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  1. Article ; Online: AS1041, a novel derivative of marine natural compound Aspergiolide A, induces senescence of leukemia cells via oxidative stress-induced DNA damage and BCR-ABL degradation.

    Lu, Xuxiu / Yuan, Fengli / Qiao, Liang / Liu, Yankai / Gu, Qianqun / Qi, Xin / Li, Jing / Li, Dehai / Liu, Ming

    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

    2024  Volume 171, Page(s) 116099

    Abstract: Chronic myelogenous leukemia (CML) is characterized by the constitutive activation of BCR-ABL tyrosine kinase. Imatinib was approved for CML therapy, however, BCR-ABL-dependent drug resistance, especially BCR-ABL-T315I mutation, restricts its clinical ... ...

    Abstract Chronic myelogenous leukemia (CML) is characterized by the constitutive activation of BCR-ABL tyrosine kinase. Imatinib was approved for CML therapy, however, BCR-ABL-dependent drug resistance, especially BCR-ABL-T315I mutation, restricts its clinical application. In this study, we reported anthraquinone lactone AS1041, a synthesized derivative of marine natural compound Aspergiolide A, showed anti-leukemia effect in vitro and in vivo by promoting cell senescence. Mechanistic study revealed the pro-senescence effect of AS1041 was dependent on oxidative stress-induced DNA damage, and the resultant activation of P53/P21 and P16
    MeSH term(s) Humans ; Imatinib Mesylate/pharmacology ; Drug Resistance, Neoplasm ; Apoptosis ; Cell Proliferation ; Fusion Proteins, bcr-abl/metabolism ; Oxidative Stress ; Leukemia, Myelogenous, Chronic, BCR-ABL Positive/drug therapy ; DNA Damage ; Protein Kinase Inhibitors/pharmacology ; Anthraquinones
    Chemical Substances Imatinib Mesylate (8A1O1M485B) ; aspergiolide A ; Fusion Proteins, bcr-abl (EC 2.7.10.2) ; Protein Kinase Inhibitors ; Anthraquinones
    Language English
    Publishing date 2024-01-02
    Publishing country France
    Document type Journal Article
    ZDB-ID 392415-4
    ISSN 1950-6007 ; 0753-3322 ; 0300-0893
    ISSN (online) 1950-6007
    ISSN 0753-3322 ; 0300-0893
    DOI 10.1016/j.biopha.2023.116099
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    In stock of ZB MED Cologne/Königswinter

    Ud II Zs.198: Show issues Location:
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  2. Article: Polyhydroxy p-Terphenyls from a Mangrove Endophytic Fungus Aspergillus candidus LDJ-5

    Zhou, Guoliang / Zhang, Xiaomin / Shah, Mudassir / Che, Qian / Zhang, Guojian / Gu, Qianqun / Zhu, Tianjiao / Li, Dehai

    Marine drugs. 2021 Feb. 02, v. 19, no. 2

    2021  

    Abstract: Six undescribed polyhydroxy p-terphenyls, namely asperterphenyllins A–F, were isolated from an endophytic fungus Aspergillus candidus LDJ-5. Their structures were determined by NMR and MS data. Differing from the previously reported p-terphenyls, ... ...

    Abstract Six undescribed polyhydroxy p-terphenyls, namely asperterphenyllins A–F, were isolated from an endophytic fungus Aspergillus candidus LDJ-5. Their structures were determined by NMR and MS data. Differing from the previously reported p-terphenyls, asperterphenyllin A represents the first p-terphenyl dimer connected by a C-C bond. Asperterphenyllin A displayed anti-influenza virus A (H1N1) activity and protein tyrosine phosphatase 1B (PTP1B) inhibitory activity with IC₅₀ values of 53 μM and 21 μM, respectively. The anti-influenza virus A (H1N1) activity and protein tyrosine phosphatase 1B (PTP1B) inhibitory activity of p-terphenyls are reported for the first time. Asperterphenyllin G exhibited cytotoxicity against nine cell lines with IC₅₀ values ranging from 0.4 to 1.7 μM. Asperterphenyllin C showed antimicrobial activity against Proteus species with a MIC value of 19 μg/mL.
    Keywords Aspergillus candidus ; Proteus ; antimicrobial properties ; cytotoxicity ; endophytes ; fungi ; protein-tyrosine-phosphatase ; viruses
    Language English
    Dates of publication 2021-0202
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    ZDB-ID 2175190-0
    ISSN 1660-3397
    ISSN 1660-3397
    DOI 10.3390/md19020082
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  3. Article: Ascandinines A–D, Indole Diterpenoids, from the Sponge-Derived Fungus Aspergillus candidus HDN15-152

    Zhou, Guoliang / Sun, Chunxiao / Hou, Xuewen / Che, Qian / Zhang, Guojian / Gu, Qianqun / Liu, Chenguang / Zhu, Tianjiao / Li, Dehai

    Journal of organic chemistry. 2021 Jan. 20, v. 86, no. 3

    2021  

    Abstract: Four new indole diterpenoids, ascandinines A–D (1–4), were isolated from an Antarctic sponge-derived fungus Aspergillus candidus HDN15-152. Their structures, including absolute configurations, were established based on NMR data, computational ... ...

    Abstract Four new indole diterpenoids, ascandinines A–D (1–4), were isolated from an Antarctic sponge-derived fungus Aspergillus candidus HDN15-152. Their structures, including absolute configurations, were established based on NMR data, computational calculations, and biosynthetic considerations. Ascandinine A (1) possesses an unprecedented 2-oxabicyclo[2.2.2]octan-3-ol motif embedded in a pentacyclic ring system, while compounds 2–4 represent a rare type of indole diterpenoid featuring the 6/5/5/6/6/6/6-fused ring system. Compound 3 displayed anti-influenza virus A (H1N1) activity with an IC₅₀ value of 26 μM, while compound 4 showed cytotoxicity against HL-60 cells with an IC₅₀ value of 7.8 μM.
    Keywords Aspergillus candidus ; biosynthesis ; cytotoxicity ; diterpenoids ; fungi ; indoles ; organic chemistry ; viruses ; Antarctic region
    Language English
    Dates of publication 2021-0120
    Size p. 2431-2436.
    Publishing place American Chemical Society
    Document type Article
    ZDB-ID 123490-0
    ISSN 1520-6904 ; 0022-3263
    ISSN (online) 1520-6904
    ISSN 0022-3263
    DOI 10.1021/acs.joc.0c02575
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    In stock of ZB MED Bonn / Germany

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  4. Article: Pyrazinopyrimidine alkaloids from a mangrove-derived fungus Aspergillus versicolor HDN11-84

    Li, Feng / Sun, Chunxiao / Che, Qian / Zhu, Tianjiao / Gu, Qianqun / Guan, Huashi / Zhang, Guojian / Li, Dehai

    Phytochemistry. 2021 Aug., v. 188

    2021  

    Abstract: Pyrazinopyrimidine-type alkaloids bearing a pyrazino[1,2-a] pyrimidine moiety, often have different functional groups substituted at C-8′ or C-2′/C-8′, generally further forming unique spiro-/conjugated ring systems. Four undescribed pyrazinopyrimidine- ... ...

    Abstract Pyrazinopyrimidine-type alkaloids bearing a pyrazino[1,2-a] pyrimidine moiety, often have different functional groups substituted at C-8′ or C-2′/C-8′, generally further forming unique spiro-/conjugated ring systems. Four undescribed pyrazinopyrimidine-type alkaloids, including three natural products pyrasplorines A-C and an artifact deg-pyrasplorine B, as well as a biogenetically related versicoloid A were discovered from the extract of a mangrove-derived fungus Apergillus verisicolor HDN11-84. Pyrasplorine A contains unique spiral-type skeleton (composed of cyclopentenone ring with the pyrazino[1,2-a] pyrimidine core) which is unprecedented in pyrazinopyrimidine-type alkaloids. The deg-pyrasplorine B could be spontaneously converted from pyrasplorine B in mild conditions. Their structures including absolute configurations were elucidated based on NMR spectroscopic analysis, computational calculations and Marfey's method. The absolute configuration of versicoloid A was re-assigned in this study. All the isolated compounds are non-cytotoxic and deg-pyrasplorine B showed anti-influenza A virus H1N1 activity with the IC₅₀ of 50 μM.
    Keywords Aspergillus versicolor ; fungi ; moieties ; plant biochemistry ; spectral analysis ; viruses
    Language English
    Dates of publication 2021-08
    Publishing place Elsevier Ltd
    Document type Article
    ZDB-ID 208884-8
    ISSN 1873-3700 ; 0031-9422
    ISSN (online) 1873-3700
    ISSN 0031-9422
    DOI 10.1016/j.phytochem.2021.112817
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  5. Article ; Online: Nonenzymatic Self-Assembly Access to Diverse

    Wu, Guangwei / Qian, Xuan / Huang, Yeqiang / Liu, Yujia / Zhou, Luning / Wang, Wei / Li, Jing / Zhu, Tianjiao / Gu, Qianqun / Li, Dehai

    Organic letters

    2022  Volume 24, Issue 28, Page(s) 5235–5239

    Abstract: A nonenzymatic self-assembly program was introduced to explore diverse clavatol-based pseudonatural products (PNPs) in a marine-derived fungus. Intermolecular couplings of the ... ...

    Abstract A nonenzymatic self-assembly program was introduced to explore diverse clavatol-based pseudonatural products (PNPs) in a marine-derived fungus. Intermolecular couplings of the chemoreactive
    MeSH term(s) Indolequinones
    Chemical Substances Indolequinones ; quinone methide (138230-21-4)
    Language English
    Publishing date 2022-07-10
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1523-7052
    ISSN (online) 1523-7052
    DOI 10.1021/acs.orglett.2c02268
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  6. Article: Nonenzymatic Self-Assembly Access to Diverse ortho-Quinone Methide-Based Pseudonatural Products

    Wu, Guangwei / Qian, Xuan / Huang, Yeqiang / Liu, Yujia / Zhou, Luning / Wang, Wei / Li, Jing / Zhu, Tianjiao / Gu, Qianqun / Li, Dehai

    Organic letters. 2022 July 10, v. 24, no. 28

    2022  

    Abstract: A nonenzymatic self-assembly program was introduced to explore diverse clavatol-based pseudonatural products (PNPs) in a marine-derived fungus. Intermolecular couplings of the chemoreactive ortho-quinone methide of clavatol with native acceptors led to ... ...

    Abstract A nonenzymatic self-assembly program was introduced to explore diverse clavatol-based pseudonatural products (PNPs) in a marine-derived fungus. Intermolecular couplings of the chemoreactive ortho-quinone methide of clavatol with native acceptors led to 14 clavatol-based PNPs with five categories, and compounds 1, 2, 5–10, and 12 are new. In particular, 1 and 2 possessed an unprecedented oxa-angular tetracyclic scaffold with highly oxidized modification and exhibited cytotoxicity. Such a program is proven to be of great advantage in constructing bioactive PNPs.
    Keywords cytotoxicity ; fungi ; oxidation
    Language English
    Dates of publication 2022-0710
    Size p. 5235-5239.
    Publishing place American Chemical Society
    Document type Article
    ISSN 1523-7052
    DOI 10.1021/acs.orglett.2c02268
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  7. Article ; Online: Correction: Undecylprodigiosin Induced Apoptosis in P388 Cancer Cells Is Associated with Its Binding to Ribosome.

    Liu, Ping / Wang, Yuan-Yuan / Qi, Xin / Gu, QianQun / Geng, Meiyu / Li, Jing

    PloS one

    2020  Volume 15, Issue 7, Page(s) e0236282

    Abstract: This corrects the article DOI: 10.1371/journal.pone.0065381.]. ...

    Abstract [This corrects the article DOI: 10.1371/journal.pone.0065381.].
    Language English
    Publishing date 2020-07-14
    Publishing country United States
    Document type Journal Article ; Published Erratum
    ISSN 1932-6203
    ISSN (online) 1932-6203
    DOI 10.1371/journal.pone.0236282
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  8. Article: Correction to: Saroclazines A–C, thio-diketopiperazines from mangrove-derived fungi Sarocladium kiliense HDN11-84

    Li, Feng / Che, Qian / Gu, Qianqun / Guo, Wenqiang / Li, Dehai / Wu, Li / Zhu, Tianjiao

    Archives of pharmacal research. 2019 Apr., v. 42, no. 4

    2019  

    Abstract: The author would like to include conflict of interest statement of the online published article. The correct conflict of interest statement should read as. ...

    Abstract The author would like to include conflict of interest statement of the online published article. The correct conflict of interest statement should read as.
    Keywords cytotoxicity ; fungi ; mangroves (trees) ; Sarocladium
    Language English
    Dates of publication 2019-04
    Size p. 376.
    Publishing place Pharmaceutical Society of Korea
    Document type Article
    Note Published Erratum
    ZDB-ID 447623-2
    ISSN 1976-3786 ; 0253-6269
    ISSN (online) 1976-3786
    ISSN 0253-6269
    DOI 10.1007/s12272-019-01112-5
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    Zs.B 3229: Show issues Location:
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  9. Article: Correction to: Varilactones and wortmannilactones produced by Penicillium variabile cultured with histone deacetylase inhibitor

    He, Xueqian / Che, Qian / Gu, Qianqun / Li, Dehai / Zhang, Zhenzhen / Zhu, Tianjiao

    Archives of pharmacal research. 2019 Apr., v. 42, no. 4

    2019  

    Abstract: The author would like to include conflict of interest statement of the online published article. The correct conflict of interest statement should read as. ...

    Abstract The author would like to include conflict of interest statement of the online published article. The correct conflict of interest statement should read as.
    Keywords enzyme inhibitors ; histone deacetylase ; Penicillium variabile
    Language English
    Dates of publication 2019-04
    Size p. 377.
    Publishing place Pharmaceutical Society of Korea
    Document type Article
    Note Published Erratum
    ZDB-ID 447623-2
    ISSN 1976-3786 ; 0253-6269
    ISSN (online) 1976-3786
    ISSN 0253-6269
    DOI 10.1007/s12272-018-1095-2
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  10. Article: Irregularly Bridged Epipolythiodioxopiperazines and Related Analogues: Sources, Structures, and Biological Activities

    Zhu, Meilin / Zhang, Xuewen / Huang, Xuenan / Wang, Haotian / Anjum, Komal / Gu, Qianqun / Zhu, Tianjiao / Zhang, Guojian / Li, Dehai

    Journal of natural products. 2020 June 16, v. 83, no. 6

    2020  

    Abstract: Epipolythiodioxopiperazines (ETPs) are a class of biologically active fungal secondary metabolites characterized by a bridged polysulfide piperazine ring. Regularly, the sulfide functionality is attached in the α-positions of the dioxopiperazine scaffold. ...

    Abstract Epipolythiodioxopiperazines (ETPs) are a class of biologically active fungal secondary metabolites characterized by a bridged polysulfide piperazine ring. Regularly, the sulfide functionality is attached in the α-positions of the dioxopiperazine scaffold. However, ETPs possessing irregular sulfur bridges have rarely been explored. This review summarizes that 83 compounds of this subtype have been isolated and characterized since the discovery of gliovirin in 1982. Herein, particular emphasis is given to the isolation, chemistry, and biological activity of this subtype. For a better understanding, a relevant summary focusing on the source microorganisms and their taxonomy is provided and will help elucidate the fascinating chemistry and biology of these unusual ETPs.
    Keywords bioactive properties ; diketopiperazines ; fungi ; piperazine ; secondary metabolites ; sulfides ; sulfur ; taxonomy
    Language English
    Dates of publication 2020-0616
    Size p. 2045-2053.
    Publishing place American Chemical Society and American Society of Pharmacognosy
    Document type Article
    Note NAL-AP-2-clean
    ZDB-ID 304325-3
    ISSN 1520-6025 ; 0163-3864
    ISSN (online) 1520-6025
    ISSN 0163-3864
    DOI 10.1021/acs.jnatprod.9b01283
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