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Article: Shift in skin microbiota of children with atopic dermatitis after topical gentian violet application.

Krzysiek, Joanna / Żurawska-Olszewska, Joanna / Szczerba, Izabela / Lesiak, Aleksandra / Pastuszak-Lewandoska, Dorota / Grzegorczyk, Janina / Ciążyńska, Magdalena / Narbutt, Joanna

Postepy dermatologii i alergologii

2023 Volume 40, Issue 2, Page(s) 308–314

Abstract: Introduction: Increasing usage of antimicrobial agents may contribute to bacterial resistance in atopic dermatitis (AD). In this case an alternative topical treatment might be gentian violet (GV), suggested for its antibacterial and antifungal ... ...

Abstract	Introduction: Increasing usage of antimicrobial agents may contribute to bacterial resistance in atopic dermatitis (AD). In this case an alternative topical treatment might be gentian violet (GV), suggested for its antibacterial and antifungal properties. Aim: To assess the microbial composition of lesional skin in children with AD and a control group aged 2-12 years, before and after 3 days of 2% aqueous GV application. Material and methods: Skin samples were taken from 30 AD patients and 30 healthy controls aged 2-12 years. The procedure was done two times - before and after 3 days of 2% aqueous GV application. The material was collected from skin lesions in the cubital fossa using 25 cm Results: The results revealed a statistically significant reduction in total counts of bacteria in both groups of children after GV application ( Conclusions: Our study results show that GV does not damage the skin surface ecosystem and allows the reduction of excessive bacterial counts on eczematous lesions to a 'safe' level, similar to that of healthy children.
Language	English
Publishing date	2023-04-13
Publishing country	Poland
Document type	Journal Article
ZDB-ID	2596142-1
ISSN	1642-395X
ISSN	1642-395X
DOI	10.5114/ada.2023.126534
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Article: Changes in lipid and apolipoprotein levels in response to 8-week cardiac rehabilitation in men with coronary artery disease.

Gołuchowska, Agnieszka / Lipert, Anna / Grzegorczyk, Janina / Michalak, Anna / Jegier, Anna

Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego

2020 Volume 48, Issue 287, Page(s) 302–306

Abstract: Concentrations of selected lipoproteins are currently useful cardiovascular risk assessment indicators, especially in monitoring lipid-lowering therapy.: Aim: The aim was to evaluate the influence of 8-week mid-term CR on apolipoproteins: A-I, B, E ... ...

Abstract	Concentrations of selected lipoproteins are currently useful cardiovascular risk assessment indicators, especially in monitoring lipid-lowering therapy. Aim: The aim was to evaluate the influence of 8-week mid-term CR on apolipoproteins: A-I, B, E and VLDL in CAD patients in relation to conventional lipid profile and prior coronary intervention: PCI or CABG. Materials and methods: 93 male patients admitted to CR after PCI or CABG. At baseline and after CR, conventional lipid profile parameters and VLDL concentrations were evaluated. Apolipoproteins: A-I, B, E were also determined. Basic anthropometric indicators and measurements of hemodynamic and exercise tolerance at rest and peak workload in exercise testing (HR, sBP, dBP, DP, W) were measured. Results: After CR, depending on revasculazation intervention, no changes in HDL-C, LDL-C, TG and VLDL values were observed (p>0.05). Reduction in apoA-I was noted in PCI group (p=0.0254). No statistically significant changes in apoB and apoE were found in groups. Significant increase in apo B/apo A-I index was observed only in PCI group (p=0.0329). PCI and CABG patients did not differ in hemodynamic and exercise tolerance parameters, except sBP in rest and dBP at peak workload in exercise testing (p=0.014 and p=0.031). Regardless on type of intervention, there was observed statistically significant increase in Wpeak (p=0,0000 in both groups) and DPpeak (p=0.0000 in PCI-patients and p=0.0003 in CABGpatients) after CR. Conclusions: CR has various effects on lipid concentrations. Indicators of conventional lipid profile and selected apolipoproteins are not optimal parameters allowing assessment of effectiveness of CR program in such a short time, this role is well fullfilled by the hemodynamic and physical exercise indices. Apo B/apo A-I ratio value suggests an increasing risk of IHD complications, especially in post- PCI group. CR program requires intensification of lipid-reducing therapy and education on lifestyle modification.
MeSH term(s)	Apolipoproteins ; Cardiac Rehabilitation ; Coronary Artery Disease ; Humans ; Lipids ; Male ; Percutaneous Coronary Intervention
Chemical Substances	Apolipoproteins ; Lipids
Language	English
Publishing date	2020-10-22
Publishing country	Poland
Document type	Journal Article
ZDB-ID	1388406-2
ISSN	1426-9686
ISSN	1426-9686
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Article: The role of heterodimer IL-17-A/F in atopic dermatitis.

Krzysiek, Joanna / Lesiak, Aleksandra / Szybka, Małgorzata / Michalak, Anna / Pastuszak-Lewandoska, Dorota / Grzegorczyk, Janina / Ciążyńska, Magdalena / Narbutt, Joanna

Postepy dermatologii i alergologii

2022 Volume 39, Issue 6, Page(s) 1093–1100

Abstract: Introduction: The importance of multifactorial dysregulation in immune response is well recognised in atopic dermatitis (AD). Th17 family cytokine IL-17 (IL-17A-F) is of significance in both acute and chronic phase of AD.: Aim: We analysed the ... ...

Abstract	Introduction: The importance of multifactorial dysregulation in immune response is well recognised in atopic dermatitis (AD). Th17 family cytokine IL-17 (IL-17A-F) is of significance in both acute and chronic phase of AD. Aim: We analysed the differences between serum levels of IL-17A/F and IL-17A, IL-17-F, IL-13, IL-4, association of rs2275913 IL-17A and rs763780 IL-17F gene polymorphisms in paediatric AD patients and control subjects. Material and methods: We assessed 30 children with AD and 30 healthy patients aged 2-12 years. Eczema Area and Severity Index, Investigator Global Assessment and Scoring Atopic Dermatitis scales were used to analyse the severity of skin lesions in AD patients. Genotyping was performed using PCR and the serum concentrations of IL-17A/F, IL-17A, IL-17F, while IL-13 and IL-4 interleukins were determined by enzyme-linked immuno-sorbent assays (ELISA). Results: The revised median assessment scoring in disease severity showed that the studied AD population had a moderate course of the disease. The obtained results indicated elevated plasma levels of IL-17A/F and IL-17-13 in AD patients with no statistically significance of IL-17A, IL-17F and IL-4 compared to controls. AD duration was positively correlated with IL-13 levels and negatively with IL-17A/F ( Conclusions: This study demonstrates increased levels of IL-17A/F in atopic patients, which is positively correlated with severity of the disease and the early phase of the disease. These results highlight a functional role of this cytokine in the pathogenesis of AD in paediatric patients.
Language	English
Publishing date	2022-12-22
Publishing country	Poland
Document type	Journal Article
ZDB-ID	2596142-1
ISSN	1642-395X
ISSN	1642-395X
DOI	10.5114/ada.2022.122604
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Article ; Online: Flow Cytometry Analysis of Antibacterial Effects of Universal Dentin Bonding Agents on

Lapinska, Barbara / Konieczka, Magdalena / Zarzycka, Beata / Sokolowski, Krzysztof / Grzegorczyk, Janina / Lukomska-Szymanska, Monika

Molecules (Basel, Switzerland)

2019 Volume 24, Issue 3

Abstract: There is no consensus on the antibacterial activity of dentin bonding systems (DBS). Many study models have been used to evaluate the antimicrobial activity of dental materials. In this study, a novel detection method, flow cytometry, was introduced. It ... ...

Abstract	There is no consensus on the antibacterial activity of dentin bonding systems (DBS). Many study models have been used to evaluate the antimicrobial activity of dental materials. In this study, a novel detection method, flow cytometry, was introduced. It allows for evaluation of the antibacterial activity of DBS, based on assessment of the disruption of the bacterial physical membrane induced by DBS. The aim of the study was to evaluate the antibacterial properties of selected dentin bonding systems against
MeSH term(s)	Anti-Bacterial Agents/chemistry ; Anti-Bacterial Agents/classification ; Anti-Bacterial Agents/pharmacology ; Biofilms/drug effects ; Biofilms/growth & development ; Dental Caries/microbiology ; Dental Caries/prevention & control ; Dentin-Bonding Agents/chemistry ; Dentin-Bonding Agents/classification ; Dentin-Bonding Agents/pharmacology ; Dose-Response Relationship, Drug ; Flow Cytometry ; Humans ; Materials Testing ; Microbial Sensitivity Tests ; Streptococcus mutans/drug effects ; Streptococcus mutans/genetics ; Streptococcus mutans/growth & development ; Streptococcus mutans/metabolism
Chemical Substances	Anti-Bacterial Agents ; Dentin-Bonding Agents
Language	English
Publishing date	2019-02-01
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules24030532
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Article: The influence of infectious factors on dendritic cell apoptosis.

Kubicka-Sierszen, Agata / Grzegorczyk, Janina Ł

Archives of medical science : AMS

2015 Volume 11, Issue 5, Page(s) 1044–1051

Abstract: Pathogens can have a negative influence on dendritic cells (DCs), causing their apoptosis, which prevents active presentation of foreign antigens. It results in a state of immunosuppression which makes the body susceptible to secondary infections. ... ...

Abstract	Pathogens can have a negative influence on dendritic cells (DCs), causing their apoptosis, which prevents active presentation of foreign antigens. It results in a state of immunosuppression which makes the body susceptible to secondary infections. Infected immature DCs have lower expression of co-stimulatory and adhesion molecules, reduced ability to secrete cytokines and an inhibited maturation process and are incapable of effective antigen presentation and activation of T-lymphocytes. In some cases, the ability of DCs to undergo rapid apoptosis is important for the body defense, which is probably because of DCs' ability to cross-present and cooperate with other cells. Apoptotic bodies released from the infected DCs are phagocytosed by other DCs, which then stimulate the effector cells and present antigens more efficiently than infected cells. The aim of this article is to review how the DCs respond to viral and bacterial factors and which biochemical mechanisms are responsible for their apoptosis.
Language	English
Publishing date	2015-01-14
Publishing country	Poland
Document type	Journal Article
ZDB-ID	2203781-0
ISSN	1734-1922
ISSN	1734-1922
DOI	10.5114/aoms.2015.54860
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Article: An

Lapinska, Barbara / Szram, Aleksandra / Zarzycka, Beata / Grzegorczyk, Janina / Hardan, Louis / Sokolowski, Jerzy / Lukomska-Szymanska, Monika

Materials (Basel, Switzerland)

2020 Volume 13, Issue 19

Abstract: Modifying the composition of dental restorative materials with antimicrobial agents might induce their antibacterial potential against cariogenic bacteria, e.g., ...

Abstract	Modifying the composition of dental restorative materials with antimicrobial agents might induce their antibacterial potential against cariogenic bacteria, e.g.,
Language	English
Publishing date	2020-10-01
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2487261-1
ISSN	1996-1944
ISSN	1996-1944
DOI	10.3390/ma13194383
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Article: Production of recombinant colicin M in Nicotiana tabacum plants and its antimicrobial activity

Łojewska, Ewelina / Sakowicz, Tomasz / Kowalczyk, Aleksandra / Konieczka, Magdalena / Grzegorczyk, Janina / Sitarek, Przemysław / Skała, Ewa / Czarny, Piotr / Śliwiński, Tomasz / Kowalczyk, Tomasz

Plant biotechnology reports. 2020 Feb., v. 14, no. 1

2020

Abstract: Antibiotic-resistant microorganisms causing a life-threatening infection pose a serious challenge for modern science. The rapidly growing number of incidents for which the use of standard antibiotics is ineffective forces us to develop new alternative ... ...

Abstract	Antibiotic-resistant microorganisms causing a life-threatening infection pose a serious challenge for modern science. The rapidly growing number of incidents for which the use of standard antibiotics is ineffective forces us to develop new alternative methods of killing microorganisms. Antimicrobial proteins and peptides (AMPs) can be promising candidates to solve this problem. Colicin-M is one of the representatives of this group and is naturally produced by Escherichia coli acting on other closely related bacterial strains by disrupting their outer cell membrane. This bacteriocin has huge potential as a potent antimicrobial agent, especially, since it was recognized by the FDA as safe. In this work, we present the expression of colicin M in model transgenic Nicotiana tabacum L. plants. We demonstrate that purified colicin retains its antibacterial activity against the control Escherichia coli strains and clinical isolates of Escherichia coli and Klebsiella pneumoniae. Our results also show that plant-derived ColM is not toxic for L929 and HeLa cell line, which allows us to suppose that plant-based expression could be an alternative production method of such important proteins.
Keywords	Escherichia coli ; Klebsiella pneumoniae ; Nicotiana tabacum ; antibacterial properties ; antibiotic resistance ; biotechnology ; cell membranes ; colicins ; human cell lines ; peptides ; toxicity
Language	English
Dates of publication	2020-02
Size	p. 33-43.
Publishing place	Springer Singapore
Document type	Article
Note	NAL-AP-2-clean
ZDB-ID	2364226-9
ISSN	1863-5474 ; 1863-5466
ISSN (online)	1863-5474
ISSN	1863-5466
DOI	10.1007/s11816-019-00571-y
Database	NAL-Catalogue (AGRICOLA)

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Article: Impact of low-level laser therapy on the dynamics of pressure ulcer-induced changes considering an infectious agent and cathelicidin LL-37 concentration: a preliminary study.

Brauncajs, Małgorzata / Ksiąszczyk, Krzysztof / Lewandowska-Polak, Anna / Gorzela, Katarzyna / Grzegorczyk, Janina

Postepy dermatologii i alergologii

2018 Volume 35, Issue 6, Page(s) 582–586

Abstract: Introduction: Low-level laser therapy is used in managing chronic wounds including pressure ulcers. Less is known about its impact on the healing process if an inhibitive agent e.g. bacterial infection takes place. Modulating non-specific immunity ... ...

Abstract	Introduction: Low-level laser therapy is used in managing chronic wounds including pressure ulcers. Less is known about its impact on the healing process if an inhibitive agent e.g. bacterial infection takes place. Modulating non-specific immunity processes might eliminate bacteria if laser therapy is applied. Aim: To investigate the impact of low-level laser therapy on pressure ulcer dynamics considering an infectious agent and cathelicidin LL-37 concentration. Material and methods: The study comprised 6 patients with pressure ulcers ranging from stage II to III in Torrance classification and 12 patients without pressure ulcers. Venous blood sample and decubitus wound swab were taken - in study groups A at baseline and after 2 weeks; in control group B once - at a specific point of time. The swabs served for species identification. Drug susceptibility of isolated pathogens and cathelicidin LL-37 in serum concentration were measured. Results: In study group A, the following bacteria predominantly occurred: Conclusions: There is insufficient information to accurately determine the effect of LLLT on pressure ulcer dynamics considering an infectious agent. These effects may occur if innate immunity processes are modulated so that laser therapy might eliminate bacteria indirectly.
Language	English
Publishing date	2018-11-08
Publishing country	Poland
Document type	Journal Article
ZDB-ID	2596142-1
ISSN	1642-395X
ISSN	1642-395X
DOI	10.5114/ada.2018.77609
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Article ; Online: The seroprevalence of Bartonella spp. in the blood of patients with musculoskeletal complaints and blood donors, Poland: a pilot study.

Łysakowska, Monika E / Brzezińska, Olga / Szybka, Małgorzata / Konieczka, Magdalena / Moskwa, Sylwia / Brauncajs, Małgorzata / Makowska, Joanna / Pastuszak-Lewandoska, Dorota / Grzegorczyk, Janina

Clinical rheumatology

2019 Volume 38, Issue 10, Page(s) 2691–2698

Abstract: Background: Bartonella spp. can cause a variety of diseases, such as lymphadenopathies, cat scratch disease, and trench fever, but can also give rise to many non-specific symptoms. No data exists regarding the prevalence of Bartonella spp. in patients ... ...

Abstract	Background: Bartonella spp. can cause a variety of diseases, such as lymphadenopathies, cat scratch disease, and trench fever, but can also give rise to many non-specific symptoms. No data exists regarding the prevalence of Bartonella spp. in patients with musculoskeletal complaints, nor among blood donors in Poland. Methods: The presence of anti-Bartonella IgM and IgG in the serum of blood donors (n = 65) (Lodz, Poland) and in the patients of the Department of Rheumatology Clinic (n = 40) suffering from musculoskeletal symptoms was tested by immunofluorescence. Blood samples were cultured on enriched media. Epidemiological questionnaires were used to identify key potential risk factors, such as sex, age, contact with companion animals, and bites from insects or animals. Results: Altogether, 27 of the 105 tested subjects were seropositive for Bartonella henselae IgG (23%) and three for Bartonella quintana IgG (2.85%); IgMs against B. henselae were found in three individuals (2.85%), and IgMs against B. quintana were found in one (1.54%). No statistically significant difference was found between the prevalence of B. henselae in the blood of donors or patients and the presence of unexplained musculoskeletal complaints (23% vs 30%). Individuals who had kept or been scratched by cats were not more likely to be B. henselae seropositive (p > 0.01). Tick bites were more commonly reported in patients, but insignificantly (p > 0.01). Conclusion: This is the first report of a high seroprevalence of anti-Bartonella IgG in patients with musculoskeletal symptoms and in blood donors in Poland. The obtained results indicate that such seroprevalence may have a possible significance in the development of musculoskeletal symptoms, although it should be confirmed on a larger group of patients. Asymptomatic bacteremia might occur and pose a threat to recipients of blood from infected donors. Hence, there is a need for more detailed research, including molecular biology methods, to clarify the potential risk of Bartonella spp. being spread to immunocompromised individuals. Key points: • This is the first study presenting high seroprevalence of Bartonella spp. in Poland. • IgG and IgM antibodies against B. quintana were found in blood samples of blood donors.
MeSH term(s)	Adult ; Aged ; Antibodies, Bacterial/blood ; Bacteremia ; Bartonella/isolation & purification ; Bartonella Infections/blood ; Bartonella Infections/complications ; Bites and Stings ; Blood Donors ; Female ; Humans ; Immunoglobulin G/immunology ; Immunoglobulin M/immunology ; Insect Bites and Stings ; Male ; Middle Aged ; Musculoskeletal Diseases/blood ; Musculoskeletal Diseases/complications ; Musculoskeletal Diseases/microbiology ; Pilot Projects ; Poland ; Risk Factors ; Seroepidemiologic Studies
Chemical Substances	Antibodies, Bacterial ; Immunoglobulin G ; Immunoglobulin M
Language	English
Publishing date	2019-05-22
Publishing country	Germany
Document type	Journal Article
ZDB-ID	604755-5
ISSN	1434-9949 ; 0770-3198
ISSN (online)	1434-9949
ISSN	0770-3198
DOI	10.1007/s10067-019-04591-5
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Zs.A 1740: Show issues

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Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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Article: Antibacterial Activity of Commercial Dentine Bonding Systems against E. faecalis-Flow Cytometry Study.

Lukomska-Szymanska, Monika / Konieczka, Magdalena / Zarzycka, Beata / Lapinska, Barbara / Grzegorczyk, Janina / Sokolowski, Jerzy

Materials (Basel, Switzerland)

2017 Volume 10, Issue 5

Abstract: Literature presents inconsistent results on the antibacterial activity of dentine bonding systems (DBS). Antibacterial activity of adhesive systems depends on several factors, including composition and acidity. Flow cytometry is a novel detection method ... ...

Abstract	Literature presents inconsistent results on the antibacterial activity of dentine bonding systems (DBS). Antibacterial activity of adhesive systems depends on several factors, including composition and acidity. Flow cytometry is a novel detection method to measure multiple characteristics of a single cell: total cell number, structural (size, shape), and functional parameters (viability, cell cycle). The LIVE/DEAD® BacLightTM bacterial viability assay was used to evaluate an antibacterial activity of DBS by assessing physical membrane disruption of bacteria mediated by DBS. Ten commercial DBSs: four total-etching (TE), four self-etching (SE) and two selective enamel etching (SEE) were tested. Both total-etching DBS ExciTE F and OptiBond Solo Plus showed comparatively low antibacterial activity against E. faecalis. The lowest activity of all tested TE systems showed Te-Econom Bond. Among SE DBS, G-ænial Bond (92.24% dead cells) followed by Clearfil S3 Bond Plus (88.02%) and Panavia F 2.0 ED Primer II (86.67%) showed the highest antibacterial activity against E. faecalis, which was comparable to isopropranol (positive control). In the present study, self-etching DBS exhibited higher antimicrobial activity than tested total-etching adhesives against E. faecalis.
Language	English
Publishing date	2017-04-29
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2487261-1
ISSN	1996-1944
ISSN	1996-1944
DOI	10.3390/ma10050481
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