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Article ; Online: Endoscopic Posterior Cricoid Split and Rib Graft Without Tracheostomy: Case and Literature Review.

Jang, Minyoung / Grunstein, Eli

2021 Volume 131, Issue 9, Page(s) E2599–E2602

Abstract: Endoscopic posterior cricoid split and rib grafting (EPCS/RG) for the treatment of posterior laryngeal stenosis has some advantages over traditional open approaches, including improved surgical visualization and decreased morbidity. Many pediatric ... ...

Abstract	Endoscopic posterior cricoid split and rib grafting (EPCS/RG) for the treatment of posterior laryngeal stenosis has some advantages over traditional open approaches, including improved surgical visualization and decreased morbidity. Many pediatric patients who undergo EPCS/RG have indwelling tracheostomy, which may be utilized to help manage the airway perioperatively. The role for de novo tracheostomy placement at the time of EPCS/RG is less clear. We present three cases from a tertiary children's hospital in which EPCS/RG was safely performed without tracheostomy. For patients with posterior laryngeal stenosis but without tracheostomy, EPCS/RG with endotracheal tube stenting might be a safe option. Laryngoscope, 131:E2599-E2602, 2021.
Language	English
Publishing date	2021-02-17
Publishing country	United States
Document type	Case Reports
ZDB-ID	80180-x
ISSN	1531-4995 ; 0023-852X
ISSN (online)	1531-4995
ISSN	0023-852X
DOI	10.1002/lary.29449
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Article: Mallampati and Brodsky Classification and Children's Risk for Sleep Related Breathing Disorder.

Lesavoy, Bret / Lumsden, Christie / Grunstein, Eli / Yoon, Richard

The Journal of clinical pediatric dentistry

2022 Volume 46, Issue 4, Page(s) 280–286

Abstract: Objective: To evaluate associations between Mallampati and Brodsky classification and children's risk for sleep related breathing disorder (SRBD).: Study design: This study recruited well-children 2-11 years old and legal guardians over 18 years from ...

Abstract	Objective: To evaluate associations between Mallampati and Brodsky classification and children's risk for sleep related breathing disorder (SRBD). Study design: This study recruited well-children 2-11 years old and legal guardians over 18 years from a community dental clinic. Modified Mallampati classification (IIV) and Brodsky grade (0-4) were classified by a single dentist. Guardians completed the validated 22-item pediatric sleep questionnaire (PSQ) to identify children at risk of SRBD. Associations between Mallampati and Brodsky classifications with risk for SRBD as defined by PSQ were determined by Chi-square, Kruskal-Wallis, and simple logistic regression models. Results: Of 150 children included (M=5.9 years), 76 (51%) female, 108 (72%) Latino/Hispanic, 82 (55%) were classified as Mallampati class I or II, 68 (45%) class III or IV, 119 (79%) were identified as Brodsky grade 0, 1, or 2, and 31 (21%) grade 3 or 4. Children with Mallampati class III and IV and Brodsky grade 3 and 4 collectively had a 5.24-fold and 2.8-fold increase in SRBD risk per PSQ compared to children with class I and II and grade 1 and 2, respectively. Conclusion: Mallampati classification may be a quick, non-invasive screening tool to improve identification and timely intervention for children at risk of SRBD.
MeSH term(s)	Child ; Child, Preschool ; Female ; Humans ; Male ; Sleep ; Sleep Apnea Syndromes/diagnosis ; Sleep Apnea, Obstructive/diagnosis ; Surveys and Questionnaires
Language	English
Publishing date	2022-09-13
Publishing country	United States
Document type	Journal Article
ZDB-ID	1062408-9
ISSN	1053-4628 ; 0145-5508
ISSN	1053-4628 ; 0145-5508
DOI	10.22514/1053-4625-46.4.4
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Article ; Online: Telemedicine lessons learned during the COVID-19 pandemic: The augmented outpatient otolaryngology teleconsultation.

Sclafani, Anthony P / Shomorony, Andre / Stewart, Michael G / Grunstein, Eli / Overdevest, Jonathan B

American journal of otolaryngology

2021 Volume 42, Issue 4, Page(s) 102960

Abstract: Purpose: Telemedicine use in otolaryngology waxed and waned during the COVID-19 pandemic outbreak in the U.S. Assessing the patterns of telemedicine use and its perceived limitations during the COVID-19 outbreak in 2020 allows identification and ... ...

Abstract	Purpose: Telemedicine use in otolaryngology waxed and waned during the COVID-19 pandemic outbreak in the U.S. Assessing the patterns of telemedicine use and its perceived limitations during the COVID-19 outbreak in 2020 allows identification and correction of impediments to consistent telemedicine use by otolaryngologists. Materials and methods: Full-time faculty of 2 academic otolaryngology departments in New York City were surveyed regarding their telemedicine use from March through August 2020 during the "first wave" of the COVID-19 pandemic. Based on these findings, a method of "augmented outpatient otolaryngology teleconsultation" designed to enhance the quality of the physical examination was developed and employed from August to December 2020. Patients receiving this augmented teleconsult were anonymously surveyed about their telemedical experience. Results: Telemedicine use by faculty was minimal prior to the pandemic, but as total outpatient volume decreased 65-84% across subspecialties, it was used by all otolaryngologists during COVID-19. Physicians were less confident in making a telemedical diagnosis at all phases of the study in all subspecialties. Patients who had an augmented otolaryngology teleconsultation were satisfied with it, believed it facilitated earlier care, limited the time and cost of travel to the physician's office and felt their physician was able to perform a sufficient physical examination. Conclusions: During the COVID-19 crisis, physicians utilized teleotolaryngology to provide care but were less satisfied with their ability to make an accurate diagnosis. Inexpensive direct-to-consumer digital otoscopes can improve the quality of the physical examination provided and can address both patient and physician needs.
MeSH term(s)	Adolescent ; Adult ; Aged ; Ambulatory Care/organization & administration ; COVID-19/epidemiology ; COVID-19/prevention & control ; COVID-19/transmission ; Communicable Disease Control ; Female ; Humans ; Male ; Middle Aged ; Otolaryngology/organization & administration ; Patient Satisfaction ; Physical Examination ; Practice Patterns, Physicians' ; Remote Consultation/organization & administration ; Young Adult
Language	English
Publishing date	2021-02-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	604541-8
ISSN	1532-818X ; 0196-0709
ISSN (online)	1532-818X
ISSN	0196-0709
DOI	10.1016/j.amjoto.2021.102960
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Zs.A 1637: Show issues

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Article ; Online: Tracking Immunoglobulin Repertoire and Transcriptomic Changes in Germinal Center B Cells by Single-Cell Analysis.

Corinaldesi, Clarissa / Holmes, Antony B / Shen, Qiong / Grunstein, Eli / Pasqualucci, Laura / Dalla-Favera, Riccardo / Basso, Katia

Frontiers in immunology

2022 Volume 12, Page(s) 818758

Abstract: In response to T-cell-dependent antigens, mature B cells in the secondary lymphoid organs are stimulated to form germinal centers (GCs), which are histological structures deputed to antibody affinity maturation, a process associated with immunoglobulin ... ...

Abstract	In response to T-cell-dependent antigens, mature B cells in the secondary lymphoid organs are stimulated to form germinal centers (GCs), which are histological structures deputed to antibody affinity maturation, a process associated with immunoglobulin gene editing by somatic hypermutation (SHM) and class switch recombination (CSR). GC B cells are heterogeneous and transition across multiple stages before being eliminated by apoptosis or committing to post-GC differentiation as memory B cells or plasma cells. In order to explore the dynamics of SHM and CSR during the GC reaction, we identified GC subpopulations by single-cell (sc) transcriptomics and analyzed the load of immunoglobulin variable (V) region mutations as well as the isotype class distribution in each subpopulation. The results showed that the large majority of GC B cells display a quantitatively similar mutational load in the V regions and analogous IGH isotype class distribution, except for the precursors of memory B cells (PreM) and plasma cells (PBL). PreM showed a bimodal pattern with about half of the cells displaying high V region germline identity and enrichment for unswitched IGH, while the rest of the cells carried a mutational load similar to the bulk of GC B cells and showed a switched isotype. PBL displayed a bias toward expression of IGHG and higher V region germline identity compared to the bulk of GC B cells. Genes implicated in SHM and CSR were significantly induced in specific GC subpopulations, consistent with the occurrence of SHM in dark zone cells and suggesting that CSR can occur within the GC.
MeSH term(s)	B-Lymphocyte Subsets/immunology ; B-Lymphocyte Subsets/metabolism ; B-Lymphocytes/immunology ; B-Lymphocytes/metabolism ; Computational Biology/methods ; Gene Expression Profiling/methods ; Germinal Center/cytology ; Germinal Center/immunology ; Humans ; Immunoglobulin Class Switching ; Immunoglobulin Variable Region/genetics ; Immunologic Memory/genetics ; Plasma Cells/immunology ; Plasma Cells/metabolism ; Receptors, Antigen, B-Cell/genetics ; Receptors, Antigen, B-Cell/metabolism ; Signal Transduction ; Single-Cell Analysis/methods ; Somatic Hypermutation, Immunoglobulin ; Transcriptome
Chemical Substances	Immunoglobulin Variable Region ; Receptors, Antigen, B-Cell
Language	English
Publishing date	2022-01-12
Publishing country	Switzerland
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2021.818758
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Article ; Online: Unconventional delivery of inhaled nitric oxide during endoscopic laryngeal tracheal reconstruction in a child with pulmonary arterial hypertension: A case report.

Lee, Jennifer J / Kazim, Robert / Jang, Minyoung / Grunstein, Eli

Paediatric anaesthesia

2019 Volume 29, Issue 11, Page(s) 1146–1147

Abstract: Endoscopic laryngeal tracheal reconstruction was performed on a child with glottic stenosis and pulmonary arterial hypertension. The surgical repair was performed while delivering inhaled nitric oxide via the ventilating port of a suspension laryngoscope ...

Abstract	Endoscopic laryngeal tracheal reconstruction was performed on a child with glottic stenosis and pulmonary arterial hypertension. The surgical repair was performed while delivering inhaled nitric oxide via the ventilating port of a suspension laryngoscope with the patient maintaining spontaneous respirations. The surgery was accomplished without complications.
MeSH term(s)	Administration, Inhalation ; Child ; Humans ; Laryngoscopes ; Male ; Nitric Oxide/administration & dosage ; Pulmonary Arterial Hypertension/surgery ; Reconstructive Surgical Procedures/methods ; Trachea/surgery
Chemical Substances	Nitric Oxide (31C4KY9ESH)
Language	English
Publishing date	2019-09-17
Publishing country	France
Document type	Case Reports
ZDB-ID	1086049-6
ISSN	1460-9592 ; 1155-5645
ISSN (online)	1460-9592
ISSN	1155-5645
DOI	10.1111/pan.13732
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Article: Mapping human natural killer cell development in pediatric tonsil by imaging mass cytometry and high-resolution microscopy.

Hegewisch-Solloa, Everardo / Melsen, Janine E / Ravichandran, Hiranmayi / Rendeiro, André F / Freud, Aharon G / Mundy-Bosse, Bethany / Melms, Johannes C / Eisman, Shira E / Izar, Benjamin / Grunstein, Eli / Connors, Thomas J / Elemento, Olivier / Horowitz, Amir / Mace, Emily M

bioRxiv : the preprint server for biology

2023

Abstract: Natural killer (NK) cells develop from CD34+ progenitors in a stage-specific manner defined by changes in cell surface receptor expression and function. Secondary lymphoid tissues, including tonsil, are sites of human NK cell development. Here we present ...

Abstract	Natural killer (NK) cells develop from CD34+ progenitors in a stage-specific manner defined by changes in cell surface receptor expression and function. Secondary lymphoid tissues, including tonsil, are sites of human NK cell development. Here we present new insights into human NK cell development in pediatric tonsil using cyclic immunofluorescence and imaging mass cytometry. We show that NK cell subset localization and interactions are dependent on NK cell developmental stage and tissue residency. NK cell progenitors are found in the interfollicular domain in proximity to cytokine-expressing stromal cells that promote proliferation and maturation. Mature NK cells are primarily found in the T-cell rich parafollicular domain engaging in cell-cell interactions that differ depending on their stage and tissue residency. The presence of local inflammation results in changes in NK cell interactions, abundance, and localization. This study provides the first comprehensive atlas of human NK cell development in secondary lymphoid tissue.
Language	English
Publishing date	2023-09-06
Publishing country	United States
Document type	Preprint
DOI	10.1101/2023.09.05.556371
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Article ; Online: Development and validation of a novel informational booklet for pediatric long-term ventilation decision support.

Edwards, Jeffrey D / Panitch, Howard B / George, Maureen / Cirrilla, Anne-Marie / Grunstein, Eli / Wolfe, Joanne / Nelson, Judith E / Miller, Rachel L

Pediatric pulmonology

2020 Volume 56, Issue 5, Page(s) 1198–1204

Abstract: Objectives: To provide accessible, uniform, comprehensive, and balanced information to families deciding whether to initiate long-term ventilation (LTV) for their child, we sought to develop and validate a novel informational resource.: Methods: The ... ...

Abstract	Objectives: To provide accessible, uniform, comprehensive, and balanced information to families deciding whether to initiate long-term ventilation (LTV) for their child, we sought to develop and validate a novel informational resource. Methods: The Ottawa Decision Support Framework was followed. Previous interviews with 44 lay and 15 professional stakeholders and published literature provided content for a booklet. Iterative versions were cognitive tested with six parents facing decisions and five pediatric intensivists. Ten parents facing decisions evaluated the booklet using the Preparation for Decision Making Scale and reported their decisional conflict, which was juxtaposed to the conflict of 21 parents who did not read it, using the Decisional Conflict Scale. Twelve home ventilation program directors evaluated the booklet's clinical sensibility and sensitivity, using a self-designed six-item questionnaire. Data presented using summary statistics. Results: The illustrated booklet (6th-grade reading level) has nine topical sections on chronic respiratory failure and invasive and noninvasive LTV, including the option to forgo LTV. Ten parents who read the booklet rated it as helping "Quite a bit" or more on all items of the Preparation for Decision Making Scale and had seemingly less decisional conflict than 21 parents who did not. Twelve directors rated it highly for clinical sensibility and sensitivity. Conclusions: The LTV booklet was rigorously developed and favorably evaluated. It offers a resource to improve patient/family knowledge, supplement shared decision-making, and reduce decisional conflict around LTV decisions. Future studies should validate it in other settings and further study its effectiveness.
MeSH term(s)	Child ; Decision Making ; Family ; Heart-Assist Devices ; Humans ; Pamphlets ; Parents ; Surveys and Questionnaires
Language	English
Publishing date	2020-12-23
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	632784-9
ISSN	1099-0496 ; 8755-6863
ISSN (online)	1099-0496
ISSN	8755-6863
DOI	10.1002/ppul.25221
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Article ; Online: Differential Integrin Adhesome Expression Defines Human NK Cell Residency and Developmental Stage.

Hegewisch-Solloa, Everardo / Seo, Seungmae / Mundy-Bosse, Bethany L / Mishra, Anjali / Waldman, Erik H / Maurrasse, Sarah / Grunstein, Eli / Connors, Thomas J / Freud, Aharon G / Mace, Emily M

Journal of immunology (Baltimore, Md. : 1950)

2021 Volume 207, Issue 3, Page(s) 950–965

Abstract: NK cells are innate immune cells that reside within tissue and circulate in peripheral blood. They interact with a variety of microenvironments, yet how NK cells engage with these varied microenvironments is not well documented. The adhesome represents a ...

Abstract	NK cells are innate immune cells that reside within tissue and circulate in peripheral blood. They interact with a variety of microenvironments, yet how NK cells engage with these varied microenvironments is not well documented. The adhesome represents a molecular network of defined and predicted integrin-mediated signaling interactions. In this study, we define the integrin adhesome expression profile of NK cells from human tonsil, peripheral blood, and those derived from human hematopoietic precursors through stromal cell coculture systems. We report that the site of cell isolation and NK cell developmental stage dictate differences in expression of adhesome associated genes and proteins. Furthermore, we define differences in cortical actin content associated with differential expression of actin regulating proteins, suggesting that differences in adhesome expression are associated with differences in cortical actin homeostasis. These data provide understanding of the diversity of human NK cell populations and how they engage with their microenvironment.
MeSH term(s)	Humans ; Integrins/genetics ; Internship and Residency ; Killer Cells, Natural ; Signal Transduction
Chemical Substances	Integrins
Language	English
Publishing date	2021-07-19
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Comment
ZDB-ID	3056-9
ISSN	1550-6606 ; 0022-1767 ; 1048-3233 ; 1047-7381
ISSN (online)	1550-6606
ISSN	0022-1767 ; 1048-3233 ; 1047-7381
DOI	10.4049/jimmunol.2100162
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Ud II Zs.37: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Congenital Cytomegalovirus Testing Outcomes From the ValEAR Trial.

Orb, Quinn T / Pesch, Megan / Allen, Chelsea M / Wilkes, Ashlea / Ahmad, Iram / Alfonso, Kristan / Antonio, Stephanie Moody / Mithal, Leena Bhattacharya / Brinkmeier, Jennifer V / Carvalho, Daniela / Chan, Dylan / Cheng, Alan G / Chi, David / Cohen, Michael / Discolo, Christopher Michael / Duran, Carlos / Germiller, John / Gibson, Laura / Grunstein, Eli /

Harrison, Gail / Lee, Kenneth / Hawley, Karen / Kohlhoff, Stephan / Melvin, Ann / MacArthur, Carol / Nassar, Michel / Neff, Laura / Pecha, Phayvanh / Salvatore, Christine / Schoem, Scott / Virgin, Frank / Saunders, James / Schleiss, Mark / Smith, Richard J H / Sood, Sunil / Park, Albert H

Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery

2024 Volume 170, Issue 5, Page(s) 1430–1441

Abstract: Objective: To determine the positivity rate of congenital cytomegalovirus (cCMV) testing among universal, hearing-targeted CMV testing (HT-cCMV) and delayed targeted dried blood spot (DBS) testing newborn screening programs, and to examine the ... ...

Abstract	Objective: To determine the positivity rate of congenital cytomegalovirus (cCMV) testing among universal, hearing-targeted CMV testing (HT-cCMV) and delayed targeted dried blood spot (DBS) testing newborn screening programs, and to examine the characteristics of successful HT-cCMV testing programs. Study design: Prospective survey of birth hospitals performing early CMV testing. Setting: Multiple institutions. Methods: Birth hospitals participating in the National Institutes of Health ValEAR clinical trial were surveyed to determine the rates of cCMV positivity associated with 3 different testing approaches: universal testing, HT-cCMV, and DBS testing. A mixed methods model was created to determine associations between successful HT-cCMV screening and specific screening protocols. Results: Eighty-two birth hospitals were surveyed from February 2019 to December 2021. Seven thousand six hundred seventy infants underwent universal screening, 9017 infants HT-cCMV and 535 infants delayed DBS testing. The rates of cCMV positivity were 0.5%, 1.5%, and 7.3%, respectively. The positivity rate for universal CMV screening was less during the COVID-19 pandemic than that reported prior to the pandemic. There were no statistically significant drops in positivity for any approach during the pandemic. For HT-cCMV testing, unique order sets and rigorous posttesting protocols were associated with successful screening programs. Conclusion: Rates of cCMV positivity differed among the 3 approaches. The rates are comparable to cohort studies reported in the literature. Universal CMV prevalence decreased during the pandemic but not significantly. Institutions with specific order set for CMV testing where the primary care physician orders the test and the nurse facilitates the testing process exhibited higher rates of HT-cCMV testing.
MeSH term(s)	Humans ; Cytomegalovirus Infections/diagnosis ; Cytomegalovirus Infections/congenital ; Cytomegalovirus Infections/epidemiology ; Neonatal Screening/methods ; Infant, Newborn ; Prospective Studies ; COVID-19/epidemiology ; COVID-19/diagnosis ; United States/epidemiology ; Dried Blood Spot Testing ; Female ; Male
Language	English
Publishing date	2024-02-28
Publishing country	England
Document type	Journal Article ; Multicenter Study ; Research Support, N.I.H., Extramural
ZDB-ID	392085-9
ISSN	1097-6817 ; 0161-6439 ; 0194-5998
ISSN (online)	1097-6817
ISSN	0161-6439 ; 0194-5998
DOI	10.1002/ohn.670
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Article ; Online: Single-cell analysis of germinal-center B cells informs on lymphoma cell of origin and outcome.

Holmes, Antony B / Corinaldesi, Clarissa / Shen, Qiong / Kumar, Rahul / Compagno, Nicolo / Wang, Zhong / Nitzan, Mor / Grunstein, Eli / Pasqualucci, Laura / Dalla-Favera, Riccardo / Basso, Katia

The Journal of experimental medicine

2020 Volume 217, Issue 10

Abstract: In response to T cell-dependent antigens, mature B cells are stimulated to form germinal centers (GCs), the sites of B cell affinity maturation and the cell of origin (COO) of most B cell lymphomas. To explore the dynamics of GC B cell development beyond ...

Abstract	In response to T cell-dependent antigens, mature B cells are stimulated to form germinal centers (GCs), the sites of B cell affinity maturation and the cell of origin (COO) of most B cell lymphomas. To explore the dynamics of GC B cell development beyond the known dark zone and light zone compartments, we performed single-cell (sc) transcriptomic analysis on human GC B cells and identified multiple functionally linked subpopulations, including the distinct precursors of memory B cells and plasma cells. The gene expression signatures associated with these GC subpopulations were effective in providing a sc-COO for ∼80% of diffuse large B cell lymphomas (DLBCLs) and identified novel prognostic subgroups of DLBCL.
MeSH term(s)	B-Lymphocytes/metabolism ; B-Lymphocytes/pathology ; Cell Lineage ; Fluorescent Antibody Technique ; Gene Expression Profiling ; Germinal Center/metabolism ; Germinal Center/pathology ; Humans ; Lymphoma/metabolism ; Lymphoma/pathology ; Single-Cell Analysis
Language	English
Publishing date	2020-06-30
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	218343-2
ISSN	1540-9538 ; 0022-1007
ISSN (online)	1540-9538
ISSN	0022-1007
DOI	10.1084/jem.20200483
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