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Article ; Online: Factors associated with blood mercury concentrations and their interactions with three glutathione S-transferase genes (GSTT1, GSTM1, and GSTP1): an exposure assessment study of typically developing Jamaican children.

Zaman, Sheikh Farzana / Samms-Vaughan, Maureen / Saroukhani, Sepideh / Bressler, Jan / Hessabi, Manouchehr / Grove, Megan L / Pellington, Sydonnie Shakespeare / Loveland, Katherine A / Rahbar, Mohammad H

BMC pediatrics

2024 Volume 24, Issue 1, Page(s) 14

Abstract: Background: Jamaican soil is abundant in heavy metals including mercury (Hg). Due to availability and ease of access, fish is a traditional dietary component in Jamaica and a significant source of Hg exposure. Mercury is a xenobiotic and known neuro- ... ...

Abstract	Background: Jamaican soil is abundant in heavy metals including mercury (Hg). Due to availability and ease of access, fish is a traditional dietary component in Jamaica and a significant source of Hg exposure. Mercury is a xenobiotic and known neuro-toxicant that affects children's neurodevelopment. Human glutathione S-transferase (GST) genes, including GSTT1, GSTM1, and GSTP1, affect Hg conjugation and elimination mechanisms. Methods: In this exposure assessment study we used data from 375 typically developing (TD) 2-8-year-old Jamaican children to explore the association between environmental Hg exposure, GST genes, and their interaction effects on blood Hg concentrations (BHgCs). We used multivariable general linear models (GLMs). Results: We identified the child's age, consumption of saltwater fish, canned fish (sardine, mackerel), string beans, grain, and starches (pasta, macaroni, noodles) as the environmental factors significantly associated with BHgCs (all P < 0.05). A significant interaction between consumption of canned fish (sardine, mackerel) and GSTP1 in relation to BHgC using either a co-dominant or recessive genetic model (overall interaction P = 0.01 and P < 0.01, respectively) indicated that consumption of canned fish (sardine, mackerel) was significantly associated with higher mean BHgC only among children with the GSTP1 Ile105Val, Ile/Ile [Ratio of mean Hg (95% CI) = 1.59 (1.09, 2.32), P = 0.02] and Ile/Val [Ratio of mean Hg (95% CI) = 1.46 (1.12, 1.91), P = 0.01] genotypes. Conclusions: Since this is the first study from Jamaica to report these findings, replication in other populations is recommended.
MeSH term(s)	Child ; Child, Preschool ; Humans ; Case-Control Studies ; Genetic Predisposition to Disease ; Genotype ; Glutathione Transferase/genetics ; Jamaica ; Mercury/blood ; Polymorphism, Genetic ; Risk Factors
Chemical Substances	Glutathione Transferase (EC 2.5.1.18) ; GSTP1 protein, human (EC 2.5.1.18) ; Mercury (FXS1BY2PGL) ; glutathione S-transferase M1 (EC 2.5.1.18) ; glutathione S-transferase T1 (EC 2.5.1.-)
Language	English
Publishing date	2024-01-04
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
ZDB-ID	2041342-7
ISSN	1471-2431 ; 1471-2431
ISSN (online)	1471-2431
ISSN	1471-2431
DOI	10.1186/s12887-023-04452-w
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Article ; Online: Metabolomic profiles in Jamaican children with and without autism spectrum disorder.

Yazdani, Akram / Samms-Vaughan, Maureen / Saroukhani, Sepideh / Bressler, Jan / Hessabi, Manouchehr / Tahanan, Amirali / Grove, Megan L / Gangnus, Tanja / Putluri, Vasanta / Mostafa Kamal, Abu Hena / Putluri, Nagireddy / Loveland, Katherine A / Rahbar, Mohammad H

ArXiv

2024

Abstract: Background: Autism spectrum disorder (ASD) is a complex neurodevelopmental condition with a wide range of behavioral and cognitive impairments. While genetic and environmental factors are known to contribute to its etiology, the underlying metabolic ... ...

Abstract	Background: Autism spectrum disorder (ASD) is a complex neurodevelopmental condition with a wide range of behavioral and cognitive impairments. While genetic and environmental factors are known to contribute to its etiology, the underlying metabolic perturbations associated with ASD which can potentially connect genetic and environmental factors, remain poorly understood. Therefore, we conducted a metabolomic case-control study and performed a comprehensive analysis to identify significant alterations in metabolite profiles between children with ASD and typically developing (TD) controls. Objective: To elucidate potential metabolomic signatures associated with ASD in children and identify specific metabolites that may serve as biomarkers for the disorder. Methods: We conducted metabolomic profiling on plasma samples from participants in the second phase of Epidemiological Research on Autism in Jamaica (ERAJ-2), which was a 1:1 age (±6 months)-and sex-matched cohort of 200 children with ASD and 200 TD controls (2-8 years old). Using high-throughput liquid chromatography-mass spectrometry techniques, we performed a targeted metabolite analysis, encompassing amino acids, lipids, carbohydrates, and other key metabolic compounds. After quality control and imputation of missing values, we performed univariable and multivariable analysis using normalized metabolites while adjusting for covariates, age, sex, socioeconomic status, and child's parish of birth. Results: Our findings revealed unique metabolic patterns in children with ASD for four metabolites compared to TD controls. Notably, three of these metabolites were fatty acids, including myristoleic acid, eicosatetraenoic acid, and octadecenoic acid. Additionally, the amino acid sarcosine exhibited a significant association with ASD. Conclusions: These findings highlight the role of metabolites in the etiology of ASD and suggest opportunities for the development of targeted interventions.
Language	English
Publishing date	2024-03-11
Publishing country	United States
Document type	Preprint
ISSN	2331-8422
ISSN (online)	2331-8422
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Article ; Online: X-linked genetic associations in sporadic thoracic aortic dissection.

Musfee, Fadi I / Jun, Goo / Mitchell, Laura E / Chen, Han / Guo, Dongchuan / Prakash, Siddharth K / Adkar, Shaunak Sanjay / Grove, Megan L / Choi, Ryan Bohyun / Klarin, Derek / Boerwinkle, Eric / Milewicz, Dianna M

American journal of medical genetics. Part A

2024 , Page(s) e63644

Abstract: The male predominance in sporadic thoracic aortic aneurysm and dissection (TAD) suggests that the X chromosome contributes to TAD, but this has not been tested. We investigated whether X-linked variation-common (minor allele frequency [MAF] ≥0.01) and ... ...

Abstract	The male predominance in sporadic thoracic aortic aneurysm and dissection (TAD) suggests that the X chromosome contributes to TAD, but this has not been tested. We investigated whether X-linked variation-common (minor allele frequency [MAF] ≥0.01) and rare (MAF <0.01)-was associated with sporadic TAD in three cohorts of European descent (Discovery: 364 cases, 874 controls; Replication: 516 cases, 440,131 controls, and ARIC [Atherosclerosis Risk in Communities study]: 753 cases, 2247 controls). For analysis of common variants, we applied a sex-stratified logistic regression model followed by a meta-analysis of sex-specific odds ratios. Furthermore, we conducted a meta-analysis of overlapping common variants between the Discovery and Replication cohorts. For analysis of rare variants, we used a sex-stratified optimized sequence kernel association test model. Common variants results showed no statistically significant findings in the Discovery cohort. An intergenic common variant near SPANXN1 was statistically significant in the Replication cohort (p = 1.81 × 10
Language	English
Publishing date	2024-04-30
Publishing country	United States
Document type	Journal Article
ZDB-ID	2108614-X
ISSN	1552-4833 ; 0148-7299 ; 1552-4825
ISSN (online)	1552-4833
ISSN	0148-7299 ; 1552-4825
DOI	10.1002/ajmg.a.63644
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Article ; Online: Gut Microbiota and Blood Metabolites Related to Fiber Intake and Type 2 Diabetes.

Wang, Zheng / Peters, Brandilyn A / Yu, Bing / Grove, Megan L / Wang, Tao / Xue, Xiaonan / Thyagarajan, Bharat / Daviglus, Martha L / Boerwinkle, Eric / Hu, Gang / Mossavar-Rahmani, Yasmin / Isasi, Carmen R / Knight, Rob / Burk, Robert D / Kaplan, Robert C / Qi, Qibin

Circulation research

2024 Volume 134, Issue 7, Page(s) 842–854

Abstract: Background: Consistent evidence suggests diabetes-protective effects of dietary fiber intake. However, the underlying mechanisms, particularly the role of gut microbiota and host circulating metabolites, are not fully understood. We aimed to investigate ...

Abstract	Background: Consistent evidence suggests diabetes-protective effects of dietary fiber intake. However, the underlying mechanisms, particularly the role of gut microbiota and host circulating metabolites, are not fully understood. We aimed to investigate gut microbiota and circulating metabolites associated with dietary fiber intake and their relationships with type 2 diabetes (T2D). Methods: This study included up to 11 394 participants from the HCHS/SOL (Hispanic Community Health Study/Study of Latinos). Diet was assessed with two 24-hour dietary recalls at baseline. We examined associations of dietary fiber intake with gut microbiome measured by shotgun metagenomics (350 species/85 genera and 1958 enzymes; n=2992 at visit 2), serum metabolome measured by untargeted metabolomics (624 metabolites; n=6198 at baseline), and associations between fiber-related gut bacteria and metabolites (n=804 at visit 2). We examined prospective associations of serum microbial-associated metabolites (n=3579 at baseline) with incident T2D over 6 years. Results: We identified multiple bacterial genera, species, and related enzymes associated with fiber intake. Several bacteria (eg, Conclusions: Among United States Hispanics/Latinos, dietary fiber intake was associated with favorable profiles of gut microbiota and circulating metabolites for T2D. These findings advance our understanding of the role of gut microbiota and microbial metabolites in the relationship between diet and T2D.
MeSH term(s)	Humans ; Gastrointestinal Microbiome ; Diabetes Mellitus, Type 2/diagnosis ; Diabetes Mellitus, Type 2/microbiology ; Diet ; Bacteria ; Dietary Fiber
Chemical Substances	Dietary Fiber
Language	English
Publishing date	2024-03-28
Publishing country	United States
Document type	Journal Article
ZDB-ID	80100-8
ISSN	1524-4571 ; 0009-7330 ; 0931-6876
ISSN (online)	1524-4571
ISSN	0009-7330 ; 0931-6876
DOI	10.1161/CIRCRESAHA.123.323634
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Ui IV Zs.70: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
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Article: Detoxification Role of Metabolic Glutathione S-Transferase (GST) Genes in Blood Lead Concentrations of Jamaican Children with and without Autism Spectrum Disorder

Rahbar, Mohammad H. / Samms-Vaughan, Maureen / Kim, Sori / Saroukhani, Sepideh / Bressler, Jan / Hessabi, Manouchehr / Grove, Megan L. / Shakspeare-Pellington, Sydonnie / Loveland, Katherine A.

Genes. 2022 May 29, v. 13, no. 6

2022

Abstract: Glutathione S-transferases (GST) are involved in the detoxification of exogenous chemicals including lead (Pb). Using data from 344 pairs of autism spectrum disorder (ASD) cases and age- and sex-matched typically developing (TD) controls (2–8 years old) ... ...

Abstract	Glutathione S-transferases (GST) are involved in the detoxification of exogenous chemicals including lead (Pb). Using data from 344 pairs of autism spectrum disorder (ASD) cases and age- and sex-matched typically developing (TD) controls (2–8 years old) from Jamaica, we investigated the interaction between three GST genes and ASD status as determinants of blood Pb concentrations (BPbCs). We found that ASD cases had lower geometric mean BPbCs than TD children (1.74 vs. 2.27 µg/dL, p < 0.01). Using a co-dominant genetic model, ASD cases with the Ile/Val genotype for the GSTP1 Ile105Val polymorphism had lower GM BPbCs than TD controls, after adjusting for a known interaction between GSTP1 and GSTT1, child’s parish, socioeconomic status, consumption of lettuce, fried plantains, and canned fish (Ile/Val: 1.78 vs. 2.13 µg/dL, p = 0.03). Similarly, among carriers of the I/I or I/D (I) genotype for GSTT1 and GSTM1, ASD cases had lower adjusted GM BPbCs than TD controls (GSTT1 I: 1.61 vs. 1.91 µg/dL, p = 0.01; GSTM1 I*: 1.71 vs. 2.04 µg/dL, p = 0.01). Our findings suggest that genetic polymorphisms in GST genes may influence detoxification of Pb by the enzymes they encode in Jamaican children with and without ASD.
Keywords	autism ; blood ; canned fish ; children ; genetic models ; genotype ; glutathione transferase ; lead ; lettuce ; socioeconomic status ; Jamaica
Language	English
Dates of publication	2022-0529
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
ZDB-ID	2527218-4
ISSN	2073-4425
ISSN	2073-4425
DOI	10.3390/genes13060975
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Article ; Online: Correlation between concentrations of four heavy metals in cord blood and childhood blood of Jamaican children.

Rahbar, Mohammad H / Samms-Vaughan, Maureen / Hessabi, Manouchehr / Bressler, Jan / Gillani, Shezeen / Grove, Megan L / Shakspeare-Pellington, Sydonnie / Loveland, Katherine A

Journal of environmental science and health. Part A, Toxic/hazardous substances & environmental engineering

2021 Volume 56, Issue 11, Page(s) 1196–1205

Abstract: This study investigated whether the concentrations of four metals [lead (Pb), mercury (Hg), manganese (Mn), and aluminum (Al)] are correlated in cord blood and childhood blood samples from Jamaican children. Cord blood samples were obtained from 21 ... ...

Abstract	This study investigated whether the concentrations of four metals [lead (Pb), mercury (Hg), manganese (Mn), and aluminum (Al)] are correlated in cord blood and childhood blood samples from Jamaican children. Cord blood samples were obtained from 21 pregnant women enrolled in the second Jamaican Birth Cohort Study from July 1, 2011 to September 30, 2011, and blood samples were drawn from their children who participated in a follow up study when the children were 4-8 years old. Correlations were assessed by the Pearson or the Spearman's rank correlation coefficient. The mean ages of children at the childhood visit and their mother at the child's birth were 5.5 years and 29.8 years, respectively. About 47.6% of children were male. Statistically significant correlations between cord blood and childhood blood concentrations of Pb (
MeSH term(s)	Cadmium ; Child ; Child, Preschool ; Cohort Studies ; Female ; Fetal Blood ; Follow-Up Studies ; Humans ; Jamaica ; Male ; Metals, Heavy ; Pregnancy
Chemical Substances	Metals, Heavy ; Cadmium (00BH33GNGH)
Language	English
Publishing date	2021-09-20
Publishing country	England
Document type	Journal Article
ZDB-ID	196584-0
ISSN	1532-4117 ; 0360-1226 ; 1077-1204 ; 1093-4529
ISSN (online)	1532-4117
ISSN	0360-1226 ; 1077-1204 ; 1093-4529
DOI	10.1080/10934529.2021.1973821
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Article: Correlation between concentrations of four heavy metals in cord blood and childhood blood of Jamaican children

Rahbar, Mohammad H. / Samms-Vaughan, Maureen / Hessabi, Manouchehr / Bressler, Jan / Gillani, Shezeen / Grove, Megan L. / Shakspeare-Pellington, Sydonnie / Loveland, Katherine A.

Journal of environmental science and health. 2021 Sept. 19, v. 56, no. 11

2021

Abstract	This study investigated whether the concentrations of four metals [lead (Pb), mercury (Hg), manganese (Mn), and aluminum (Al)] are correlated in cord blood and childhood blood samples from Jamaican children. Cord blood samples were obtained from 21 pregnant women enrolled in the second Jamaican Birth Cohort Study from July 1, 2011 to September 30, 2011, and blood samples were drawn from their children who participated in a follow up study when the children were 4–8 years old. Correlations were assessed by the Pearson or the Spearman’s rank correlation coefficient. The mean ages of children at the childhood visit and their mother at the child’s birth were 5.5 years and 29.8 years, respectively. About 47.6% of children were male. Statistically significant correlations between cord blood and childhood blood concentrations of Pb (r Sₚₑₐᵣₘₐₙ =0.45; P = 0.04) and Mn (r Pₑₐᵣₛₒₙ=0.48; P = 0.03) were found, and these remained significant when adjusted for the child’s sex, age, or both. For Al and Hg, r Sₚₑₐᵣₘₐₙ=0.29 and 0.08, respectively, but the correlations were not statistically significant (both P ≥ 0.20). A significant correlation between cord blood and childhood blood Pb concentrations for children 4–8 years old has not been previously reported.
Keywords	aluminum ; blood ; childhood ; children ; cohort studies ; environmental science ; lead ; males ; manganese ; mercury
Language	English
Dates of publication	2021-0919
Size	p. 1196-1205.
Publishing place	Taylor & Francis
Document type	Article
ZDB-ID	196584-0
ISSN	1532-4117 ; 0360-1226 ; 1077-1204 ; 1093-4529
ISSN (online)	1532-4117
ISSN	0360-1226 ; 1077-1204 ; 1093-4529
DOI	10.1080/10934529.2021.1973821
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Article ; Online: Metabolomic Signatures of Sedentary Behavior and Cardiometabolic Traits in US Hispanics/Latinos: Results from HCHS/SOL.

Moon, Jee-Young / Chai, Jin Choul / Yu, Bing / Song, Rebecca J / Chen, Guo-Chong / Graff, Mariaelisa / Daviglus, Martha L / Chan, Queenie / Thyagarajan, Bharat / Castaneda, Sheila F / Grove, Megan L / Cai, Jianwen / Xue, Xiaonan / Mossavar-Rahmani, Yasmin / Vasan, Ramachandran S / Boerwinkle, Eric / Kaplan, Robert C / Qi, Qibin

Medicine and science in sports and exercise

2023 Volume 55, Issue 10, Page(s) 1781–1791

Abstract: Purpose: The aim of this study was to understand the serum metabolomic signatures of moderate-to-vigorous physical activity (MVPA) and sedentary behavior, and further associate their metabolomic signatures with incident cardiometabolic diseases.: ... ...

Abstract	Purpose: The aim of this study was to understand the serum metabolomic signatures of moderate-to-vigorous physical activity (MVPA) and sedentary behavior, and further associate their metabolomic signatures with incident cardiometabolic diseases. Methods: This analysis included 2711 US Hispanics/Latinos from the Hispanic Community Health Study/Study of Latinos (HCHS/SOL) aged 18-74 yr (2008-2011). An untargeted, liquid chromatography-mass spectrometry was used to profile the serum metabolome. The associations of metabolites with accelerometer-measured MVPA and sedentary time were examined using survey linear regressions adjusting for covariates. The weighted correlation network analysis identified modules of correlated metabolites in relation to sedentary time, and the modules were associated with incident diabetes, dyslipidemia, and hypertension over the 6-yr follow-up. Results: Of 624 metabolites, 5 and 102 were associated with MVPA and sedentary behavior at false discovery rate (FDR) <0.05, respectively, after adjusting for socioeconomic and lifestyle factors. The weighted correlation network analysis identified 8 modules from 102 metabolites associated with sedentary time. Four modules (branched-chain amino acids, erythritol, polyunsaturated fatty acid, creatine) were positively, and the other four (acyl choline, plasmalogen glycerol phosphatidyl choline, plasmalogen glycerol phosphatidyl ethanolamine, urea cycle) were negatively correlated with sedentary time. Among these modules, a higher branched-chain amino acid score and a lower plasmalogen glycerol phosphatidyl choline score were associated with increased risks of diabetes and dyslipidemia. A higher erythritol score was associated with an increased risk of diabetes, and a lower acyl choline score was linked to an increased risk of hypertension. Conclusions: In this study of US Hispanics/Latinos, we identified multiple serum metabolomic signatures of sedentary behavior and their associations with risk of incident diabetes, hypertension, and dyslipidemia. These findings suggest a potential role of circulating metabolites in the links between sedentary behavior and cardiometabolic diseases.
MeSH term(s)	Humans ; Cardiovascular Diseases ; Diabetes Mellitus ; Glycerol ; Hispanic or Latino ; Hypertension ; Metabolome ; Plasmalogens ; Risk Factors ; Sedentary Behavior ; Adolescent ; Young Adult ; Adult ; Middle Aged ; Aged
Chemical Substances	Glycerol (PDC6A3C0OX) ; Plasmalogens
Language	English
Publishing date	2023-05-12
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	603994-7
ISSN	1530-0315 ; 0195-9131 ; 0025-7990
ISSN (online)	1530-0315
ISSN	0195-9131 ; 0025-7990
DOI	10.1249/MSS.0000000000003205
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Article ; Online: Additive and Interactive Associations of Environmental and Sociodemographic Factors with the Genotypes of Three Glutathione S-Transferase Genes in Relation to the Blood Arsenic Concentrations of Children in Jamaica.

Rahbar, Mohammad H / Samms-Vaughan, Maureen / Zhao, Yuansong / Saroukhani, Sepideh / Zaman, Sheikh F / Bressler, Jan / Hessabi, Manouchehr / Grove, Megan L / Shakspeare-Pellington, Sydonnie / Loveland, Katherine A

International journal of environmental research and public health

2022 Volume 19, Issue 1

Abstract: Arsenic (As) is a metalloid that has been classified as a xenobiotic with toxic effects on human beings, especially on children. Since the soil in Jamaica contains As, dietary intake is considered the main source of As exposure in Jamaicans. In addition, ...

Abstract	Arsenic (As) is a metalloid that has been classified as a xenobiotic with toxic effects on human beings, especially on children. Since the soil in Jamaica contains As, dietary intake is considered the main source of As exposure in Jamaicans. In addition, glutathione S-transferase (GST) genes, including
MeSH term(s)	Arsenic ; Case-Control Studies ; Child ; Genetic Predisposition to Disease ; Genotype ; Glutathione S-Transferase pi/genetics ; Glutathione Transferase/genetics ; Humans ; Jamaica ; Polymorphism, Genetic ; Risk Factors ; Sociodemographic Factors
Chemical Substances	Glutathione S-Transferase pi (EC 2.5.1.18) ; Glutathione Transferase (EC 2.5.1.18) ; Arsenic (N712M78A8G)
Language	English
Publishing date	2022-01-01
Publishing country	Switzerland
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2175195-X
ISSN	1660-4601 ; 1661-7827
ISSN (online)	1660-4601
ISSN	1661-7827
DOI	10.3390/ijerph19010466
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Article ; Online: Additive or Interactive Associations of Food Allergies with Glutathione S-Transferase Genes in Relation to ASD and ASD Severity in Jamaican Children.

Saroukhani, Sepideh / Samms-Vaughan, Maureen / Bressler, Jan / Lee, MinJae / Byrd-Williams, Courtney / Hessabi, Manouchehr / Grove, Megan L / Shakespeare-Pellington, Sydonnie / Loveland, Katherine A / Rahbar, Mohammad H

Journal of autism and developmental disorders

2022 Volume 54, Issue 2, Page(s) 704–724

Abstract: To investigate additive and interactive associations of food allergies with three glutathione S-transferase (GST) genes in relation to ASD and ASD severity in Jamaican children. Using data from 344 1:1 age- and sex-matched ASD cases and typically ... ...

Abstract	To investigate additive and interactive associations of food allergies with three glutathione S-transferase (GST) genes in relation to ASD and ASD severity in Jamaican children. Using data from 344 1:1 age- and sex-matched ASD cases and typically developing controls, we assessed additive and interactive associations of food allergies with polymorphisms in GST genes (GSTM1, GSTP1 and GSTT1) in relation to ASD by applying conditional logistic regression models, and in relation to ASD severity in ASD cases as measured by the Autism Diagnostic Observation Schedule-2nd Edition (ADOS-2) total and domains specific comparison scores (CSs) by fitting general linear models. Although food allergies and GST genes were not associated with ASD, ASD cases allergic to non-dairy food had higher mean ADOS-2 Restricted and Repetitive Behaviors (RRB) CS (8.8 vs. 8.0, P = 0.04). In addition, allergy to dairy was associated with higher mean RRB CS only among ASD cases with GSTT1 DD genotype (9.9 vs. 7.8, P < 0.01, interaction P = 0.01), and GSTP1 Val/Val genotype under a recessive genetic model (9.8 vs. 7.8, P = 0.02, interaction P = 0.06). Our findings are consistent with the role for GST genes in ASD and food allergies, though require replication in other populations.
MeSH term(s)	Child ; Humans ; Jamaica ; Autism Spectrum Disorder/genetics ; Glutathione Transferase/genetics ; Polymorphism, Genetic ; Genotype ; Case-Control Studies ; Food Hypersensitivity/epidemiology ; Food Hypersensitivity/genetics ; Genetic Predisposition to Disease
Chemical Substances	Glutathione Transferase (EC 2.5.1.18)
Language	English
Publishing date	2022-11-27
Publishing country	United States
Document type	Journal Article
ZDB-ID	391999-7
ISSN	1573-3432 ; 0162-3257
ISSN (online)	1573-3432
ISSN	0162-3257
DOI	10.1007/s10803-022-05813-7
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