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  1. Article ; Online: Editorial: Faecal microbiota transplantation in IBS-Moving closer or away from success?

    Lesmana, Elvira / Grover, Madhusudan

    Alimentary pharmacology & therapeutics

    2023  Volume 58, Issue 9, Page(s) 950–951

    MeSH term(s) Humans ; Fecal Microbiota Transplantation ; Irritable Bowel Syndrome/therapy ; Feces ; Microbiota
    Language English
    Publishing date 2023-10-13
    Publishing country England
    Document type Editorial ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 639012-2
    ISSN 1365-2036 ; 0269-2813 ; 0953-0673
    ISSN (online) 1365-2036
    ISSN 0269-2813 ; 0953-0673
    DOI 10.1111/apt.17724
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  2. Article ; Online: Intestinal proteases.

    Rao, Sameer / Grover, Madhusudan

    Current opinion in gastroenterology

    2023  Volume 39, Issue 6, Page(s) 472–478

    Abstract: Purpose of review: Proteases constitute a group of enzymes that hydrolyze peptide bonds. Intestinal proteases are an integral part of gut homeostasis and digestion. This review discusses the broader classification of proteases, regulation of proteolytic ...

    Abstract Purpose of review: Proteases constitute a group of enzymes that hydrolyze peptide bonds. Intestinal proteases are an integral part of gut homeostasis and digestion. This review discusses the broader classification of proteases, regulation of proteolytic activity (PA) in the intestinal tract, and how dysregulation of intestinal proteases contributes to the pathophysiology of conditions such as irritable bowel syndrome (IBS), inflammatory bowel disease (IBD), and celiac disease. We also discuss recent advancements in therapeutic modulation that directly or indirectly target intestinal proteases and can be utilized to treat these illnesses.
    Recent findings: Host and microbiota derived proteases have been associated with symptoms in subsets of patients with IBS, IBD and celiac disease. Elevated PA mediates barrier dysfunction, visceral hypersensitivity as well as immune activation and inflammation. Recent mechanistic studies have revealed the nature of disease-associated proteases and mechanisms regulating their activity, particularly those driven by the microbiota. Advancements in activity-based probes have allowed novel ways of in vivo imaging of PA. Newer strategies targeting proteases include monoclonal antibodies, engineered microbiota as well as specific protease inhibitors.
    Summary: Significant progresses made in the detection as well as regulation of PA is likely to provide therapeutic advancements for gastrointestinal diseases.
    MeSH term(s) Humans ; Irritable Bowel Syndrome ; Peptide Hydrolases ; Celiac Disease/therapy ; Inflammatory Bowel Diseases/therapy ; Inflammation
    Chemical Substances Peptide Hydrolases (EC 3.4.-)
    Language English
    Publishing date 2023-08-29
    Publishing country United States
    Document type Review ; Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 632571-3
    ISSN 1531-7056 ; 0267-1379
    ISSN (online) 1531-7056
    ISSN 0267-1379
    DOI 10.1097/MOG.0000000000000972
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  3. Article ; Online: Gastroparesis and Functional Dyspepsia: Spectrum of Gastroduodenal Neuromuscular Disorders or Unique Entities?

    Sato, Hiroki / Grover, Madhusudan

    Gastro hep advances

    2022  Volume 2, Issue 3, Page(s) 438–448

    Abstract: Gastroparesis is defined by delayed gastric emptying in the absence of mechanical obstruction of the stomach. Patients experience symptoms of nausea, vomiting, abdominal pain, fullness, and early satiety. The recognition of the disorder has progressed ... ...

    Abstract Gastroparesis is defined by delayed gastric emptying in the absence of mechanical obstruction of the stomach. Patients experience symptoms of nausea, vomiting, abdominal pain, fullness, and early satiety. The recognition of the disorder has progressed due to availability of gastric emptying scintigraphy and advancements made in understanding its pathophysiology and treatment options. The clinical presentation and treatment of gastroparesis overlap with a more commonly recognized disorder of gut-brain interaction, functional dyspepsia. Recent studies have reenergized the discussion whether these two are separate entities or perhaps reflect a spectrum of gastroduodenal neuromuscular disorders. The societal guidelines conflict on the utility of gastric emptying scintigraphy in assessment of patients with upper gastrointestinal symptoms. A better appraisal of similarities and differences between gastroparesis and functional dyspepsia will allow targeted treatment for these disorders. This is particularly important as specific pharmacological and endoscopic treatment options are being developed for gastroparesis which are unlikely to be helpful for functional dyspepsia. This review makes the case for considering these disorders in a spectrum where identification of both would most ideally position us toward providing the optimal clinical care.
    Language English
    Publishing date 2022-10-14
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2772-5723
    ISSN (online) 2772-5723
    DOI 10.1016/j.gastha.2022.10.005
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  4. Article ; Online: Editorial: repurposed linaclotide and the quest for abdominal pain management in irritable bowel syndrome.

    Maalouf, Elisia / Grover, Madhusudan

    Alimentary pharmacology & therapeutics

    2022  Volume 57, Issue 2, Page(s) 261–262

    MeSH term(s) Humans ; Irritable Bowel Syndrome/complications ; Irritable Bowel Syndrome/drug therapy ; Pain Management ; Constipation ; Peptides ; Abdominal Pain/drug therapy ; Abdominal Pain/etiology
    Chemical Substances linaclotide (N0TXR0XR5X) ; Peptides
    Language English
    Publishing date 2022-12-23
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 639012-2
    ISSN 1365-2036 ; 0269-2813 ; 0953-0673
    ISSN (online) 1365-2036
    ISSN 0269-2813 ; 0953-0673
    DOI 10.1111/apt.17304
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  5. Article ; Online: Inclusive Clinical Trials for Disorders of Gut-Brain Interactions.

    Wieland, Mark L / Grover, Madhusudan

    Gastroenterology

    2022  Volume 163, Issue 3, Page(s) 583–585

    MeSH term(s) Brain ; Gastrointestinal Microbiome ; Humans
    Language English
    Publishing date 2022-06-30
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 80112-4
    ISSN 1528-0012 ; 0016-5085
    ISSN (online) 1528-0012
    ISSN 0016-5085
    DOI 10.1053/j.gastro.2022.06.077
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  6. Article ; Online: The COVID-19 Pandemic and Post-Infection Irritable Bowel Syndrome: What Lies Ahead for Gastroenterologists.

    Chan, Walter W / Grover, Madhusudan

    Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association

    2022  Volume 20, Issue 10, Page(s) 2195–2197

    MeSH term(s) COVID-19 ; Gastroenterologists ; Humans ; Irritable Bowel Syndrome/complications ; Irritable Bowel Syndrome/epidemiology ; Pandemics
    Language English
    Publishing date 2022-08-06
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2119789-1
    ISSN 1542-7714 ; 1542-3565
    ISSN (online) 1542-7714
    ISSN 1542-3565
    DOI 10.1016/j.cgh.2022.05.044
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  7. Article: Role of gut pathogens in development of irritable bowel syndrome.

    Grover, Madhusudan

    The Indian journal of medical research

    2014  Volume 139, Issue 1, Page(s) 11–18

    Abstract: Acute infectious gastroenteritis is one of the most commonly identifiable risk factors for the development of irritable bowel syndrome (IBS). A number of bacterial, viral and parasitic pathogens have been found to be associated with the development of ... ...

    Abstract Acute infectious gastroenteritis is one of the most commonly identifiable risk factors for the development of irritable bowel syndrome (IBS). A number of bacterial, viral and parasitic pathogens have been found to be associated with the development of IBS and other functional gastrointestinal (GI) disorders. Epidemiological studies have identified demographic and acute enteritis-related risk factors for the development of post-infectious-IBS (PI-IBS). Immune dysregulation, alterations in barrier function, serotonergic and mast cell activation have been identified as potential pathophysiological mechanisms. Additionally, variations in host genes involved in barrier function, antigen presentation and cytokine response have been associated with PI-IBS development. However, it is unknown whether specific pathogens have unique effects on long-term alterations in gut physiology or different pathogens converge to cause common alterations resulting in similar phenotype. The role of microbial virulence and pathogenicity factors in development of PI-IBS is also largely unknown. Additionally, alterations in host gut sensation, motility, secretion, and barrier function in PI-IBS need to be elucidated. Finally, both GI infections and antibiotics used to treat these infections can cause long-term alterations in host commensal microbiota. It is plausible that alteration in the commensal microbiome persists in a subset of patients predisposing them to develop PI-IBS.
    MeSH term(s) Anti-Bacterial Agents/therapeutic use ; Campylobacter jejuni/pathogenicity ; Gastroenteritis/microbiology ; Gastroenteritis/pathology ; Gastroenteritis/therapy ; Gastrointestinal Tract/microbiology ; Gastrointestinal Tract/pathology ; Humans ; Infections/microbiology ; Infections/pathology ; Infections/therapy ; Irritable Bowel Syndrome/microbiology ; Irritable Bowel Syndrome/pathology ; Irritable Bowel Syndrome/therapy ; Risk Factors
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2014-03-07
    Publishing country India
    Document type Journal Article ; Review
    ZDB-ID 390883-5
    ISSN 0971-5916 ; 0019-5340
    ISSN 0971-5916 ; 0019-5340
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  8. Article ; Online: Colonic expression of

    Edwinson, Adam / Yang, Lu / Chen, Jun / Grover, Madhusudan

    Gut microbes

    2021  Volume 13, Issue 1, Page(s) 1984105

    Abstract: Infection with severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) is responsible for the COVID-19 pandemic. Angiotensin-converting enzyme 2 ( ...

    Abstract Infection with severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) is responsible for the COVID-19 pandemic. Angiotensin-converting enzyme 2 (
    MeSH term(s) Angiotensin-Converting Enzyme 2/metabolism ; Animals ; Colon/metabolism ; Colon/microbiology ; Dysbiosis ; Gastrointestinal Microbiome ; Gene Expression Regulation ; Germ-Free Life ; Humans ; Inflammatory Bowel Diseases/microbiology ; Mice ; Receptors, Virus/metabolism ; SARS-CoV-2
    Chemical Substances Receptors, Virus ; ACE2 protein, human (EC 3.4.17.23) ; Angiotensin-Converting Enzyme 2 (EC 3.4.17.23)
    Language English
    Publishing date 2021-10-14
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2575755-6
    ISSN 1949-0984 ; 1949-0984
    ISSN (online) 1949-0984
    ISSN 1949-0984
    DOI 10.1080/19490976.2021.1984105
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  9. Article ; Online: Post-infection Irritable Bowel Syndrome.

    Berumen, Antonio / Edwinson, Adam L / Grover, Madhusudan

    Gastroenterology clinics of North America

    2021  Volume 50, Issue 2, Page(s) 445–461

    Abstract: Epidemiologic data support that acute gastrointestinal infection is one of the strongest risk factors for development of irritable bowel syndrome (IBS). Risk of post-infection IBS (PI-IBS) seems to be greater with bacterial and protozoal than viral ... ...

    Abstract Epidemiologic data support that acute gastrointestinal infection is one of the strongest risk factors for development of irritable bowel syndrome (IBS). Risk of post-infection IBS (PI-IBS) seems to be greater with bacterial and protozoal than viral enterocolitis. Younger individuals, women, and those with severe enterocolitis are more likely to develop PI-IBS. Disease mechanisms in animal models and humans involve chronic perturbation of intestinal microbiome, epithelial and neuronal remodeling, and immune activation. These mechanisms can lead to luminal (increased proteolytic activity, altered bile acid composition) and physiologic (increased permeability, transit changes, and visceral hypersensitivity) alterations that can mediate PI-IBS symptoms.
    MeSH term(s) Animals ; Female ; Gastrointestinal Microbiome ; Humans ; Infections ; Irritable Bowel Syndrome/etiology
    Language English
    Publishing date 2021-04-23
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 92114-2
    ISSN 1558-1942 ; 0889-8553
    ISSN (online) 1558-1942
    ISSN 0889-8553
    DOI 10.1016/j.gtc.2021.02.007
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  10. Article ; Online: Epidemiology of Gastroparesis in the United States.

    Grover, Madhusudan / Parkman, Henry P / Pasricha, Pankaj J

    Gastroenterology

    2021  Volume 162, Issue 7, Page(s) 2136–2137

    MeSH term(s) Gastroparesis/epidemiology ; Hospitalization ; Humans ; United States/epidemiology
    Language English
    Publishing date 2021-10-28
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 80112-4
    ISSN 1528-0012 ; 0016-5085
    ISSN (online) 1528-0012
    ISSN 0016-5085
    DOI 10.1053/j.gastro.2021.10.030
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