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  1. Article ; Online: Use of High-Fidelity Simulation to Enhance Interdisciplinary Collaboration and Reduce Patient Falls.

    Bursiek, April A / Hopkins, Matthew R / Breitkopf, Daniel M / Grubbs, Pamela L / Joswiak, Mary Ellen / Klipfel, Janee M / Johnson, Kristine M

    Journal of patient safety

    2017  Volume 16, Issue 3, Page(s) 245–250

    Abstract: Objectives: This pilot study aimed to determine the effect of nurse/physician interdisciplinary team training on patient falls. Specifically, we evaluated team training in a simulation center as a method for targeting and minimizing breakdowns in ... ...

    Abstract Objectives: This pilot study aimed to determine the effect of nurse/physician interdisciplinary team training on patient falls. Specifically, we evaluated team training in a simulation center as a method for targeting and minimizing breakdowns in perceptions of respect, collaboration, communication, and role misunderstanding behaviors between care disciplines.
    Methods: Registered nurses (RNs) were randomly assigned to participate. Residents were divided into groups and assigned based on their availability and clinical responsibility. All participants completed a demographic form, the Professional Practice Environment Assessment Scale (PPEAS), and the Mayo High Performance Teamwork Scale (MHPTS) after consenting and before participation in simulation training. The PPEAS and the MHPTS were readministered at 2 and 6 months after the simulation experience. Differences in MHPTS and PPEAS scores between the baseline and 2- and 6-month assessments were analyzed; fall rates over time were evaluated using Cochran-Armitage trend tests.
    Results: After the team training exercises, teamwork as measured by the MHPTS improved significantly at both 2 and 6 months (P = 0.01; P < 0.001) compared with baseline measurement. Practice environment subscores, with the exception of positive organizational characteristics, also increased when measured 6 months after training. The primary outcome, reduction in anticipated patient falls, improved significantly (P = 0.02) over the course of the study.
    Conclusions: Results of this pilot study show that team training exercises result in improvement in both patient safety (anticipated patient falls) and team member perception of their work environment. If validated by other studies, improvement in this patient safety metric would represent an important benefit of simulation and team training.
    MeSH term(s) Accidental Falls/prevention & control ; Adult ; Female ; High Fidelity Simulation Training ; Humans ; Interdisciplinary Placement/methods ; Male ; Middle Aged ; Patient Safety/standards ; Patient Simulation ; Young Adult
    Language English
    Publishing date 2017-02-27
    Publishing country United States
    Document type Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
    ZDB-ID 2394324-5
    ISSN 1549-8425 ; 1549-8417
    ISSN (online) 1549-8425
    ISSN 1549-8417
    DOI 10.1097/PTS.0000000000000277
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Pressure Ulcer Prevention: Where Practice and Education Meet.

    Bos, Brenda S / Wangen, Tina M / Elbing, Carl E / Rowekamp, Debra J / Kruggel, Heather A / Conlon, Patricia M / Scroggins, Leann M / Schad, Shauna P / Neumann, Julie A / Barth, Melissa M / Grubbs, Pamela L / Sievers, Beth A

    Journal for nurses in professional development

    2016  Volume 32, Issue 2, Page(s) 94–98

    Abstract: This article describes the processes used to implement a pressure ulcer management program in a Midwest academic medical center, which led to a decrease in reportable pressure ulcers. A learning needs assessment was completed, and a workgroup was formed ... ...

    Abstract This article describes the processes used to implement a pressure ulcer management program in a Midwest academic medical center, which led to a decrease in reportable pressure ulcers. A learning needs assessment was completed, and a workgroup was formed to address the learning needs. Methods, materials, and processes included lectures, technology-enhanced learning, and interactive stations with mannequins and pressure ulcer moulages. The processes and outcome measures used to measure effectiveness of the program are discussed.
    MeSH term(s) Academic Medical Centers ; Computer-Assisted Instruction/methods ; Humans ; Midwestern United States ; Needs Assessment ; Pressure Ulcer/prevention & control ; Program Development ; Program Evaluation ; Skin Care/nursing ; Skin Care/standards
    Language English
    Publishing date 2016-03
    Publishing country United States
    Document type Journal Article
    ISSN 2169-981X
    ISSN (online) 2169-981X
    DOI 10.1097/NND.0000000000000228
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Enhanced recovery after surgery in microvascular breast reconstruction.

    Batdorf, Niles J / Lemaine, Valerie / Lovely, Jenna K / Ballman, Karla V / Goede, Whitney J / Martinez-Jorge, Jorys / Booth-Kowalczyk, Andria L / Grubbs, Pamela L / Bungum, Lisa D / Saint-Cyr, Michel

    Journal of plastic, reconstructive & aesthetic surgery : JPRAS

    2015  Volume 68, Issue 3, Page(s) 395–402

    Abstract: Background: Enhanced recovery after surgery (ERAS) pathways have been shown in multiple surgical specialties to decrease hospital length of stay (LOS) after surgery, but they have not been described for patients undergoing microvascular breast ... ...

    Abstract Background: Enhanced recovery after surgery (ERAS) pathways have been shown in multiple surgical specialties to decrease hospital length of stay (LOS) after surgery, but they have not been described for patients undergoing microvascular breast reconstruction.
    Study design: A standardized ERAS pathway was developed through multidisciplinary collaboration which addressed all phases of surgical care for patients undergoing free-flap breast reconstruction using an abdominal donor site. Two surgeons used the ERAS pathway, and results were compared with a historical cohort of the same 2 surgeons' patients treated by traditional care after surgery (TRAS). All patients underwent surgery between September 2010 and September 2013. The primary outcome measure was hospital LOS.
    Results: A total of 100 patients were analyzed: 49 in the ERAS cohort, and 51 in the TRAS cohort, with a total of 181 flaps. Mean hospital LOS was shorter with ERAS than TRAS (3.9 vs 5.5 days; P<0.001). Total inpatient postoperative opioid usage for the first 3 days, in oral morphine equivalents, was less for ERAS than TRAS (167.3 vs 574.3 mg; P<0.001), a decrease of 71%, with similar pain scores for the 2 groups. Overall 30-day major complication rates were not significantly different between the groups (P=0.21).
    Conclusions: The initiation of an ERAS pathway significantly decreased hospital LOS in our study. The pathway also significantly decreased the amount of opioids used postoperatively by 71%, without a consequent increase in patient-reported pain.
    MeSH term(s) Female ; Humans ; Length of Stay/statistics & numerical data ; Mammaplasty/methods ; Microsurgery ; Middle Aged ; Pain Management ; Pain Measurement ; Postoperative Complications ; Retrospective Studies ; Surgical Flaps ; Treatment Outcome ; Wound Healing/physiology
    Language English
    Publishing date 2015-03
    Publishing country Netherlands
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Video-Audio Media
    ZDB-ID 2217750-4
    ISSN 1878-0539 ; 1748-6815 ; 0007-1226
    ISSN (online) 1878-0539
    ISSN 1748-6815 ; 0007-1226
    DOI 10.1016/j.bjps.2014.11.014
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Using Bundled Interventions to Reduce Surgical Site Infection After Major Gynecologic Cancer Surgery.

    Johnson, Megan P / Kim, Sharon J / Langstraat, Carrie L / Jain, Sneha / Habermann, Elizabeth B / Wentink, Jean E / Grubbs, Pamela L / Nehring, Sharon A / Weaver, Amy L / McGree, Michaela E / Cima, Robert R / Dowdy, Sean C / Bakkum-Gamez, Jamie N

    Obstetrics and gynecology

    2015  Volume 127, Issue 6, Page(s) 1135–1144

    Abstract: Objective: To investigate whether implementing a bundle, defined as a set of evidence-based practices performed collectively, can reduce 30-day surgical site infections.: Methods: Baseline surgical site infection rates were determined retrospectively ...

    Abstract Objective: To investigate whether implementing a bundle, defined as a set of evidence-based practices performed collectively, can reduce 30-day surgical site infections.
    Methods: Baseline surgical site infection rates were determined retrospectively for cases of open uterine cancer, ovarian cancer without bowel resection, and ovarian cancer with bowel resection between January 1, 2010, and December 31, 2012, at an academic center. A perioperative bundle was prospectively implemented during the intervention period (August 1, 2013, to September 30, 2014). Prior established elements were: patient education, 4% chlorhexidine gluconate shower before surgery, antibiotic administration, 2% chlorhexidine gluconate and 70% isopropyl alcohol coverage of incisional area, and cefazolin redosing 3-4 hours after incision. New elements initiated were: sterile closing tray and staff glove change for fascia and skin closure, dressing removal at 24-48 hours, dismissal with 4% chlorhexidine gluconate, and follow-up nursing phone call. Surgical site infection rates were examined using control charts, compared between periods using χ or Fisher exact test, and validated against the American College of Surgeons National Surgical Quality Improvement Program decile ranking.
    Results: The overall 30-day surgical site infection rate was 38 of 635 (6.0%) among all cases in the preintervention period, with 11 superficial (1.7%), two deep (0.3%), and 25 organ or space infections (3.9%). In the intervention period, the overall rate was 2 of 190 (1.1%), with two organ or space infections (1.1%). Overall, the relative risk reduction in surgical site infection was 82.4% (P=.01). The surgical site infection relative risk reduction was 77.6% among ovarian cancer with bowel resection, 79.3% among ovarian cancer without bowel resection, and 100% among uterine cancer. The American College of Surgeons National Surgical Quality Improvement Program decile ranking improved from the 10th decile to first decile; risk-adjusted odds ratio for surgical site infection decreased from 1.6 (95% confidence interval 1.0-2.6) to 0.6 (0.3-1.1).
    Conclusion: Implementation of an evidence-based surgical site infection reduction bundle was associated with substantial reductions in surgical site infection in high-risk cancer procedures.
    MeSH term(s) Evidence-Based Medicine ; Female ; Genital Neoplasms, Female/surgery ; Humans ; Interdisciplinary Communication ; Middle Aged ; Minnesota ; Outcome and Process Assessment, Health Care ; Patient Care Bundles/standards ; Prospective Studies ; Quality Improvement ; Surgical Wound Infection/prevention & control
    Language English
    Publishing date 2015-12-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 207330-4
    ISSN 1873-233X ; 0029-7844
    ISSN (online) 1873-233X
    ISSN 0029-7844
    DOI 10.1097/AOG.0000000000001449
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Enhanced recovery in gynecologic surgery.

    Kalogera, Eleftheria / Bakkum-Gamez, Jamie N / Jankowski, Christopher J / Trabuco, Emanuel / Lovely, Jenna K / Dhanorker, Sarah / Grubbs, Pamela L / Weaver, Amy L / Haas, Lindsey R / Borah, Bijan J / Bursiek, April A / Walsh, Michael T / Cliby, William A / Dowdy, Sean C

    Obstetrics and gynecology

    2013  Volume 122, Issue 2 Pt 1, Page(s) 319–328

    Abstract: Objective: To investigate the effects of enhanced recovery (a multimodal perioperative care enhancement protocol) in patients undergoing gynecologic surgery.: Methods: Consecutive patients managed under an enhanced recovery pathway and undergoing ... ...

    Abstract Objective: To investigate the effects of enhanced recovery (a multimodal perioperative care enhancement protocol) in patients undergoing gynecologic surgery.
    Methods: Consecutive patients managed under an enhanced recovery pathway and undergoing cytoreduction, surgical staging, or pelvic organ prolapse surgery between June 20, 2011, and December 20, 2011, were compared with consecutive historical controls (March to December 2010) matched by procedure. Wilcoxon rank-sum, χ, and Fisher's exact tests were used for comparisons. Direct medical costs incurred in the first 30 days were obtained from the Olmsted County Healthcare Expenditure and Utilization Database and standardized to 2011 Medicare dollars.
    Results: A total of 241 enhanced recovery women in the case group (81 cytoreduction, 84 staging, and 76 vaginal surgery) were compared with women in the control groups. In the cytoreductive group, patient-controlled anesthesia use decreased from 98.7% to 33.3% and overall opioid use decreased by 80% in the first 48 hours with no change in pain scores. Enhanced recovery resulted in a 4-day reduction in hospital stay with stable readmission rates (25.9% of women in the case group compared with 17.9% of women in the control group) and 30-day cost savings of more than $7,600 per patient (18.8% reduction). No differences were observed in rate (63% compared with 71.8%) or severity of postoperative complications (grade 3 or more: 21% compared with 20.5%). Similar, albeit less dramatic, improvements were observed in the other two cohorts. Ninety-five percent of patients rated satisfaction with perioperative care as excellent or very good.
    Conclusions: Implementation of enhanced recovery was associated with acceptable pain management with reduced opioids, reduced length of stay with stable readmission and morbidity rates, good patient satisfaction, and substantial cost reductions.
    Level of evidence: II.
    MeSH term(s) Aged ; Female ; Genital Neoplasms, Female/surgery ; Gynecologic Surgical Procedures/adverse effects ; Gynecologic Surgical Procedures/economics ; Gynecologic Surgical Procedures/rehabilitation ; Humans ; Length of Stay/statistics & numerical data ; Middle Aged ; Patient Satisfaction ; Pelvic Organ Prolapse/surgery ; Perioperative Care/methods ; Retrospective Studies
    Language English
    Publishing date 2013-08-21
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S.
    ZDB-ID 207330-4
    ISSN 1873-233X ; 0029-7844
    ISSN (online) 1873-233X
    ISSN 0029-7844
    DOI 10.1097/AOG.0b013e31829aa780
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Implementation of preemptive DNA sequence-based pharmacogenomics testing across a large academic medical center: The Mayo-Baylor RIGHT 10K Study.

    Wang, Liewei / Scherer, Steven E / Bielinski, Suzette J / Muzny, Donna M / Jones, Leila A / Black, John Logan / Moyer, Ann M / Giri, Jyothsna / Sharp, Richard R / Matey, Eric T / Wright, Jessica A / Oyen, Lance J / Nicholson, Wayne T / Wiepert, Mathieu / Sullard, Terri / Curry, Timothy B / Rohrer Vitek, Carolyn R / McAllister, Tammy M / St Sauver, Jennifer L /
    Caraballo, Pedro J / Lazaridis, Konstantinos N / Venner, Eric / Qin, Xiang / Hu, Jianhong / Kovar, Christie L / Korchina, Viktoriya / Walker, Kimberly / Doddapaneni, HarshaVardhan / Wu, Tsung-Jung / Raj, Ritika / Denson, Shawn / Liu, Wen / Chandanavelli, Gauthami / Zhang, Lan / Wang, Qiaoyan / Kalra, Divya / Karow, Mary Beth / Harris, Kimberley J / Sicotte, Hugues / Peterson, Sandra E / Barthel, Amy E / Moore, Brenda E / Skierka, Jennifer M / Kluge, Michelle L / Kotzer, Katrina E / Kloke, Karen / Vander Pol, Jessica M / Marker, Heather / Sutton, Joseph A / Kekic, Adrijana / Ebenhoh, Ashley / Bierle, Dennis M / Schuh, Michael J / Grilli, Christopher / Erickson, Sara / Umbreit, Audrey / Ward, Leah / Crosby, Sheena / Nelson, Eric A / Levey, Sharon / Elliott, Michelle / Peters, Steve G / Pereira, Naveen / Frye, Mark / Shamoun, Fadi / Goetz, Matthew P / Kullo, Iftikhar J / Wermers, Robert / Anderson, Jan A / Formea, Christine M / El Melik, Razan M / Zeuli, John D / Herges, Joseph R / Krieger, Carrie A / Hoel, Robert W / Taraba, Jodi L / St Thomas, Scott R / Absah, Imad / Bernard, Matthew E / Fink, Stephanie R / Gossard, Andrea / Grubbs, Pamela L / Jacobson, Therese M / Takahashi, Paul / Zehe, Sharon C / Buckles, Susan / Bumgardner, Michelle / Gallagher, Colette / Fee-Schroeder, Kelliann / Nicholas, Nichole R / Powers, Melody L / Ragab, Ahmed K / Richardson, Darcy M / Stai, Anthony / Wilson, Jaymi / Pacyna, Joel E / Olson, Janet E / Sutton, Erica J / Beck, Annika T / Horrow, Caroline / Kalari, Krishna R / Larson, Nicholas B / Liu, Hongfang / Wang, Liwei / Lopes, Guilherme S / Borah, Bijan J / Freimuth, Robert R / Zhu, Ye / Jacobson, Debra J / Hathcock, Matthew A / Armasu, Sebastian M / McGree, Michaela E / Jiang, Ruoxiang / Koep, Tyler H / Ross, Jason L / Hilden, Matthew G / Bosse, Kathleen / Ramey, Bronwyn / Searcy, Isabelle / Boerwinkle, Eric / Gibbs, Richard A / Weinshilboum, Richard M

    Genetics in medicine : official journal of the American College of Medical Genetics

    2022  Volume 24, Issue 5, Page(s) 1062–1072

    Abstract: Purpose: The Mayo-Baylor RIGHT 10K Study enabled preemptive, sequence-based pharmacogenomics (PGx)-driven drug prescribing practices in routine clinical care within a large cohort. We also generated the tools and resources necessary for clinical PGx ... ...

    Abstract Purpose: The Mayo-Baylor RIGHT 10K Study enabled preemptive, sequence-based pharmacogenomics (PGx)-driven drug prescribing practices in routine clinical care within a large cohort. We also generated the tools and resources necessary for clinical PGx implementation and identified challenges that need to be overcome. Furthermore, we measured the frequency of both common genetic variation for which clinical guidelines already exist and rare variation that could be detected by DNA sequencing, rather than genotyping.
    Methods: Targeted oligonucleotide-capture sequencing of 77 pharmacogenes was performed using DNA from 10,077 consented Mayo Clinic Biobank volunteers. The resulting predicted drug response-related phenotypes for 13 genes, including CYP2D6 and HLA, affecting 21 drug-gene pairs, were deposited preemptively in the Mayo electronic health record.
    Results: For the 13 pharmacogenes of interest, the genomes of 79% of participants carried clinically actionable variants in 3 or more genes, and DNA sequencing identified an average of 3.3 additional conservatively predicted deleterious variants that would not have been evident using genotyping.
    Conclusion: Implementation of preemptive rather than reactive and sequence-based rather than genotype-based PGx prescribing revealed nearly universal patient applicability and required integrated institution-wide resources to fully realize individualized drug therapy and to show more efficient use of health care resources.
    MeSH term(s) Academic Medical Centers ; Base Sequence ; Cytochrome P-450 CYP2D6/genetics ; Genotype ; Humans ; Pharmacogenetics/methods
    Chemical Substances Cytochrome P-450 CYP2D6 (EC 1.14.14.1)
    Language English
    Publishing date 2022-03-21
    Publishing country United States
    Document type Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 1455352-1
    ISSN 1530-0366 ; 1098-3600
    ISSN (online) 1530-0366
    ISSN 1098-3600
    DOI 10.1016/j.gim.2022.01.022
    Database MEDical Literature Analysis and Retrieval System OnLINE

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