Article ; Online: Mucosal cytokine profiles in paediatric eosinophilic oesophagitis: a case-control study.
2014 Volume 46, Issue 7, Page(s) 590–595
Abstract: Background: Eosinophilic oesophagitis is an inflammatory condition characterized by a dense eosinophilic infiltrate. The migration of eosinophils into the oesophagus is influenced by cytokines such as IL-5, IL-13 and eotaxin-3. The aim of this study was ...
Abstract | Background: Eosinophilic oesophagitis is an inflammatory condition characterized by a dense eosinophilic infiltrate. The migration of eosinophils into the oesophagus is influenced by cytokines such as IL-5, IL-13 and eotaxin-3. The aim of this study was to evaluate changes in the cytokine expression profiles (IL-5, IL-13 and eotaxin-3/CCL26) in children after topical steroid treatment. Methods: a prospective case-control study was performed in 23 paediatric patients (age 5-16 years) with a histological diagnosis of eosinophilic oesophagitis. Histological evaluation and cytokine levels assay (IL-5, IL-13 and eotaxin-3/CCL26) in the proximal and distal oesophagus were performed before, and after 8 weeks of topical budesonide. Data were compared with a matched healthy control group. Results: quantitative expression levels of IL-5, IL-13 and eotaxin-3 were significantly higher in the eosinophilic oesophagitis group both compared to healthy subjects (p<0.0001). A significant reduction of the eosinophil infiltrate as well as of IL-5, IL-13 and eotaxin-3 mucosal profiles was observed after steroid treatment both at the proximal and distal oesophagus (p<0.0001). Conclusions: IL-5, IL-13 and eotaxin-3/CCL26 are significantly over-expressed in the oesophageal epithelium of children with eosinophilic oesophagitis. Topical steroid treatment (inhaled and swallowed budesonide) can induce clinical response with partial mucosal remission. |
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MeSH term(s) | Administration, Topical ; Adolescent ; Anti-Inflammatory Agents/administration & dosage ; Budesonide/administration & dosage ; Case-Control Studies ; Chemokine CCL26 ; Chemokines, CC/metabolism ; Child ; Cytokines/metabolism ; Eosinophilic Esophagitis/drug therapy ; Eosinophilic Esophagitis/metabolism ; Eosinophilic Esophagitis/pathology ; Esophagus/metabolism ; Female ; Humans ; Interleukin-13/metabolism ; Interleukin-5/metabolism ; Male ; Mucous Membrane/metabolism ; Prospective Studies |
Chemical Substances | Anti-Inflammatory Agents ; CCL26 protein, human ; Chemokine CCL26 ; Chemokines, CC ; Cytokines ; Interleukin-13 ; Interleukin-5 ; Budesonide (51333-22-3) |
Language | English |
Publishing date | 2014-07 |
Publishing country | Netherlands |
Document type | Journal Article |
ZDB-ID | 1459373-7 |
ISSN | 1878-3562 ; 1125-8055 |
ISSN (online) | 1878-3562 |
ISSN | 1125-8055 |
DOI | 10.1016/j.dld.2014.03.003 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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