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Article ; Online: Anticancer Activity of Modified Tongyou Decoction on Eca109 Esophageal Cancer Cell Invasion and Metastasis through Regulation of the Epithelial-Mesenchymal Transition Mediated by the HIF-1α-Snail Axis

Yongsen Jia / Xin Yan / Ying Cao / Wei Song / Guangji Zhang / Xueqin Hu

Evidence-Based Complementary and Alternative Medicine, Vol

2020 Volume 2020

Abstract: Background. To explore the activity of Modified Tongyou Decoction (MTD) against Eca109 esophageal cancer (EC) cell invasion and metastasis and to ascertain the mechanism of its anticancer activity during the epithelial-mesenchymal transition (EMT) as ... ...

Abstract	Background. To explore the activity of Modified Tongyou Decoction (MTD) against Eca109 esophageal cancer (EC) cell invasion and metastasis and to ascertain the mechanism of its anticancer activity during the epithelial-mesenchymal transition (EMT) as mediated by the HIF-1α-Snail axis. Methods. Herbal compounds were prepared by ethanol extraction, and 6 herbs composing into MTD were dipped in water-free ethanol and filtered. The filtrate was collected and centrifuged. The remains were concentrated into a paste which was adjusted to 5000mg/mL concentration with DMSO. PBS was used to dilute the herbal solution to the half maximal inhibitory concentration. A hypoxic microenvironment was induced with CoCl2 in RPMI 1640 medium, in which Eca109 cells were cultured. The cytotoxicity of MTD was determined with CCK-8 assay. The activity of MTD against cell invasion and metastasis was explored with scratch assay and transwell assay. Western blot analysis was conducted to analyze the anticancer effects of MTD on the expression of HIF-1α-Snail axis- and EMT-related proteins. Quantitative RT-PCR was used to assess the mRNA expression of Snail. Immunofluorescence labeling was performed to examine how MTD affected the coexpression of Snail and HIF-1α. Results. The fifty percent inhibitory dose of MTD was 1410 μg/mL in the normoxic environment and 1823 μg/mL in the hypoxic environment based on the CCK-8 assay. The scratch assay showed that MTD significantly inhibited cell migration in both the normoxic and hypoxic microenvironments compared with the control groups (P < 0.05). The transwell assay showed that MTD significantly inhibited cell invasion in both the normoxic and hypoxic environments compared with the control groups (P < 0.05). Western blot showed that MTD significantly inhibited the expression of the HIF-1α, Snail, Vimentin, MMP-2, MMP-9, and VE-cadherin proteins and significantly induced the expression of E-cadherin in both the normoxic and hypoxic microenvironments compared with the control groups (P < ...
Keywords	Other systems of medicine ; RZ201-999
Subject code	630
Language	English
Publishing date	2020-01-01T00:00:00Z
Publisher	Hindawi Limited
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Creating Coordination Mismatch in MOFs: Tuning from Pore Structure of the Derived Supported Catalysts to Their Catalytic Performance

Tang, Feiying / Liqiang Wang / Guangji Zhang / Min Zhang / You-Nian Liu

Industrial & engineering chemistry process design and development. 2019 Mar. 18, v. 58, no. 14

2019

Abstract: Hollow porous carbon (HPC) composed of inner voids and outer shells, is receiving increasing attention in constructing supported catalysts for diverse applications. It is of great allure but still challenging to controllably tune the secondary porous ... ...

Abstract	Hollow porous carbon (HPC) composed of inner voids and outer shells, is receiving increasing attention in constructing supported catalysts for diverse applications. It is of great allure but still challenging to controllably tune the secondary porous structure (pore in the outer shells) of the HPC support to improve the performance of the catalysts. Herein, a Ni-substituted ZIF-67 was used as a precursor to prepare HPC-supported catalysts. We found that Ni²⁺ can partially substitute Co²⁺ to create “defected structure” within ZIF-67, and the secondary pore structure of the derived HPC can be facilely tuned by adjusting the ratio of Ni²⁺ to Co²⁺. Catalyst HPC-Ni-ZIF–1 with hierarchical secondary pore and the largest pore volume exhibits an excellent catalytic performance for the hydrogenation of nitro compounds to corresponding amino compounds.
Keywords	amino compounds ; carbon ; catalysts ; catalytic activity ; cobalt ; hydrogenation ; nickel ; nitro compounds ; process design
Language	English
Dates of publication	2019-0318
Size	p. 5543-5551.
Publishing place	American Chemical Society
Document type	Article
ZDB-ID	1484436-9
ISSN	1520-5045 ; 0888-5885
ISSN (online)	1520-5045
ISSN	0888-5885
DOI	10.1021/acs.iecr.9b01096
Database	NAL-Catalogue (AGRICOLA)

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Article: Complete mitochondrial genome sequence for the endangered Knysna seahorse Hippocampus capensis Boulenger 1900

Ge, Yuqing / Lingyan Zhu / Meng Chen / Guangji Zhang / Zhen Huang / Rubin Cheng

Conservation genetics resources. 2018 Sept., v. 10, no. 3

2018

Abstract: The Knysna seahorse Hippocampus capensis Boulenger, 1900 was the first seahorse species listed as endangered on the IUCN Red List due to its limited distribution range, small population size and vulnerability to natural and anthropogenic disturbances. In ...

Abstract	The Knysna seahorse Hippocampus capensis Boulenger, 1900 was the first seahorse species listed as endangered on the IUCN Red List due to its limited distribution range, small population size and vulnerability to natural and anthropogenic disturbances. In the present study, the complete mitogenome of H. capensis was determined. It is 16,529 bp in length and contains 13 protein-coding (PCG) genes, 22 tRNA genes, two rRNA genes, one origin of replication on the light-strand (OL) and a control region (CR). The overall base composition is 32.46, 29.48, 23.35 and 14.71% for A, T, C and G, respectively, with a slight AT bias of 61.93%. The 13 PCGs encode 3798 amino acids in total, most of which use the initiation codon ATG except COX1 starts with GTG. Seven genes applied TAA or TAG as the stop codon, except ND2, COX2, COX3, ND3, ND4 and Cytb use an incomplete stop codon T. The lengths of 12S rRNA and 16S rRNA are 937 and 1696 bp, respectively. Phylogenetic tree analysis based on the complete mitochondrial genome suggests H. capensis is closely related to the kuda complex species H. kuda and H. reidi. This work provides fundamental molecular data which will be useful for species identification, forensic genetics and further management and conservation of this endangered marine fish.
Keywords	Hippocampus kuda ; Hippocampus reidi ; amino acids ; anthropogenic activities ; forensic sciences ; hippocampus ; marine fish ; mitochondrial genome ; phylogeny ; population size ; replication origin ; ribosomal RNA ; species identification ; start codon ; stop codon ; transfer RNA
Language	English
Dates of publication	2018-09
Size	p. 461-465.
Publishing place	Springer Netherlands
Document type	Article
ZDB-ID	2508018-0
ISSN	1877-7260 ; 1877-7252
ISSN (online)	1877-7260
ISSN	1877-7252
DOI	10.1007/s12686-017-0849-3
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Article: The complete mitochondrial genome of the short snouted seahorse Hippocampus hippocampus Linnaeus 1758 (Syngnathiformes: Syngnathidae) and its phylogenetic implications

Chen, Meng / Lingyan Zhu / Jianzhen Chen / Guangji Zhang / Rubin Cheng / Yuqing Ge

Conservation genetics resources. 2018 Dec., v. 10, no. 4

2018

Abstract: The short-snouted seahorse Hippocampus hippocampus Linnaeus 1758 is a native European seahorse within the Family Syngnathidae. To facilitate its conservation genetic studies, the complete mitochondrial genome of H. hippocampus was determined and analyzed. ...

Abstract	The short-snouted seahorse Hippocampus hippocampus Linnaeus 1758 is a native European seahorse within the Family Syngnathidae. To facilitate its conservation genetic studies, the complete mitochondrial genome of H. hippocampus was determined and analyzed. The circular genome of the H. hippocampus is 16,529 bp in length, with a overall nucleotide composition of 32.03, 24.06, 15.05 and 28.86% for A, C, G and T, respectively, indicating an obvious AT rich feature (60.89%). Similar to other Hippocampus species, it contains 13 protein-coding genes (PCGs), 22 tRNA genes, two rRNA genes, one origin of replication on the light-strand and one control region. The 13 PCGs encode 3798 amino acids in total, most of which use the initiation codon ATG except COI gene starts with GTG. For the stop codon, six genes use an an incomplete stop codon T, while the other seven genes apply TAA or TAG as the stop codon. The lengths of 12S and 16S rRNA are 937 and 1695 bp, respectively. Phylogenetic tree analysis based on the complete mitochondrial genome showed that H. hippocampus is closely related to the lined seahorse H. erectus. This work provides basic genetic data of H. hippocampus which will be helpful for further researches on genetic diversity and species identification.
Keywords	Hippocampus erectus ; Hippocampus hippocampus ; amino acids ; genetic variation ; hippocampus ; mitochondrial genome ; phylogeny ; replication origin ; ribosomal RNA ; species identification ; start codon ; stop codon ; transfer RNA
Language	English
Dates of publication	2018-12
Size	p. 783-787.
Publishing place	Springer Netherlands
Document type	Article
ZDB-ID	2508018-0
ISSN	1877-7260 ; 1877-7252
ISSN (online)	1877-7260
ISSN	1877-7252
DOI	10.1007/s12686-017-0930-y
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Article: Anti-tumor effect of evodiamine by inducing Akt-mediated apoptosis in hepatocellular carcinoma

Yang, Fan / Fangfang Zhu / Guangji Zhang / Le Shi / Leilei Ji / Li Xu / Tao Liang / Yang Shen

Biochemical and biophysical research communications. 2017 Mar. 25, v. 485, no. 1

2017

Abstract: Evodiamine is an alkaloid extracted from Euodia rutaecarpa (Juss.) Benth. There is little information about the mechanisms of evodiamine on the apoptosis of hepatocellular carcinoma (HCC).A xenograft model and CCK8 assay were used to investigate the anti- ...

Abstract	Evodiamine is an alkaloid extracted from Euodia rutaecarpa (Juss.) Benth. There is little information about the mechanisms of evodiamine on the apoptosis of hepatocellular carcinoma (HCC).A xenograft model and CCK8 assay were used to investigate the anti-HCC effect of evodiamine. The effect of evodiamine on apoptosis was evaluated by DAPI staining and flow cytometry. Western blot analyses and immunohistochemistry were processed to assess the protein expressions of Akt and apoptotic proteins.Evodiamine suppressed tumor growth, improved the expression of cleaved-caspase3 and decreased tumor specific growth factor (TSGF) and alpha fetoprotein (AFP) activities. Furthermore, evodiamine inhibited cell viability and induced cell cycle arrest. DAPI staining revealed nuclear condensation in evodiamine-treated groups. Meanwhile, evodiamine increased the number of apoptotic cells. Furthermore, evodiamine suppressed Akt and regulated apoptotic proteins in HepG2 cells. Evodiamine decreased p-Akt levels activated by SC79, which led to the increase of bax/bcl-2 and cleaved-caspase3.Our findings suggested that evodiamine could exert anti-HCC effect through inducing Akt-mediated apoptosis. Evodiamine has the potential to be a therapeutic medicine for HCCs.
Keywords	4',6-diamidino-2-phenylindole ; alkaloids ; apoptosis ; cell cycle checkpoints ; cell viability ; Euodia ; flow cytometry ; hepatoma ; human cell lines ; immunohistochemistry ; models ; proteins ; staining ; Western blotting
Language	English
Dates of publication	2017-0325
Size	p. 54-61.
Publishing place	Elsevier Inc.
Document type	Article
ZDB-ID	205723-2
ISSN	0006-291X ; 0006-291X
ISSN (online)	0006-291X
ISSN	0006-291X
DOI	10.1016/j.bbrc.2017.02.017
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: THE SELECTION AND CONTENT DETERMINATION OF AN ANTI-MIGRAINE EFFECTIVE FRACTION SEPARATED FROM TIANMA GOUTENG DECOCTION BY MACROPOROUS RESIN

Zhaohuan Lou / Bohou Xia / Junyan Zhao / Yuefang Huang / Mingjie Hu / Guangji Zhang

Journal of Experimental Biology and Agricultural Sciences, Vol 2, Iss IV, Pp 264-

2014 Volume 372

Abstract: The objective of the present study was to obtain an effective part of Tianma Gouteng decoction (TMGTD) on anti-migraine and to establish a RP-HPLC method for the content determination of Jasminoidin and Baicalin in the part. For this study, TMGTD extract ...

Abstract	The objective of the present study was to obtain an effective part of Tianma Gouteng decoction (TMGTD) on anti-migraine and to establish a RP-HPLC method for the content determination of Jasminoidin and Baicalin in the part. For this study, TMGTD extract was prepared by decoction with water and 30%, 60% and 90% part of TMGTD were made by D-101 macroporous resin. Migraine rat model induced by subcutaneous injection of Nitroglycerine was applied to evaluate the anti-migraine effect of the samples. RP-HPLC coupled with liquid-solid extraction method was applied for the content determination of Jasminoidin and Baicalin. Results: 60% fraction was the most effective part of TMGTD on anti-migraine, with significant effect on reducing the frequency of head scratching and regulating the abnormal content of 5-HT, DA, NE and E in serum and brain tissue of migraine rats. The calibration curve of Jasminoidin and Baicalin was linear (r＞0.999) over the range of 0.0153 to 0.183 μg and 0.334 to 4.013 μg respectively, and the average recovery of each component was from 96.1% to 100.1% and 97.6% to 102.7% respectively. The content of Jasminoidin and Baicalin in 60% fraction was 1.03% and 29.6%, which was significantly higher than that in the fraction before purification process optimization. Conclusions: This was the first report on anti-migraine effective part selection and main components content determination of TMGTD. The result may provide a meaningful basis for the clinical application of TMGTD on anti migraine headache and for the new product development of TMGTD effective part.
Keywords	Migraine ; Jasminoidin ; Baicalin ; Traditional Chinese medicine ; RP-HPLC ; Biology (General) ; QH301-705.5 ; Science ; Q
Subject code	670
Language	English
Publishing date	2014-08-01T00:00:00Z
Publisher	Journal of Experimental Biology and Agricultural Sciences
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Traditional Chinese Medicine Formula “Xiaofeng granules” suppressed gouty arthritis animal models and inhibited the proteoglycan degradation on chondrocytes induced by monosodium urate

Shi, Le / Fan Yang / Fangfang Zhu / Fangli Zhao / Guangji Zhang / Li Xu / Lian Yin / Yuqiong Liang

Journal of ethnopharmacology. 2016 Sept. 15, v. 191

2016

Abstract: Xiaofeng Granules (XF) is a kind of granules prepared by the famous traditional Chinese medicine formula for its efficiency in treating gouty diseases.We investigated the relevance between XF that made from Modified simiaowan (MSW) as the anti-gouty ... ...

Abstract	Xiaofeng Granules (XF) is a kind of granules prepared by the famous traditional Chinese medicine formula for its efficiency in treating gouty diseases.We investigated the relevance between XF that made from Modified simiaowan (MSW) as the anti-gouty arthritis drugs and protective mechanisms for cartilage matrix in order to provide the evidence for new drug application.In the present study, we evaluated the anti-gouty arthritis activity of XF in rats and rabbits models induced by MSU together with chondrocytes focusing on the link to proteoglycan degradation in vitro studies.The results demonstrated that XF significantly reduced the swelling rate and attenuated the pathological changes in joints. The XF-containing serum were used medicated serum in cellular experiments. The in vitro data were in accordance with the in vivo results, showing that the constituents in XF-containing serum had obvious inhibitory effects on the activation of pro-inflammatory mediators in chondrocytes. Moreover, XF-containing serum substantially inhibited MSU-induced expression of glycosaminoglycans(GAG) and hydroxyproline(Hyp), and up regulated proteoglycan, which might be associated with the regulation of the balance of MMP-3/TIMP-1and ADAMTS-4/TIMP-3 inchondrocytes.In conclusion, XF that made from MSW showed obvious effects on acute gouty arthritis, which also provided an effective protection on cartilage matrix degradation.
Keywords	acute effects ; animal models ; arthritis ; blood serum ; cartilage ; chondrocytes ; drugs ; glycosaminoglycans ; granules ; hydroxyproline ; municipal solid waste ; Oriental traditional medicine ; proteoglycans ; rabbits ; rats
Language	English
Dates of publication	2016-0915
Size	p. 254-263.
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	134511-4
ISSN	1872-7573 ; 0378-8741
ISSN (online)	1872-7573
ISSN	0378-8741
DOI	10.1016/j.jep.2016.06.008
Database	NAL-Catalogue (AGRICOLA)

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Article: Evaluation of the change in sphingolipids in the human multiple myeloma cell line U266 and gastric cancer cell line MGC-803 treated with arsenic trioxide

Zou, Jianhua / Fanfan Zhu / Guangji Zhang / Li Shen / Liting Zhou / Xiaoqiong Ma / Yu Yu / Zhe Chen

Journal of Chromatography B. 2015 Nov. 01, v. 1004

2015

Abstract: Arsenic trioxide (As2O3) has been found to display anticancer activity against many types of tumors and has been developed into an anticancer drug in clinical treatments. Sphingolipids are membrane lipids that participate in many signal transduction ... ...

Abstract	Arsenic trioxide (As2O3) has been found to display anticancer activity against many types of tumors and has been developed into an anticancer drug in clinical treatments. Sphingolipids are membrane lipids that participate in many signal transduction pathways. In this paper, the changes in sphingolipids of the human multiple myeloma cell line U266 and the gastric cancer cell line MGC-803 treated with arsenic trioxide were investigated using an HPLC-ESIâMS/MS method. Analytes were separated by an XBridge BEH C8 column used for Cer, HexCer, LacCer and SM chromatographic separation, and a Capcell PAK MG II C18 column was used for Sph, dhSph, S1P and dhS1P chromatographic separation and gradient elution with acetonitrileâwater containing 0.1% formic acid as a mobile phase. A tandem mass spectrometer QTrap in SRM mode was employed in combination with RPLC as a detector for quantitative analysis. The ceramide/sphingolipid internal standard (IS) mixture was used to quantify the levels of sphingolipids. The distributions of sphingolipids were found to be different in the human multiple myeloma cell line U266 and the gastric cancer cell line MGC-803. Ceramide (Cer), hexosylceramide (HexCer) and dihexosylceramide (Hex2Cer) levels in U266 cell line are higher than those in MGC-803 cell line. Additionally, sphingomyelin (SM), sphingosine-1-phosphate (S1P) and sphinganine-1-phosphate (dhS1P) levels in the MGC-803 cell line are higher than those in the U266 cell line. When treated with arsenic trioxide (1â5Î¼M iAsIII(AsIII ions)), the levels of Hex2Cer in the human multiple myeloma cell line U266 decreased, and the levels of S1P and dhS1P in the human gastric cancer cell line MGC-803 decreased. The decrease of Hex2Cer, S1P and dhS1P in the human multiple myeloma cell line U266 and gastric cancer cell line MGC-803 were observed when the concentration of iAsIII is 1.0Î¼M. Therefore, arsenic trioxide exhibits anti-cancer activity by altering the sphingolipid pathway in the human multiple myeloma cell line U266 and the gastric cancer cell line MGC-803.
Keywords	antineoplastic activity ; antineoplastic agents ; arsenic ; ceramides ; chromatography ; formic acid ; humans ; ions ; myeloma ; quantitative analysis ; signal transduction ; spectrometers ; sphingomyelins ; stomach neoplasms
Language	English
Dates of publication	2015-1101
Size	p. 98-107.
Publishing place	Elsevier B.V.
Document type	Article
ISSN	1570-0232
DOI	10.1016/j.jchromb.2015.09.015
Database	NAL-Catalogue (AGRICOLA)

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Article: Combination of the fluorescent conjugated polymer and 1, 4, 7, 10- tetraazacyclododecane-1, 4, 7-triacetic acid gadolinium chelate as an agent for dual-modal imaging

Yan, Luomei / Cunqi Wu / Guangji Zhang / Hua Zhou / Jingwei Xu / Lidan Wang / Liqiao Shen / Wei Yang / Xuexun Fang / Yongxia Zhao

Tetrahedron. 2016 Dec. 29, v. 72, no. 52

2016

Abstract: The macromolecule, PPV-NMe3+-DO3A-Gd, in which paramagnetic DO3A-Gd units were introduced into a fluorescent polymer PPV-NMe3+, was synthesized. It inherited the fluorescent properties of PPV-NMe3+ and gained the magnetic relaxivity of DO3A-Gd. PPV-NMe3+- ...

Abstract	The macromolecule, PPV-NMe3+-DO3A-Gd, in which paramagnetic DO3A-Gd units were introduced into a fluorescent polymer PPV-NMe3+, was synthesized. It inherited the fluorescent properties of PPV-NMe3+ and gained the magnetic relaxivity of DO3A-Gd. PPV-NMe3+-DO3A-Gd was potential to function as a fluorescent/MRI dual-modal contrast agent.
Keywords	chemical reactions ; chemical structure ; fluorescence ; gadolinium ; image analysis ; magnetic resonance imaging ; magnetism ; polymers
Language	English
Dates of publication	2016-1229
Size	p. 8578-8583.
Publishing place	Elsevier Ltd
Document type	Article
ZDB-ID	204285-x
ISSN	1464-5416 ; 0040-4020 ; 0563-2064
ISSN (online)	1464-5416
ISSN	0040-4020 ; 0563-2064
DOI	10.1016/j.tet.2016.11.036
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: The number of CD34+CD38+CD117+HLA-DR+CD13+CD33+ cells indicates post-chemotherapy hematopoietic recovery in patients with acute myeloid leukemia.

Runxia Gu / Hui Wei / Ying Wang / Dong Lin / Bingcheng Liu / Chunlin Zhou / Kaiqi Liu / Benfa Gong / Shuning Wei / Guangji Zhang / Xiaoyuan Gong / Yuntao Liu / Yan Li / Xingli Zhao / Shaowei Qiu / Huijun Wang / Min Wang / Yingchang Mi / Jianxiang Wang

PLoS ONE, Vol 12, Iss 7, p e

2017 Volume 0180624

Abstract: Hematopoietic recovery is considered to be associated with the number of multipotent hematopoietic stem cells in the bone marrow, as observed in functional assays involving stem cell transplantation. However, there is little evidence related to ... ...

Abstract	Hematopoietic recovery is considered to be associated with the number of multipotent hematopoietic stem cells in the bone marrow, as observed in functional assays involving stem cell transplantation. However, there is little evidence related to hematopoietic recovery in non-transplantation settings, which is accomplished by endogenous hematopoietic cells. A recent study suggested that progenitors are the main contributors during this steady-state hematopoiesis, which differs from exogenous transplantation. We hypothesized that endogenous progenitor support post-chemotherapy hematopoietic recovery. To investigate the potential impact of these progenitor cell percentage on hematopoietic recovery, we retrospectively analyzed the percentage of CD34+CD38+CD117+HLA-DR+CD13+CD33+ cells (P cells) and hematopoietic recovery in 223 newly diagnosed acute myeloid leukemia patients during two courses of consolidation chemotherapy after complete remission. We found that a lower P cell percentage was significantly associated with prolonged neutropenia recovery time after the first and second courses of consolidation chemotherapy (p = 0.001; p = 0.045, respectively). We also observed similar results with regard to platelet recovery time after the first course of consolidation chemotherapy (p = 0.000). Univariate analysis showed that P cell percentage and consolidation chemotherapy regimens, and not gender, age, induction chemotherapy regimens, infection grade, WHO classification and NCCN risk category, were associated with neutrophil recovery after chemotherapy. Multivariate analysis demonstrated that P cell percentage is an independent factor affecting neutrophil recovery capacity for both the first and second courses (p = 0.008; p = 0.032, respectively). Our results indicate that CD34+CD38+CD117+HLA-DR+CD13+CD33+ cells before each course of chemotherapy is independently associated with chemotherapy-related hematopoietic reconstitution capacity. These findings may help modify future chemotherapy regimens based on progenitor ...
Keywords	Medicine ; R ; Science ; Q
Subject code	610
Language	English
Publishing date	2017-01-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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