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  1. Article ; Online: COVID-19 crisis and residency education: A moment to seize the opportunity and create a new road map!

    Grover, Ashok Kumar

    Indian journal of ophthalmology

    2020  Volume 68, Issue 6, Page(s) 959–960

    MeSH term(s) Betacoronavirus ; COVID-19 ; Coronavirus Infections ; India ; Internship and Residency ; Ophthalmology ; Pandemics ; Pneumonia, Viral ; SARS-CoV-2 ; Surveys and Questionnaires
    Keywords covid19
    Language English
    Publishing date 2020-05-27
    Publishing country India
    Document type Editorial ; Comment
    ZDB-ID 187392-1
    ISSN 1998-3689 ; 0301-4738
    ISSN (online) 1998-3689
    ISSN 0301-4738
    DOI 10.4103/ijo.IJO_1498_20
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Commentary: Thyroid eye disease-does the profile differ in India?

    Grover, Ashok Kumar

    Indian journal of ophthalmology

    2020  Volume 68, Issue 8, Page(s) 1635

    MeSH term(s) Graves Ophthalmopathy/diagnosis ; Graves Ophthalmopathy/epidemiology ; Humans ; India/epidemiology ; Severity of Illness Index
    Language English
    Publishing date 2020-07-22
    Publishing country India
    Document type Journal Article ; Comment
    ZDB-ID 187392-1
    ISSN 1998-3689 ; 0301-4738
    ISSN (online) 1998-3689
    ISSN 0301-4738
    DOI 10.4103/ijo.IJO_2274_20
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Residency training in India: Time for a course correction.

    Grover, Ashok Kumar

    Indian journal of ophthalmology

    2018  Volume 66, Issue 6, Page(s) 743–744

    MeSH term(s) Clinical Competence ; Education, Medical, Graduate/methods ; Humans ; India ; Internship and Residency/methods ; Ophthalmology/education
    Language English
    Publishing date 2018
    Publishing country India
    Document type Editorial
    ZDB-ID 187392-1
    ISSN 1998-3689 ; 0301-4738
    ISSN (online) 1998-3689
    ISSN 0301-4738
    DOI 10.4103/ijo.IJO_328_18
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: COVID-19 crisis and residency education

    Grover, AshokKumar

    Indian Journal of Ophthalmology

    A moment to seize the opportunity and create a new road map!

    2020  Volume 68, Issue 6, Page(s) 959

    Keywords Ophthalmology ; covid19
    Language English
    Publisher Medknow
    Publishing country in
    Document type Article ; Online
    ZDB-ID 187392-1
    ISSN 0301-4738
    ISSN 0301-4738
    DOI 10.4103/ijo.ijo_1498_20
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Management of nasolacrimal duct obstruction in children: How is it changing?

    Grover, Ashok Kumar

    Indian journal of ophthalmology

    2017  Volume 65, Issue 10, Page(s) 910–911

    Language English
    Publishing date 2017-10
    Publishing country India
    Document type Editorial
    ZDB-ID 187392-1
    ISSN 1998-3689 ; 0301-4738
    ISSN (online) 1998-3689
    ISSN 0301-4738
    DOI 10.4103/ijo.IJO_719_17
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  7. Article ; Online: Use of allosteric targets in the discovery of safer drugs.

    Grover, Ashok Kumar

    Medical principles and practice : international journal of the Kuwait University, Health Science Centre

    2013  Volume 22, Issue 5, Page(s) 418–426

    Abstract: The need for drugs with fewer side effects cannot be overemphasized. Today, most drugs modify the actions of enzymes, receptors, transporters and other molecules by directly binding to their active (orthosteric) sites. However, orthosteric site ... ...

    Abstract The need for drugs with fewer side effects cannot be overemphasized. Today, most drugs modify the actions of enzymes, receptors, transporters and other molecules by directly binding to their active (orthosteric) sites. However, orthosteric site configuration is similar in several proteins performing related functions and this leads to a lower specificity of a drug for the desired protein. Consequently, such drugs may have adverse side effects. A new basis of drug discovery is emerging based on the binding of the drug molecules to sites away (allosteric) from the orthosteric sites. It is possible to find allosteric sites which are unique and hence more specific as targets for drug discovery. Of many available examples, two are highlighted here. The first is caloxins - a new class of highly specific inhibitors of plasma membrane Ca²⁺ pumps. The second concerns the modulation of receptors for the neurotransmitter acetylcholine, which binds to 12 types of receptors. Exploitation of allosteric sites has led to the discovery of drugs which can selectively modulate the activation of only 1 (M1 muscarinic) out of the 12 different types of acetylcholine receptors. These drugs are being tested for schizophrenia treatment. It is anticipated that the drug discovery exploiting allosteric sites will lead to more effective therapeutic agents with fewer side effects.
    MeSH term(s) Acetylcholine/metabolism ; Allosteric Regulation/drug effects ; Allosteric Regulation/physiology ; Allosteric Site/drug effects ; Allosteric Site/physiology ; Calcium/metabolism ; Drug Design ; Drug Discovery/methods ; Humans ; Peptides/chemistry ; Plasma Membrane Calcium-Transporting ATPases/drug effects ; Plasma Membrane Calcium-Transporting ATPases/metabolism ; Protein Binding/drug effects ; Protein Binding/physiology ; Receptor, Muscarinic M1/drug effects ; Receptor, Muscarinic M1/metabolism
    Chemical Substances Peptides ; Receptor, Muscarinic M1 ; Plasma Membrane Calcium-Transporting ATPases (EC 3.6.3.8) ; Acetylcholine (N9YNS0M02X) ; Calcium (SY7Q814VUP)
    Language English
    Publishing date 2013-05-23
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 645108-1
    ISSN 1423-0151 ; 1011-7571
    ISSN (online) 1423-0151
    ISSN 1011-7571
    DOI 10.1159/000350417
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Why fruits are rich in antioxidants? An opinion review.

    Grover, Ashok Kumar

    Canadian journal of physiology and pharmacology

    2013  Volume 91, Issue 3, Page(s) 191–197

    Abstract: We rarely consider whether and how plants benefit from making antioxidant-rich fruits, despite our dependence on fruits as routine sources of these compounds. The hypothesis presented here is that storage of the antioxidant materials is advantageous to ... ...

    Abstract We rarely consider whether and how plants benefit from making antioxidant-rich fruits, despite our dependence on fruits as routine sources of these compounds. The hypothesis presented here is that storage of the antioxidant materials is advantageous to the survival of the plant species. This hypothesis is based on the premise that at different stages from flower bud opening to seedling formation, the concentrations of the reactive oxygen species (ROS) needed vary tremendously. Exposing seeds of several plant species to ROS aids germination. However, ROS can cause considerable damage by mutagenesis during plant embryogenesis. It is suggested that the antioxidant-rich environment in fruits protects the developing plant embryos from this damage. It also allows for an antioxidant environment for packaging the embryos into seeds with tight seed coats. After fruit maturation and seed dispersal, a prolonged exposure to oxygen and moisture enables the seeds to produce the ROS needed for seed germination. There is a simultaneous increase in the ROS scavenging systems to allow for protection of the dividing cells afterwards. These observations are unified into the hypothesis that the antioxidant rich fruits aid in the survival of plant species, and discussed in the context of vascular plant evolution.
    MeSH term(s) Antioxidants/metabolism ; Fruit/growth & development ; Fruit/metabolism ; Germination/physiology ; Reactive Oxygen Species/metabolism ; Seedlings/growth & development ; Seedlings/metabolism ; Seeds/growth & development ; Seeds/metabolism
    Chemical Substances Antioxidants ; Reactive Oxygen Species
    Language English
    Publishing date 2013-03
    Publishing country Canada
    Document type Journal Article ; Review
    ZDB-ID 127527-6
    ISSN 1205-7541 ; 0008-4212
    ISSN (online) 1205-7541
    ISSN 0008-4212
    DOI 10.1139/cjpp-2012-0244
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Dog tick (Rhipecephalus) causing Lyme disease in an adult human.

    Grover, Ashok Kumar / Singh, Purneetha / Puri, Saurabh / Jindal, Saurabh / Choudhary, Pankaj Nand

    Journal of family medicine and primary care

    2022  Volume 11, Issue 8, Page(s) 4824–4826

    Abstract: Lyme disease is a tick-borne multisystem disorder transmitted by the family of Ixodes and caused by a spirochete, ...

    Abstract Lyme disease is a tick-borne multisystem disorder transmitted by the family of Ixodes and caused by a spirochete,
    Language English
    Publishing date 2022-08-30
    Publishing country India
    Document type Case Reports
    ZDB-ID 2735275-4
    ISSN 2278-7135 ; 2249-4863
    ISSN (online) 2278-7135
    ISSN 2249-4863
    DOI 10.4103/jfmpc.jfmpc_33_22
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Commentary: Dengue hemorrhagic fever: Panophthalmitis or sterile sclerocorneal melt?

    Grover, Ashok Kumar / Bageja, Shaloo / Mittal, Shilpa Taneja

    Indian journal of ophthalmology

    2019  Volume 67, Issue 10, Page(s) 1777–1778

    MeSH term(s) Cornea ; Corneal Diseases ; Humans ; Panophthalmitis ; Severe Dengue
    Language English
    Publishing date 2019-09-20
    Publishing country India
    Document type Journal Article ; Comment
    ZDB-ID 187392-1
    ISSN 1998-3689 ; 0301-4738
    ISSN (online) 1998-3689
    ISSN 0301-4738
    DOI 10.4103/ijo.IJO_1268_19
    Database MEDical Literature Analysis and Retrieval System OnLINE

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