azathioprine/therapeutic use ; Coronary Thrombosis/complications ; Coronary Thrombosis/diagnostic imaging ; Coronary Thrombosis/surgery ; Crohn Disease/complications ; Crohn Disease/drug therapy ; Diagnosis, Differential ; Echocardiography, Transesophageal/methods ; Female ; Gastrointestinal Agents ; Heart Atria/diagnostic imaging ; Heart Atria/surgery ; Humans ; Immunosuppressive Agents ; Incidental Findings ; Infliximab/therapeutic use ; Myxoma ; Tomography, X-Ray Computed/methods
    Chemical Substances Gastrointestinal Agents ; Immunosuppressive Agents ; Infliximab (B72HH48FLU) ; Azathioprine (MRK240IY2L)
    Language English
    Publishing date 2017-08-22
    Publishing country England
    Document type Case Reports ; Journal Article
    ISSN 1757-790X
    ISSN (online) 1757-790X
    DOI 10.1136/bcr-2017-222044
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  3. Article ; Online: Drug-Drug Interactions in the Treatment of Cancer-Associated Venous Thromboembolism with Direct Oral Anticoagulants.

    Hellfritzsch, Maja / Henriksen, Jakob Nørgaard / Holt, Marianne Ingerslev / Grove, Erik Lerkevang

    Seminars in thrombosis and hemostasis

    2023  Volume 50, Issue 3, Page(s) 489–498

    Abstract: Venous thromboembolism (VTE) is a frequent complication of cancer, and management of cancer-associated thrombosis (CAT) is challenging due to increased risks of bleeding and recurrent VTE. Recent trials have shown an acceptable efficacy and safety of ... ...

    Abstract Venous thromboembolism (VTE) is a frequent complication of cancer, and management of cancer-associated thrombosis (CAT) is challenging due to increased risks of bleeding and recurrent VTE. Recent trials have shown an acceptable efficacy and safety of direct oral anticoagulants (DOACs) in the treatment of CAT compared to low-molecular weight heparin. Although DOACs provide an effective and convenient treatment option in CAT, the need to assess the risk of drug-drug interactions (DDI) with antineoplastic therapies poses a barrier to their use in clinical practice. With the aim of supporting the assessment of CAT patients for treatment with DOAC, this review provides a comprehensive overview of the compatibility of antineoplastic therapies with the individual DOACs (apixaban, dabigatran, edoxaban, and rivaroxaban). Using several data sources, we characterized 100 widely used antineoplastic agents with regard to their effect on p-glycoprotein and cytochrome P450, both important in the transport and elimination of DOACs. This enabled us to evaluate 400 "DOAC-antineoplastic agent"-pairs regarding their likelihood to interact (unlikely, potential, or likely), ultimately leading to clinical recommendations on the appropriateness of concomitant use for each pair. A potential or likely DDI was identified for 12% of the evaluated pairs. For nearly all antineoplastic agents, at least one DOAC was considered compatible.
    MeSH term(s) Humans ; Venous Thromboembolism/etiology ; Venous Thromboembolism/complications ; Anticoagulants/therapeutic use ; Dabigatran/therapeutic use ; Rivaroxaban/therapeutic use ; Neoplasms/complications ; Neoplasms/drug therapy ; Antineoplastic Agents/adverse effects ; Drug Interactions ; Administration, Oral
    Chemical Substances Anticoagulants ; Dabigatran (I0VM4M70GC) ; Rivaroxaban (9NDF7JZ4M3) ; Antineoplastic Agents
    Language English
    Publishing date 2023-02-02
    Publishing country United States
    Document type Review ; Journal Article
    ZDB-ID 196901-8
    ISSN 1098-9064 ; 0094-6176
    ISSN (online) 1098-9064
    ISSN 0094-6176
    DOI 10.1055/s-0043-1762596
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  4. Article ; Online: Contemporary Clinical Use of Aspirin: Mechanisms of Action, Current Concepts, Unresolved Questions, and Future Perspectives.

    Christiansen, Mikael / Grove, Erik Lerkevang / Hvas, Anne-Mette

    Seminars in thrombosis and hemostasis

    2021  Volume 47, Issue 7, Page(s) 800–814

    Abstract: The ability of aspirin to inhibit platelet aggregation has positioned this agent within the most frequently used drugs worldwide. The aim of this article is to review the contemporary clinical use of aspirin and also to discuss unresolved issues not yet ... ...

    Abstract The ability of aspirin to inhibit platelet aggregation has positioned this agent within the most frequently used drugs worldwide. The aim of this article is to review the contemporary clinical use of aspirin and also to discuss unresolved issues not yet translated into clinical practice. Results from several clinical trials have led to strong guideline recommendations for aspirin use in the acute management and secondary prevention of cardiovascular disease. On the contrary, guidelines regarding aspirin use as primary prevention of cardiovascular disease are almost conservative, supported by recent trials reporting that the bleeding risk outweighs the potential benefits in most patients. In pregnancy, aspirin has proved efficient in preventing preeclampsia and small-for-gestational-age births in women at high risk, and is hence widely recommended in clinical guidelines. Despite the vast amount of clinical data on aspirin, several unresolved questions remain. Randomized trials have reported that aspirin reduces the risk of recurrent venous thromboembolism, but the clinical relevance remains limited, because direct oral anticoagulants are more effective. Laboratory studies suggest that a twice-daily dosing regimen or evening intake may lead to more efficient platelet inhibition, and the potential clinical benefit of such strategies is currently being explored in ongoing clinical trials. Enteric-coated formulations of aspirin are frequently used, but it remains unclear if they are safer and as efficient as plain aspirin. In the future, aspirin use after percutaneous coronary interventions might not be mandatory in patients who also need anticoagulant therapy, as several trials support shorter aspirin duration strategies. On the other hand, new treatment indications for aspirin will likely arise, as there is growing evidence that aspirin may reduce the risk of colorectal cancer and other types of cancer.
    MeSH term(s) Anticoagulants ; Aspirin/therapeutic use ; Clinical Trials as Topic ; Female ; Humans ; Platelet Aggregation ; Platelet Aggregation Inhibitors/therapeutic use ; Pregnancy ; Venous Thromboembolism
    Chemical Substances Anticoagulants ; Platelet Aggregation Inhibitors ; Aspirin (R16CO5Y76E)
    Language English
    Publishing date 2021-06-15
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 196901-8
    ISSN 1098-9064 ; 0094-6176
    ISSN (online) 1098-9064
    ISSN 0094-6176
    DOI 10.1055/s-0041-1726096
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  5. Article ; Online: A 19-Year-Old Man with a History of Recreational Inhalation of Nitrous Oxide with Severe Peripheral Neuropathy and Central Pulmonary Embolism.

    Pedersen, Oliver Buchhave / Hvas, Anne-Mette / Grove, Erik Lerkevang

    The American journal of case reports

    2021  Volume 22, Page(s) e931936

    Abstract: BACKGROUND Recreational use of nitrous oxide (laughing gas) is a growing phenomenon among young people due to easy accessibility and a presumed innocent effect. However, complications have been reported, especially following high and long-term use, ... ...

    Abstract BACKGROUND Recreational use of nitrous oxide (laughing gas) is a growing phenomenon among young people due to easy accessibility and a presumed innocent effect. However, complications have been reported, especially following high and long-term use, including nerve damage, spontaneous pneumo-mediastinum, myocardial infarction, and macrocytic anemia. CASE REPORT We report a case of a 19-year-old previously healthy man with occasional recreational use of nitrous oxide of up to 10 times within recent months, who presented with severe peripheral neuropathy. Laboratory examination revealed severely elevated homocysteine values of 92 µmol/L (reference range, <10 µmol/L), strongly elevated methylmalonic acid level of >10 µmol/L (range, 0.1-0.4 µmol/L), vitamin B₁₂ level of 234 pmol/L (range, 200-600 pmol/L), hemoglobin level of 9.3 mmol/L (range, 8.3-10.5 mmol/L), platelets of 384×10⁹/L (range, 145-350×10⁹/L), and leucocytes of 6.2×10⁹/L (range, 3.5-10.0×10⁹/L). Nitrous oxide can result in vitamin B₁₂ inactivation and nerve damage due to lack of myelination. During hospitalization, the patient had a bilateral central pulmonary embolism, probably caused by a combination of nitrous oxide abuse and some extent of immobilization. After 6 months of nitrous oxide cessation and treatment with B vitamins, the patient experienced almost no residual symptoms, and homocysteine and methylmalonic acid levels normalized. CONCLUSIONS Our case shows that even moderate recreational use of nitrous oxide can lead to severe peripheral neuropathy as well as increase the risk of thromboembolic complications. Especially young and previously healthy individuals presenting with unexplained neuropathy or thromboembolic events should therefore be asked about possible use of nitrous oxide.
    MeSH term(s) Adolescent ; Adult ; Humans ; Male ; Nitrous Oxide/adverse effects ; Peripheral Nervous System Diseases ; Pulmonary Embolism/chemically induced ; Vitamin B 12 ; Vitamin B 12 Deficiency/chemically induced ; Vitamin B 12 Deficiency/complications ; Young Adult
    Chemical Substances Nitrous Oxide (K50XQU1029) ; Vitamin B 12 (P6YC3EG204)
    Language English
    Publishing date 2021-08-11
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 2517183-5
    ISSN 1941-5923 ; 1941-5923
    ISSN (online) 1941-5923
    ISSN 1941-5923
    DOI 10.12659/AJCR.931936
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  6. Article ; Online: Safety and effectiveness of direct oral anticoagulants in patients with nephrotic syndrome: a report of 21 cases.

    Kelddal, Sarah / Hvas, Anne-Mette / Grove, Erik Lerkevang / Birn, Henrik

    BMC nephrology

    2022  Volume 23, Issue 1, Page(s) 305

    Abstract: Background: Nephrotic syndrome (NS) is associated with increased risk of thromboembolic events (TE) adding to the morbidity and mortality. International guidelines recommend prophylactic anticoagulation in patients with NS and high risk of TE, but no ... ...

    Abstract Background: Nephrotic syndrome (NS) is associated with increased risk of thromboembolic events (TE) adding to the morbidity and mortality. International guidelines recommend prophylactic anticoagulation in patients with NS and high risk of TE, but no studies have identified the optimal type of anticoagulation in NS. We aimed to assess the effectiveness and safety of direct oral anticoagulant (DOAC) by analyzing the thromboembolic and bleeding events in NS patients prescribed DOAC as primary prophylaxis to prevent TE or as treatment for TE occurring in relation to NS.
    Methods: We performed a single-center, retrospective study including patients with NS, a plasma albumin less than 25 g/L and prophylactic anticoagulation treatment with DOAC at the Department of Renal Medicine at Aarhus University Hospital, Denmark from July 2016 to June 2021. Patients treated with DOAC as thromboprophylaxis for other indications than NS were excluded. Baseline characteristics and outcomes, including TE, bleeding and other adverse effects associated with DOAC were obtained from medical records.
    Results: We identified 268 patients treated with DOAC of which 21 patients with NS were included in the study. Nineteen patients were prescribed DOAC as thromboprophylaxis and two patients received DOAC due to previous TE, which was considered associated with the NS. The type of DOAC prescribed was apixaban (n = 10) and rivaroxaban (n = 11). No patients experienced TE during DOAC treatment, while five patients had a minor bleeding episode. Patients who experienced bleeding episodes were older (median 62 vs 51 years), more often female (80%) and had been on DOAC for a longer period (204 days vs 47 days). Neither the HAS-BLED score nor GN-risk-score predicted the risk of minor bleedings in this population.
    Conclusions: In this case series, no new TE and only minor bleeding complications were observed among adult NS patients treated with DOAC.
    MeSH term(s) Administration, Oral ; Adult ; Anticoagulants/adverse effects ; Atrial Fibrillation/complications ; Female ; Hemorrhage/chemically induced ; Hemorrhage/epidemiology ; Humans ; Nephrotic Syndrome/chemically induced ; Nephrotic Syndrome/complications ; Nephrotic Syndrome/drug therapy ; Retrospective Studies ; Venous Thromboembolism/chemically induced ; Venous Thromboembolism/complications ; Venous Thromboembolism/drug therapy
    Chemical Substances Anticoagulants
    Language English
    Publishing date 2022-09-05
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 2041348-8
    ISSN 1471-2369 ; 1471-2369
    ISSN (online) 1471-2369
    ISSN 1471-2369
    DOI 10.1186/s12882-022-02929-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  7. Article ; Online: Hudnekrose og følgevirkninger efter utilsigtet subkutan indgift af amiodaron.

    Grove, Erik Lerkevang

    Ugeskrift for laeger

    2015  Volume 177, Issue 24

    Title translation Skin necrosis and consequences of accidental subcutaneous administration of amiodarone.
    MeSH term(s) Aged ; Amiodarone/administration & dosage ; Amiodarone/adverse effects ; Anti-Arrhythmia Agents/administration & dosage ; Anti-Arrhythmia Agents/adverse effects ; Drug Eruptions/etiology ; Hand/pathology ; Humans ; Male ; Necrosis/chemically induced ; Skin/pathology
    Chemical Substances Anti-Arrhythmia Agents ; Amiodarone (N3RQ532IUT)
    Language Danish
    Publishing date 2015-06-02
    Publishing country Denmark
    Document type Case Reports
    ZDB-ID 124102-3
    ISSN 1603-6824 ; 0041-5782
    ISSN (online) 1603-6824
    ISSN 0041-5782
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  8. Article ; Online: Antithrombotic treatment for chronic coronary syndrome: Evidence and future perspectives.

    Kulasingam, Archana / Pareek, Manan / Gragnano, Felice / Würtz, Morten / Pryds, Kasper / Calabrò, Paolo / Grove, Erik Lerkevang

    Cardiology

    2024  

    Abstract: Background The clinical presentation of coronary artery disease can range from asymptomatic, through stable disease in the form of chronic coronary syndrome, to acute coronary syndrome. Chronic coronary syndrome is a frequent condition, and secondary ... ...

    Abstract Background The clinical presentation of coronary artery disease can range from asymptomatic, through stable disease in the form of chronic coronary syndrome, to acute coronary syndrome. Chronic coronary syndrome is a frequent condition, and secondary prevention of ischaemic events is essential. Summary Antithrombotic therapy is a key component of secondary prevention strategies, and it may vary in type and intensity depending on patient characteristics, comorbidities, and revascularisation modalities. Dual antiplatelet therapy is the default strategy in patients with chronic coronary syndrome and recent coronary stent implantation, while antiplatelet monotherapy is commonly prescribed for long-term prevention of cardiovascular events. Oral anticoagulation, in combination with antiplatelet therapy or alone, is used in patients with e.g., concomitant atrial fibrillation or venous thromboembolism. Key messages This review provides an overview of antithrombotic treatment strategies in patients with chronic coronary syndrome. Key messages from current guidelines are conveyed, and we provide future perspectives on long-term antithrombotic strategies.
    Language English
    Publishing date 2024-02-14
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 80092-2
    ISSN 1421-9751 ; 0008-6312
    ISSN (online) 1421-9751
    ISSN 0008-6312
    DOI 10.1159/000537706
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  9. Article ; Online: Immature platelets and cardiovascular events in patients with stable coronary artery disease.

    Pedersen, Oliver Buchhave / Larsen, Sanne Bøjet / Kristensen, Steen Dalby / Hvas, Anne-Mette / Grove, Erik Lerkevang

    Platelets

    2023  Volume 34, Issue 1, Page(s) 2217960

    Abstract: Many patients with coronary artery disease (CAD) have reduced the effect of aspirin, which may partly be explained by immature platelets. We aimed to investigate whether immature platelet markers can predict cardiovascular events in a large cohort of ... ...

    Abstract Many patients with coronary artery disease (CAD) have reduced the effect of aspirin, which may partly be explained by immature platelets. We aimed to investigate whether immature platelet markers can predict cardiovascular events in a large cohort of stable CAD patients. A total of 900 stable CAD patients were included and followed for a median of 3 years. We measured markers of immature platelets (platelet count, immature platelet count, immature platelet fraction, mean platelet volume, platelet distribution width, platelet mass, and thrombopoietin) using automated flow cytometry and studied their relation to cardiovascular events. Our primary endpoint was a composite of acute myocardial infarction (MI), ischemic stroke, and cardiovascular death. A composite of MI, ischemic stroke, stent thrombosis and all-cause mortality was analyzed as a secondary endpoint. We found no difference in immature platelet markers between CAD patients with or without cardiovascular events. Regression analysis using hazards rates showed that markers of immature platelets did not have any predictive value for endpoints (p-values >.05). Markers of immature platelets did not predict future cardiovascular events during a 3-year follow-up period in CAD patients. This suggests that immature platelets measured in a stable phase does not have a major role in predicting future cardiovascular events.
    MeSH term(s) Humans ; Coronary Artery Disease/complications ; Blood Platelets ; Myocardial Infarction/complications ; Aspirin/adverse effects ; Ischemic Stroke/complications ; Platelet Aggregation Inhibitors/adverse effects
    Chemical Substances Aspirin (R16CO5Y76E) ; Platelet Aggregation Inhibitors
    Language English
    Publishing date 2023-05-25
    Publishing country England
    Document type Journal Article
    ZDB-ID 1034283-7
    ISSN 1369-1635 ; 0953-7104
    ISSN (online) 1369-1635
    ISSN 0953-7104
    DOI 10.1080/09537104.2023.2217960
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  10. Article ; Online: Performance-based outcome measures for assessing physical capacity in patients with pulmonary embolism: A scoping review.

    Caspersen, Christina Krogner / Ingemann-Molden, Stian / Grove, Erik Lerkevang / Højen, Anette Arbjerg / Andreasen, Jane / Klok, Frederikus A / Rolving, Nanna

    Thrombosis research

    2024  Volume 235, Page(s) 52–67

    Abstract: Introduction: Up to 50 % of patients surviving a pulmonary embolism (PE) report persisting shortness of breath, reduced physical capacity and psychological distress. As the PE population is heterogeneous compared to other cardiovascular patient groups, ... ...

    Abstract Introduction: Up to 50 % of patients surviving a pulmonary embolism (PE) report persisting shortness of breath, reduced physical capacity and psychological distress. As the PE population is heterogeneous compared to other cardiovascular patient groups, outcome measures for assessing physical capacity traditionally used in cardiac populations may not be reliable for the PE population as a whole. This scoping review aims to 1) map performance-based outcome measures (PBOMs) used for assessing physical capacity in PE research, and 2) to report the psychometric properties of the identified PBOMs in a PE population.
    Methods: The review was conducted according to the Joanna Briggs Institute framework for scoping reviews and reported according to the PRISMA-Extension for Scoping Reviews guideline.
    Results: The systematic search of five databases identified 4585 studies, of which 243 studies met the inclusion criteria. Of these, 185 studies focused on a subgroup of patients with chronic thromboembolic pulmonary hypertension. Ten different PBOMs were identified in the included studies. The 6-minute walk test (6MWT) and cardiopulmonary exercise test (CPET) were the most commonly used, followed by the (Modified) Bruce protocol and Incremental Shuttle Walk test. No studies reported psychometric properties of any of the identified PBOMs in a PE population.
    Conclusions: Publication of studies measuring physical capacity within PE populations has increased significantly over the past 5-10 years. Still, not one study was identified, reporting the validity, reliability, or responsiveness for any of the identified PBOMs in a PE population. This should be a priority for future research in the field.
    MeSH term(s) Humans ; Reproducibility of Results ; Exercise Test ; Pulmonary Embolism/diagnosis ; Psychometrics ; Outcome Assessment, Health Care
    Language English
    Publishing date 2024-01-15
    Publishing country United States
    Document type Systematic Review ; Journal Article ; Review
    ZDB-ID 121852-9
    ISSN 1879-2472 ; 0049-3848
    ISSN (online) 1879-2472
    ISSN 0049-3848
    DOI 10.1016/j.thromres.2024.01.008
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

To top