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  1. Article: Comparing Spinal Chloroprocaine to Hyperbaric and Isobaric Bupivacaine for Total Hip and Knee Arthroplasties: A Retrospective Study.

    Gu, Lisa / Smith, Cameron R / Ihnatsenka, Barys / Zasimovich, Yury / Le-Wendling, Linda

    Cureus

    2023  Volume 15, Issue 3, Page(s) e35729

    Abstract: Introduction: Spinal anesthesia is commonly used for total knee and hip arthroplasties (TKA/THA). The rising popularity of ambulatory TKA and THAs require anesthetic techniques that provide rapid recovery of motor and sensory function while minimizing ... ...

    Abstract Introduction: Spinal anesthesia is commonly used for total knee and hip arthroplasties (TKA/THA). The rising popularity of ambulatory TKA and THAs require anesthetic techniques that provide rapid recovery of motor and sensory function while minimizing side effects like postoperative urinary retention. This single-center retrospective observational study compares the recovery profile of patients undergoing TKA and THA under chloroprocaine spinals compared to hyperbaric and isobaric bupivacaine spinals.
    Methods: One hundred and twelve patients undergoing primary TKA and THA under spinal anesthesia at University of Florida Health were identified between September 1, 2019 and February 21, 2020. Their electronic medical records were reviewed. Patients were categorized based on the local anesthetic used in the spinal. Various demographic, intraoperative, and postoperative data were compiled and compared, including duration of surgery, time to physical therapy, time to post-anesthesia care unit (PACU) discharge, and time to spontaneous micturition.
    Results: Time to spontaneous micturition and PACU discharge were significantly lower in the chloroprocaine spinal group compared to the hyperbaric bupivacaine group by 193 minutes and 42 minutes, respectively. Fewer patients receiving chloroprocaine spinals had their first physical therapy session limited by residual motor weakness compared to those in both bupivacaine groups. Additionally, mean duration of surgery was shorter in the chloroprocaine group compared to both bupivacaine groups (89 minutes compared to 111 minutes). Time to physical therapy completion was not different. All groups had <10% conversion to general anesthesia.
    Conclusion: Chloroprocaine spinals can be feasible options for TKAs and THAs with improved postoperative recovery profiles compared to bupivacaine spinals.
    Language English
    Publishing date 2023-03-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.35729
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Health-Oriented Marketing on Alcoholic Drinks: An Online Audit and Comparison of Nutrition Content of Australian Products.

    Haynes, Ashleigh / Chen, Yan Jun Michelle / Dixon, Helen / Ng Krattli, Shannon / Gu, Lisa / Wakefield, Melanie

    Journal of studies on alcohol and drugs

    2022  Volume 83, Issue 5, Page(s) 750–759

    Abstract: Objective: Marketing, label design, and product innovation strategies are being used by the alcohol industry to position some products as "healthier choices." The aim of this study was to systematically document the content and prevalence of health- ... ...

    Abstract Objective: Marketing, label design, and product innovation strategies are being used by the alcohol industry to position some products as "healthier choices." The aim of this study was to systematically document the content and prevalence of health-oriented marketing on alcohol products on the Australian market and to compare the online availability of nutrition information and the alcohol and nutrient content between products with and without such features.
    Method: Health-oriented marketing features on all beer, cider, and ready-to-drink (RTD) premixed drinks, and selected wines on the website of the largest liquor retailer in Australia were audited using a systematic coding protocol. Nutrition information was sought from manufacturer/brand websites.
    Results: A total of 54% of beers, ciders, and RTDs featured health-oriented marketing, the most common forms being natural imagery or descriptors, or references to fruit ingredients. Twenty-one percent of audited wines featured health-oriented marketing. The prevalence of specific features varied by product category. Online availability of nutrition information for alcohol products was poor (12% of beer, cider, and RTDs). Products with health-oriented marketing were lower in energy and alcohol content than those without but were still classed as full-strength alcohol on average.
    Conclusions: Health-oriented marketing is prevalent on alcohol products sold in Australia. In the absence of universal and standardized health warning and energy content information on labels, permitted health-oriented marketing has the potential to mislead consumers about product healthiness or to detract from the perceived harm associated with alcohol consumption. Research to test this proposition is now needed to guide labeling policy reform.
    MeSH term(s) Alcohol Drinking/epidemiology ; Alcoholic Beverages ; Australia/epidemiology ; Ethanol ; Humans ; Marketing/methods ; Product Labeling
    Chemical Substances Ethanol (3K9958V90M)
    Language English
    Publishing date 2022-09-22
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2266450-6
    ISSN 1938-4114 ; 1934-2683 ; 1937-1888 ; 0096-882X
    ISSN (online) 1938-4114 ; 1934-2683
    ISSN 1937-1888 ; 0096-882X
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Serial liquid biopsies for detection of treatment failure and profiling of resistance mechanisms in

    Dietz, Steffen / Christopoulos, Petros / Gu, Lisa / Volckmar, Anna-Lena / Endris, Volker / Yuan, Zhao / Ogrodnik, Simon J / Zemojtel, Tomasz / Heussel, Claus-Peter / Schneider, Marc A / Meister, Michael / Muley, Thomas / Reck, Martin / Schlesner, Matthias / Thomas, Michael / Stenzinger, Albrecht / Sültmann, Holger

    Cold Spring Harbor molecular case studies

    2019  Volume 5, Issue 6

    Abstract: Genetic rearrangements involving the anaplastic lymphoma kinase ( ...

    Abstract Genetic rearrangements involving the anaplastic lymphoma kinase (
    MeSH term(s) Aged ; Anaplastic Lymphoma Kinase/genetics ; Carcinoma, Non-Small-Cell Lung/drug therapy ; Carcinoma, Non-Small-Cell Lung/genetics ; Crizotinib/therapeutic use ; DNA Copy Number Variations/genetics ; Drug Resistance, Neoplasm/genetics ; Female ; Gene Rearrangement/genetics ; Humans ; Liquid Biopsy/methods ; Lung Neoplasms/drug therapy ; Lung Neoplasms/genetics ; Microtubule-Associated Proteins/genetics ; Protein Kinase Inhibitors/therapeutic use ; Proto-Oncogene Proteins c-mdm2/genetics ; Receptor Protein-Tyrosine Kinases/genetics ; Treatment Failure
    Chemical Substances Microtubule-Associated Proteins ; Protein Kinase Inhibitors ; kinesin light-chain proteins ; Crizotinib (53AH36668S) ; MDM2 protein, human (EC 2.3.2.27) ; Proto-Oncogene Proteins c-mdm2 (EC 2.3.2.27) ; ALK protein, human (EC 2.7.10.1) ; Anaplastic Lymphoma Kinase (EC 2.7.10.1) ; Receptor Protein-Tyrosine Kinases (EC 2.7.10.1)
    Language English
    Publishing date 2019-12-13
    Publishing country United States
    Document type Case Reports ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2835759-0
    ISSN 2373-2873 ; 2373-2873
    ISSN (online) 2373-2873
    ISSN 2373-2873
    DOI 10.1101/mcs.a004630
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Longitudinal therapy monitoring of ALK-positive lung cancer by combined copy number and targeted mutation profiling of cell-free DNA.

    Dietz, Steffen / Christopoulos, Petros / Yuan, Zhao / Angeles, Arlou Kristina / Gu, Lisa / Volckmar, Anna-Lena / Ogrodnik, Simon J / Janke, Florian / Fratte, Chiara Dalle / Zemojtel, Tomasz / Schneider, Marc A / Kazdal, Daniel / Endris, Volker / Meister, Michael / Muley, Thomas / Cecchin, Erika / Reck, Martin / Schlesner, Matthias / Thomas, Michael /
    Stenzinger, Albrecht / Sültmann, Holger

    EBioMedicine

    2020  Volume 62, Page(s) 103103

    Abstract: Background: Targeted therapies (TKI) have improved the prognosis of ALK-rearranged lung cancer (ALK: Methods: 271 longitudinal plasma DNA samples from 73 patients with TKI-treated metastatic ALK: Findings: cfDNA mutations were identified in 58% of ...

    Abstract Background: Targeted therapies (TKI) have improved the prognosis of ALK-rearranged lung cancer (ALK
    Methods: 271 longitudinal plasma DNA samples from 73 patients with TKI-treated metastatic ALK
    Findings: cfDNA mutations were identified in 58% of patients. They included several potentially actionable alterations, e.g. in the genes BRAF, ERBB2, and KIT. sWGS detected CNVs in 18% of samples, compared to 6% using targeted sequencing. Several of the CNVs included potentially druggable targets, such as regions harboring EGFR, ERBB2, and MET. Circulating tumour DNA (ctDNA) mutations and t-MAD scores increased during treatment, correlated with markers of higher molecular risk, such as the EML4-ALK variant 3 and/or TP53 mutations, and were associated with shorter patient survival. Importantly, t-MAD scores reflected the tumour remission status in serial samples similar to mutant ctDNA allele frequencies, and increased with disease progression in 79% (34/43) of cases, including those without detectable single nucleotide variant (SNV).
    Interpretation: Combined copy number and targeted mutation profiling could improve monitoring of ALK
    Funding: This work was supported by the German Center for Lung Research (DZL), by the German Cancer Consortium (DKTK), by the Heidelberg Center for Personalized Oncology at the German Cancer Research Center (DKFZ-HIPO), and by Roche Sequencing Solutions (Pleasanton, CA, USA).
    MeSH term(s) Aged ; Biomarkers, Tumor ; Circulating Tumor DNA ; DNA Copy Number Variations ; Female ; High-Throughput Nucleotide Sequencing ; Humans ; Lung Neoplasms/diagnosis ; Lung Neoplasms/drug therapy ; Lung Neoplasms/genetics ; Lung Neoplasms/mortality ; Male ; Middle Aged ; Molecular Targeted Therapy/adverse effects ; Molecular Targeted Therapy/methods ; Mutation ; Prognosis ; Protein Kinase Inhibitors/pharmacology ; Protein Kinase Inhibitors/therapeutic use ; Treatment Outcome
    Chemical Substances Biomarkers, Tumor ; Circulating Tumor DNA ; Protein Kinase Inhibitors
    Language English
    Publishing date 2020-11-09
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2851331-9
    ISSN 2352-3964
    ISSN (online) 2352-3964
    DOI 10.1016/j.ebiom.2020.103103
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 7090: Show issues Location:
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  5. Article: In vitro assembly properties of mutant and chimeric intermediate filament proteins: insight into the function of sequences in the rod and end domains of IF.

    Gu, Lisa / Troncoso, Juan C / Wade, James B / Monteiro, Mervyn J

    Experimental cell research

    2004  Volume 298, Issue 1, Page(s) 249–261

    Abstract: The factors and mechanisms regulating assembly of intermediate filament (IF) proteins to produce filaments with their characteristic 10 nm diameter are not fully understood. All IF proteins contain a central rod domain flanked by variable head and tail ... ...

    Abstract The factors and mechanisms regulating assembly of intermediate filament (IF) proteins to produce filaments with their characteristic 10 nm diameter are not fully understood. All IF proteins contain a central rod domain flanked by variable head and tail domains. To elucidate the role that different domains of IF proteins play in filament assembly, we used negative staining and electron microscopy (EM) to study the in vitro assembly properties of purified bacterially expressed IF proteins, in which specific domains of the proteins were either mutated or swapped between a cytoplasmic (mouse neurofilament-light (NF-L) subunit) and nuclear intermediate filament protein (human lamin A). Our results indicate that filament formation is profoundly influenced by the composition of the assembly buffer. Wild type (wt) mouse NF-L formed 10 nm filaments in assembly buffer containing 175 mM NaCl, whereas a mutant deleted of 18 NH2-terminal amino acids failed to assemble under similar conditions. Instead, the mutant assembled efficiently in buffers containing CaCl2 > or = 6 mM forming filaments that were 10 times longer than those formed by wt NF-L, although their diameter was significantly smaller (6-7 nm). These results suggest that the 18 NH2-terminal sequence of NF-L might serve two functions, to inhibit filament elongation and to promote lateral association of NF-L subunits. We also demonstrate that lengthening of the NF-L rod domain, by inserting a 42 aa sequence unique to nuclear IF proteins, does not compromise filament assembly in any noticeable way. Our results suggests that the known inability of nuclear lamin proteins to assemble into 10 nm filaments in vitro cannot derive solely from their longer rod domain. Finally, we demonstrate that the head domain of lamin A can substitute for that of NF-L in filament assembly, whereas substitution of both the head and tail domains of lamins for those of NF-L compromises assembly. Therefore, the effect of lamin A "tail" domain alone, or the synergistic effect of lamin "head" and the "tail" domains together, interferes with assembly into 10-nm filaments.
    MeSH term(s) Amino Acid Sequence/genetics ; Animals ; Calcium Chloride/chemistry ; Cell Line ; Humans ; Intermediate Filament Proteins/biosynthesis ; Intermediate Filament Proteins/genetics ; Intermediate Filament Proteins/ultrastructure ; Lamin Type A/biosynthesis ; Lamin Type A/genetics ; Lamin Type A/ultrastructure ; Mice ; Microscopy, Electron ; Molecular Structure ; Mutagenesis, Site-Directed ; Protein Structure, Tertiary/genetics ; Protein Structure, Tertiary/physiology ; Recombinant Fusion Proteins/biosynthesis ; Recombinant Fusion Proteins/genetics ; Recombinant Fusion Proteins/ultrastructure ; Sequence Deletion ; Sodium Chloride/chemistry ; Structure-Activity Relationship
    Chemical Substances Intermediate Filament Proteins ; Lamin Type A ; Recombinant Fusion Proteins ; Sodium Chloride (451W47IQ8X) ; Calcium Chloride (M4I0D6VV5M)
    Language English
    Publishing date 2004-08-01
    Publishing country United States
    Document type Journal Article ; Research Support, U.S. Gov't, P.H.S.
    ZDB-ID 1493-x
    ISSN 1090-2422 ; 0014-4827
    ISSN (online) 1090-2422
    ISSN 0014-4827
    DOI 10.1016/j.yexcr.2004.04.020
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 563: Show issues Location:
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  6. Article ; Online: Peripheral blood blast clearance is an independent prognostic factor for survival and response to acute myeloid leukemia induction chemotherapy.

    Short, Nicholas J / Benton, Christopher B / Chen, Hsiang-Chun / Qiu, Peng / Gu, Lisa / Pierce, Sherry / Brandt, Mark / Maiti, Abhishek / Min, Taejin L / Naqvi, Kiran / Quintas-Cardama, Alfonso / Konopleva, Marina / Kadia, Tapan / Cortes, Jorge / Garcia-Manero, Guillermo / Ravandi, Farhad / Jabbour, Elias / Kantarjian, Hagop / Andreeff, Michael

    American journal of hematology

    2016  Volume 91, Issue 12, Page(s) 1221–1226

    Abstract: In patients with acute myeloid leukemia (AML), rapid reduction of circulating blasts with induction chemotherapy may serve as an in vivo marker of chemosensitivity. We performed a retrospective analysis of 363 patients with untreated AML who received ... ...

    Abstract In patients with acute myeloid leukemia (AML), rapid reduction of circulating blasts with induction chemotherapy may serve as an in vivo marker of chemosensitivity. We performed a retrospective analysis of 363 patients with untreated AML who received induction chemotherapy in order to determine the relationship between day of blast disappearance (DOBD) and complete remission (CR) rates, event-free survival (EFS), and overall survival (OS). DOBD ≤ 5 vs. >5 was identified as the most discriminating cutoff for OS. DOBD > 5 was observed in 35 patients (9.6%). The CR rate for patients with DOBD ≤ 5 vs. >5 was 74.0 and 28.6%, median EFS was 9.4 and 1.8 months, and median OS was 17.1 and 5.8 months, respectively (P < 0.001 for all). DOBD > 5 was independently associated with a lower CR rate and shorter EFS and OS (P < 0.001 for all). DOBD > 5 retained prognostic significance for EFS and OS when patients were stratified by cytogenetic risk group, de novo vs. secondary or therapy-related AML, European LeukemiaNet-based risk groups, and whether CR was achieved. We propose DOBD > 5 as a simple and early marker of disease resistance that identifies patients with poor prognosis who otherwise may not be identified with existing risk stratification systems. Am. J. Hematol. 91:1221-1226, 2016. © 2016 Wiley Periodicals, Inc.
    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; Biomarkers/blood ; Blast Crisis/blood ; Blast Crisis/mortality ; Blast Crisis/pathology ; Disease-Free Survival ; Humans ; Induction Chemotherapy/methods ; Leukemia, Myeloid, Acute/diagnosis ; Leukemia, Myeloid, Acute/drug therapy ; Leukemia, Myeloid, Acute/mortality ; Leukemia, Myeloid, Acute/pathology ; Middle Aged ; Prognosis ; Remission Induction/methods ; Retrospective Studies ; Risk Factors ; Survival Analysis ; Time Factors
    Chemical Substances Biomarkers
    Language English
    Publishing date 2016-08-29
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 196767-8
    ISSN 1096-8652 ; 0361-8609
    ISSN (online) 1096-8652
    ISSN 0361-8609
    DOI 10.1002/ajh.24500
    Database MEDical Literature Analysis and Retrieval System OnLINE

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