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Book ; Online: Hydrology of Artificial and Controlled Experiments

Liu, Jiu-Fu / Gu, Wei-Zu

2018

Keywords	Hydrology & the hydrosphere ; soil erosion, water cycle, climate change, agriculture, evapotranspiration, microbiology
Language	English
Size	1 electronic resource (296 pages)
Publisher	IntechOpen
Document type	Book ; Online
Note	English
HBZ-ID	HT030646039
ISBN	9781838812386 ; 1838812385
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article ; Online: Propofol attenuates hypoxia-induced inflammation and apoptosis in rat pheochromocytoma cell line PC12

GU Wei, ZHU Jianping, WU Pinwen

Jichu yixue yu linchuang, Vol 43, Iss 1, Pp 137-

2023 Volume 143

Abstract: Objective To investigate whether propofol inhibits the expression of miR-141-3p and reduces the molecular mechanism of hypoxia-induced inflammation and apoptosis of pheochromocytoma cell line PC12. Methods PC12 cells were divided into control group, ... ...

Abstract	Objective To investigate whether propofol inhibits the expression of miR-141-3p and reduces the molecular mechanism of hypoxia-induced inflammation and apoptosis of pheochromocytoma cell line PC12. Methods PC12 cells were divided into control group, hypoxia group, (5, 10, 20)μmol/L propofol+hypoxia group, anti-miR-con+hypoxia group, anti-miR-141-3p+hypoxia group, miR-con+20 μmol/L propofol+hypoxia group, miR-141-3p+20 μmol/L propofol+hypoxia group. Flow cytometry was used to detect the apoptosis of PC12 cells; Western blot was employed to determine the expression of activated cleaved caspase-3 (cleaved caspase-3) protein, and the kits were implemented to monitor malondialdehyde (MDA) content and superoxide dismutase (SOD) activity; Reactive oxygen species fluorescent probe DCFH-DA method to determine reactive oxygen species (ROS) content; ELISA kits to assay tumor necrosis factor-α (TNF-α), interleukin (IL)-1β, IL-6 content, RT-qPCR to detect the expression of miR-141-3p. Results Compared with the control group, the apoptosis rate, cleaved caspase-3 protein expression level, MDA, ROS, TNF-α, IL-1β, IL-6 content and miR-141-3p expression of PC12 cells in hypoxia group were all increased, while SOD activity weakened (PPPPConclusions Propofol can alleviate the inflammatory response, oxidative stress and apoptosis of PC12 cells induced by hypoxia by inhibiting the expression of miR-141-3p.
Keywords	pc12 cells\|inflammatory response\|oxidative stress\|apoptosis\|mir-141-3p ; Medicine ; R
Subject code	610
Language	Chinese
Publishing date	2023-01-01T00:00:00Z
Publisher	Institute of Basic Medical Sciences and Peking Union Medical College Hospital, Chinese Academy of Medical Sciences / Peking Union Medical College.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: [Research on Life Cycle Management of Medical Consumables Based on Hospital Resource Planning System].

Liu, Bin / Gu, Wei

Zhongguo yi liao qi xie za zhi = Chinese journal of medical instrumentation

2023 Volume 47, Issue 3, Page(s) 346–350

Abstract: Objective: In order to improve the compatibility of the hospital resource planning (HRP) system for the whole life cycle of medical consumables, and to improve the management and control capabilities of hospital institutions on medical consumables.: ... ...

Abstract	Objective: In order to improve the compatibility of the hospital resource planning (HRP) system for the whole life cycle of medical consumables, and to improve the management and control capabilities of hospital institutions on medical consumables. Methods: Based on the traditional HRP system, a secondary development and design of a medical consumables whole life-cycle artificial intelligence module was conducted, and a neural network machine learning algorithm module was introduced to enhance its big data integration and analysis capabilities. Results: The simulation analysis found that after adding this module, the proportion of minimum inventory, the proportion of procurement cost difference and the expiration rate of consumables all decreased significantly, and the differences were statistically significant ( Conclusions: The whole life cycle module of medical consumables based on HRP system can effectively improve the management efficiency of hospital medical consumables, adjust the warehouse inventory management ability, and improve the overall management level of medical consumables.
MeSH term(s)	Artificial Intelligence ; Hospitals
Language	Chinese
Publishing date	2023-06-06
Publishing country	China
Document type	English Abstract ; Journal Article
ISSN	1671-7104
ISSN	1671-7104
DOI	10.3969/j.issn.1671-7104.2023.03.024
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Distinctive presentation of neurobrucellosis as myelitis: A case report and literature review.

Yin, Jiali / Gu, Wei / Huan, Ying / Li, Zhengnan

Indian journal of pathology & microbiology

2024

Abstract: Abstract: Brucellosis is a zoonotic infectious allergic disease caused by Brucella that is widely distributed throughout the world. Brucella can invade various systems of the human body, such as the joints, the reproductive system, the spine, and the ... ...

Abstract	Abstract: Brucellosis is a zoonotic infectious allergic disease caused by Brucella that is widely distributed throughout the world. Brucella can invade various systems of the human body, such as the joints, the reproductive system, the spine, and the nervous system. Among patients with brucellosis, neurobrucellosis (NB) mainly manifests as nervous system symptoms in only 1.7-10% of patients and can cause a misdiagnosis. We reported a case of NB that presented as myelitis as the main clinical presentation and reviewed the relevant literature. It is suggested that clinicians should consider NB, especially atypical neurological symptoms, when there is a suspicious contact history.
Language	English
Publishing date	2024-03-25
Publishing country	India
Document type	Journal Article
ZDB-ID	197621-7
ISSN	0974-5130 ; 0377-4929
ISSN (online)	0974-5130
ISSN	0377-4929
DOI	10.4103/ijpm.ijpm_991_22
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Article ; Online: Clinical Value of the Serum Procalcitonin to Albumin Ratio in the Diagnosis and Prognosis of Sepsis-Associated ARDS Patients: A Retrospective Study.

Huang, Lihua / Li, Fuxing / Gu, Wei / Zhao, Weidong

Annals of clinical and laboratory science

2024 Volume 53, Issue 6, Page(s) 946–958

Abstract: Objective: To evaluate the diagnostic and prognostic value of the Serum Procalcitonin (PCT) to Albumin (ALB) ratio in sepsis-associated ARDS patients.: Methods: We conducted a retrospective study including 349 septic patients (159 and 190 with and ... ...

Abstract	Objective: To evaluate the diagnostic and prognostic value of the Serum Procalcitonin (PCT) to Albumin (ALB) ratio in sepsis-associated ARDS patients. Methods: We conducted a retrospective study including 349 septic patients (159 and 190 with and without ARDS, respectively). The serum PCT/ALB ratio was measured at admission, and participants' 28-day mortality and Sequential Organ Failure Assessment (SOFA) scores were compared. Results: Compared to patients without sepsis-associated ARDS, sepsis-associated ARDS patients had a higher PCT/ALB ratio ( Conclusions: The PCT/ALB ratio is a potential biomarker for the diagnosis and prognosis of sepsis-associated ARDS patients.
MeSH term(s)	Humans ; Procalcitonin ; Retrospective Studies ; Prognosis ; Serum Albumin ; Sepsis/complications ; Sepsis/diagnosis ; Respiratory Distress Syndrome/diagnosis ; Respiratory Distress Syndrome/etiology
Chemical Substances	Procalcitonin ; Serum Albumin
Language	English
Publishing date	2024-01-04
Publishing country	United States
Document type	Journal Article
ZDB-ID	193092-8
ISSN	1550-8080 ; 0091-7370 ; 0095-8905
ISSN (online)	1550-8080
ISSN	0091-7370 ; 0095-8905
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Article: Unlocking the Potential: Quercetin and Its Natural Derivatives as Promising Therapeutics for Sepsis.

Wang, Tian / Lv, Linxi / Feng, Hui / Gu, Wei

Biomedicines

2024 Volume 12, Issue 2

Abstract: Sepsis is a syndrome of organ dysfunction caused by an uncontrolled inflammatory response, which can seriously endanger life. Currently, there is still a shortage of specific therapeutic drugs. Quercetin and its natural derivatives have received a lot of ...

Abstract	Sepsis is a syndrome of organ dysfunction caused by an uncontrolled inflammatory response, which can seriously endanger life. Currently, there is still a shortage of specific therapeutic drugs. Quercetin and its natural derivatives have received a lot of attention recently for their potential in treating sepsis. Here, we provide a comprehensive summary of the recent research progress on quercetin and its derivatives, with a focus on their specific mechanisms of antioxidation and anti-inflammation. To obtain the necessary information, we conducted a search in the PubMed, Web of Science, EBSCO, and Cochrane library databases using the keywords sepsis, anti-inflammatory, antioxidant, anti-infection, quercetin, and its natural derivatives to identify relevant research from 6315 articles published in the last five years. At present, quercetin and its 11 derivatives have been intensively studied. They primarily exert their antioxidation and anti-inflammation effects through the PI3K/AKT/NF-κB, Nrf2/ARE, and MAPK pathways. The feasibility of these compounds in experimental models and clinical application were also discussed. In conclusion, quercetin and its natural derivatives have good application potential in the treatment of sepsis.
Language	English
Publishing date	2024-02-16
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2720867-9
ISSN	2227-9059
ISSN	2227-9059
DOI	10.3390/biomedicines12020444
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Article ; Online: Proteomic Biomarkers of Intrahepatic Cholestasis of Pregnancy.

Zeng, Weijian / Hou, Yanyan / Gu, Wei / Chen, Zheng

Reproductive sciences (Thousand Oaks, Calif.)

2024

Abstract: Intrahepatic cholestasis of pregnancy (ICP) is a pregnancy-specific liver disease, which can lead to adverse fetal outcomes, including preterm labor and intrauterine death. The pathogenesis of ICP is still unclear. We hypothesized that pathological index ...

Abstract	Intrahepatic cholestasis of pregnancy (ICP) is a pregnancy-specific liver disease, which can lead to adverse fetal outcomes, including preterm labor and intrauterine death. The pathogenesis of ICP is still unclear. We hypothesized that pathological index leads to abnormal placenta changes in ICP. Investigation of these differences in protein expression in parallel profiling is essential to understand the comprehensive pathophysiological mechanism underlying ICP. The present study screened differentially expressed proteins (DEPs) as novel diagnostic markers for ICP. Proteomic profiles of placental tissues from 32 ICP patients and 24 healthy volunteers (controls) were analyzed. Our founding was valid by following western blotting and immunohistochemistry staining, respectively. The association of the key protein expression with clinicopathological features of ICP was further analyzed. A total of 178 DEPs were identified between the ICP and control groups. Functional enrichment analysis showed these proteins were significantly enriched in the PPAR singling pathway by KEGG and PPARα/RXRα activation by IPA. Apolipoprotein A2 (APOA2) was the only upregulated protein, which uniquely identified in ICP groups and related to both pathways. Validation of western blotting and immunohistochemical staining analysis showed significantly higher APOA2 expression in the ICP group than in the control group. Furthermore, the expression of APOA2 is associated with clinicopathological features in ICP groups. Receiver operating characteristic (ROC) curve analyses showed that the AUC of APOA2 was 0.8984 (95% confidence interval (CI): 0.772-1.000). This study has identified up-regulated APOA2 associated with PPAR singling pathway and PPARα/RXRα activation in ICP. Thus, APOA2 may be involved in ICP pathogenesis, serving as a novel biomarker for its diagnosis.
Language	English
Publishing date	2024-01-04
Publishing country	United States
Document type	Journal Article
ZDB-ID	2276411-2
ISSN	1933-7205 ; 1933-7191
ISSN (online)	1933-7205
ISSN	1933-7191
DOI	10.1007/s43032-023-01437-z
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Article ; Online: p53 in ferroptosis regulation: the new weapon for the old guardian.

Liu, Yanqing / Gu, Wei

Cell death and differentiation

2022 Volume 29, Issue 5, Page(s) 895–910

Abstract: Although the conventional activities of p53 such as cell cycle arrest, senescence, and apoptosis are well accepted as the major checkpoints in stress responses, accumulating evidence implicates the importance of other tumor suppression mechanisms. Among ... ...

Abstract	Although the conventional activities of p53 such as cell cycle arrest, senescence, and apoptosis are well accepted as the major checkpoints in stress responses, accumulating evidence implicates the importance of other tumor suppression mechanisms. Among these unconventional activities, an iron-dependent form of non-apoptotic cell death, termed ferroptosis, attracts great interest. Unlike apoptotic cell death, activation of p53 alone is not sufficient to induce ferroptosis directly; instead, through its metabolic targets, p53 is able to modulate the ferroptosis response in the presence of ferroptosis inducers such as GPX4 inhibitors or high levels of ROS. Here, we review the role of ferroptosis in p53-mediated tumor suppression, with a focus on what cellular factors are critical for p53-dependent ferroptosis during tumor suppression and how p53 modulates both the canonical (GPX4-dependent) and the non-canonical (GPX4-independent) ferroptosis pathways. We also discuss the possibility of targeting p53-mediated ferroptotic responses for the treatment of human cancers and potentially, other diseases.
MeSH term(s)	Apoptosis ; Ferroptosis ; Humans ; Neoplasms/pathology ; Reactive Oxygen Species/metabolism ; Tumor Suppressor Protein p53/metabolism
Chemical Substances	Reactive Oxygen Species ; Tumor Suppressor Protein p53
Language	English
Publishing date	2022-01-27
Publishing country	England
Document type	Journal Article ; Review ; Research Support, N.I.H., Extramural
ZDB-ID	1225672-9
ISSN	1476-5403 ; 1350-9047
ISSN (online)	1476-5403
ISSN	1350-9047
DOI	10.1038/s41418-022-00943-y
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Zs.A 4230: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Tracheoesophageal Diversion and Laryngotracheal Separation Procedures for Radiotherapy-Related Intractable Aspiration Pneumonia in Nasopharyngeal Carcinoma.

Gu, Wei / Wang, Jian

BioMed research international

2022 Volume 2022, Page(s) 2162936

Abstract: Background: Intractable aspiration and aspiration pneumonia are complications after radiotherapy for nasopharyngeal carcinoma (NPC), and they may be life-threatening in severe cases. In the past, the efficacy of controlling aspiration and aspiration ... ...

Abstract	Background: Intractable aspiration and aspiration pneumonia are complications after radiotherapy for nasopharyngeal carcinoma (NPC), and they may be life-threatening in severe cases. In the past, the efficacy of controlling aspiration and aspiration pneumonia in such patients was not ideal. Objectives: We aimed to evaluate the effect of tracheoesophageal diversion and laryngotracheal separation (TED-LTS) procedures for these patients. Results: Intractable aspiration and aspiration pneumonia were completely controlled in all cases, and the patients' body weight increased from 46.46 ± 4.6 (38.9-50.3) kg to 55.32 ± 2.7 (51.4-56.7) kg. Four patients were able to consume an oral semisolid diet, and one patient maintained an oral liquid diet. Tube feeding was not required in 4 patients. One patient developed postoperative esophageal fistula, which improved after conservative treatment. Conclusion: TED-LTS is effective for intractable aspiration and aspiration pneumonia caused by NPC radiotherapy and can be used to restore partial oral feeding. However, strict surgical indications should be followed.
MeSH term(s)	Body Weight ; Deglutition Disorders/etiology ; Humans ; Larynx/surgery ; Nasopharyngeal Carcinoma/radiotherapy ; Nasopharyngeal Carcinoma/surgery ; Nasopharyngeal Neoplasms ; Pneumonia, Aspiration/complications ; Pneumonia, Aspiration/surgery ; Postoperative Complications ; Retrospective Studies ; Trachea/surgery
Language	English
Publishing date	2022-07-23
Publishing country	United States
Document type	Journal Article
ZDB-ID	2698540-8
ISSN	2314-6141 ; 2314-6133
ISSN (online)	2314-6141
ISSN	2314-6133
DOI	10.1155/2022/2162936
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Liquid Biopsy Based on Cell-Free DNA and RNA.

Loy, Conor / Ahmann, Lauren / De Vlaminck, Iwijn / Gu, Wei

Annual review of biomedical engineering

2024

Abstract: This review delves into the rapidly evolving landscape of liquid biopsy technologies based on cell-free DNA (cfDNA) and cell-free RNA (cfRNA) and their increasingly prominent role in precision medicine. With the advent of high-throughput DNA sequencing, ... ...

Abstract	This review delves into the rapidly evolving landscape of liquid biopsy technologies based on cell-free DNA (cfDNA) and cell-free RNA (cfRNA) and their increasingly prominent role in precision medicine. With the advent of high-throughput DNA sequencing, the use of cfDNA and cfRNA has revolutionized noninvasive clinical testing. Here, we explore the physical characteristics of cfDNA and cfRNA, present an overview of the essential engineering tools used by the field, and highlight clinical applications, including noninvasive prenatal testing, cancer testing, organ transplantation surveillance, and infectious disease testing. Finally, we discuss emerging technologies and the broadening scope of liquid biopsies to new areas of diagnostic medicine. Expected final online publication date for the
Language	English
Publishing date	2024-02-12
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	1448425-0
ISSN	1545-4274 ; 1523-9829
ISSN (online)	1545-4274
ISSN	1523-9829
DOI	10.1146/annurev-bioeng-110222-111259
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