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  1. Article: Case Report: Early detection of lung carcinoid in an asymptomatic individual by blood-test initiated PET-CT imaging.

    Burg, Simon / Smeets, Ralf / Gosau, Martin / Failing, Katja / Grust, Audrey Laure Céline

    Frontiers in oncology

    2023  Volume 13, Page(s) 1177237

    Abstract: We present the case of a 53-year-old woman who was diagnosed with early-stage lung cancer by targeted cancer screening consisting of an immunological biopsy-based blood test followed by radiological imaging. The PanTum Detect blood test detects the ... ...

    Abstract We present the case of a 53-year-old woman who was diagnosed with early-stage lung cancer by targeted cancer screening consisting of an immunological biopsy-based blood test followed by radiological imaging. The PanTum Detect blood test detects the biomarkers Apo10/DNaseX and Transketolase-like 1 (TKTL1) in circulating macrophage-like cells from peripheral blood samples to identify asymptomatic individuals with a high risk for malignancy. The elevated blood test values initiated an
    Language English
    Publishing date 2023-06-06
    Publishing country Switzerland
    Document type Case Reports
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2023.1177237
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Doping of casted silk fibroin membranes with extracellular vesicles for regenerative therapy: a proof of concept.

    Fuest, Sandra / Salviano-Silva, Amanda / Maire, Cecile L / Xu, Yong / Apel, Christian / Grust, Audrey Laure Céline / Delle Coste, Arianna / Gosau, Martin / Ricklefs, Franz L / Smeets, Ralf

    Scientific reports

    2024  Volume 14, Issue 1, Page(s) 3553

    Abstract: Bioactive material concepts for targeted therapy have been an important research focus in regenerative medicine for years. The aim of this study was to investigate a proof-of-concept composite structure in the form of a membrane made of natural silk ... ...

    Abstract Bioactive material concepts for targeted therapy have been an important research focus in regenerative medicine for years. The aim of this study was to investigate a proof-of-concept composite structure in the form of a membrane made of natural silk fibroin (SF) and extracellular vesicles (EVs) from gingival fibroblasts. EVs have multiple abilities to act on their target cell and can thus play crucial roles in both physiology and regeneration. This study used pH neutral, degradable SF-based membranes, which have excellent cell- and tissue-specific properties, as the carrier material. The characterization of the vesicles showed a size range between 120 and 180 nm and a high expression of the usual EV markers (e.g. CD9, CD63 and CD81), measured by nanoparticle tracking analysis (NTA) and single-EV flow analysis (IFCM). An initial integration of the EVs into the membrane was analyzed using scanning and transmission electron microscopy (SEM and TEM) and vesicles were successfully detected, even if they were not homogeneously distributed in the membrane. Using direct and indirect tests, the cytocompatibility of the membranes with and without EVs could be proven and showed significant differences compared to the toxic control (p < 0.05). Additionally, proliferation of L929 cells was increased on membranes functionalized with EVs (p > 0.05).
    MeSH term(s) Fibroins/metabolism ; Extracellular Vesicles/metabolism ; Membranes ; Nanoparticles/chemistry ; Fibroblasts
    Chemical Substances Fibroins (9007-76-5)
    Language English
    Publishing date 2024-02-12
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-024-54014-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Silk proteins in reconstructive surgery: Do they possess an inherent antibacterial activity? A systematic review.

    Schäfer, Sogand / Aavani, Farzaneh / Köpf, Marius / Drinic, Aleksander / Stürmer, Ewa K / Fuest, Sandra / Grust, Audrey Laure Céline / Gosau, Martin / Smeets, Ralf

    Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society

    2022  Volume 31, Issue 1, Page(s) 99–110

    Abstract: The field of reconstructive surgery encompasses a wide range of surgical procedures and regenerative approaches to treat various tissue types. Every surgical procedure is associated with the risk of surgical site infections, which are not only a ... ...

    Abstract The field of reconstructive surgery encompasses a wide range of surgical procedures and regenerative approaches to treat various tissue types. Every surgical procedure is associated with the risk of surgical site infections, which are not only a financial burden but also increase patient morbidity. The surgical armamentarium in this area are biomaterials, particularly natural, biodegradable, biocompatible polymers, including the silk proteins fibroin (SF) and sericin (SS). Silk is known to be derived from silkworms and is mainly composed of 60-80% fibroin, which provides the structural form, and 15-35% sericin, which acts as a glue-like substance for the SF threads. Silk proteins possess most of the desired properties for biomedical applications, including biocompatibility, biodegradability, minimal immunogenicity, and tunable biomechanical behaviour. In an effort to alleviate or even prevent infections associated with the use of biomaterials in surgery, antibacterial/antimicrobial properties have been investigated in numerous studies. In this systematic review, the following question was addressed: Do silk proteins, SF and SS, possess an intrinsic antibacterial property and how could these materials be tailored to achieve such a property?
    MeSH term(s) Anti-Bacterial Agents/pharmacology ; Biocompatible Materials/pharmacology ; Fibroins/chemistry ; Fibroins/pharmacology ; Sericins/pharmacology ; Sericins/chemistry ; Surgery, Plastic ; Wound Healing
    Chemical Substances Anti-Bacterial Agents ; Biocompatible Materials ; Fibroins (9007-76-5) ; Sericins
    Language English
    Publishing date 2022-09-30
    Publishing country United States
    Document type Systematic Review ; Journal Article ; Review
    ZDB-ID 1174873-4
    ISSN 1524-475X ; 1067-1927
    ISSN (online) 1524-475X
    ISSN 1067-1927
    DOI 10.1111/wrr.13049
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  4. Article ; Online: Layer-by-Layer Deposition of Regenerated Silk Fibroin─An Approach to the Surface Coating of Biomedical Implant Materials.

    Fuest, Sandra / Smeets, Ralf / Gosau, Martin / Aavani, Farzaneh / Knipfer, Christian / Grust, Audrey Laure Céline / Kopp, Alexander / Becerikli, Mustafa / Behr, Björn / Matthies, Levi

    ACS biomaterials science & engineering

    2023  Volume 9, Issue 12, Page(s) 6644–6657

    Abstract: Biomaterials and coating techniques unlock major benefits for advanced medical therapies. Here, we explored layer-by-layer (LbL) deposition of silk fibroin (SF) by dip coating to deploy homogeneous films on different materials (titanium, magnesium, and ... ...

    Abstract Biomaterials and coating techniques unlock major benefits for advanced medical therapies. Here, we explored layer-by-layer (LbL) deposition of silk fibroin (SF) by dip coating to deploy homogeneous films on different materials (titanium, magnesium, and polymers) frequently used for orthopedic and other bone-related implants. Titanium and magnesium specimens underwent preceding plasma electrolytic oxidation (PEO) to increase hydrophilicity. This was determined as surface properties were visualized by scanning electron microscopy and contact angle measurements as well as Fourier transform infrared spectroscopy (FTIR) analysis. Finally, biological in vitro evaluations of hemocompatibility, THP-1 cell culture, and TNF-α assays were conducted. A more hydrophilic surface could be achieved using the PEO surface, and the contact angle for magnesium and titanium showed a reduction from 73 to 18° and from 58 to 17°, respectively. Coating with SF proved successful on all three surfaces, and coating thicknesses of up to 5.14 μm (±SD 0.22 μm) were achieved. Using FTIR analysis, it was shown that the insolubility of the material was achieved by post-treatment with water vapor annealing, although the random coil peak (1640-1649 cm
    MeSH term(s) Fibroins/pharmacology ; Titanium/pharmacology ; Titanium/chemistry ; Magnesium/chemistry ; Magnesium/pharmacology ; Tumor Necrosis Factor-alpha ; Coated Materials, Biocompatible/pharmacology ; Coated Materials, Biocompatible/chemistry ; Polymers
    Chemical Substances Fibroins (9007-76-5) ; Titanium (D1JT611TNE) ; Magnesium (I38ZP9992A) ; Tumor Necrosis Factor-alpha ; Coated Materials, Biocompatible ; Polymers
    Language English
    Publishing date 2023-11-20
    Publishing country United States
    Document type Journal Article
    ISSN 2373-9878
    ISSN (online) 2373-9878
    DOI 10.1021/acsbiomaterials.3c00852
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Tissue Adhesives in Reconstructive and Aesthetic Surgery-Application of Silk Fibroin-Based Biomaterials.

    Smeets, Ralf / Tauer, Nathalie / Vollkommer, Tobias / Gosau, Martin / Henningsen, Anders / Hartjen, Philip / Früh, Leonie / Beikler, Thomas / Stürmer, Ewa K / Rutkowski, Rico / Grust, Audrey Laure Céline / Fuest, Sandra / Gaudin, Robert / Aavani, Farzaneh

    International journal of molecular sciences

    2022  Volume 23, Issue 14

    Abstract: Tissue adhesives have been successfully used in various kind of surgeries such as oral and maxillofacial surgery for some time. They serve as a substitute for suturing of tissues and shorten treatment time. Besides synthetic-based adhesives, a number of ... ...

    Abstract Tissue adhesives have been successfully used in various kind of surgeries such as oral and maxillofacial surgery for some time. They serve as a substitute for suturing of tissues and shorten treatment time. Besides synthetic-based adhesives, a number of biological-based formulations are finding their way into research and clinical application. In natural adhesives, proteins play a crucial role, mediating adhesion and cohesion at the same time. Silk fibroin, as a natural biomaterial, represents an interesting alternative to conventional medical adhesives. Here, the most commonly used bioadhesives as well as the potential of silk fibroin as natural adhesives will be discussed.
    MeSH term(s) Biocompatible Materials/therapeutic use ; Fibroins/therapeutic use ; Silk ; Surgery, Plastic ; Tissue Adhesives/therapeutic use ; Tissue Engineering ; Tissue Scaffolds
    Chemical Substances Biocompatible Materials ; Silk ; Tissue Adhesives ; Fibroins (9007-76-5)
    Language English
    Publishing date 2022-07-12
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms23147687
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Effects of a Novel Cold Atmospheric Plasma Treatment of Titanium on the Proliferation and Adhesion Behavior of Fibroblasts.

    Yan, Ming / Hartjen, Philip / Gosau, Martin / Vollkommer, Tobias / Grust, Audrey Laure Céline / Fuest, Sandra / Kluwe, Lan / Burg, Simon / Smeets, Ralf / Henningsen, Anders

    International journal of molecular sciences

    2021  Volume 23, Issue 1

    Abstract: Cold plasma treatment increases the hydrophilicity of the surfaces of implants and may enhance their integration with the surrounding tissues. The implaPrep prototype device from Relyon Plasma generates cold atmospheric plasma via dielectric barrier ... ...

    Abstract Cold plasma treatment increases the hydrophilicity of the surfaces of implants and may enhance their integration with the surrounding tissues. The implaPrep prototype device from Relyon Plasma generates cold atmospheric plasma via dielectric barrier discharge (DBD). In this study, titanium surfaces were treated with the implaPrep device for 20 s and assessed as a cell culture surface for fibroblasts. One day after seeding, significantly more cells were counted on the surfaces treated with cold plasma than on the untreated control titanium surface. Additionally, the viability assay revealed significantly higher viability on the treated surfaces. Morphological observation of the cells showed certain differences between the treated and untreated titanium surfaces. While conventional plasma devices require compressed gas, such as oxygen or argon, the implaPrep device uses atmospheric air as the gas source. It is, therefore, compact in size and simple to handle, and may provide a safe and convenient tool for treating the surfaces of dental implants, which may further improve the implantation outcome.
    MeSH term(s) Acid Etching, Dental ; Animals ; Cell Adhesion/drug effects ; Cell Count ; Cell Death/drug effects ; Cell Line ; Cell Proliferation/drug effects ; Dental Implants ; Fibroblasts/cytology ; Fibroblasts/drug effects ; Mice ; Plasma Gases/pharmacology ; Titanium/pharmacology ; Water
    Chemical Substances Dental Implants ; Plasma Gases ; Water (059QF0KO0R) ; Titanium (D1JT611TNE)
    Language English
    Publishing date 2021-12-31
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms23010420
    Database MEDical Literature Analysis and Retrieval System OnLINE

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