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  1. Article: Assessment of novel POCT to evaluate liver function.

    Minea, Carmen / Gruson, Damien

    Practical laboratory medicine

    2024  Volume 39, Page(s) e00367

    Abstract: Objectives: Point of care testing (POCT) offers the possibility of near bedside patient testing with a reduction of the turn-around time of analysis. The aim of our study was to determine the analytical performances and usability of a recently developed ...

    Abstract Objectives: Point of care testing (POCT) offers the possibility of near bedside patient testing with a reduction of the turn-around time of analysis. The aim of our study was to determine the analytical performances and usability of a recently developed POCT device for the measurement of tests related to liver function. We evaluated the performance of a liver tests panel performed on the LINX EVO® POCT device.
    Design and methods: The imprecision was determined with the Bio-Rad Liquichek Unassayed Chemistry Control. Method comparison was performed with a Cobas® 8000 analyzer. Samples from twenty healthy volunteers were used to verify the reference intervals. Furthermore, practicality was assessed by the healthcare staff handling the POCT device through a dedicated questionnaire.
    Results: The imprecision observed was matching the criteria for the in-lab assay with only one exception, globulin, with an observed imprecision of 6.3 % and a criteria of 5.7 %. With the exception of total and direct bilirubin, the POCT method showed good agreement with the in-lab methods. The verification of reference intervals showed that more than 90 % of the healthy volunteer values were included into the reference interval claimed by the manufacturer except for glucose and globulin. The POCT practicality questionnaire was satisfying overall for users.
    Conclusions: Our study showed very good analytical performances overall for the liver test panel performed on the LINX EVO® POCT instrument.
    Language English
    Publishing date 2024-01-30
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2834973-8
    ISSN 2352-5517
    ISSN 2352-5517
    DOI 10.1016/j.plabm.2024.e00367
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Controlling Reliability, Interoperability and Security of Mobile Health Solutions.

    Gruson, Damien

    EJIFCC

    2021  Volume 32, Issue 2, Page(s) 118–123

    Abstract: Mobile health (mHealth), including mobile devices and digital services, is a component of the transforming health ecosystem. The validation of the scientific validity, analytical performance, clinical performance and security of mHealth solutions is ... ...

    Abstract Mobile health (mHealth), including mobile devices and digital services, is a component of the transforming health ecosystem. The validation of the scientific validity, analytical performance, clinical performance and security of mHealth solutions is critical to guarantee patient care and safety. To this end, laboratory experts, scientific societies and notified bodies should define and recommend validation framework addressing multiple dimensions.
    Language English
    Publishing date 2021-06-29
    Publishing country Italy
    Document type Journal Article ; Review
    ISSN 1650-3414
    ISSN (online) 1650-3414
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  3. Article ; Online: Big Data, artificial intelligence and laboratory medicine: time for integration.

    Gruson, Damien

    Advances in laboratory medicine

    2021  Volume 2, Issue 1, Page(s) 1–7

    Language Spanish
    Publishing date 2021-02-10
    Publishing country Germany
    Document type Editorial
    ISSN 2628-491X
    ISSN (online) 2628-491X
    DOI 10.1515/almed-2021-0003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Emerging Technologies in Healthcare and Laboratory Medicine: Trends and Need for a Roadmap to Sustainable Implementation

    Gruson, Damien / Kemaloğlu Öz, Tuğba

    Balkan medical journal

    2024  Volume 41, Issue 2, Page(s) 85–86

    MeSH term(s) Humans ; Delivery of Health Care
    Language English
    Publishing date 2024-01-18
    Publishing country Turkey
    Document type Journal Article
    ZDB-ID 2612982-6
    ISSN 2146-3131 ; 2146-3131
    ISSN (online) 2146-3131
    ISSN 2146-3131
    DOI 10.4274/balkanmedj.galenos.2024.2024-1-16
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  5. Article ; Online: PTH and cardiovascular risk.

    Gruson, Damien

    Annales d'endocrinologie

    2020  Volume 82, Issue 3-4, Page(s) 149–150

    Abstract: Cardiovascular diseases remain the leading cause of non-communicable chronic diseases, are related to high morbidity and mortality and are associated to a huge impact on healthcare budgets. Biomarkers play an important role for the diagnosis and ... ...

    Abstract Cardiovascular diseases remain the leading cause of non-communicable chronic diseases, are related to high morbidity and mortality and are associated to a huge impact on healthcare budgets. Biomarkers play an important role for the diagnosis and prognosis of cardiovascular diseases and are recognized tools for value-based care. Parathyroid hormone (PTH) is a major systemic calcium-regulating hormone and an important regulator of bone and mineral homeostasis. PTH 1-84, the biologically active hormone produced by the parathyroid glands and secreted into the systemic circulation, exerts its biological effects through the interaction of its first 34 amino acids with PTH receptors. PTH levels are raised in several cardio-renal disorders and hyperparathyroidism have detrimental effects on the heart and cardiac cells such as cardiac hypertrophy, remodeling and arrhythmias. High circulating PTH levels, through an increase in intracellular calcium, contribute also to the impairment of mitochondrial function and ATP production and to oxidative stress as well as inflammation states and, at the end, to cardiomyocytes necrosis. The interplay between PTH, fibroblast growth factor 23 and aldosterone is also detrimental for cardiovascular system and participate to endothelial dysfunction. Measurement of PTH levels could be therefore relevant in high risk individuals and could provide added value to established cardiac biomarkers for the sub-phenotyping of patients and treatment selection.
    MeSH term(s) Calcium/metabolism ; Cardiovascular Diseases/etiology ; Cardiovascular Diseases/metabolism ; Heart Disease Risk Factors ; Heart Diseases/etiology ; Heart Diseases/metabolism ; Humans ; Hyperparathyroidism/complications ; Hyperparathyroidism/metabolism ; Parathyroid Hormone/physiology ; Risk Factors
    Chemical Substances PTH protein, human ; Parathyroid Hormone ; Calcium (SY7Q814VUP)
    Language English
    Publishing date 2020-02-28
    Publishing country France
    Document type Journal Article ; Review
    ZDB-ID 299-9
    ISSN 2213-3941 ; 0003-4266
    ISSN (online) 2213-3941
    ISSN 0003-4266
    DOI 10.1016/j.ando.2020.02.005
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    In stock of ZB MED Cologne/Königswinter

    Uh III Zs.132: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Erratum to 'Oxytocin testing and reproductive health: Status and clinical applications' [Clinical Biochemistry 62 (2018) 55-61].

    Gruson, Damien

    Clinical biochemistry

    2019  Volume 66, Page(s) 107

    Language English
    Publishing date 2019-03-26
    Publishing country United States
    Document type Journal Article ; Published Erratum
    ZDB-ID 390372-2
    ISSN 1873-2933 ; 0009-9120
    ISSN (online) 1873-2933
    ISSN 0009-9120
    DOI 10.1016/j.clinbiochem.2019.03.010
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    Zs.A 624: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Oxytocin testing and reproductive health: Status and clinical applications.

    Gruson, Damien

    Clinical biochemistry

    2018  Volume 62, Page(s) 55–61

    Abstract: Oxytocin (OT) is a nonapeptide hormone mainly synthesized in the magnocellular neurons of the paraventricular and supraoptic nucleus of the hypothalamus. In the extra-hypothalamic brain areas, OT acts like neurotransmitters and modulators. The ... ...

    Abstract Oxytocin (OT) is a nonapeptide hormone mainly synthesized in the magnocellular neurons of the paraventricular and supraoptic nucleus of the hypothalamus. In the extra-hypothalamic brain areas, OT acts like neurotransmitters and modulators. The physiological functions of OT are multiple. OT participates to the coordination and control of gonadal development and reproduction. OT appears also as an important regulator of social behaviors such as affiliative, parental, and romantic behaviors. Recent evidence suggests other roles for OT such as potent effects on cardiometabolic functions or involvement in stress-related disorders. The growing interest around the clinical role of OT raised the question of the measurement of OT levels and performances of assays.
    MeSH term(s) Animals ; Biomarkers/analysis ; Evidence-Based Medicine ; Female ; Humans ; Male ; Models, Biological ; Neurons/physiology ; Oxytocin/analysis ; Oxytocin/physiology ; Paraventricular Hypothalamic Nucleus/physiology ; Paraventricular Hypothalamic Nucleus/physiopathology ; Pregnancy ; Reproductive Health ; Social Behavior ; Supraoptic Nucleus/physiology ; Supraoptic Nucleus/physiopathology
    Chemical Substances Biomarkers ; Oxytocin (50-56-6)
    Language English
    Publishing date 2018-10-27
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 390372-2
    ISSN 1873-2933 ; 0009-9120
    ISSN (online) 1873-2933
    ISSN 0009-9120
    DOI 10.1016/j.clinbiochem.2018.10.016
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 624: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article: New Solutions for the Sample Transport and Results Delivery: A Digital Lab.

    Gruson, Damien

    EJIFCC

    2018  Volume 29, Issue 3, Page(s) 210–214

    Abstract: The consolidation of laboratories, the evolution to integrated care network as well as an environment of consumerization are disrupting laboratory services and operations. The switch to SMART (Speed Metrics Automation Remote Technologies) digital ... ...

    Abstract The consolidation of laboratories, the evolution to integrated care network as well as an environment of consumerization are disrupting laboratory services and operations. The switch to SMART (Speed Metrics Automation Remote Technologies) digital laboratories based health ecosystems depends on several prerequisites for successes. Intelligent processes, integration of big data and real-time data management, automation, blockchain, Internet of things and enhancement of user experiences are key element of the smart digital laboratory. Safety, security and cost-effectiveness are pillars for the credibility and transferability of such smart digital laboratory environment. This transforming ecosystem will also trigger novel human - machine interfaces and we will be the gatekeepers for this new "click to brick" ecosystem.
    Language English
    Publishing date 2018-11-07
    Publishing country Italy
    Document type Journal Article
    ISSN 1650-3414
    ISSN 1650-3414
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  9. Article ; Online: High-sensitive cardiac troponin T: are turbulences coming?

    Deltombe, Matthieu / Gruson, Damien

    Clinical chemistry and laboratory medicine

    2022  Volume 61, Issue 1, Page(s) e11–e12

    MeSH term(s) Humans ; Troponin T ; Troponin I ; Myocardium
    Chemical Substances Troponin T ; Troponin I
    Language English
    Publishing date 2022-08-23
    Publishing country Germany
    Document type Letter
    ZDB-ID 1418007-8
    ISSN 1437-4331 ; 1434-6621 ; 1437-8523
    ISSN (online) 1437-4331
    ISSN 1434-6621 ; 1437-8523
    DOI 10.1515/cclm-2022-0497
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 121: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  10. Article ; Online: Measurement of Anti-Mullerian Hormone: Preliminary Evaluation of an ABEI-Based Fully Automated Immunoassay.

    Gruson, Damien / Siham, Akdim / Fillée, Catherine

    EJIFCC

    2023  Volume 34, Issue 1, Page(s) 4–9

    Abstract: Background: The added value of Anti-Müllerian hormone (AMH) measurement is recognized for several clinical applications such as assessment of the ovarian reserve, monitoring of : Methods: We evaluated the performances of the Maglumi: Results: The ... ...

    Abstract Background: The added value of Anti-Müllerian hormone (AMH) measurement is recognized for several clinical applications such as assessment of the ovarian reserve, monitoring of
    Methods: We evaluated the performances of the Maglumi
    Results: The within-run and between-run coefficients of variation (CVs) were below
    Conclusions: Our preliminary evaluation showed overall good analytical performances for the Maglumi
    Language English
    Publishing date 2023-04-18
    Publishing country Italy
    Document type Journal Article
    ISSN 1650-3414
    ISSN (online) 1650-3414
    Database MEDical Literature Analysis and Retrieval System OnLINE

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