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  1. Article ; Online: The effect of thiazolidinediones on adiponectin serum level: a meta-analysis.

    Riera-Guardia, N / Rothenbacher, D

    Diabetes, obesity & metabolism

    2008  Volume 10, Issue 5, Page(s) 367–375

    Abstract: Background and aims: Adiponectin is a hormone mainly produced by white adipose tissue. Decreased levels of adiponectin are linked with visceral obesity, insulin resistance states, and cardiovascular diseases. Recently, several studies have pointed out ... ...

    Abstract Background and aims: Adiponectin is a hormone mainly produced by white adipose tissue. Decreased levels of adiponectin are linked with visceral obesity, insulin resistance states, and cardiovascular diseases. Recently, several studies have pointed out an increase in adiponectin serum levels in subjects undergoing treatment with thiazolidinediones (TZD). The aim of this study is to systematically review the current state of evidence of the effect of TZD on adiponectin serum level with special attention to avoid publication bias.
    Materials and methods: An extensive literature search was performed. Meta Analysis Version 2.0 computer program was used to calculate statistical differences in means and 95% confidence interval (CI). Publication bias was assessed using different statistical approaches.
    Results: In the meta-analysis including 19 studies the overall standardized mean difference was 0.94 (95% CI, 0.81-1.06) which means that subjects treated with TZDs on average had means of adiponectin concentration that were about 1 standard deviation higher than the comparison groups even after controlling for possible biases.
    Conclusions: The results obtained agree with a moderate increase of serum adiponectin. The results clearly reveal an increase of endogenous serum adiponectin levels by intake of TZDs and may point to a potential new option to manage obesity-related diseases.
    MeSH term(s) Adiponectin/blood ; Adult ; Aged ; Diabetes Mellitus, Type 2/blood ; Diabetes Mellitus, Type 2/drug therapy ; Female ; Humans ; Hypoglycemic Agents/pharmacology ; Male ; Middle Aged ; Publication Bias ; Thiazolidinediones/pharmacology
    Chemical Substances Adiponectin ; Hypoglycemic Agents ; Thiazolidinediones
    Language English
    Publishing date 2008-05
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1454944-x
    ISSN 1463-1326 ; 1462-8902
    ISSN (online) 1463-1326
    ISSN 1462-8902
    DOI 10.1111/j.1463-1326.2007.00755.x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: The effect of thiazolidinediones on adiponectin serum level: a meta-analysis

    Riera-Guardia, N / Rothenbacher, D

    Diabetes, obesity & metabolism. 2008 May, v. 10, no. 5

    2008  

    Abstract: Adiponectin is a hormone mainly produced by white adipose tissue. Decreased levels of adiponectin are linked with visceral obesity, insulin resistance states, and cardiovascular diseases. Recently, several studies have pointed out an increase in ... ...

    Abstract Adiponectin is a hormone mainly produced by white adipose tissue. Decreased levels of adiponectin are linked with visceral obesity, insulin resistance states, and cardiovascular diseases. Recently, several studies have pointed out an increase in adiponectin serum levels in subjects undergoing treatment with thiazolidinediones (TZD). The aim of this study is to systematically review the current state of evidence of the effect of TZD on adiponectin serum level with special attention to avoid publication bias. An extensive literature search was performed. M eta A nalysis Version 2.0 computer program was used to calculate statistical differences in means and 95% confidence interval (CI). Publication bias was assessed using different statistical approaches. In the meta-analysis including 19 studies the overall standardized mean difference was 0.94 (95% CI, 0.81-1.06) which means that subjects treated with TZDs on average had means of adiponectin concentration that were about 1 standard deviation higher than the comparison groups even after controlling for possible biases. The results obtained agree with a moderate increase of serum adiponectin. The results clearly reveal an increase of endogenous serum adiponectin levels by intake of TZDs and may point to a potential new option to manage obesity-related diseases.
    Keywords diabetes mellitus ; meta-analysis ; adiponectin
    Language English
    Dates of publication 2008-05
    Size p. 367-375.
    Publisher Blackwell Publishing Ltd
    Publishing place Oxford, UK
    Document type Article
    ZDB-ID 1454944-x
    ISSN 1463-1326 ; 1462-8902
    ISSN (online) 1463-1326
    ISSN 1462-8902
    DOI 10.1111/j.1463-1326.2007.00755.x
    Database NAL-Catalogue (AGRICOLA)

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  3. Article ; Online: Cardiovascular risk associated with the use of glitazones, metformin and sufonylureas: meta-analysis of published observational studies.

    Pladevall, Manel / Riera-Guardia, Nuria / Margulis, Andrea V / Varas-Lorenzo, Cristina / Calingaert, Brian / Perez-Gutthann, Susana

    BMC cardiovascular disorders

    2016  Volume 16, Page(s) 14

    Abstract: Background: The results of observational studies evaluating and comparing the cardiovascular safety of glitazones, metformin and sufonylureas are inconsistent.To conduct and evaluate heterogeneity in a meta-analysis of observational studies on the risk ... ...

    Abstract Background: The results of observational studies evaluating and comparing the cardiovascular safety of glitazones, metformin and sufonylureas are inconsistent.To conduct and evaluate heterogeneity in a meta-analysis of observational studies on the risk of acute myocardial infarction (AMI) or stroke in patients with type 2 diabetes using non-insulin blood glucose-lowering drugs (NIBGLD).
    Methods: We systematically identified and reviewed studies evaluating NIBGLD in patients with type 2 diabetes indexed in Medline, Embase, or the Cochrane Library that met prespecified criteria. The quality of included studies was assessed with the RTI item bank. Results were combined using fixed- and random-effects models, and the Higgins I(2) statistic was used to evaluate heterogeneity. Sensitivity analyses by study quality were conducted.
    Results: The summary relative risk (sRR) (95% CI) of AMI for rosiglitazone versus pioglitazone was 1.13 (1.04-1.24) [I(2) = 55%]. In the sensitivity analysis, heterogeneity was reduced [I(2) = 16%]. The sRR (95% CI) of stroke for rosiglitazone versus pioglitazone was 1.18 (1.02-1.36) [I(2)  = 42%]. There was strong evidence of heterogeneity related to study quality in the comparisons of rosiglitazone versus metformin and rosiglitazone versus sulfonylureas (I (2) ≥ 70%). The sRR (95% CI) of AMI for sulfonylurea versus metformin was 1.24 (1.14-1.34) [I(2) = 41%] and for pioglitazone versus metformin was 1.02 (0.75-1.38) [I(2) = 17%]. Sensitivity analyses decreased heterogeneity in most comparisons.
    Conclusion/interpretation: Sulfonylureas increased the risk of AMI by 24% compared with metformin; an imprecise point estimate indicated no difference in risk of AMI when comparing pioglitazone with metformin. The presence of heterogeneity precluded any conclusions on the other comparisons. The quality assessment was valuable in identifying methodological problems in the individual studies and for analysing potential sources of heterogeneity.
    MeSH term(s) Cardiovascular Diseases/epidemiology ; Diabetes Mellitus, Type 2/drug therapy ; Humans ; Hypoglycemic Agents/therapeutic use ; Metformin/therapeutic use ; Myocardial Infarction/epidemiology ; Observational Studies as Topic ; Risk Factors ; Stroke/epidemiology ; Sulfonylurea Compounds/therapeutic use ; Thiazolidinediones/therapeutic use
    Chemical Substances Hypoglycemic Agents ; Sulfonylurea Compounds ; Thiazolidinediones ; rosiglitazone (05V02F2KDG) ; Metformin (9100L32L2N) ; pioglitazone (X4OV71U42S)
    Language English
    Publishing date 2016-01-15
    Publishing country England
    Document type Journal Article ; Meta-Analysis
    ZDB-ID 2059859-2
    ISSN 1471-2261 ; 1471-2261
    ISSN (online) 1471-2261
    ISSN 1471-2261
    DOI 10.1186/s12872-016-0187-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Quality assessment of observational studies in a drug-safety systematic review, comparison of two tools

    Margulis AV / Pladevall M / Riera-Guardia N / Varas-Lorenzo C / Hazell L / Berkman ND / Viswanathan M / Perez-Gutthann S

    Clinical Epidemiology, Vol 2014, Iss default, Pp 359-

    the Newcastle–Ottawa Scale and the RTI item bank

    2014  Volume 368

    Abstract: Andrea V Margulis,1 Manel Pladevall,1 Nuria Riera-Guardia,1 Cristina Varas-Lorenzo,1 Lorna Hazell,2,3 Nancy D Berkman,4 Meera Viswanathan,4 Susana Perez-Gutthann,1 1RTI Health Solutions, Barcelona, Spain; 2Drug Safety Research Unit, Southampton, UK; ... ...

    Abstract Andrea V Margulis,1 Manel Pladevall,1 Nuria Riera-Guardia,1 Cristina Varas-Lorenzo,1 Lorna Hazell,2,3 Nancy D Berkman,4 Meera Viswanathan,4 Susana Perez-Gutthann,1 1RTI Health Solutions, Barcelona, Spain; 2Drug Safety Research Unit, Southampton, UK; 3Associate Department of the School of Pharmacy and Biomedical Sciences, University of Portsmouth, Portsmouth, UK; 4RTI International, Research Triangle Park, NC, USA Background: The study objective was to compare the Newcastle–Ottawa Scale (NOS) and the RTI item bank (RTI-IB) and estimate interrater agreement using the RTI-IB within a systematic review on the cardiovascular safety of glucose-lowering drugs. Methods: We tailored both tools and added four questions to the RTI-IB. Two reviewers assessed the quality of the 44 included studies with both tools, (independently for the RTI-IB) and agreed on which responses conveyed low, unclear, or high risk of bias. For each question in the RTI-IB (n=31), the observed interrater agreement was calculated as the percentage of studies given the same bias assessment by both reviewers; chance-adjusted interrater agreement was estimated with the first-order agreement coefficient (AC1) statistic. Results: The NOS required less tailoring and was easier to use than the RTI-IB, but the RTI-IB produced a more thorough assessment. The RTI-IB includes most of the domains measured in the NOS. Median observed interrater agreement for the RTI-IB was 75% (25th percentile [p25] =61%; p75 =89%); median AC1 statistic was 0.64 (p25 =0.51; p75 =0.86). Conclusion: The RTI-IB facilitates a more complete quality assessment than the NOS but is more burdensome. The observed agreement and AC1 statistic in this study were higher than those reported by the RTI-IB's developers. Keywords: systematic review, meta-analysis, quality assessment, AC1
    Keywords Infectious and parasitic diseases ; RC109-216 ; Internal medicine ; RC31-1245 ; Medicine ; R
    Language English
    Publishing date 2014-10-01T00:00:00Z
    Publisher Dove Medical Press
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Conference proceedings: The effect of thiazolidinediones on adiponectin serums level: a meta-analysis

    Riera Guardia, Nuria / Rothenbacher, Dietrich

    2007  , Page(s) 07gmds325

    Event/congress Kongress Medizin und Gesellschaft 2007; Augsburg; ; Medizinischer Dienst der Krankenversicherung in Bayern; 2007
    Keywords Medizin, Gesundheit
    Publishing date 2007-09-06
    Publisher German Medical Science GMS Publishing House; Düsseldorf
    Document type Conference proceedings
    Database German Medical Science

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  6. Article: Analgesia y asepsia en el examen oftalmológico del recién nacido prematuro.

    López Escobar, A / Martín Del Valle, F / González Carrasco, E / Martínez Guardia, N

    Anales de pediatria (Barcelona, Spain : 2003)

    2005  Volume 62, Issue 5, Page(s) 484–485

    Title translation Analgesia and asepsis in ophthalmological examination of premature neonates.
    MeSH term(s) Analgesia/adverse effects ; Asepsis/methods ; Humans ; Infant, Newborn ; Infant, Premature ; Ophthalmology/methods
    Language Spanish
    Publishing date 2005-03-15
    Publishing country Spain
    Document type Case Reports ; Comment ; Letter
    ZDB-ID 2102669-5
    ISSN 1695-4033
    ISSN 1695-4033
    DOI 10.1157/13074629
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Síndrome de Miller-Dieker.

    Iglesias Escalera, G / Carrasco Marina, M L / Martín Del Valle, F / Martínez Guardia, N / Rodríguez, L / Martínez-Fernández, M L

    Anales de pediatria (Barcelona, Spain : 2003)

    2009  Volume 70, Issue 3, Page(s) 304–306

    Title translation Miller-Dieker syndrome.
    MeSH term(s) Classical Lissencephalies and Subcortical Band Heterotopias/diagnosis ; Classical Lissencephalies and Subcortical Band Heterotopias/genetics ; Humans ; Infant ; Male
    Language Spanish
    Publishing date 2009-03
    Publishing country Spain
    Document type Case Reports ; Letter
    ZDB-ID 2102669-5
    ISSN 1695-4033
    ISSN 1695-4033
    DOI 10.1016/j.anpedi.2008.11.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  8. Book: Labour migration patterns in Europe

    Diez Guardia, Nuria / Pichelmann, Karl

    recent trends. future challenges

    (European economy : Economic papers ; 256)

    2006  

    Institution Europäische Union
    Author's details Nuria Diez Guardia and Karl Pichelmann
    Series title European economy : Economic papers ; 256
    Keywords Arbeitsmobilität ; Migration ; Regionale Arbeitsmobilität ; Arbeitsmarkt ; EU-Mitgliedschaft ; EU-Staaten
    Language English
    Size 50 S., graph. Darst.
    Document type Book
    Note Literaturverz. S. 48 - 50
    ISBN 9279011979 ; 9789279011979
    Database ECONomics Information System

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  9. Book: Regulating e-commerce in financial services

    Diez Guardia, Nuria

    report of a joint CEPS/ECRI working party

    (Report of a CEPS working party ; [38])

    2001  

    Author's details Nuria Diez Guardia
    Series title Report of a CEPS working party ; [38]
    Keywords Finanzdienstleistung ; E-Business ; Verbraucherschutz ; EU-Staaten
    Language English
    Size II, 33 S
    Publisher CEPS
    Publishing place Brussels
    Document type Book
    ISBN 929079349X ; 9789290793496
    Database ECONomics Information System

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  10. Article: Quality assessment of observational studies in a drug-safety systematic review, comparison of two tools: the Newcastle-Ottawa Scale and the RTI item bank.

    Margulis, Andrea V / Pladevall, Manel / Riera-Guardia, Nuria / Varas-Lorenzo, Cristina / Hazell, Lorna / Berkman, Nancy D / Viswanathan, Meera / Perez-Gutthann, Susana

    Clinical epidemiology

    2014  Volume 6, Page(s) 359–368

    Abstract: Background: The study objective was to compare the Newcastle-Ottawa Scale (NOS) and the RTI item bank (RTI-IB) and estimate interrater agreement using the RTI-IB within a systematic review on the cardiovascular safety of glucose-lowering drugs.: ... ...

    Abstract Background: The study objective was to compare the Newcastle-Ottawa Scale (NOS) and the RTI item bank (RTI-IB) and estimate interrater agreement using the RTI-IB within a systematic review on the cardiovascular safety of glucose-lowering drugs.
    Methods: We tailored both tools and added four questions to the RTI-IB. Two reviewers assessed the quality of the 44 included studies with both tools, (independently for the RTI-IB) and agreed on which responses conveyed low, unclear, or high risk of bias. For each question in the RTI-IB (n=31), the observed interrater agreement was calculated as the percentage of studies given the same bias assessment by both reviewers; chance-adjusted interrater agreement was estimated with the first-order agreement coefficient (AC1) statistic.
    Results: The NOS required less tailoring and was easier to use than the RTI-IB, but the RTI-IB produced a more thorough assessment. The RTI-IB includes most of the domains measured in the NOS. Median observed interrater agreement for the RTI-IB was 75% (25th percentile [p25] =61%; p75 =89%); median AC1 statistic was 0.64 (p25 =0.51; p75 =0.86).
    Conclusion: The RTI-IB facilitates a more complete quality assessment than the NOS but is more burdensome. The observed agreement and AC1 statistic in this study were higher than those reported by the RTI-IB's developers.
    Language English
    Publishing date 2014-10-10
    Publishing country New Zealand
    Document type Journal Article
    ZDB-ID 2494772-6
    ISSN 1179-1349
    ISSN 1179-1349
    DOI 10.2147/CLEP.S66677
    Database MEDical Literature Analysis and Retrieval System OnLINE

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