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Article ; Online: Impact of sarcopenia in elderly patients undergoing elective total hip arthroplasty on postoperative outcomes: a propensity score-matched study.

Su, Yan / Peng, Liangyu / Dong, Daoqian / Ma, Zhengliang / Gu, Xiaoping

2024 Volume 24, Issue 1, Page(s) 158

Abstract: Objective: Frailty poses a crucial risk for postoperative complications in the elderly, with sarcopenia being a key component. The impact of sarcopenia on postoperative outcomes after total hip arthroplasty (THA) is still unclear. This study ... ...

Abstract	Objective: Frailty poses a crucial risk for postoperative complications in the elderly, with sarcopenia being a key component. The impact of sarcopenia on postoperative outcomes after total hip arthroplasty (THA) is still unclear. This study investigated the potential link between sarcopenia and postoperative outcomes among elderly THA patients. Methods: Totally 198 older patients were enrolled in this study. Sarcopenia in this group was determined by assessing the skeletal muscle index, which was measured using computed tomography at the 12th thoracic vertebra and analyzed semi-automatically with MATLAB R2020a. Propensity score matching (PSM) was employed to evaluate postoperative complications of grade II and above (POCIIs). Results: The variables balanced using PSM contained age, sex and comorbidities including hypertension, diabetes, hyperlipidemia and COPD. Before PSM, sarcopenic patients with reduced BMI (24.02 ± 0.24 vs. 27.11 ± 0.66, P < 0.001) showed higher POCIIs rates (48.31% vs. 15%, P = 0.009) and more walking-assisted discharge instances (85.96% vs. 60%, P = 0.017) compared with non-sarcopenia patients. After PSM, this group maintained reduced BMI (23.47 ± 0.85 vs. 27.11 ± 0.66, P = 0.002), with increased POCIIs rates (54.41% vs. 15%, P = 0.002) and heightened reliance on walking assistance at discharge (86.96% vs. 60%, P = 0.008). Conclusion: Sarcopenia patients exhibited a higher incidence of POCIIs and poorer physical function at discharge. Sarcopenia could serve as a valuable prognostic indicator for elderly patients undergoing elective THA.
MeSH term(s)	Humans ; Sarcopenia/epidemiology ; Male ; Female ; Arthroplasty, Replacement, Hip ; Aged ; Propensity Score ; Postoperative Complications/epidemiology ; Elective Surgical Procedures/adverse effects ; Aged, 80 and over ; Retrospective Studies
Language	English
Publishing date	2024-04-24
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2091252-3
ISSN	1471-2253 ; 1471-2253
ISSN (online)	1471-2253
ISSN	1471-2253
DOI	10.1186/s12871-024-02538-1
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Article ; Online: Sensors and algorithms for locomotion intention detection of lower limb exoskeletons.

Wang, Duojin / Gu, Xiaoping / Yu, Hongliu

Medical engineering & physics

2023 Volume 113, Page(s) 103960

Abstract: In recent years, lower limb exoskeletons (LLEs) have received much attention due to the potential to help people with paraplegia regain the ability of upright-legged locomotion. However, one major hindrance to converting prototypes into actual products ... ...

Abstract	In recent years, lower limb exoskeletons (LLEs) have received much attention due to the potential to help people with paraplegia regain the ability of upright-legged locomotion. However, one major hindrance to converting prototypes into actual products is the lack of a balance recovery function. Locomotion intentions can be the first step for balance assistance. Therefore, its significance continues to grow. Many researchers focus on this topic, but there is a lack of a general discussion on the research phenomenon. Therefore, the purpose of this work is to systematize these data and benefit future research. This review is divided into two parts, the location of sensors/devices and the evaluation criteria of algorithms, which are the main components of locomotion intentions. We found that sensor/device placement is still concentrated in the lower limbs, but most researchers have found the importance of the chest. The peak power of the signal collected from the chest may be overestimated because it undergoes higher vertical velocity and acceleration during a rotation. However, despite the differences in peak power between the upper and lower back, high correlations were found for the tasks, especially from sitting to standing. Since peak power is based on vertical acceleration and velocity, it can be considered a metric that is more robust to changes in sensor location. Therefore, data acquisition from the chest is effective. In this paper, it is pointed out that sensors placed on the chest may have a tendency to change, as some researchers have realized in the field of locomotion intention recognition. In the evaluation criteria, we also found that deep learning algorithm (such as Back Propagation Artificial Neural Network (BPANN)) is outstanding, and Support Vector Machine (SVM) is the most cost-effective algorithm. In terms of accuracy, sensitivity, and specificity, BPANN achieved nearly 100%. SVM has different types; the best one achieves 98% accuracy, 100% sensitivity, and 100% specificity. But it also has 87.8% accuracy, which is not stable. Convolutional Neural Networks (CNN) can be used for image classification and have an accuracy of around 87%. Compared to the above two algorithms, CNN may have lower performance. Other algorithms also have higher accuracy, sensitivity, and specificity. These evaluation criteria, however, were not all ideal at the same time. Based on these results, we also point out the existing problems. In general, the application of these algorithms to LLE can contribute to its intention recognition, which can be helpful in balancing research. Finally, this can help make LLE more suitable for daily use.
MeSH term(s)	Humans ; Exoskeleton Device ; Intention ; Algorithms ; Locomotion ; Lower Extremity
Language	English
Publishing date	2023-02-17
Publishing country	England
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	1181080-4
ISSN	1873-4030 ; 1350-4533
ISSN (online)	1873-4030
ISSN	1350-4533
DOI	10.1016/j.medengphy.2023.103960
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Article ; Online: Remifentanil-induced postoperative hyperalgesia is attenuated by inhibition of NMDAR-cADPR-RyRs signaling pathway in the spinal cord of rats

QIAN Yue / WANG Fang / ZHANG Jing / XIA Tianjiao / GU Xiaoping

Jichu yixue yu linchuang, Vol 43, Iss 9, Pp 1335-

2023 Volume 1340

Abstract: Objective To investigate the role of NMDAR-cADPR-RyRs signaling pathway in remifentanil-induced hyperalgesia(RIH). Methods The rat model of postoperative hyperalgesia induced by remifentanil was established. SD rats were randomly divided into 6 groups as: ...

Abstract	Objective To investigate the role of NMDAR-cADPR-RyRs signaling pathway in remifentanil-induced hyperalgesia(RIH). Methods The rat model of postoperative hyperalgesia induced by remifentanil was established. SD rats were randomly divided into 6 groups as: control group, model group, RIH group, RIH+saline group, RIH+ketamine group and RIH+8-Br-cADPR group with 6 animals in each. N-methy-D-aspartic acid receptor(NMDA) antagonist ketamine or cyclic ADP-ribose(cADPR) antagonist 8-Br-cADPR was injected intrathecally 30 minutes before surgical operation in group RIH+ketamine and group RIH+8-Br-cADPR respectively. PWMT and PWTL were measured before operation and on the 1st, 2nd and 3rd days after operation. Western blotwas used to detect the protein level of p-NR2B, p-CaMKII, RyR1 and RyR3 in spinal dorsal horn neurons. The concentration of cADPR was measured by enzyme cycling assay. Results Compared with model group, PWMT and PWTL in RIH group decreased significantly on the first and the second day after remifentanil infusion, while p-NR2B, p-CaMKII, RyR1, RyR3 and cADPR in the spinal dorsal horn increased significantly (P＜0.05). After intrathecal injection of ketamine or 8-Br-cADPR, hypersensitivity to mechanical pain and thermal pain was alleviated in RIH+ketamine group and RIH+8-Br-cADPR group, and the expression level of p-NR2B, p-CaMKII, RyR1, RyR3 and cADPR decreased as compared with RIH group (P＜0.05). Conclusions Remifentanil-induced postoperative hyperalgesia of rat is attenuated by blocking NMDAR-cADPR-RyRs signaling pathway.
Keywords	remifentanil\|hyperalgesia\|ketamine\|8-br-cadpr\|ryanodine receptors ; Medicine ; R
Subject code	571
Language	Chinese
Publishing date	2023-09-01T00:00:00Z
Publisher	Institute of Basic Medical Sciences and Peking Union Medical College Hospital, Chinese Academy of Medical Sciences / Peking Union Medical College.
Document type	Article ; Online
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Article ; Online: USP18 overexpression protects against spinal cord ischemia/reperfusion injury via regulating autophagy.

Yuan, Libang / Xu, Jin / Qin, Fuen / Yi, Xiaobo / Zhong, Zuling / Gu, Xiaoping / Gong, Gu

Neuroscience letters

2023 Volume 810, Page(s) 137359

Abstract: Background: Spinal cord ischemia-reperfusion injury (SCII) is usually caused by spinal surgery, often leading to severe neurological deficits. The ubiquitin-specific protease 18 (USP18) plays a significant role in neurological diseases.: Objective: ... ...

Abstract	Background: Spinal cord ischemia-reperfusion injury (SCII) is usually caused by spinal surgery, often leading to severe neurological deficits. The ubiquitin-specific protease 18 (USP18) plays a significant role in neurological diseases. Objective: The present study was designed to assess the effects and mechanisms of USP18 on SCII. Methods: By inducing transient aortic occlusion and subsequent reperfusion, a rat model of SCII was successfully established. The Basso-Beattie-Bresnahan scores, the inclined plane test, and hematoxylin and eosin (HE) were used to measure locomotor activity and histological changes in the injured spinal cords. Moreover, the SCII cell model was established using PC12 cells under oxygen-glucose deprivation and reoxygenation (OGD/R). Proinflammatory factors (TNF-α, IL-6, and INF-α) were examined using an ELISA kit. Cell apoptosis was assessed by Annexin V-FITC/PI double-staining and TUNEL assays. Western blot was used to detect the expression levels of proteins related to apoptosis and autophagy. Results: USP18 expression was decreasedin vivo and in vitro SCII models. The upregulation of USP18 ameliorated hind limbs' motor function, inhibiting inflammation and apoptosis after SCII in rats. USP18 overexpression in vitro may protect PC12 cells from OGD/R-induced damage by modulating inflammatory responses and apoptosis. Moreover, Overexpression of USP18 enhanced autophagy to inhibit cell apoptosis induced by SCII in vivo and in vitro. Conclusions: In summary, USP18 overexpression protects against SCII via regulating autophagy.
MeSH term(s)	Animals ; Rats ; Apoptosis ; Autophagy ; Rats, Sprague-Dawley ; Reperfusion Injury/metabolism ; Spinal Cord/metabolism ; Spinal Cord Ischemia/metabolism
Chemical Substances	Usp18 protein, rat
Language	English
Publishing date	2023-06-24
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	194929-9
ISSN	1872-7972 ; 0304-3940
ISSN (online)	1872-7972
ISSN	0304-3940
DOI	10.1016/j.neulet.2023.137359
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Article: Long-term sevoflurane exposure relieves stress-enhanced fear learning and anxiety in PTSD mice.

Du, Ying / Xu, Minhui / Su, Yan / Liu, Yujia / Zhou, Yiming / Gu, Xiaoping / Xia, Tianjiao

Translational neuroscience

2023 Volume 14, Issue 1, Page(s) 20220313

Abstract: Objectives: Post-traumatic stress disorder (PTSD) is characterized by recurrent episodes of severe anxiety after exposure to traumatic events. It is believed that these episodes are triggered at least in part by environmental stimuli associated with the ...

Abstract	Objectives: Post-traumatic stress disorder (PTSD) is characterized by recurrent episodes of severe anxiety after exposure to traumatic events. It is believed that these episodes are triggered at least in part by environmental stimuli associated with the precipitating trauma through classical conditioning, termed conditioned fear. However, traditional methods of conditioned fear memory extinction are frequently ineffective for PTSD treatment due to the contribution of non-associative sensitization caused by trauma. Anesthetics have shown promise for treating various psychiatric diseases such as depression. Methods: In this study, we examined if the inhaled anesthetic sevoflurane can suppress stress-enhanced fear learning (SEFL) in PTSD model mice. Model mice exposed to 2.4% sevoflurane for 6 h exhibited reduced freezing time and behavioral anxiety compared to sham-treated model mice. To explore the underlying mechanisms, we evaluated the regional expression levels of glucocorticoid receptors (GRs), cannabinoid CB1 receptors (CB1Rs), D1 dopamine receptors (D1Rs), and D2 dopamine receptors (D2Rs). Results: We verified that both GR and CB1R were significantly upregulated in the hippocampus, amygdaloid nucleus, and prefrontal cortex (PFC) of model mice, while D1R and D2R were downregulated. All of these expression changes were partially normalized in the PFC by 6 h but not with 2 h sevoflurane exposure. Conclusions: These results showed that sevoflurane exposure following traumatic events may be an effective treatment for PTSD.
Language	English
Publishing date	2023-10-28
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2581219-1
ISSN	2081-6936 ; 2081-3856
ISSN (online)	2081-6936
ISSN	2081-3856
DOI	10.1515/tnsci-2022-0313
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Article ; Online: The Role of Health Education in Vaccination Nursing.

Yao, Mengjiao / Gu, Xiaoping / Mo, Yujie / Xia, Chunjing / Tang, Liwei

publication RETRACTED

Journal of healthcare engineering

2022 Volume 2022, Page(s) 6078846

Abstract: The role of health education in vaccination is very important. Through various forms of activities, comprehensive and systematic education of health knowledge for people can promote students and others to be aware of vaccination and actively cooperate ... ...

Abstract	The role of health education in vaccination is very important. Through various forms of activities, comprehensive and systematic education of health knowledge for people can promote students and others to be aware of vaccination and actively cooperate with vaccination work. Therefore, this article intends to conduct an in-depth study of the role of health education in prevention and treatment and to enhance people's awareness of vaccination. This article mainly uses questionnaire survey method, interview method, and controlled experiment to explain and analyze the effect of health education. The subjects of this questionnaire are students, parents, and staff. They have mixed reviews for its role in vaccination, but the overall situation is positive. 239 out of 500 people believe that health education can reduce allergic reactions and improve the effectiveness of vaccines. In the control experiment, after health education and publicity training, the parents of the observation group were significantly better than the control group in terms of mastering the relevant knowledge of vaccination, successfully vaccinating unplanned vaccines, etc. This shows that the importance of health education in vaccination care is incomparable.
MeSH term(s)	Health Education ; Health Knowledge, Attitudes, Practice ; Humans ; Students ; Surveys and Questionnaires ; Vaccination
Language	English
Publishing date	2022-04-18
Publishing country	England
Document type	Journal Article ; Retracted Publication
ZDB-ID	2545054-2
ISSN	2040-2309 ; 2040-2295
ISSN (online)	2040-2309
ISSN	2040-2295
DOI	10.1155/2022/6078846
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Article ; Online: Ultrasound-Guided Rhomboid Block versus Paravertebral Block in Postoperative Analgesia for Video-Assisted Thoracoscopic Surgery: A Prospective Randomized Controlled Clinical Trial.

Wang, Yan / Gu, Xiaoping / Huang, Simin / Shi, Minke / He, Xiaofeng / Ma, Zhengliang

Pain research & management

2023 Volume 2023, Page(s) 3924511

Abstract: Introduction: The anesthetic efficacy of the ultrasound-guided rhomboid intercostal block (RIB) in alleviating postoperative pain has been well concerned. This study aims to compare the effectiveness between ultrasound-guided RIB and paravertebral block ...

Abstract	Introduction: The anesthetic efficacy of the ultrasound-guided rhomboid intercostal block (RIB) in alleviating postoperative pain has been well concerned. This study aims to compare the effectiveness between ultrasound-guided RIB and paravertebral block (PVB) in alleviating acute pain following video-assisted thoracic surgery. Methods: It was a prospective, randomized, double-blinded clinical trial involving 132 patients with video-assisted thoracic surgery divided into three groups: the general anesthesia (GA) group, RIB group, and PVB group on T5 vertebra, using 0.4% ropivacaine at 3 mg/kg, registered in the Chinese Clinical Trial Registry (ChiCTR2100054057, "https://www.chictr.org.cn"). The visual analogue scale (VAS) scores at rest and cough during 48 h postoperatively and the postoperative consumption of pain rescue were the primary outcomes, and the QoR15 score 48 h postoperatively, the usage of opioids during and after operation, and nerve block-related complications were the secondary outcomes. Demographic characteristics, surgery characteristics, and primary outcomes between the groups were compared. Results: A total of 120 eligible patients were recruited, including 40 in each group. Baseline and surgery characteristics between the groups were comparable (all Conclusion: Both PVB and RIB can provide adequate analgesia and accelerate the recovery of patients. Compared with PVB, RIB has a better analgesic effect, especially to avoid paravertebral pain caused by block, and the operation of RIB is more straightforward and the safety is higher.
MeSH term(s)	Humans ; Thoracic Surgery, Video-Assisted/adverse effects ; Prospective Studies ; Nerve Block/adverse effects ; Pain, Postoperative/etiology ; Analgesia ; Ultrasonography, Interventional
Language	English
Publishing date	2023-03-01
Publishing country	United States
Document type	Randomized Controlled Trial ; Journal Article
ZDB-ID	2041085-2
ISSN	1918-1523 ; 1203-6765
ISSN (online)	1918-1523
ISSN	1203-6765
DOI	10.1155/2023/3924511
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Article ; Online: The Role of ESRP1 in the Regulation of PHGDH in Estrogen Receptor-Positive Breast Cancer.

Gökmen-Polar, Yesim / Gu, Yuan / Polar, Alper / Gu, Xiaoping / Badve, Sunil S

Laboratory investigation; a journal of technical methods and pathology

2023 Volume 103, Issue 3, Page(s) 100002

Abstract: Resistance to hormone therapy leads to a recurrence of estrogen receptor-positive breast cancer. We have demonstrated that the epithelial splicing regulatory protein 1 (ESRP1) significantly affects cell/tumor growth and metabolism and is associated with ... ...

Abstract	Resistance to hormone therapy leads to a recurrence of estrogen receptor-positive breast cancer. We have demonstrated that the epithelial splicing regulatory protein 1 (ESRP1) significantly affects cell/tumor growth and metabolism and is associated with a poor prognosis in this breast cancer subtype. In this study, we aimed to investigate the ESRP1 protein-messenger RNA (mRNA) interaction in hormone therapy-resistant breast cancer. RNA-binding protein immunoprecipitation (RIP) followed by Clariom D (Applied Biosystems/Thermo Fisher Scientific) transcriptomics microarray (RIP-Chip) was performed to identify mRNA-binding partners of ESRP1. The integration of RIP-Chip and immunoprecipitation-mass spectrometry analyses identified phosphoglycerate dehydrogenase (PHGDH), a key metabolic enzyme, as a binding partner of ESRP1 in hormone-resistant breast cancer. Bioinformatic analysis showed ESRP1 binding to the 5' untranslated region of PHGDH. RNA electrophoresis mobility shift assay and RIP-quantitative reverse transcription-polymerase chain reaction further validated the ESRP1-PHGDH binding. In addition, knockdown of ESRP1 decreased PHGDH mRNA stability significantly, suggesting the posttranscriptional regulation of PHGDH by ESRP1. The presence or absence of ESRP1 levels significantly affected the stability in tamoxifen-resistant LCC2 and fulvestrant-resistant LCC9 cells. PHGDH knockdown in tamoxifen-resistant cells further reduced the oxygen consumption rate (ranging from P = .005 and P = .02), mimicking the effects of ESRP1 knockdown. Glycolytic parameters were also altered (ranging P = .001 and P = .005). ESRP1 levels did not affect the stability of PHGDH in T-47D cells, although knockdown of PHGDH affected the growth of these cells. In conclusion, to our knowledge, this study, for the first time, reports that ESRP1 binds to the 5' untranslated region of PHGDH, increasing its mRNA stability in hormone therapy-resistant estrogen receptor-positive breast cancer. These findings provide evidence for a novel mechanism of action of RNA-binding proteins such as ESRP1. These new insights could assist in developing novel strategies for the treatment of hormone therapy-resistant breast cancer.
MeSH term(s)	Humans ; Female ; Breast Neoplasms/pathology ; Receptors, Estrogen/genetics ; Receptors, Estrogen/metabolism ; Phosphoglycerate Dehydrogenase/genetics ; Phosphoglycerate Dehydrogenase/metabolism ; 5' Untranslated Regions ; Tamoxifen/pharmacology ; Transcription Factors/metabolism ; RNA-Binding Proteins/genetics ; RNA-Binding Proteins/metabolism ; Hormones ; Cell Line, Tumor
Chemical Substances	Receptors, Estrogen ; Phosphoglycerate Dehydrogenase (EC 1.1.1.95) ; 5' Untranslated Regions ; Tamoxifen (094ZI81Y45) ; Transcription Factors ; RNA-Binding Proteins ; Hormones ; ESRP1 protein, human
Language	English
Publishing date	2023-01-10
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	80178-1
ISSN	1530-0307 ; 0023-6837
ISSN (online)	1530-0307
ISSN	0023-6837
DOI	10.1016/j.labinv.2022.100002
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Article ; Online: Complex Topology of Ubiquitin Chains Mediates Lysosomal Degradation of MrgC Proteins.

Yu, Jiacheng / Li, Dan / Xie, Mingming / Xie, Jun / Wang, Zhen / Gu, Xiaoping / Ma, Zhengliang / Sun, Yu'e

Cell biochemistry and biophysics

2024

Abstract: Background: Activation of Mas-related G protein-coupled receptor C (MrgC) receptors relieves pain, but also leads to ubiquitination of MrgC receptors. Ubiquitination mediates MrgC receptor endocytosis and degradation. However, MrgC degradation pathways ... ...

Abstract	Background: Activation of Mas-related G protein-coupled receptor C (MrgC) receptors relieves pain, but also leads to ubiquitination of MrgC receptors. Ubiquitination mediates MrgC receptor endocytosis and degradation. However, MrgC degradation pathways and ubiquitin-linked chain types are not known. Methods: N2a cells were treated with cycloheximide (CHX, protein synthesis inhibitor), Mg132 (proteasome inhibitor), 3-Methyladenine (3MA, autophagy lysosome inhibitor) and Chloroquine (CQ, autophagy lysosome inhibitor) to observe the half-life and degradation pathway of MrgC. The location of internalized MrgC receptors and lysosomes (Lyso-Tracker) was observed by immunofluorescence staining. N2a cells were transfected with Myc-MrgC and a series of HA-tagged ubiquitin mutants to study the ubiquitin-linked chain type of MrgC. Results: The amount of MrgC protein decreased with time after CHX treatment of N2a cells. Autophagy lysosome inhibitors can inhibit the degradation of MrgC. The amount of MrgC protein decreased with time after CHX treatment of N2a cells. 3-MA and CQ inhibited the degradation of MrgC protein, whereas Mg-132 did not inhibit it. Partially internalized MrgC receptors were co-labeled with lysosomes. MrgC proteins have multiple topologies of ubiquitin-modified chains. Conclusion: As a member of the G protein-coupled receptor family, MrgC receptors can be degraded over time. The complex topology of the ubiquitin-linked chain mediates the lysosomal degradation of MrgC proteins.
Language	English
Publishing date	2024-01-30
Publishing country	United States
Document type	Journal Article
ZDB-ID	1357904-6
ISSN	1559-0283 ; 1085-9195
ISSN (online)	1559-0283
ISSN	1085-9195
DOI	10.1007/s12013-023-01204-6
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Article ; Online: Mitochondrial Quality Control in Cerebral Ischemia-Reperfusion Injury.

Wu, Mimi / Gu, Xiaoping / Ma, Zhengliang

Molecular neurobiology

2021 Volume 58, Issue 10, Page(s) 5253–5271

Abstract: Ischemic stroke is one of the leading causes of death and also a major cause of adult disability worldwide. Revascularization via reperfusion therapy is currently a standard clinical procedure for patients with ischemic stroke. Although the restoration ... ...

Abstract	Ischemic stroke is one of the leading causes of death and also a major cause of adult disability worldwide. Revascularization via reperfusion therapy is currently a standard clinical procedure for patients with ischemic stroke. Although the restoration of blood flow (reperfusion) is critical for the salvage of ischemic tissue, reperfusion can also, paradoxically, exacerbate neuronal damage through a series of cellular alterations. Among the various theories postulated for ischemia/reperfusion (I/R) injury, including the burst generation of reactive oxygen species (ROS), activation of autophagy, and release of apoptotic factors, mitochondrial dysfunction has been proposed to play an essential role in mediating these pathophysiological processes. Therefore, strict regulation of the quality and quantity of mitochondria via mitochondrial quality control is of great importance to avoid the pathological effects of impaired mitochondria on neurons. Furthermore, timely elimination of dysfunctional mitochondria via mitophagy is also crucial to maintain a healthy mitochondrial network, whereas intensive or excessive mitophagy could exacerbate cerebral I/R injury. This review will provide a comprehensive overview of the effect of mitochondrial quality control on cerebral I/R injury and introduce recent advances in the understanding of the possible signaling pathways of mitophagy and potential factors responsible for the double-edged roles of mitophagy in the pathological processes of cerebral I/R injury.
MeSH term(s)	Animals ; Antioxidants/administration & dosage ; Brain Ischemia/drug therapy ; Brain Ischemia/metabolism ; Brain Ischemia/pathology ; Humans ; Ischemic Stroke/drug therapy ; Ischemic Stroke/metabolism ; Ischemic Stroke/pathology ; Mitochondria/drug effects ; Mitochondria/metabolism ; Mitochondria/pathology ; Mitochondrial Dynamics/drug effects ; Mitochondrial Dynamics/physiology ; Mitophagy/drug effects ; Mitophagy/physiology ; Nicorandil/administration & dosage ; Reperfusion Injury/drug therapy ; Reperfusion Injury/metabolism ; Reperfusion Injury/pathology ; Vasodilator Agents/administration & dosage
Chemical Substances	Antioxidants ; Vasodilator Agents ; Nicorandil (260456HAM0)
Language	English
Publishing date	2021-07-18
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	645020-9
ISSN	1559-1182 ; 0893-7648
ISSN (online)	1559-1182
ISSN	0893-7648
DOI	10.1007/s12035-021-02494-8
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