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Article ; Online: Gregor Gryglewski ist Researcher of the Month Juni 2015.

Gryglewski, Gregor

2015 Volume 127, Issue 11-12, Page(s) 499–500

Title translation	Gregor Gryglewski is Researcher of the Month, June 2015.
MeSH term(s)	Austria ; Awards and Prizes ; Depression/history ; History, 21st Century ; Molecular Biology/history ; Molecular Imaging/history ; Neurosciences/history
Language	German
Publishing date	2015-06
Publishing country	Austria
Document type	Biography ; Historical Article ; Journal Article ; Portraits
ZDB-ID	200462-8
ISSN	1613-7671 ; 0043-5325 ; 0300-5178
ISSN (online)	1613-7671
ISSN	0043-5325 ; 0300-5178
DOI	10.1007/s00508-015-0826-3
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Article: Meta-analysis of molecular imaging of translocator protein in major depression.

Eggerstorfer, Benjamin / Kim, Jong-Hoon / Cumming, Paul / Lanzenberger, Rupert / Gryglewski, Gregor

Frontiers in molecular neuroscience

2022 Volume 15, Page(s) 981442

Abstract: Molecular neuroimaging studies provide mounting evidence that neuroinflammation plays a contributory role in the pathogenesis of major depressive disorder (MDD). This has been the focus of a number of positron emission tomography (PET) studies of the 17- ... ...

Abstract	Molecular neuroimaging studies provide mounting evidence that neuroinflammation plays a contributory role in the pathogenesis of major depressive disorder (MDD). This has been the focus of a number of positron emission tomography (PET) studies of the 17-kDa translocator protein (TSPO), which is expressed by microglia and serves as a marker of neuroinflammation. In this meta-analysis, we compiled and analyzed all available molecular imaging studies comparing cerebral TSPO binding in MDD patients with healthy controls. Our systematic literature search yielded eight PET studies encompassing 238 MDD patients and 164 healthy subjects. The meta-analysis revealed relatively increased TSPO binding in several cortical regions (anterior cingulate cortex: Hedges'
Language	English
Publishing date	2022-09-26
Publishing country	Switzerland
Document type	Systematic Review
ZDB-ID	2452967-9
ISSN	1662-5099
ISSN	1662-5099
DOI	10.3389/fnmol.2022.981442
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Article ; Online: Correlation of receptor density and mRNA expression patterns in the human cerebral cortex.

Murgaš, Matej / Michenthaler, Paul / Reed, Murray Bruce / Gryglewski, Gregor / Lanzenberger, Rupert

NeuroImage

2022 Volume 256, Page(s) 119214

Abstract: Changes in distribution of associated molecular targets have been reported across several neuropsychiatric disorders. However, the high-resolution topology of most proteins is unknown and simultaneous in vivo measurement in multi-receptor systems is ... ...

Abstract	Changes in distribution of associated molecular targets have been reported across several neuropsychiatric disorders. However, the high-resolution topology of most proteins is unknown and simultaneous in vivo measurement in multi-receptor systems is complicated. To account for the missing proteomic information, messenger ribonucleic acid (mRNA) transcripts are typically used as a surrogate. Nonetheless, post-transcriptional and post-translational processes might cause the discrepancy between the final distribution of proteins and gene expression patterns. Therefore, this study aims to investigate ex vivo links between mRNA expression and corresponding receptor density in the human cerebral cortex. To this end, autoradiography data on the density of 15 different receptors in 38 brain regions were correlated with the expression patterns of 50 associated genes derived from microarray data (mA), RNA sequencing data (RNA-Seq) provided by the Allen Human Brain Atlas and predicted mRNA expression patterns (pred-mRNA). Spearman's rank correlation was used to evaluate the possible links between proteomic data and mRNA expression patterns. Correlations between mRNA and protein density varied greatly between targets: Positive associations were found for e.g. the serotonin 1A (pred-mRNA: r
MeSH term(s)	Autoradiography ; Brain/metabolism ; Cerebral Cortex/diagnostic imaging ; Cerebral Cortex/metabolism ; Gene Expression Profiling ; Humans ; Proteomics/methods ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Receptors, Cell Surface/genetics ; Receptors, Cell Surface/metabolism ; Receptors, GABA-A/metabolism
Chemical Substances	RNA, Messenger ; Receptors, Cell Surface ; Receptors, GABA-A
Language	English
Publishing date	2022-04-19
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1147767-2
ISSN	1095-9572 ; 1053-8119
ISSN (online)	1095-9572
ISSN	1053-8119
DOI	10.1016/j.neuroimage.2022.119214
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Article ; Online: Regional gene expression patterns are associated with task-specific brain activation during reward and emotion processing measured with functional MRI.

Komorowski, Arkadiusz / Murgaš, Matej / Vidal, Ramon / Singh, Aditya / Gryglewski, Gregor / Kasper, Siegfried / Wiltfang, Jens / Lanzenberger, Rupert / Goya-Maldonado, Roberto

Human brain mapping

2022 Volume 43, Issue 17, Page(s) 5266–5280

Abstract: The exploration of the spatial relationship between gene expression profiles and task-evoked response patterns known to be altered in neuropsychiatric disorders, for example depression, can guide the development of more targeted therapies. Here, we ... ...

Abstract	The exploration of the spatial relationship between gene expression profiles and task-evoked response patterns known to be altered in neuropsychiatric disorders, for example depression, can guide the development of more targeted therapies. Here, we estimated the correlation between human transcriptome data and two different brain activation maps measured with functional magnetic resonance imaging (fMRI) in healthy subjects. Whole-brain activation patterns evoked during an emotional face recognition task were associated with topological mRNA expression of genes involved in cellular transport. In contrast, fMRI activation patterns related to the acceptance of monetary rewards were associated with genes implicated in cellular localization processes, metabolism, translation, and synapse regulation. An overlap of these genes with risk genes from major depressive disorder genome-wide association studies revealed the involvement of the master regulators TCF4 and PAX6 in emotion and reward processing. Overall, the identification of stable relationships between spatial gene expression profiles and fMRI data may reshape the prospects for imaging transcriptomics studies.
MeSH term(s)	Humans ; Depressive Disorder, Major ; Genome-Wide Association Study ; Brain/physiology ; Magnetic Resonance Imaging/methods ; Emotions/physiology ; Reward ; Brain Mapping/methods ; Gene Expression
Language	English
Publishing date	2022-07-07
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1197207-5
ISSN	1097-0193 ; 1065-9471
ISSN (online)	1097-0193
ISSN	1065-9471
DOI	10.1002/hbm.26001
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Article ; Online: Impact of genetic variants within serotonin turnover enzymes on human cerebral monoamine oxidase A in vivo.

Spies, Marie / Murgaš, Matej / Vraka, Chrysoula / Philippe, Cecile / Gryglewski, Gregor / Nics, Lukas / Balber, Theresa / Baldinger-Melich, Pia / Hartmann, Annette M / Rujescu, Dan / Hacker, Marcus / Winkler-Pjrek, Edda / Winkler, Dietmar / Lanzenberger, Rupert

Translational psychiatry

2023 Volume 13, Issue 1, Page(s) 208

Abstract: Variants within the monoamine oxidase A (MAO-A, MAOA) and tryptophan hydroxylase 2 (TPH2) genes, the main enzymes in cerebral serotonin (5-HT) turnover, affect risk for depression. Depressed cohorts show increased cerebral MAO-A in positron emission ... ...

Abstract	Variants within the monoamine oxidase A (MAO-A, MAOA) and tryptophan hydroxylase 2 (TPH2) genes, the main enzymes in cerebral serotonin (5-HT) turnover, affect risk for depression. Depressed cohorts show increased cerebral MAO-A in positron emission tomography (PET) studies. TPH2 polymorphisms might also influence brain MAO-A because availability of substrates (i.e. monoamine concentrations) were shown to affect MAO-A levels. We assessed the effect of MAOA (rs1137070, rs2064070, rs6323) and TPH2 (rs1386494, rs4570625) variants associated with risk for depression and related clinical phenomena on global MAO-A distribution volume (V
MeSH term(s)	Humans ; Brain/diagnostic imaging ; Brain/metabolism ; Harmine/metabolism ; Monoamine Oxidase/genetics ; Monoamine Oxidase/metabolism ; Seasonal Affective Disorder/metabolism ; Serotonin/metabolism
Chemical Substances	Harmine (4FHH5G48T7) ; Monoamine Oxidase (EC 1.4.3.4) ; Serotonin (333DO1RDJY) ; monoamine oxidase A, human (EC 1.4.3.4.)
Language	English
Publishing date	2023-06-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	2609311-X
ISSN	2158-3188 ; 2158-3188
ISSN (online)	2158-3188
ISSN	2158-3188
DOI	10.1038/s41398-023-02506-2
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Article ; Online: Striatal dopaminergic alterations in Tourette's syndrome: a meta-analysis based on 16 PET and SPECT neuroimaging studies.

Hienert, Marius / Gryglewski, Gregor / Stamenkovic, Mara / Kasper, Siegfried / Lanzenberger, Rupert

Translational psychiatry

2018 Volume 8, Issue 1, Page(s) 143

Abstract: Despite intense research, the underlying mechanisms and the etiology of Tourette's syndrome (TS) remain unknown. Data from molecular imaging studies targeting the dopamine system in Tourette patients are inconclusive. For a better understanding of the ... ...

Abstract	Despite intense research, the underlying mechanisms and the etiology of Tourette's syndrome (TS) remain unknown. Data from molecular imaging studies targeting the dopamine system in Tourette patients are inconclusive. For a better understanding of the striatal dopamine function in adult dopamine-antagonist-free patients we performed a systematic review in August 2017 identifying 49 PET and SPECT studies on the topic of TS. A total of 8 studies appraised the dopamine transporter (DAT) with 111 Tourette patients and 93 healthy controls, and could be included in a meta-analytic approach. We found a significantly increased striatal DAT binding in Tourette patients (Hedges' g = 0.49; 95% CI: (0.01-0.98)), although this effect did not remain significant after correcting for age differences between cohorts. A second meta-analysis was performed for the striatal dopamine receptor including 8 studies with a total of 72 Tourette patients and 71 controls. This analysis revealed a nonsignificant trend toward lower dopamine 2/3 receptor binding in striatum of Tourette patients. Other analyses regarding study population characteristics in both the DAT and receptor meta-analysis did not show any meaningful results. Our results indicate that dopaminergic alterations in TS are likely and thereby this data would be in line with the current pathophysiological hypotheses of a dysfunction in the dopamine system, e.g., the hypothesis of tonic-phasic dysfunction. However, these analyses suffer from low effect sizes probably due to the heterogeneity of TS and highlight the need for further large-scaled neuroimaging studies.
MeSH term(s)	Case-Control Studies ; Dopamine/physiology ; Dopamine Antagonists/administration & dosage ; Dopamine Plasma Membrane Transport Proteins/metabolism ; Humans ; Neostriatum/diagnostic imaging ; Neuroimaging ; Positron-Emission Tomography ; Receptors, Dopamine D2/metabolism ; Tomography, Emission-Computed, Single-Photon ; Tourette Syndrome/diagnostic imaging
Chemical Substances	Dopamine Antagonists ; Dopamine Plasma Membrane Transport Proteins ; Receptors, Dopamine D2 ; Dopamine (VTD58H1Z2X)
Language	English
Publishing date	2018-08-02
Publishing country	United States
Document type	Journal Article ; Meta-Analysis ; Systematic Review
ZDB-ID	2609311-X
ISSN	2158-3188 ; 2158-3188
ISSN (online)	2158-3188
ISSN	2158-3188
DOI	10.1038/s41398-018-0202-y
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Article ; Online: Enrichment of Disease-Associated Genes in Cortical Areas Defined by Transcriptome-Based Parcellation.

Gryglewski, Gregor / Murgaš, Matej / Klöbl, Manfred / Reed, Murray Bruce / Unterholzner, Jakob / Michenthaler, Paul / Lanzenberger, Rupert

Biological psychiatry. Cognitive neuroscience and neuroimaging

2021 Volume 7, Issue 1, Page(s) 10–23

Abstract: Background: Parcellation of the cerebral cortex serves the investigation of the emergence of uniquely human brain functions and disorders. Transcriptome data enable the characterization of the molecular properties of cortical areas in unprecedented ... ...

Abstract	Background: Parcellation of the cerebral cortex serves the investigation of the emergence of uniquely human brain functions and disorders. Transcriptome data enable the characterization of the molecular properties of cortical areas in unprecedented detail. Previously, we predicted the expression of 18,686 genes in the entire human brain based on microarray data. Here, we employed these data to parcellate the cortex and study the regional enrichment of disease-associated genes. Methods: We performed agglomerative hierarchical clustering based on normalized transcriptome data to delineate areas with distinct gene expression profiles. Subsequently, we tested these profiles for the enrichment of gene sets associated with brain disorders by genome-wide association studies and expert-curated databases using gene set enrichment analysis. Results: Transcriptome-based parcellation identified borders in line with major anatomical landmarks and the functional differentiation of primary motor, somatosensory, visual, and auditory areas. Gene set enrichment analysis based on curated databases suggested new roles of specific areas in psychiatric and neurological disorders while reproducing well-established links for movement and neurodegenerative disorders, for example, amyotrophic lateral sclerosis (motor cortex) and Alzheimer's disease (entorhinal cortex). Meanwhile, gene sets derived from genome-wide association studies on psychiatric disorders exhibited similar enrichment patterns driven by pleiotropic genes expressed in the posterior fusiform gyrus and inferior parietal lobule. Conclusions: The identified enrichment patterns suggest the vulnerability of specific cortical areas to various influences that might alter the risk of developing one or several brain disorders. For several diseases, specific genes were highlighted, which could lead to the discovery of novel disease mechanisms and urgently needed treatments.
MeSH term(s)	Alzheimer Disease/genetics ; Auditory Cortex ; Brain ; Genome-Wide Association Study ; Humans ; Transcriptome
Language	English
Publishing date	2021-03-09
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2879089-3
ISSN	2451-9030 ; 2451-9022
ISSN (online)	2451-9030
ISSN	2451-9022
DOI	10.1016/j.bpsc.2021.02.012
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Article ; Online: Meta-analysis of brain structural changes after electroconvulsive therapy in depression.

Gryglewski, Gregor / Lanzenberger, Rupert / Silberbauer, Leo R / Pacher, Daniel / Kasper, Siegfried / Rupprecht, Rainer / Frey, Richard / Baldinger-Melich, Pia

Brain stimulation

2021 Volume 14, Issue 4, Page(s) 927–937

Abstract: Background: Increases in the volume of the amygdala and hippocampus after electroconvulsive therapy (ECT) are among the most robust effects known to the brain-imaging field. Recent advances in the segmentation of substructures of these regions allow for ...

Abstract	Background: Increases in the volume of the amygdala and hippocampus after electroconvulsive therapy (ECT) are among the most robust effects known to the brain-imaging field. Recent advances in the segmentation of substructures of these regions allow for novel insights on the relationship between brain structure and clinical outcomes of ECT. Objective: We aimed to provide a comprehensive synthesis of evidence available on changes in brain structure after ECT, including recently published data on hippocampal subfields. Methods: A meta-analysis of published studies was carried out using random-effects models of standardized mean change of regional brain volumes measured with longitudinal magnetic resonance imaging of depressive patients before and after a series of ECT. Results: Data from 21 studies (543 depressed patients) were analysed, including 6 studies (118 patients) on hippocampal subfields. Meta-analyses could be carried out for seven brain regions for which data from at least three published studies was available. We observed increases in left and right hippocampi, amygdalae, cornua ammonis (CA) 1, CA 2/3, dentate gyri (DG) and subicula with standardized mean change scores ranging between 0.34 and 1.15. The model did not reveal significant volume increases in the caudate. Meta-regression indicated a negative relationship between the reported increases in the DG and relative symptom improvement (-0.27 (SE: 0.09) per 10%). Conclusions: ECT is accompanied by significant volume increases in the bilateral hippocampus and amygdala that are not associated with treatment outcome. Among hippocampal subfields, the most robust volume increases after ECT were measured in the dentate gyrus. The indicated negative correlation of this effect with antidepressant efficacy warrants replication in data of individual patients.
MeSH term(s)	Amygdala/diagnostic imaging ; Depression ; Electroconvulsive Therapy ; Hippocampus/diagnostic imaging ; Humans ; Magnetic Resonance Imaging
Language	English
Publishing date	2021-06-11
Publishing country	United States
Document type	Journal Article ; Meta-Analysis
ZDB-ID	2394410-9
ISSN	1876-4754 ; 1935-861X
ISSN (online)	1876-4754
ISSN	1935-861X
DOI	10.1016/j.brs.2021.05.014
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Article: Regional gene expression patterns are associated with task-specific brain activation during reward and emotion processing measured with functional MRI

Komorowski, Arkadiusz / Murgas, Matej / Vidal, Ramon / Singh, Aditya / Gryglewski, Gregor / Kasper, Siegfried / Wiltfang, Jens / Lanzenberger, Rupert / Goya-Maldonado, Roberto

Human Brain Mapping

2022 Volume 43, Issue 17, Page(s) 5266–5280

Title translation	Regionale Genexpressionsmuster stehen im Zusammenhang mit aufgabenspezifischer Hirnaktivierung während der Belohnungs- und Emotionsverarbeitung, gemessen mit funktioneller MRT (DeepL)
Abstract	The exploration of the spatial relationship between gene expression profiles and task-evoked response patterns known to be altered in neuropsychiatric disorders, for example depression, can guide the development of more targeted therapies. Here, we estimated the correlation between human transcriptome data and two different brain activation maps measured with functional magnetic resonance imaging (fMRI) in healthy subjects. Whole-brain activation patterns evoked during an emotional face recognition task were associated with topological mRNA expression of genes involved in cellular transport. In contrast, fMRI activation patterns related to the acceptance of monetary rewards were associated with genes implicated in cellular localization processes, metabolism, translation, and synapse regulation. An overlap of these genes with risk genes from major depressive disorder genome-wide association studies revealed the involvement of the master regulators TCF4 and PAX6 in emotion and reward processing. Overall, the identification of stable relationships between spatial gene expression profiles and fMRI data may reshape the prospects for imaging transcriptomics studies.
Keywords	Belohnungen ; Emotion Recognition ; Emotionen ; Emotions ; Emotionserkennung ; Face Perception ; Functional Magnetic Resonance Imaging ; Funktionelle Magnetresonanztomographie ; Gene ; Gene Expression ; Genes ; Genexpression ; Gesichterwahrnehmung ; Rewards
Language	English
Document type	Article
ZDB-ID	1282068-4
ISSN	1065-9471
ISSN	1065-9471
DOI	10.1002/hbm.26001
Database	PSYNDEX

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Article ; Online: Simultaneous radiomethylation of [

Vraka, Chrysoula / Murgaš, Matej / Rischka, Lucas / Geist, Barbara Katharina / Lanzenberger, Rupert / Gryglewski, Gregor / Zenz, Thomas / Wadsak, Wolfgang / Mitterhauser, Markus / Hacker, Marcus / Philippe, Cécile / Pichler, Verena

Scientific reports

2022 Volume 12, Issue 1, Page(s) 3283

Abstract: Simultaneous characterization of pathologies by multi-tracer positron emission tomography (PET) is among the most promising applications in nuclear medicine. Aim of this work was the simultaneous production of two PET-tracers in one module and test the ... ...

Abstract	Simultaneous characterization of pathologies by multi-tracer positron emission tomography (PET) is among the most promising applications in nuclear medicine. Aim of this work was the simultaneous production of two PET-tracers in one module and test the relevance for human application. [
MeSH term(s)	Brain/diagnostic imaging ; Harmine ; Humans ; Neuroimaging ; Positron-Emission Tomography/methods ; Tomography, X-Ray Computed
Chemical Substances	Harmine (4FHH5G48T7)
Language	English
Publishing date	2022-02-28
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-022-06906-0
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