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Article: Protective effects of mung bean (Vigna radiata L.) and pea (Pisum sativum L.) against high-fat-induced oxidative stress

Guan, Xiao

Food Science & Nutrition, 7(12):4063-4075

2019

Abstract: Hyperlipidemia is closely related to oxidative stress, and it has been proved that the intake of legumes can protect the body from chronic diseases related to oxidative stress. In this study, we investigated the protective effects of mung beans and peas ... ...

Abstract	Hyperlipidemia is closely related to oxidative stress, and it has been proved that the intake of legumes can protect the body from chronic diseases related to oxidative stress. In this study, we investigated the protective effects of mung beans and peas against high-fat-diet-induced rats. It was found that, with 50% addition of mung beans or peas, the intake of mung beans and peas could significantly restore the levels of serum total cholesterol, low-density lipoprotein cholesterol, and high-density lipoprotein cholesterol. Liver staining also showed that high-fat diet (HFD) led to liver lesions, whereas whole-grain intake could significantly relieve these symptoms. Compared with the HFD group, the antioxidant defense system and antioxidant gene expression in administered legume groups improved markedly. Furthermore, the antioxidant activities of the two legume extracts were determined. Characterization showed that the ethanol extracts of mung beans and peas possessed high antioxidant activities, for their ability to scavenge ABTS and DPPH, reduce Fe3+ and their antilipid peroxidation capacity. Treatments with ethanol extracts at different doses could restore the levels of intracellular lipid, malondialdehyde, and antioxidant enzyme activities in oleic acid-induced HepG2 cells. All these results suggested that mung beans and peas or their extracts may be utilized as good candidates of natural antioxidant agents.
Keywords	antioxidant capacity ; ethanol extracts ; mung beans ; peas
Language	English
Document type	Article
Database	Repository for Life Sciences

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Article: Effects of Ultrasonic-Microwave-Assisted Technology on Hordein Extraction from Barley and Optimization of Process Parameters Using Response Surface Methodology

Guan, Xiao

Journal of food quality, 2018:9280241

2018

Abstract: We investigated the process intensification of ultrasonic-microwave-assisted technology for hordein extraction from barley. Response surface methodology was utilized to optimize the extraction conditions and to analyze the interaction between four ... ...

Abstract	We investigated the process intensification of ultrasonic-microwave-assisted technology for hordein extraction from barley. Response surface methodology was utilized to optimize the extraction conditions and to analyze the interaction between four selected variables: temperature, microwave power, ultrasonic power, and extraction time. The validated extraction yield of hordein reached 8.84% at 78°C, microwave power 298 W, and ultrasonic power 690 W after 20 min as optimum conditions. Compared with traditional water-bath extraction (4.7%), the ultrasonic-microwave-assisted technology effectively increased the hordein extraction yield and shortened the extraction time. According to the obtained quadratic model (R2 = 0.9457), ultrasonic power and extraction time were the first two significant factors. However, temperature limited the effects of other factors during extraction. SDS-PAGE and scanning electron microscopy were used to identify the hordein extract and to clarify the difference between the two hordein fractions extracted with new and traditional methods, respectively. Ultrasonic-microwave-assisted technology provided a new way to improve hordein extraction yield from barley and could be a good candidate for industrial application of process intensification.
Language	English
Document type	Article
Database	Repository for Life Sciences

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Article: Roles and application of exosomes in the development, diagnosis and treatment of gastric cancer.

Guan, Xiao-Li / Guan, Xiao-Ying / Zhang, Zheng-Yi

World journal of gastrointestinal oncology

2024 Volume 16, Issue 3, Page(s) 630–642

Abstract: As important messengers of intercellular communication, exosomes can regulate local and distant cellular communication by transporting specific exosomal contents and can also promote or suppress the development and progression of gastric cancer (GC) by ... ...

Abstract	As important messengers of intercellular communication, exosomes can regulate local and distant cellular communication by transporting specific exosomal contents and can also promote or suppress the development and progression of gastric cancer (GC) by regulating the growth and proliferation of tumor cells, the tumor-related immune response and tumor angiogenesis. Exosomes transport bioactive molecules including DNA, proteins, and RNA (coding and noncoding) from donor cells to recipient cells, causing reprogramming of the target cells. In this review, we will describe how exosomes regulate the cellular immune response, tumor angiogenesis, proliferation and metastasis of GC cells, and the role and mechanism of exosome-based therapy in human cancer. We will also discuss the potential application value of exosomes as biomarkers in the diagnosis and treatment of GC and their relationship with drug resistance.
Language	English
Publishing date	2024-04-03
Publishing country	China
Document type	Journal Article ; Review
ZDB-ID	2573696-6
ISSN	1948-5204
ISSN	1948-5204
DOI	10.4251/wjgo.v16.i3.630
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Mechanisms and applications of ferroptosis-associated regulators in cancer therapy and drug resistance.

Guan, Xiao-Ying / Guan, Xiao-Li / Zhu, Jia-Rui

Journal of chemotherapy (Florence, Italy)

2023 Volume 35, Issue 8, Page(s) 671–688

Abstract: Iron is an essential element for almost all living things. Both iron excess and iron deficiency can damage the body's health, but the body has developed complex mechanisms to regulate iron balance. The imbalance of iron homeostasis and lipid peroxidation ...

Abstract	Iron is an essential element for almost all living things. Both iron excess and iron deficiency can damage the body's health, but the body has developed complex mechanisms to regulate iron balance. The imbalance of iron homeostasis and lipid peroxidation are important features of ferroptosis. In this review, we summarize the latest regulatory mechanisms of ferroptosis, the roles of relevant regulators that target ferroptosis for cancer therapy, and their relationship to drug resistance. In conclusion, targeting ferroptosis is an important strategy for cancer therapy.
MeSH term(s)	Humans ; Ferroptosis ; Neoplasms/drug therapy ; Iron ; Drug Resistance ; Lipid Peroxidation
Chemical Substances	Iron (E1UOL152H7)
Language	English
Publishing date	2023-02-10
Publishing country	England
Document type	Review ; Journal Article
ZDB-ID	1036294-0
ISSN	1973-9478 ; 1120-009X
ISSN (online)	1973-9478
ISSN	1120-009X
DOI	10.1080/1120009X.2023.2177808
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Article ; Online: Improving therapeutic resistance: beginning with targeting the tumor microenvironment.

Guan, Xiao-Ying / Guan, Xiao-Li / Jiao, Zuo-Yi

Journal of chemotherapy (Florence, Italy)

2021 Volume 34, Issue 8, Page(s) 492–516

Abstract: Cancer is a serious threat to human health and life. The tumor microenvironment (TME) not only plays a key role in the occurrence, development and metastasis of cancer, but also has a profound impact on treatment resistance. To improve and solve this ... ...

Abstract	Cancer is a serious threat to human health and life. The tumor microenvironment (TME) not only plays a key role in the occurrence, development and metastasis of cancer, but also has a profound impact on treatment resistance. To improve and solve this problem, an increasing number of strategies targeting the TME have been proposed, and great progress has been made in recent years. This article reviews the characteristics and functions of the main matrix components of the TME and the mechanisms by which each component affects drug resistance. Furthermore, this article elaborates on targeting the TME as a strategy to treat acquired drug resistance, reduce tumor metastasis, recurrence, and improve efficacy.
MeSH term(s)	Humans ; Tumor Microenvironment ; Drug Resistance, Neoplasm ; Neoplasms/drug therapy ; Neoplasms/pathology
Language	English
Publishing date	2021-12-07
Publishing country	England
Document type	Review ; Journal Article
ZDB-ID	1036294-0
ISSN	1973-9478 ; 1120-009X
ISSN (online)	1973-9478
ISSN	1120-009X
DOI	10.1080/1120009X.2021.2011661
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Article ; Online: The role of

Baker, Christa A / Guan, Xiao-Juan / Choi, Minseung / Murthy, Mala

Science advances

2024 Volume 10, Issue 11, Page(s) eadk1273

Abstract: Sex-specific behaviors are critical for reproduction and species survival. The sex-specifically spliced transcription ... ...

Abstract	Sex-specific behaviors are critical for reproduction and species survival. The sex-specifically spliced transcription factor
MeSH term(s)	Animals ; Female ; Male ; Drosophila/genetics ; Drosophila/metabolism ; Drosophila melanogaster/genetics ; Drosophila melanogaster/metabolism ; Drosophila Proteins/genetics ; Drosophila Proteins/metabolism ; Courtship ; Sexual Behavior, Animal ; Nerve Tissue Proteins/metabolism ; Transcription Factors/metabolism
Chemical Substances	Drosophila Proteins ; fru protein, Drosophila ; Nerve Tissue Proteins ; Transcription Factors
Language	English
Publishing date	2024-03-13
Publishing country	United States
Document type	Journal Article
ZDB-ID	2810933-8
ISSN	2375-2548 ; 2375-2548
ISSN (online)	2375-2548
ISSN	2375-2548
DOI	10.1126/sciadv.adk1273
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Article ; Online: Effect of milling on in vitro Digestion-Induced release and bioaccessibility of active compounds in rice.

Fu, Tiantian / Cao, Hongwei / Zhang, Yu / Guan, Xiao

Food chemistry

2023 Volume 437, Issue Pt 2, Page(s) 137936

Abstract: To investigate the impact of milling on the active components in rice, this study examined the stability of phenols, vitamin B1 (VB1), and alpha-aminobutyric acid (α-GABA) during cooking and digestion of rice and their distribution in digestive juices ... ...

Abstract	To investigate the impact of milling on the active components in rice, this study examined the stability of phenols, vitamin B1 (VB1), and alpha-aminobutyric acid (α-GABA) during cooking and digestion of rice and their distribution in digestive juices and residue by adjusting the degree of milling (DOM). The findings revealed that milling exacerbated the instability of γ-GABA during cooking and VB1 during digestion. Their total losses peaked at 19.76% and 39.53% as DOM respectively reached 6.07% and 8.06%. In vitro digestion combined with release mathematical models demonstrated the impact of milling on their bioaccessibility. This effect increased the small intestinal bioaccessibility of phenols and γ-GABA, whilst reducing that of VB1. This was attributed to milling-induced pre-gastric full release of VB1, which amplifies its intestinal susceptibility and induces its re-entry into digestive residues. In conclusion, this study recommends keeping DOM below 6.07% to optimize the bioaccessibility of these active compounds.
MeSH term(s)	Oryza/chemistry ; Digestion ; Cooking ; Phenols/analysis ; gamma-Aminobutyric Acid
Chemical Substances	Phenols ; gamma-Aminobutyric Acid (56-12-2)
Language	English
Publishing date	2023-11-04
Publishing country	England
Document type	Journal Article
ZDB-ID	243123-3
ISSN	1873-7072 ; 0308-8146
ISSN (online)	1873-7072
ISSN	0308-8146
DOI	10.1016/j.foodchem.2023.137936
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Article ; Online: Dietary components regulate chronic diseases through gut microbiota: a review.

Zhang, Ying / Zhou, Ming / Zhou, Yaqin / Guan, Xiao

Journal of the science of food and agriculture

2023 Volume 103, Issue 14, Page(s) 6752–6766

Abstract: In recent years, gut microbiota as an immune organ has gradually become the mainstream of research. When the composition of the gut microbiota is changed significantly, this may affect human health. This review details the major microbiota composition ... ...

Abstract	In recent years, gut microbiota as an immune organ has gradually become the mainstream of research. When the composition of the gut microbiota is changed significantly, this may affect human health. This review details the major microbiota composition and metabolites in the gut and discusses chronic diseases based on gut dysbiosis, including obesity, liver injury, colon cancer, atherosclerosis, and central nervous system diseases. We comprehensively summarize the changes in abundance of relevant gut microbiota by ingesting different diet components (such as food additives, dietary polyphenols, polysaccharides, fats, proteins) and their influence on the microbial quorum sensing system, thereby regulating related diseases. We believe that quorum sensing can be used as a new entry point to explain the mechanism of ingesting dietary components to improve gut microbiota and thereby regulate related diseases. This review hopes to provide a theoretical basis for future research on improving disease symptoms by ingesting functional foods containing dietary components. © 2023 Society of Chemical Industry.
MeSH term(s)	Humans ; Gastrointestinal Microbiome/physiology ; Diet ; Obesity ; Microbiota ; Chronic Disease ; Dysbiosis
Language	English
Publishing date	2023-06-16
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	184116-6
ISSN	1097-0010 ; 0022-5142
ISSN (online)	1097-0010
ISSN	0022-5142
DOI	10.1002/jsfa.12732
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Article ; Online: Dietary components regulate chronic diseases through gut microbiota: a review

Zhang, Ying / Zhou, Ming / Zhou, Yaqin / Guan, Xiao

Journal of the Science of Food and Agriculture. 2023 Nov., v. 103, no. 14, p. 6752-6766

2023 , Page(s) 6752–6766

Abstract	In recent years, gut microbiota as an immune organ has gradually become the mainstream of research. When the composition of the gut microbiota is changed significantly, this may affect human health. This review details the major microbiota composition and metabolites in the gut and discusses chronic diseases based on gut dysbiosis, including obesity, liver injury, colon cancer, atherosclerosis, and central nervous system diseases. We comprehensively summarize the changes in abundance of relevant gut microbiota by ingesting different diet components (such as food additives, dietary polyphenols, polysaccharides, fats, proteins) and their influence on the microbial quorum sensing system, thereby regulating related diseases. We believe that quorum sensing can be used as a new entry point to explain the mechanism of ingesting dietary components to improve gut microbiota and thereby regulate related diseases. This review hopes to provide a theoretical basis for future research on improving disease symptoms by ingesting functional foods containing dietary components. © 2023 Society of Chemical Industry.
Keywords	agriculture ; atherosclerosis ; central nervous system ; colorectal neoplasms ; diet ; dysbiosis ; human health ; intestinal microorganisms ; liver ; metabolites ; obesity ; polyphenols ; polysaccharides
Language	English
Dates of publication	2023-11
Size	p. 6752-6766
Publishing place	John Wiley & Sons, Ltd.
Document type	Article ; Online
Note	REVIEW
ZDB-ID	184116-6
ISSN	1097-0010 ; 0022-5142
ISSN (online)	1097-0010
ISSN	0022-5142
DOI	10.1002/jsfa.12732
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Identification and target of action of cholecystokinin‐releasing peptides from simulated digestion hydrolysate of wheat protein

Song, Hongdong / Wang, Qingyu / Shao, Zhuwei / Wang, Xinyue / Cao, Hongwei / Huang, Kai / Guan, Xiao

Journal of the Science of Food and Agriculture 2024 Jan.15, v. 104, no. 1, p. 295-302

2024 , Page(s) 295–302

Abstract: BACKGROUND: Wheat protein intake leads to improved appetite control. However, the active components causing appetite in wheat have not been fully clarified. Gut cholecystokinin (CCK) plays a vital role in appetite control. This study aimed to investigate ...

Abstract	BACKGROUND: Wheat protein intake leads to improved appetite control. However, the active components causing appetite in wheat have not been fully clarified. Gut cholecystokinin (CCK) plays a vital role in appetite control. This study aimed to investigate the ability of wheat protein digest (WPD) to stimulate CCK secretion and clarify the active components and target of action. RESULTS: WPD was prepared by a simulated gastrointestinal digestion model. WPD treatment with a concentration of 5 mg mL⁻¹ significantly stimulated CCK secretion in enteroendocrine STC‐1 cells (P < 0.05). Furthermore, oral gavage with WPD in mice significantly increased plasma CCK level at 60 min (P < 0.01). Preparative C18 column separation was used to isolate peptide fractions associated with CCK secretion and peptide sequences were identified by liquid chromatography–tandem mass spectrometry. A new CCK‐releasing peptide, RYIVPL, that potently stimulated CCK secretion was successfully identified. After pretreatment with a specific calcium‐sensing receptor (CaSR) antagonist, NPS 2143, CCK secretion induced by WPD or RYIVPL was greatly suppressed, suggesting that CaSR was involved in WPD‐ or RYIVPL‐induced CCK secretion. CONCLUSION: The present study demonstrated that WPD has an ability to stimulate CCK secretion in vitro and in vivo, and determined that peptide RYIVPL in WPD could stimulate CCK secretion through CaSR. © 2023 Society of Chemical Industry.
Keywords	agriculture ; antagonists ; appetite ; calcium receptors ; cholecystokinin ; digestive system ; hydrolysates ; in vitro digestion ; liquid chromatography ; models ; protein intake ; secretion ; tandem mass spectrometry ; wheat ; wheat protein
Language	English
Dates of publication	2024-0115
Size	p. 295-302
Publishing place	John Wiley & Sons, Ltd.
Document type	Article ; Online
Note	JOURNAL ARTICLE ; Use and reproduction
ZDB-ID	184116-6
ISSN	1097-0010 ; 0022-5142
ISSN (online)	1097-0010
ISSN	0022-5142
DOI	10.1002/jsfa.12918
Database	NAL-Catalogue (AGRICOLA)

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