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Article ; Online: TMED2 promotes glioma tumorigenesis by being involved in EGFR recycling transport.

Sun, Changning / Zhang, Yihan / Wang, Zhuangzhi / Chen, Jin / Zhang, Junhua / Gu, Yuchao

International journal of biological macromolecules

2024 Volume 262, Issue Pt 2, Page(s) 130055

Abstract: Aberrant epidermal growth factor receptor (EGFR) signaling is the core signaling commonly activated in glioma. The transmembrane emp24 protein transport domain protein 2 (TMED2) interacts with cargo proteins involved in protein sorting and transport ... ...

Abstract	Aberrant epidermal growth factor receptor (EGFR) signaling is the core signaling commonly activated in glioma. The transmembrane emp24 protein transport domain protein 2 (TMED2) interacts with cargo proteins involved in protein sorting and transport between endoplasmic reticulum (ER) and Golgi apparatus. In this study, we found the correlation between TMED2 with glioma progression and EGFR signaling through database analysis. Moreover, we demonstrated that TMED2 is essential for glioma cell proliferation, migration, and invasion at the cellular levels, as well as tumor formation in mouse models, underscoring its significance in the pathobiology of gliomas. Mechanistically, TMED2 was found to enhance EGFR-AKT signaling by facilitating EGFR recycling, thereby providing the initial evidence of TMED2's involvement in the membrane protein recycling process. In summary, our findings shed light on the roles and underlying mechanisms of TMED2 in the regulation of glioma tumorigenesis and EGFR signaling, suggesting that targeting TMED2 could emerge as a promising therapeutic strategy for gliomas and other tumors associated with aberrant EGFR signaling.
MeSH term(s)	Mice ; Animals ; ErbB Receptors/metabolism ; Glioma/drug therapy ; Signal Transduction ; Cell Proliferation ; Carcinogenesis/genetics ; Cell Transformation, Neoplastic ; Cell Line, Tumor
Chemical Substances	ErbB Receptors (EC 2.7.10.1)
Language	English
Publishing date	2024-02-12
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	282732-3
ISSN	1879-0003 ; 0141-8130
ISSN (online)	1879-0003
ISSN	0141-8130
DOI	10.1016/j.ijbiomac.2024.130055
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Zs.B 2374: Show issues

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Article ; Online: Mirror QCD phase transition as the origin of the nanohertz Stochastic Gravitational-Wave Background.

Zu, Lei / Zhang, Chi / Li, Yao-Yu / Gu, Yuchao / Tsai, Yue-Lin Sming / Fan, Yi-Zhong

Science bulletin

2024 Volume 69, Issue 6, Page(s) 741–746

Abstract: Several Pulsar Timing Array (PTA) Collaborations have recently provided strong evidence for a nHz Stochastic Gravitational-Wave Background (SGWB). Here we investigate the implications of a first-order phase transition occurring within the early Universe' ... ...

Abstract	Several Pulsar Timing Array (PTA) Collaborations have recently provided strong evidence for a nHz Stochastic Gravitational-Wave Background (SGWB). Here we investigate the implications of a first-order phase transition occurring within the early Universe's dark quantum chromodynamics epoch, specifically within the framework of the mirror twin Higgs dark sector model. Our analysis indicates a distinguishable SGWB signal originating from this phase transition, which can explain the measurements obtained by PTAs. Remarkably, a significant portion of the parameter space for the SGWB signal also effectively resolves the existing tensions in both the H
Language	English
Publishing date	2024-01-30
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2816140-3
ISSN	2095-9281 ; 2095-9273
ISSN (online)	2095-9281
ISSN	2095-9273
DOI	10.1016/j.scib.2024.01.037
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Article: [Preparation and application of rabbit polyclonal antibody against human glutamine fructose-6-phosphate amidotransferase 1(GFPT1)].

Wu, Shaochun / Liu, Lin / Gao, Yanchun / Gu, Yuchao

Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology

2022 Volume 38, Issue 7, Page(s) 651–656

Abstract: Objective To prepare rabbit polyclonal antibody specifically against human glutamine fructose-6-phosphate amidotransferase 1(GFPT1). Methods The protein sequences of GFPT1 and its highly homologous isozyme GFPT2 were compared. Two peptides for the ... ...

Abstract	Objective To prepare rabbit polyclonal antibody specifically against human glutamine fructose-6-phosphate amidotransferase 1(GFPT1). Methods The protein sequences of GFPT1 and its highly homologous isozyme GFPT2 were compared. Two peptides for the specific sequence of GFPT1 were designed and synthesized. New Zealand rabbits were immunized by peptide coupled with Keyhole Limpet hemocyanin (KLH) as antigen. Antiserum was obtained after 3 booster immunizations. The titer of the antiserum against GFPT1 were detected by ELISA. The E.coli expression vectors of GFPT1 and GFPT2 were constructed, and the recombinant proteins of GFPT1 and GFPT2 were obtained by induced expression. GFPT1 and GFPT2 recombinant proteins were analyzed by Western blot to verify the specificity of the antiserum. Immuno-fluorescence cytochemical staining for GFPT1 expression in 786-O cells was verified as for whether the obtained antiserum could recognize the endogenously expressed GFPT1. Results Polyclonal antibody specifically recognizing GFPT1 was obtained and the titer of polyclonal antibody reached 1:1 458 000. Conclusion The experiment successfully prepared the specific rabbit polyclonal antibody against GFPT1.
MeSH term(s)	Animals ; Antibodies ; Escherichia coli/genetics ; Fructosephosphates ; Glutamine ; Glutamine-Fructose-6-Phosphate Transaminase (Isomerizing) ; Humans ; Immune Sera ; Rabbits ; Recombinant Proteins
Chemical Substances	Antibodies ; Fructosephosphates ; Immune Sera ; Recombinant Proteins ; Glutamine (0RH81L854J) ; fructose-6-phosphate (6814-87-5) ; GFPT1 protein, human (EC 2.6.1.16) ; Glutamine-Fructose-6-Phosphate Transaminase (Isomerizing) (EC 2.6.1.16)
Language	Chinese
Publishing date	2022-07-03
Publishing country	China
Document type	Journal Article
ISSN	1007-8738
ISSN	1007-8738
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Article ; Online: Screening and optimization of shark nanobodies against SARS-CoV-2 spike RBD.

Liu, Xiaochun / Wang, Yanqing / Sun, Lishan / Xiao, Guokai / Hou, Ning / Chen, Jin / Wang, Wei / Xu, Ximing / Gu, Yuchao

Antiviral research

2024 Volume 226, Page(s) 105898

Abstract: SARS-CoV-2 continues to threaten human health, antibody therapy is one way to control the infection. Because new SARS-CoV-2 mutations are constantly emerging, there is an urgent need to develop broadly neutralizing antibodies to block the viral entry ... ...

Abstract	SARS-CoV-2 continues to threaten human health, antibody therapy is one way to control the infection. Because new SARS-CoV-2 mutations are constantly emerging, there is an urgent need to develop broadly neutralizing antibodies to block the viral entry into host cells. VNAR from sharks is the smallest natural antigen binding domain, with the advantages of small size, flexible paratopes, good stability, and low manufacturing cost. Here, we used recombinant SARS-CoV-2 Spike-RBD to immunize sharks and constructed a VNAR phage display library. VNAR R1C2, selected from the library, efficiently binds to the RBD domain and blocks the infection of ACE2-positive cells by pseudovirus. Next, homologous bivalent VNARs were constructed through the tandem fusion of two R1C2 units, which enhanced both the affinity and neutralizing activity of R1C2. R1C2 was predicted to bind to a relatively conserved region within the RBD. By introducing mutations at four key binding sites within the CDR3 and HV2 regions of R1C2, the affinity and neutralizing activity of R1C2 were significantly improved. Furthermore, R1C2 also exhibits an effective capacity of binding to the Omicron variants (BA.2 and XBB.1). Together, these results suggest that R1C2 could serve as a valuable candidate for preventing and treating SARS-CoV-2 infections.
Language	English
Publishing date	2024-04-29
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	306628-9
ISSN	1872-9096 ; 0166-3542
ISSN (online)	1872-9096
ISSN	0166-3542
DOI	10.1016/j.antiviral.2024.105898
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Zs.A 1627: Show issues

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Article ; Online: Novel MAGL Inhibitors Alleviate LPS-Induced Acute Kidney Injury by Inhibiting NLRP3 Inflammatory Vesicles, Modulating Intestinal Flora, Repairing the Intestinal Barrier, and Interfering with Serum Metabolism.

Xiang, Haixin / Wang, Yangui / Yang, Lan / Liu, Mingfei / Sun, Chenghong / Gu, Yuchao / Yao, Jingchun

Molecules (Basel, Switzerland)

2023 Volume 28, Issue 21

Abstract: Acute kidney injury (AKI) is a complication of a wide range of serious illnesses for which there is still no better therapeutic agent. We demonstrated that M-18C has a favorable inhibitory effect on monoacylglycerol lipase (MAGL), and several studies ... ...

Abstract	Acute kidney injury (AKI) is a complication of a wide range of serious illnesses for which there is still no better therapeutic agent. We demonstrated that M-18C has a favorable inhibitory effect on monoacylglycerol lipase (MAGL), and several studies have demonstrated that nerve inflammation could be effectively alleviated by inhibiting MAGL, suggesting that M-18C has good anti-inflammatory activity. In this study, we investigated the effect of M-18C on LPS-induced acute kidney injury (AKI), both in vivo and in vitro, by using liquid chromatography-mass spectrometry (LC-MS), 16S rRNA gene sequencing, Western blot, and immunohistochemistry. The results showed that both in vivo and in vitro M-18C reduced the release of TNF-α and IL-1β by inhibiting the expression of NOD-like receptor thermal protein domain-associated protein 3 (NLRP3) and apoptosis-associated speck-like protein containing a CARD (ASC) protein; in addition, M-18C was able to intervene in LPS-induced AKI by ameliorating renal pathological injury, repairing the intestinal barrier, and regulating gut bacterial flora and serum metabolism. In conclusion, this study suggests that M-18C has the potential to be a new drug for the treatment of AKI.
MeSH term(s)	Humans ; NLR Family, Pyrin Domain-Containing 3 Protein/metabolism ; Monoacylglycerol Lipases ; Lipopolysaccharides/adverse effects ; Gastrointestinal Microbiome ; RNA, Ribosomal, 16S ; Acute Kidney Injury/chemically induced ; Acute Kidney Injury/drug therapy ; Acute Kidney Injury/metabolism ; Inflammasomes/metabolism
Chemical Substances	NLR Family, Pyrin Domain-Containing 3 Protein ; Monoacylglycerol Lipases (EC 3.1.1.23) ; Lipopolysaccharides ; RNA, Ribosomal, 16S ; Inflammasomes
Language	English
Publishing date	2023-10-24
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules28217245
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Zs.MO 81: Show issues

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Article: Evaluation of the

Iqbal, Muhammad Omer / Gu, Yuchao / Khan, Imran Ahmad / Wang, Ruihong / Chen, Jin

Frontiers in chemistry

2023 Volume 11, Page(s) 1283618

Abstract: Introduction: ...

Abstract	Introduction:
Language	English
Publishing date	2023-12-18
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2711776-5
ISSN	2296-2646
ISSN	2296-2646
DOI	10.3389/fchem.2023.1283618
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Article ; Online: MobileSal: Extremely Efficient RGB-D Salient Object Detection.

Wu, Yu-Huan / Liu, Yun / Xu, Jun / Bian, Jia-Wang / Gu, Yu-Chao / Cheng, Ming-Ming

IEEE transactions on pattern analysis and machine intelligence

2022 Volume 44, Issue 12, Page(s) 10261–10269

Abstract: The high computational cost of neural networks has prevented recent successes in RGB-D salient object detection (SOD) from benefiting real-world applications. Hence, this article introduces a novel network, MobileSal, which focuses on efficient RGB-D SOD ...

Abstract	The high computational cost of neural networks has prevented recent successes in RGB-D salient object detection (SOD) from benefiting real-world applications. Hence, this article introduces a novel network, MobileSal, which focuses on efficient RGB-D SOD using mobile networks for deep feature extraction. However, mobile networks are less powerful in feature representation than cumbersome networks. To this end, we observe that the depth information of color images can strengthen the feature representation related to SOD if leveraged properly. Therefore, we propose an implicit depth restoration (IDR) technique to strengthen the mobile networks' feature representation capability for RGB-D SOD. IDR is only adopted in the training phase and is omitted during testing, so it is computationally free. Besides, we propose compact pyramid refinement (CPR) for efficient multi-level feature aggregation to derive salient objects with clear boundaries. With IDR and CPR incorporated, MobileSal performs favorably against state-of-the-art methods on six challenging RGB-D SOD datasets with much faster speed (450fps for the input size of 320×320) and fewer parameters (6.5M). The code is released at https://mmcheng.net/mobilesal.
MeSH term(s)	Image Processing, Computer-Assisted/methods ; Algorithms ; Neural Networks, Computer
Language	English
Publishing date	2022-11-07
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1939-3539
ISSN (online)	1939-3539
DOI	10.1109/TPAMI.2021.3134684
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Article ; Online: Identification and characterization of shark VNARs targeting the

Gao, Yanchun / Wang, Ruihong / Liu, Lin / Feng, Shitao / Xi, Xiaozhi / Yu, Wengong / Gu, Yuchao / Wang, Ye

Artificial cells, nanomedicine, and biotechnology

2023 Volume 51, Issue 1, Page(s) 509–519

Abstract: Helicobacter ... ...

Abstract	Helicobacter pylori
MeSH term(s)	Animals ; Helicobacter pylori ; Antibodies ; Enzyme-Linked Immunosorbent Assay ; Epitopes ; Sharks
Chemical Substances	Antibodies ; Epitopes
Language	English
Publishing date	2023-09-11
Publishing country	England
Document type	Journal Article
ZDB-ID	2723095-8
ISSN	2169-141X ; 2169-1401
ISSN (online)	2169-141X
ISSN	2169-1401
DOI	10.1080/21691401.2023.2255635
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Zs.A 1164: Show issues

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Article ; Online: A SIRT6 Inhibitor, Marine-Derived Pyrrole-Pyridinimidazole Derivative 8a, Suppresses Angiogenesis.

Song, Nannan / Tang, Yanfei / Wang, Yangui / Guan, Xian / Yu, Wengong / Jiang, Tao / Lu, Ling / Gu, Yuchao

Marine drugs

2023 Volume 21, Issue 10

Abstract: Angiogenesis refers to the process of growing new blood vessels from pre-existing capillaries or post-capillary veins. This process plays a critical role in promoting tumorigenesis and metastasis. As a result, developing antiangiogenic agents has become ... ...

Abstract	Angiogenesis refers to the process of growing new blood vessels from pre-existing capillaries or post-capillary veins. This process plays a critical role in promoting tumorigenesis and metastasis. As a result, developing antiangiogenic agents has become an attractive strategy for tumor treatment. Sirtuin6 (SIRT6), a member of nicotinamide adenine (NAD
MeSH term(s)	Humans ; Mice ; Animals ; Signal Transduction ; Neovascularization, Pathologic/metabolism ; Zebrafish/metabolism ; Neoplasms/drug therapy ; Angiogenesis Inhibitors/pharmacology ; Angiogenesis Inhibitors/therapeutic use ; Sirtuins/metabolism ; Human Umbilical Vein Endothelial Cells
Chemical Substances	Angiogenesis Inhibitors ; Sirtuins (EC 3.5.1.-) ; SIRT6 protein, human (EC 3.5.1.-)
Language	English
Publishing date	2023-09-28
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2175190-0
ISSN	1660-3397 ; 1660-3397
ISSN (online)	1660-3397
ISSN	1660-3397
DOI	10.3390/md21100517
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Article ; Online: Identification of pivotal genes with prognostic evaluation value in lung adenocarcinoma by bioinformatics analysis.

Wang, Yushan / Wang, Ruihong / Ma, Ji / Wang, Tingting / Ma, Cuiping / Gu, Yuchao / Xu, Yanxia / Wang, Ye

Cellular and molecular biology (Noisy-le-Grand, France)

2023 Volume 69, Issue 8, Page(s) 221–225

Abstract: Lung cancer remains the leading cause of cancer morbidity and mortality worldwide, and over-diagnosis causes various unnecessary losses in patients' lives and health. How to more effectively screen lung cancer patients and their potential prognostic risk ...

Abstract	Lung cancer remains the leading cause of cancer morbidity and mortality worldwide, and over-diagnosis causes various unnecessary losses in patients' lives and health. How to more effectively screen lung cancer patients and their potential prognostic risk become the focus of our current study. By analyzing the LUAD expression profile in The Cancer Genome Atlas (TCGA), we constructed a weighted gene co-expression network using differentially expressed genes (DEGs) to find the key modules and pivotal genes. A COX proportional risk regression model based on the least absolute shrinkage and selection operator (LASSO) was used to assess the predictive value of the model for the prognosis of LUAD patients. A total of 4107 up-regulated DEGs and 2022 down-regulated DEGs were identified in this study, and enrichment analysis showed that these analyzes were associated with the extracellular matrix of cells and adhesion. Ten gene markers consisting of LDHA, TOP2A, UBE2C, TYMS, TRIP13, EXO1, TTK, TPX2, ZWINT, and UHRF1 were established by extracting the central genes in the key modules, and the upregulation of these genes was accompanied by an increased prognostic risk of patients. Among them, high expression of LDHA, TRIP13, and TTK in LUAD was associated with shorter overall survival and could be used as independent prognostic factors to participate in metabolic processes such as tumor NAD. The present study provides a powerful molecular target for the study of LUAD prognosis and provides a theoretical basis for the diagnosis and treatment of LUAD and the development of targeted inhibitors.
MeSH term(s)	Humans ; Prognosis ; Adenocarcinoma of Lung/genetics ; Lung Neoplasms/diagnosis ; Lung Neoplasms/genetics ; Computational Biology ; Extracellular Matrix ; CCAAT-Enhancer-Binding Proteins ; Ubiquitin-Protein Ligases ; ATPases Associated with Diverse Cellular Activities ; Cell Cycle Proteins
Chemical Substances	UHRF1 protein, human (EC 2.3.2.27) ; CCAAT-Enhancer-Binding Proteins ; Ubiquitin-Protein Ligases (EC 2.3.2.27) ; TRIP13 protein, human (EC 3.6.4.-) ; ATPases Associated with Diverse Cellular Activities (EC 3.6.4.-) ; Cell Cycle Proteins
Language	English
Publishing date	2023-08-31
Publishing country	France
Document type	Journal Article
ZDB-ID	1161779-2
ISSN	1165-158X ; 0145-5680
ISSN (online)	1165-158X
ISSN	0145-5680
DOI	10.14715/cmb/2023.69.8.34
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Zs.A 3812: Show issues

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