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  1. Article: Open globe injury with an interesting intra-ocular foreign body.

    Gill, Ekjyot / Shulman, Matthew / Schechet, Sid / Grumbine, Lawson

    GMS ophthalmology cases

    2017  Volume 7, Page(s) Doc17

    Abstract: Introduction: ...

    Abstract Introduction:
    Language English
    Publishing date 2017-07-07
    Publishing country Germany
    Document type Case Reports
    ZDB-ID 2628607-5
    ISSN 2193-1496
    ISSN 2193-1496
    DOI 10.3205/oc000068
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Open globe injury with an interesting intra-ocular foreign body

    Gill, Ekjyot / Shulman, Matthew / Schechet, Sid / Grumbine, Lawson

    GMS Ophthalmology Cases - An Open Access Journal

    2017  Volume 7, Page(s) 17

    Abstract: Introduction: Cases of penetrating ocular trauma due to osseous material are limited, so reported incidents are valuable in determining outcomes and proper treatment courses.: Case description: We report a case of an open globe injury of the left eye ... ...

    Abstract Introduction: Cases of penetrating ocular trauma due to osseous material are limited, so reported incidents are valuable in determining outcomes and proper treatment courses.
    Case description: We report a case of an open globe injury of the left eye with an intraocular foreign body occurring after a firework exploded in the hand of a 22-year-old man. The patient presented with light perception vision in the injured eye with a full-thickness limbal laceration and dense hyphema obscuring fundoscopy. CT scan revealed a hyperdense foreign body juxtaposed to the lens. Immediate surgical intervention to repair the globe rupture revealed a defect in the anterior capsule and small, white objects in the posterior chamber that were promptly removed. Pathologic investigation determined these fragments to be cortical bone likely from the patient’s phalanges.
    Results and discussion: There was no evidence of endophthalmitis or keratitis from time of injury to the five-month follow-up, suggesting that the risk of infection may be low and therefore it may be reasonable to manage these injuries with a period of observation.
    Keywords Medizin, Gesundheit
    Publishing date 2017-07-07
    Publisher German Medical Science GMS Publishing House; Düsseldorf
    Document type Article ; Online
    ISSN 2193-1496
    ISSN (online) 2193-1496
    DOI 10.3205/oc000068
    Database German Medical Science

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  3. Article ; Online: A Consistent, Reliable Landmark to Assist in Placement of Orbital Floor Reconstruction Plates After Blowout Fractures.

    Amin, Julian D / Rizzi, Christopher J / Trent, Graham / Greywoode, Jewel / Grumbine, Lawson / Raghavan, Prashant / Vakharia, Kalpesh T

    The Journal of craniofacial surgery

    2019  Volume 30, Issue 7, Page(s) 2277–2279

    Abstract: Objective: To define a reliable and consistent landmark, the superior posterior wall of the maxillary sinus, and to describe how this landmark can be used when repairing orbital floor fractures.: Methods: Retrospective chart review. Patients >18 ... ...

    Abstract Objective: To define a reliable and consistent landmark, the superior posterior wall of the maxillary sinus, and to describe how this landmark can be used when repairing orbital floor fractures.
    Methods: Retrospective chart review. Patients >18 years old diagnosed with unilateral orbital floor and/or zygomaticomaxillary complex fractures.
    Main outcomes: The distance from the inferior orbital rim to the superior posterior wall of the maxillary sinus (landmark distance), and the distance from the landmark to the entrance of the optic canal were reported.
    Results: Eighty patients were included in the study. Each had unilateral isolated orbital floor fractures (n = 46) or unilateral zygomaticomaxillary complex fractures with an orbital floor component (n = 34). The contralateral eye in all patients was uninjured, and was used as an internal control. In orbital floor fractures, the mean landmark distance was 38.8 ± 1.4 mm, with a mean distance on the normal side of 38.8 ± 1.6 mm (P = 0.49). Distance to the optic canal on the injured side in isolated orbital floor fracture patients was 9.0 ± 0.8 mm with the same measurement on the normal side being 8.8 ± 0.7 (P = 0.21). In the setting of zygomaticomaxillary complex fracture, the orbital floor length was 38.2 ± 1.3 mm with a mean normal floor length of 37.8 ± 1.1 mm (P = 0.18). The mean distance from the superior posterior wall to optic canal in zygomaticomaxillary complex fractured orbits was 9.2 ± 1.1 mm with a normal side mean length of 9.5 ± 1.0 mm (P = 0.23). No significant difference was found between the measured distances in the fractured orbit and its normal counterpart for both fracture groups.
    Conclusions and relevance: The superior posterior wall of the maxillary sinus is a reliable landmark that can be used to assist in placement of an orbital floor reconstructive plate. The landmark is unchanged despite the presence of an orbital floor or zygomaticomaxillary sinus fracture.
    MeSH term(s) Bone Plates ; Humans ; Maxillary Sinus/surgery ; Orbit/surgery ; Orbital Fractures/surgery ; Reconstructive Surgical Procedures ; Retrospective Studies ; Tomography, X-Ray Computed
    Language English
    Publishing date 2019-10-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1159501-2
    ISSN 1536-3732 ; 1049-2275
    ISSN (online) 1536-3732
    ISSN 1049-2275
    DOI 10.1097/SCS.0000000000005873
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Frequency and phenotypic implications of mitochondrial DNA mutations in human squamous cell cancers of the head and neck.

    Zhou, Shaoyu / Kachhap, Sushant / Sun, Wenyue / Wu, Guojun / Chuang, Alice / Poeta, Luana / Grumbine, Lawson / Mithani, Suhail K / Chatterjee, Aditi / Koch, Wayne / Westra, William H / Maitra, Anirban / Glazer, Chad / Carducci, Michael / Sidransky, David / McFate, Thomas / Verma, Ajay / Califano, Joseph A

    Proceedings of the National Academy of Sciences of the United States of America

    2007  Volume 104, Issue 18, Page(s) 7540–7545

    Abstract: Mitochondrial genomic mutations are found in a variety of human cancers; however, the frequency of mitochondrial DNA (mtDNA) mutations in coding regions remains poorly defined, and the functional effects of mitochondrial mutations found in primary human ... ...

    Abstract Mitochondrial genomic mutations are found in a variety of human cancers; however, the frequency of mitochondrial DNA (mtDNA) mutations in coding regions remains poorly defined, and the functional effects of mitochondrial mutations found in primary human cancers are not well described. Using MitoChip, we sequenced the whole mitochondrial genome in 83 head and neck squamous cell carcinomas. Forty-one of 83 (49%) tumors contained mtDNA mutations. Mutations occurred within noncoding (D-loop) and coding regions. A nonrandom distribution of mutations was found throughout the mitochondrial enzyme complex components. Sequencing of margins with dysplasia demonstrated an identical nonconservative mitochondrial mutation (A76T in ND4L) as the tumor, suggesting a role of mtDNA mutation in tumor progression. Analysis of p53 status showed that mtDNA mutations correlated positively with p53 mutations (P < 0.002). To characterize biological function of the mtDNA mutations, we cloned NADH dehydrogenase subunit 2 (ND2) mutants based on primary tumor mutations. Expression of the nuclear-transcribed, mitochondrial-targeted ND2 mutants resulted in increased anchorage-dependent and -independent growth, which was accompanied by increased reactive oxygen species production and an aerobic glycolytic metabolic phenotype with hypoxia-inducible factor (HIF)-1alpha induction that is reversible by ascorbate. Cancer-specific mitochondrial mutations may contribute to development of a malignant phenotype by direct genotoxic effects from increased reactive oxygen species production as well as induction of aerobic glycolysis and growth promotion.
    MeSH term(s) DNA, Mitochondrial/genetics ; Gene Expression Regulation, Neoplastic ; HeLa Cells ; Head and Neck Neoplasms/genetics ; Head and Neck Neoplasms/metabolism ; Head and Neck Neoplasms/pathology ; Humans ; Hypoxia-Inducible Factor 1, alpha Subunit/biosynthesis ; Lactic Acid/biosynthesis ; Mutation/genetics ; Neoplasms, Squamous Cell/genetics ; Neoplasms, Squamous Cell/metabolism ; Neoplasms, Squamous Cell/pathology ; Phenotype ; Pyruvates/metabolism ; Reactive Oxygen Species/metabolism ; Tumor Suppressor Protein p53/genetics
    Chemical Substances DNA, Mitochondrial ; HIF1A protein, human ; Hypoxia-Inducible Factor 1, alpha Subunit ; Pyruvates ; Reactive Oxygen Species ; Tumor Suppressor Protein p53 ; Lactic Acid (33X04XA5AT)
    Language English
    Publishing date 2007-05-01
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 209104-5
    ISSN 1091-6490 ; 0027-8424
    ISSN (online) 1091-6490
    ISSN 0027-8424
    DOI 10.1073/pnas.0610818104
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1148: Show issues Location:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
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  5. Article: Frequency and phenotypic implications of mitochondrial DNA mutations in human squamous cell cancers of the head and neck

    Zhou, Shaoyu / Kachhap, Sushant / Sun, Wenyue / Wu, Guojun / Chuang, Alice / Poeta, Luana / Grumbine, Lawson / Mithani, Suhail K / Chatterjee, Aditi / Koch, Wayne / Westra, William H / Maitra, Anirban / Glazer, Chad / Carducci, Michael / Sidransky, David / McFate, Thomas / Verma, Ajay / Califano, Joseph A

    Proceedings of the National Academy of Sciences of the United States of America. 2007 May 1, v. 104, no. 18

    2007  

    Abstract: Mitochondrial genomic mutations are found in a variety of human cancers; however, the frequency of mitochondrial DNA (mtDNA) mutations in coding regions remains poorly defined, and the functional effects of mitochondrial mutations found in primary human ... ...

    Abstract Mitochondrial genomic mutations are found in a variety of human cancers; however, the frequency of mitochondrial DNA (mtDNA) mutations in coding regions remains poorly defined, and the functional effects of mitochondrial mutations found in primary human cancers are not well described. Using MitoChip, we sequenced the whole mitochondrial genome in 83 head and neck squamous cell carcinomas. Forty-one of 83 (49%) tumors contained mtDNA mutations. Mutations occurred within noncoding (D-loop) and coding regions. A nonrandom distribution of mutations was found throughout the mitochondrial enzyme complex components. Sequencing of margins with dysplasia demonstrated an identical nonconservative mitochondrial mutation (A76T in ND4L) as the tumor, suggesting a role of mtDNA mutation in tumor progression. Analysis of p53 status showed that mtDNA mutations correlated positively with p53 mutations (P < 0.002). To characterize biological function of the mtDNA mutations, we cloned NADH dehydrogenase subunit 2 (ND2) mutants based on primary tumor mutations. Expression of the nuclear-transcribed, mitochondrial-targeted ND2 mutants resulted in increased anchorage-dependent and -independent growth, which was accompanied by increased reactive oxygen species production and an aerobic glycolytic metabolic phenotype with hypoxia-inducible factor (HIF)-1α induction that is reversible by ascorbate. Cancer-specific mitochondrial mutations may contribute to development of a malignant phenotype by direct genotoxic effects from increased reactive oxygen species production as well as induction of aerobic glycolysis and growth promotion.
    Language English
    Dates of publication 2007-0501
    Size p. 7540-7545.
    Publishing place National Academy of Sciences
    Document type Article
    ZDB-ID 209104-5
    ISSN 1091-6490 ; 0027-8424
    ISSN (online) 1091-6490
    ISSN 0027-8424
    Database NAL-Catalogue (AGRICOLA)

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