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  1. Article: IL13Rα2 siRNA inhibited cell proliferation, induced cell apoptosis, and suppressed cell invasion in papillary thyroid carcinoma cells.

    Gu, Mingjun

    OncoTargets and therapy

    2018  Volume 11, Page(s) 1345–1352

    Abstract: Aim: Papillary thyroid carcinoma (PTC) is the most common type of thyroid cancer. Infiltrative growth and metastasis are the two most intractable characteristics of PTC. Interleukin-13 receptor α2 (IL13Rα2) with high affinity for Th2-derived cytokine IL- ...

    Abstract Aim: Papillary thyroid carcinoma (PTC) is the most common type of thyroid cancer. Infiltrative growth and metastasis are the two most intractable characteristics of PTC. Interleukin-13 receptor α2 (IL13Rα2) with high affinity for Th2-derived cytokine IL-13 has been reported to be overexpressed in several tumors. In this study, an analysis of IL13Rα2 expression in PTC and matched paracancerous tissues was undertaken, and its biologic functions in PTC were assessed.
    Methods: IL13Rα2 and vascular endothelial growth factor (VEGF) expression were detected by using real-time polymerase chain reaction and immunohistochemistry analyses. Cell proliferation, invasion, apoptosis, and caspase activity were measured with the Cell Counting Kit-8, Transwell, flow cytometry analyses, and biochemistry assay, respectively.
    Results: Upregulation of IL13Rα2 and VEGF was observed in PTC tissues compared with matched paracancerous tissues. Pearson's correlation analysis indicated that IL13Rα2 mRNA level in the tested PTC tissues was positively correlated with VEGF mRNA level. Besides, inhibited cell proliferation, induced cell apoptosis, and suppressed cell invasion were detected in IL13Rα2-silenced TPC-1 cells. Increased activity of Caspase 3 and Caspase 9, along with elevated cleaved Caspase 3 and poly (ADP)-ribose polymerase indicated the signal pathway of cell apoptosis induced by IL13Rα2 siRNA. In addition, downregulated metastasis- and angiogenesis-related proteins VEGF, VEGFR2, MMP2, and MMP9 indicated the decreased number of invading cells after knockdown of IL13Rα2.
    Conclusion: The results demonstrate that IL13Rα2 plays an important role in the progress of PTC. IL13Rα2 knockdown in PTC cells inhibited cell proliferation, induced cell apoptosis, and suppressed cell invasion. These data suggest that IL13Rα2 may be a novel therapeutic target in the treatment of PTC clinically.
    Language English
    Publishing date 2018-03-09
    Publishing country New Zealand
    Document type Journal Article
    ZDB-ID 2495130-4
    ISSN 1178-6930
    ISSN 1178-6930
    DOI 10.2147/OTT.S153703
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: PIWIL2 restrains the progression of thyroid cancer via interaction with miR-146a-3p.

    Lu, Xiaoxiao / Zhu, Qingyun / Du, Hong / Gu, Mingjun / Li, Xiangqi

    BMC endocrine disorders

    2023  Volume 23, Issue 1, Page(s) 184

    Abstract: Objective: The classical role of PIWIL2 is to regulate reproduction by binding to piRNA, but its tumor-related function has received increasing attention in recent years. This study aims to explore its role in the progression of thyroid cancer (TC).: ... ...

    Abstract Objective: The classical role of PIWIL2 is to regulate reproduction by binding to piRNA, but its tumor-related function has received increasing attention in recent years. This study aims to explore its role in the progression of thyroid cancer (TC).
    Methods: First, we measured and analyzed the levels of PIWIL2 and miR-146a-3p in TC tissue and adjacent tissues as well as several TC cell lines. We demonstrated the clinical significance of PIWIL2 and miR-146a-3p through the survival rate. Based on these results, we selected TPC-1 and KTC-3 cell lines for our cell experiments. We treated these cell lines with PIWIL2 lentivirus, PIWIL2 siRNA, miR-146a-3p mimic, or miR-146a-3p inhibitor and measured cell proliferation, cell cycle, apoptosis, migration, and invasion. We used PCR and Western blot to quantify the mRNA and protein levels of PIWIL2, while we used luciferase reporter assay and RNA binding protein immunoprecipitation to explore the relationship between miR-146a-3p and PIWIL2. Finally, we developed a xenograft tumor model to confirm the effects of the miR-146a-3p/PIWIL2 axis on TC progression in vivo.
    Results: We identified that PIWIL2 and miR-146a-3p exhibit opposite expression alterations in TC tissues and that PIWIL2 serves as a 'sponge' by adsorbing miR-146a-3p. Up-regulating PIWIL2 decelerated the proliferation, metastasis, and cell cycle progression of TPC-1 and KTC-3 cells, but accelerated the apoptosis of TC cells, while miR-146a-3p exhibited opposite effects. Finally, overexpressing PIWIL2 restrained the progression of TC in nude mice, which can be reversed by increasing miR-146a-3p expression. Inhibiting PIWIL2, on the other hand, promoted the progression of TC in vivo, which can be reversed by inhibiting miR-146a-3p.
    Conclusion: PIWIL2 may inhibit the progression of TC by sponging miR-146a-3p, providing new insights into the early treatment, recrudescence treatment, and metastasis treatment of TC.
    MeSH term(s) Humans ; Animals ; Mice ; Mice, Nude ; Neoplasm Recurrence, Local ; Thyroid Neoplasms/genetics ; Apoptosis ; Disease Models, Animal ; MicroRNAs/genetics ; Argonaute Proteins/genetics
    Chemical Substances MicroRNAs ; PIWIL2 protein, human ; Argonaute Proteins
    Language English
    Publishing date 2023-08-29
    Publishing country England
    Document type Journal Article
    ZDB-ID 2091323-0
    ISSN 1472-6823 ; 1472-6823
    ISSN (online) 1472-6823
    ISSN 1472-6823
    DOI 10.1186/s12902-023-01416-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Assessment for the Correlation Between Diabetic Retinopathy and Metabolic Syndrome: A Cross-Sectional Study.

    Sun, Qing / Tang, Liang / Zeng, Qiurong / Gu, Mingjun

    Diabetes, metabolic syndrome and obesity : targets and therapy

    2021  Volume 14, Page(s) 1773–1781

    Abstract: Purpose: In this study, we explored the correlation between diabetic retinopathy (DR) and metabolic syndrome (MetS) among diabetes mellitus (DM) patients.: Methods: Logistic regression analysis was utilized to test the effects of MetS and its ... ...

    Abstract Purpose: In this study, we explored the correlation between diabetic retinopathy (DR) and metabolic syndrome (MetS) among diabetes mellitus (DM) patients.
    Methods: Logistic regression analysis was utilized to test the effects of MetS and its indicators on the incidence of DR and vision-related functional burden. The spline smoothing functions of continuous indicators of MetS were used to establish the logistic generalized additive model (GAM). The effective degree of freedom (EDF) =1 was served as a sign of linear relationship. EDF>1 was a sign of a more complex association between MetS and DR.
    Results: The proportion of difficulties of looking for objects on the crowded shelves in the DR group was higher than that in the non-DR group (19.40 vs 12.10,
    Conclusion: Both Glu and blood pressure were associated with the occurrence of DR and vision-related functional burden. Controlling the levels of Glu and blood pressure may reduce the risk of DR and vision loss among DM patients.
    Language English
    Publishing date 2021-04-22
    Publishing country New Zealand
    Document type Journal Article
    ZDB-ID 2494854-8
    ISSN 1178-7007
    ISSN 1178-7007
    DOI 10.2147/DMSO.S265214
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Existing bitter medicines for fighting 2019-nCoV-associated infectious diseases.

    Li, Xiangqi / Zhang, Chaobao / Liu, Lianyong / Gu, Mingjun

    FASEB journal : official publication of the Federation of American Societies for Experimental Biology

    2020  Volume 34, Issue 5, Page(s) 6008–6016

    Abstract: The sudden outbreak of COVID-19 has led to more than seven thousand deaths. Unfortunately, there are no specific drugs available to cure this disease. Type 2 taste receptors (TAS2Rs) may play an important role in host defense mechanisms. Based on the ... ...

    Abstract The sudden outbreak of COVID-19 has led to more than seven thousand deaths. Unfortunately, there are no specific drugs available to cure this disease. Type 2 taste receptors (TAS2Rs) may play an important role in host defense mechanisms. Based on the idea of host-directed therapy (HDT), we performed a negative co-expression analysis using big data of 60 000 Affymetrix expression arrays and 5000 TCGA data sets to determine the functions of TAS2R10, which can be activated by numerous bitter substances. Excitingly, we found that the main functions of TAS2R10 involved controlling infectious diseases caused by bacteria, viruses, and parasites, suggesting that TAS2R10 is a key trigger of host defense pathways. To quickly guide the clinical treatment of 2019-nCoV, we searched currently available drugs that are agonists of TAS2Rs. We identified many cheap, available, and safe medicines, such as diphenidol, quinine, chloroquine, artemisinin, chlorpheniramine, yohimbine, and dextromethorphan, which may target the most common symptoms caused by 2019-nCoV. We suggest that a cocktail-like recipe of existing bitter drugs may help doctors to fight this catastrophic disease and that the general public may drink or eat bitter substances, such as coffee, tea, or bitter vegetables, to reduce the risk of infection.
    MeSH term(s) Antiviral Agents/pharmacology ; Antiviral Agents/therapeutic use ; Betacoronavirus ; COVID-19 ; Computational Biology ; Coronavirus Infections/drug therapy ; Databases, Genetic ; Databases, Pharmaceutical ; Gene Expression Profiling ; Gene Expression Regulation/drug effects ; Humans ; Pandemics ; Pneumonia, Viral/drug therapy ; Receptors, Cell Surface/genetics ; Receptors, Cell Surface/metabolism ; Receptors, G-Protein-Coupled/agonists ; Receptors, G-Protein-Coupled/genetics ; SARS-CoV-2
    Chemical Substances Antiviral Agents ; Receptors, Cell Surface ; Receptors, G-Protein-Coupled ; TAS2R10 protein, human ; taste receptors, type 2
    Keywords covid19
    Language English
    Publishing date 2020-04-13
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 639186-2
    ISSN 1530-6860 ; 0892-6638
    ISSN (online) 1530-6860
    ISSN 0892-6638
    DOI 10.1096/fj.202000502
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Asymptomatic Transmissibility Calls for Implementing a Zero-COVID Strategy to End the Current Global Crisis.

    Zhang, Chaobao / Wang, Hongzhi / Wen, Zilu / Gu, Mingjun / Liu, Lianyong / Li, Xiangqi

    Frontiers in cellular and infection microbiology

    2022  Volume 12, Page(s) 836409

    Abstract: The coronavirus disease 2019 (COVID-19) pandemic has led to unprecedented global challenges. A zero-COVID strategy is needed to end the crisis, but there is a lack of biological evidence. In the present study, we collected available data on SARS, MERS, ... ...

    Abstract The coronavirus disease 2019 (COVID-19) pandemic has led to unprecedented global challenges. A zero-COVID strategy is needed to end the crisis, but there is a lack of biological evidence. In the present study, we collected available data on SARS, MERS, and COVID-19 to perform a comprehensive comparative analysis and visualization. The study results revealed that the fatality rate of COVID-19 is low, whereas its death toll is high compared to SARS and MERS. Moreover, COVID-19 had a higher asymptomatic rate. In particular, COVID-19 exhibited unique asymptomatic transmissibility. Further, we developed a foolproof operating software in Python language to simulate COVID-19 spread in Wuhan, showing that the cumulative cases of existing asymptomatic spread would be over 100 times higher than that of only symptomatic spread. This confirmed the essential role of asymptomatic transmissibility in the uncontrolled global spread of COVID-19, which enables the necessity of implementing the zero-COVID policy. In conclusion, we revealed the triggering role of the asymptomatic transmissibility of COVID-19 in this unprecedented global crisis, which offers support to the zero-COVID strategy against the recurring COVID-19 spread.
    MeSH term(s) COVID-19/epidemiology ; Humans ; Pandemics/prevention & control ; SARS-CoV-2
    Language English
    Publishing date 2022-04-19
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2619676-1
    ISSN 2235-2988 ; 2235-2988
    ISSN (online) 2235-2988
    ISSN 2235-2988
    DOI 10.3389/fcimb.2022.836409
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: New values of a type 2 taste receptor TAS2R14 in thyroid cancer.

    Liu, Lianyong / Zhu, Qingyun / Du, Hong / Shi, Chao / Gu, Mingjun / Li, Xiangqi

    Acta biochimica et biophysica Sinica

    2022  Volume 54, Issue 4, Page(s) 587–589

    MeSH term(s) Humans ; Receptors, G-Protein-Coupled/genetics ; Taste ; Thyroid Neoplasms/genetics
    Chemical Substances Receptors, G-Protein-Coupled
    Language English
    Publishing date 2022-05-23
    Publishing country China
    Document type Journal Article
    ZDB-ID 2175256-4
    ISSN 1745-7270 ; 0582-9879 ; 1672-9145
    ISSN (online) 1745-7270
    ISSN 0582-9879 ; 1672-9145
    DOI 10.3724/abbs.2022026
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Crocin protects the renal tubular epithelial cells against high glucose-induced injury and oxidative stress via regulation of the SIRT1/Nrf2 pathway.

    Zhang, Jichen / Zhao, Xuemei / Zhu, Hongling / Wang, Jingnan / Ma, Junhua / Gu, Mingjun

    Iranian journal of basic medical sciences

    2022  Volume 25, Issue 2, Page(s) 193–197

    Abstract: Objectives: Renal tubular damage is critical pathological feathers of diabetic nephropathy (DN). This study aimed to explore the protective activity and related mechanisms of crocin in renal epithelial cell injury induced by high glucose.: Materials ... ...

    Abstract Objectives: Renal tubular damage is critical pathological feathers of diabetic nephropathy (DN). This study aimed to explore the protective activity and related mechanisms of crocin in renal epithelial cell injury induced by high glucose.
    Materials and methods: Renal tubular epithelial HK-2 cells were cultured with D-glucose to establish an in vitro DN model. Cell viability was evaluated by CCK-8 assay. Apoptosis was detected by Annexin V-FITC kit. Oxidative stress was evaluated by colorimetry. RT-qPCR was carried out to determine the mRNA expressions of NF-E2-related factor 2 (Nrf2) and its pathway genes. Western blot was applied to determine the protein expressions of Nrf2 and related proteins.
    Results: High glucose (5.5, 30, and 50 mM D-glucose) decreased cell viability at 72 hr, which was attenuated by crocin (25 and 50 μM). Crocin also attenuated the high glucose (30 mM D-glucose) induced apoptosis of HK-2 cells, decreased MDA content, and increased SOD activity in culture media. Crocin increased mRNA levels of Nrf2, HO-1, and NQO1. Moreover, crocin increased protein expressions of Nrf2, Sirtuin 1 (SIRT1), and p-Akt (Ser473). Inhibition of Nrf2 using siRNA, and inhibitors of SIRT1 (nicotinamide, NAM, 20 μM) and PI3K/Akt (LY294002, 50 μM) all attenuated the protective effect of crocin. Nrf2 siRNA and NAM also partially attenuated the inhibitory effect on oxidative stress and increase in the Nrf2 protein by crocin treatment.
    Conclusion: Crocin protects renal epithelial cells against injury induced by high glucose, and the mechanism is associated with partial activation of the SIRT1-Nrf2 pathway.
    Language English
    Publishing date 2022-05-17
    Publishing country Iran
    Document type Journal Article
    ZDB-ID 2500485-2
    ISSN 2008-3874 ; 2008-3866
    ISSN (online) 2008-3874
    ISSN 2008-3866
    DOI 10.22038/IJBMS.2022.51597.11708
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: A simple and rapid model of vascular calcification.

    Gu, Mingjun / Liu, Lianyong / Zhang, Chaobao / Chen, Juan / Li, Xiangqi

    Acta biochimica et biophysica Sinica

    2020  Volume 53, Issue 5, Page(s) 640–641

    MeSH term(s) Cell Culture Techniques/methods ; Cells, Cultured ; Culture Media, Serum-Free ; Humans ; Models, Biological ; Muscle, Smooth, Vascular/growth & development ; Muscle, Smooth, Vascular/ultrastructure ; Vascular Calcification
    Chemical Substances Culture Media, Serum-Free
    Language English
    Publishing date 2020-11-20
    Publishing country China
    Document type Journal Article
    ZDB-ID 2175256-4
    ISSN 1745-7270 ; 0582-9879 ; 1672-9145
    ISSN (online) 1745-7270
    ISSN 0582-9879 ; 1672-9145
    DOI 10.1093/abbs/gmab025
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Artificial intelligence modeling of vascular calcification.

    Gu, Mingjun / Zhou, Lin / Wang, Xing / Shi, Chao / Li, Xiangqi

    Acta biochimica et biophysica Sinica

    2020  Volume 52, Issue 11, Page(s) 1296–1298

    MeSH term(s) Artificial Intelligence ; Humans ; Models, Cardiovascular ; Vascular Calcification/metabolism ; Vascular Calcification/pathology ; Vascular Calcification/physiopathology
    Language English
    Publishing date 2020-10-31
    Publishing country China
    Document type Journal Article
    ZDB-ID 2175256-4
    ISSN 1745-7270 ; 0582-9879 ; 1672-9145
    ISSN (online) 1745-7270
    ISSN 0582-9879 ; 1672-9145
    DOI 10.1093/abbs/gmaa106
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Association of Serum Melatonin Level with Mild Cognitive Impairment in Type 2 Diabetic Patients: A Cross-Sectional Study.

    Zhang, Jichen / Lu, Jiancan / Zhu, Hongling / Zhou, Xinglu / Wei, Xijuan / Gu, Mingjun

    International journal of endocrinology

    2021  Volume 2021, Page(s) 5566019

    Abstract: Objectives: Melatonin is an essential neuroendocrine hormone that participates in the regulation of sleep rhythm and cognitive function. This study aimed to determine serum melatonin levels with mild cognitive impairment (MCI) in patients with type 2 ... ...

    Abstract Objectives: Melatonin is an essential neuroendocrine hormone that participates in the regulation of sleep rhythm and cognitive function. This study aimed to determine serum melatonin levels with mild cognitive impairment (MCI) in patients with type 2 diabetes (T2DM).
    Methods: A total of 247 T2DM patients were recruited in this retrospective study and divided into 75 subjects with MCI and 172 with normal cognition. Cognitive function was evaluated by the Montreal Cognitive Assessment (MoCA). Their blood sample was examined for the level of melatonin and other biochemical parameters.
    Results: Melatonin concentration was decreased in MCI patients to non-MCI patients (
    Conclusion: Lower melatonin level was associated with cognitive impairment in patients with T2DM. Melatonin might serve as a potential protective molecule against cognitive dysfunction in T2DM.
    Language English
    Publishing date 2021-04-28
    Publishing country Egypt
    Document type Journal Article
    ZDB-ID 2502951-4
    ISSN 1687-8345 ; 1687-8337
    ISSN (online) 1687-8345
    ISSN 1687-8337
    DOI 10.1155/2021/5566019
    Database MEDical Literature Analysis and Retrieval System OnLINE

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