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  1. Article ; Online: Editorial.

    Yu, Guang-Yan

    The Chinese journal of dental research : the official journal of the Scientific Section of the Chinese Stomatological Association (CSA)

    2021  Volume 23, Issue 4, Page(s) 233

    Language English
    Publishing date 2021-01-24
    Publishing country England
    Document type Journal Article
    ZDB-ID 2129164-0
    ISSN 1867-5646 ; 1462-6446
    ISSN (online) 1867-5646
    ISSN 1462-6446
    DOI 10.3290/j.cjdr.b867881
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5843: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article: Risk factors for intracerebral hemorrhage in patients undergoing maintenance hemodialysis.

    Yu-Huan, Song / Guang-Yan, Cai / Yue-Fei, Xiao

    Frontiers in neurology

    2023  Volume 14, Page(s) 1111865

    Abstract: Background: In patients undergoing hemodialysis, intracerebral hemorrhage (ICH) is the main cause of mortality among stroke subtypes. It is unclear whether, along with traditional cardiovascular risk factors, the risk factors unique to the uraemic ... ...

    Abstract Background: In patients undergoing hemodialysis, intracerebral hemorrhage (ICH) is the main cause of mortality among stroke subtypes. It is unclear whether, along with traditional cardiovascular risk factors, the risk factors unique to the uraemic environment, such as the abnormal metabolism of intact parathyroid hormone (iPTH), can contribute to the risk of ICH in these patients.
    Methods: This retrospective case-control study included 25 patients undergoing hemodialysis with ICH at a single center between 30 June 2015 and 10 October 2022. The controls were 95 patients undergoing maintenance hemodialysis treated at the same dialysis center in July 2020. We compared the characteristics of patients with ICH with those of the control group to identify factors that contributed to the development of ICH.
    Results: Intracerebral hemorrhage (ICH) was located in the basal ganglia (14/25), cerebellum (6/25), and brainstem (6/25) in 25 patients. A total of 17 patients died in the first 16 days due to neurological complications. Univariate analysis showed significant differences in systolic BP, diastolic BP, iPTH, and alkaline phosphatase between the two groups (
    Conclusion: Higher systolic BP and abnormal iPTH metabolism might be associated with ICH in patients undergoing hemodialysis. Comprehensive control of hypertension and iPTH may be a fundamental preventive strategy for ICH in these patients.
    Language English
    Publishing date 2023-03-22
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2564214-5
    ISSN 1664-2295
    ISSN 1664-2295
    DOI 10.3389/fneur.2023.1111865
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Editorial.

    Yu, Guang-Yan

    The Chinese journal of dental research : the official journal of the Scientific Section of the Chinese Stomatological Association (CSA)

    2020  Volume 23, Issue 1, Page(s) 9

    Language English
    Publishing date 2020-03-30
    Publishing country England
    Document type Journal Article
    ZDB-ID 2129164-0
    ISSN 1867-5646 ; 1462-6446
    ISSN (online) 1867-5646
    ISSN 1462-6446
    DOI 10.3290/j.cjdr.a44348
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5843: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Lacrimo-auriculo-dento-digital syndrome with AIRE mutation: A case report.

    Zhu, Hui / Yu, Guang-Yan

    Journal of stomatology, oral and maxillofacial surgery

    2022  Volume 123, Issue 6, Page(s) e988–e990

    Abstract: Congenital absence or hypoplasia of the major salivary glands is rarely observed and easily overlooked in the clinic. Lacrimo-auriculo-dento-digital syndrome (LADD) is a congenital anomaly disorder that is characterized by aplasia, atresia, or hypoplasia ...

    Abstract Congenital absence or hypoplasia of the major salivary glands is rarely observed and easily overlooked in the clinic. Lacrimo-auriculo-dento-digital syndrome (LADD) is a congenital anomaly disorder that is characterized by aplasia, atresia, or hypoplasia of the lacrimal and salivary glands and caused by FGFR2, FGFR3, or FGF10 gene mutation. Autoimmune polyendocrine syndrome type 1 (APS-I) caused by an AIRE gene mutation is a rare inherited autoimmune disease characterized by chronic mucocutaneous candidiasis, Addison disease, and hypoparathyroidism. However, simultaneous mutations in pathogenic genes of the two syndromes (LADD and APS-I) in one patient is rarely observed. Herein, we have presented a patient with main complaints of xerostomia and xerophthalmia that was diagnosed with LADD syndrome with AIRE mutation.
    MeSH term(s) Humans ; Tooth Abnormalities/diagnosis ; Tooth Abnormalities/genetics ; Tooth Abnormalities/pathology ; Syndactyly/genetics ; Lacrimal Apparatus Diseases/genetics ; Mutation
    Language English
    Publishing date 2022-07-21
    Publishing country France
    Document type Case Reports ; Research Support, Non-U.S. Gov't
    ZDB-ID 2916276-2
    ISSN 2468-7855 ; 2468-8509
    ISSN (online) 2468-7855
    ISSN 2468-8509
    DOI 10.1016/j.jormas.2022.07.014
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Application and prospects of computer-assisted surgery in oral and maxillofacial oncology.

    Peng, Xin / Acero, Julio / Yu, Guang-Yan

    Science bulletin

    2023  Volume 68, Issue 3, Page(s) 236–239

    MeSH term(s) Surgery, Computer-Assisted ; Oral Surgical Procedures
    Language English
    Publishing date 2023-01-20
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2816140-3
    ISSN 2095-9281 ; 2095-9273
    ISSN (online) 2095-9281
    ISSN 2095-9273
    DOI 10.1016/j.scib.2023.01.030
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: A Cross-Sectional Study on the Psychological Changes of Medical Personnel in Hospitals Who Experienced Special COVID-19 Situations

    Hwa Yeon Sun / Xiao Guang Yan / Byung Wook Yoo

    Inquiry: The Journal of Health Care Organization, Provision, and Financing, Vol

    2023  Volume 60

    Abstract: The COVID-19 pandemic contributed to an increase in mental health issues; Psychological changes occur in health professionals who are more susceptible to infection. The purpose of this study was to investigate health professionals’ levels of anxiety, ... ...

    Abstract The COVID-19 pandemic contributed to an increase in mental health issues; Psychological changes occur in health professionals who are more susceptible to infection. The purpose of this study was to investigate health professionals’ levels of anxiety, rage, and depression in COVID-related special circumstances. A general hospital in Korea experienced a widespread COVID-19 outbreak. There was a total of 149 involved frontline and non-frontline health professionals surveyed. The State-Trait Anger Expression Inventory, General Anxiety Disorder-7, and Korean Screening Tool for Depressive Disorders were utilized in the evaluation of their rage, anxiety, and depression. Anxiety and depression were found to be significantly higher among health professionals by occupation than among non-health professionals. Frontline workers were more depressed than non-frontline workers, according to type of work. These psychological changes can cause PTSD, so it is necessary to check and care for the mental health of health care workers working in medical institutions in the event of mass infections. These issues have been confirmed through studies related to the occurrence of mass infections such as SARS and MERS that the occurrence of mass infections can cause PTSD. The findings proved that the COVID-19 pandemic had a psychological impact on healthcare workers. During the COVID-19 pandemic, it is critical to raise awareness of post-traumatic stress disorder among healthcare professionals.
    Keywords Public aspects of medicine ; RA1-1270
    Subject code 150 ; 360
    Language English
    Publishing date 2023-03-01T00:00:00Z
    Publisher SAGE Publishing
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article: Sepsis one-hour bundle management combined with psychological intervention on negative emotion and sleep quality in patients with sepsis.

    Xia, Ming / Dong, Guang-Yan / Zhu, Shi-Chao / Xing, Huan-Min / Li, Li-Ming

    World journal of psychiatry

    2024  Volume 14, Issue 2, Page(s) 266–275

    Abstract: Background: Sepsis is a serious infectious disease caused by various systemic inflammatory responses and is ultimately life-threatening. Patients usually experience depression and anxiety, which affect their sleep quality and post-traumatic growth ... ...

    Abstract Background: Sepsis is a serious infectious disease caused by various systemic inflammatory responses and is ultimately life-threatening. Patients usually experience depression and anxiety, which affect their sleep quality and post-traumatic growth levels.
    Aim: To investigate the effects of sepsis, a one-hour bundle (H1B) management was combined with psychological intervention in patients with sepsis.
    Methods: This retrospective analysis included 300 patients with sepsis who were admitted to Henan Provincial People's Hospital between June 2022 and June 2023. According to different intervention methods, the participants were divided into a simple group (SG,
    Results: After intervention (T1), the scores of the Hamilton Anxiety scale and Hamilton Depression scale in the CG were significantly lower than those in the SG (
    Conclusion: H1B management combined with psychological intervention can effectively alleviate the negative emotions of patients with sepsis and increase their quality of sleep and life.
    Language English
    Publishing date 2024-02-19
    Publishing country United States
    Document type Journal Article
    ISSN 2220-3206
    ISSN 2220-3206
    DOI 10.5498/wjp.v14.i2.266
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: The role and mechanism of tight junctions in the regulation of salivary gland secretion.

    Cong, Xin / Mao, Xiang-Di / Wu, Li-Ling / Yu, Guang-Yan

    Oral diseases

    2023  Volume 30, Issue 1, Page(s) 3–22

    Abstract: Tight junctions (TJs) are cell-cell interactions that localize at the most apical portion of epithelial/endothelial cells. One of the predominant functions of TJs is to regulate material transport through paracellular pathway, which serves as a selective ...

    Abstract Tight junctions (TJs) are cell-cell interactions that localize at the most apical portion of epithelial/endothelial cells. One of the predominant functions of TJs is to regulate material transport through paracellular pathway, which serves as a selective barrier. In recent years, the expression and function of TJs in salivary glands has attracted great interest. The characteristics of multiple salivary gland TJ proteins have been identified. During salivation, the activation of muscarinic acetylcholine receptor and transient receptor potential vanilloid subtype 1, as well as other stimuli, promote the opening of acinar TJs by inducing internalization of TJs, thereby contributing to increased paracellular permeability. Besides, endothelial TJs are also redistributed with leakage of blood vessels in cholinergic-stimulated submandibular glands. Furthermore, under pathological conditions, such as Sjögren's syndrome, diabetes mellitus, immunoglobulin G4-related sialadenitis, and autotransplantation, the integrity and barrier function of TJ complex are impaired and may contribute to hyposalivation. Moreover, in submandibular glands of Sjögren's syndrome mouse model and patients, the endothelial barrier is disrupted and involved in hyposecretion and lymphocytic infiltration. These findings enrich our understanding of the secretory mechanisms that link the importance of epithelial and endothelial TJ functions to salivation under both physiological and pathophysiological conditions.
    MeSH term(s) Mice ; Animals ; Humans ; Tight Junctions/metabolism ; Tight Junctions/pathology ; Sjogren's Syndrome/pathology ; Endothelial Cells ; Salivary Glands/pathology ; Saliva/metabolism ; Submandibular Gland/metabolism ; Sialorrhea
    Language English
    Publishing date 2023-03-21
    Publishing country Denmark
    Document type Journal Article ; Review
    ZDB-ID 1290529-x
    ISSN 1601-0825 ; 1354-523X
    ISSN (online) 1601-0825
    ISSN 1354-523X
    DOI 10.1111/odi.14549
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4427: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: On-Surface Cross-Coupling Reactions.

    Xing, Guang-Yan / Zhu, Ya-Cheng / Li, Deng-Yuan / Liu, Pei-Nian

    The journal of physical chemistry letters

    2023  Volume 14, Issue 19, Page(s) 4462–4470

    Abstract: On-surface synthesis, as a bottom-up synthetic method, has been proven to be a powerful tool for atomically precise fabrication of low-dimensional carbon nanomaterials over the past 15 years. This method relies on covalent coupling reactions that occur ... ...

    Abstract On-surface synthesis, as a bottom-up synthetic method, has been proven to be a powerful tool for atomically precise fabrication of low-dimensional carbon nanomaterials over the past 15 years. This method relies on covalent coupling reactions that occur on solid substrates such as metal or metal oxide surfaces under ultra-high-vacuum conditions, and the achievements with this method have greatly enriched fundamental science and technology. However, due to the complicated reactivity of organic groups, distinct diffusion of reactants and intermediates, and irreversibility of covalent bonds, achieving the high selectivity of covalent coupling reactions on surfaces remains a great challenge. As a result, only a few on-surface covalent coupling reactions, mainly involving dehalogenation and dehydrogenation homocoupling, are frequently used in the synthesis of low-dimensional carbon nanosystems. In this Perspective, we focus on the development and synthetic applications of on-surface cross-coupling reactions, mainly Ullmann, Sonogashira, Heck, and divergent cross-coupling reactions.
    Language English
    Publishing date 2023-05-08
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 1948-7185
    ISSN (online) 1948-7185
    DOI 10.1021/acs.jpclett.3c00344
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Emerging novel targets for nonalcoholic fatty liver disease treatment: Evidence from recent basic studies.

    Wang, Guang-Yan / Zhang, Xiao-Yan / Wang, Chun-Jiong / Guan, You-Fei

    World journal of gastroenterology

    2023  Volume 29, Issue 1, Page(s) 75–95

    Abstract: Nonalcoholic fatty liver disease (NAFLD), a leading chronic disease worldwide, affects approximately a quarter of the global population. Nonalcoholic steatohepatitis (NASH) is an advanced form of NAFLD and is more likely to progress to liver fibrosis ... ...

    Abstract Nonalcoholic fatty liver disease (NAFLD), a leading chronic disease worldwide, affects approximately a quarter of the global population. Nonalcoholic steatohepatitis (NASH) is an advanced form of NAFLD and is more likely to progress to liver fibrosis than simple steatosis. NASH is also identified as the most rapidly growing cause of hepatocellular carcinoma. Although in the past decade, several phase II/III clinical trials have shown promising results in the use of novel drugs targeting lipid synthase, farnesoid X receptor signaling, peroxisome proliferator-activated receptor signaling, hepatocellular injury, and inflammatory signaling, proven pharmaceutical agents to treat NASH are still lacking. Thus, continuous exploration of the mechanism underlying the pathogenesis of NAFLD and the identification of novel therapeutic targets remain urgent tasks in the field. In the current review, we summarize studies reported in recent years that not only provide new insights into the mechanisms of NAFLD development but also explore the possibility of treating NAFLD by targeting newly identified signaling pathways. We also discuss evidence focusing on the intrahepatic targets involved in the pathogenesis of NAFLD as well as extrahepatic targets affecting liver metabolism and function.
    MeSH term(s) Humans ; Non-alcoholic Fatty Liver Disease/metabolism ; Carcinoma, Hepatocellular/pathology ; Liver Cirrhosis/metabolism ; Signal Transduction ; Liver Neoplasms/pathology ; Liver/pathology
    Language English
    Publishing date 2023-01-04
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2185929-2
    ISSN 2219-2840 ; 1007-9327
    ISSN (online) 2219-2840
    ISSN 1007-9327
    DOI 10.3748/wjg.v29.i1.75
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6039: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
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