LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 6 of total 6

Search options

  1. Article ; Online: Cepharanthine Dry Powder Inhaler for the Treatment of Acute Lung Injury

    Di Liang / Wanmei Wang / Guangrui Chen / Jian Li / Guifang Dou / Hui Gan / Peng Han / Lina Du / Ruolan Gu

    Molecules, Vol 28, Iss 4441, p

    2023  Volume 4441

    Abstract: Severe acute respiratory syndrome Coronavirus 2 (SARS-CoV-2) induces a severe cytokine storm that may cause acute lung injury/acute respiratory distress syndrome (ALI/ARDS) with high clinical morbidity and mortality in infected individuals. Cepharanthine ...

    Abstract Severe acute respiratory syndrome Coronavirus 2 (SARS-CoV-2) induces a severe cytokine storm that may cause acute lung injury/acute respiratory distress syndrome (ALI/ARDS) with high clinical morbidity and mortality in infected individuals. Cepharanthine (CEP) is a bisbenzylisoquinoline alkaloid isolated and extracted from Stephania cepharantha Hayata . It exhibits various pharmacological effects, including antioxidant, anti-inflammatory, immunomodulatory, anti-tumor, and antiviral activities. The low oral bioavailability of CEP can be attributed to its poor water solubility. In this study, we utilized the freeze-drying method to prepare dry powder inhalers (DPI) for the treatment of acute lung injury (ALI) in rats via pulmonary administration. According to the powder properties study, the aerodynamic median diameter (D a ) of the DPIs was 3.2 μm, and the in vitro lung deposition rate was 30.26; thus, meeting the Chinese Pharmacopoeia standard for pulmonary inhalation administration. We established an ALI rat model by intratracheal injection of hydrochloric acid (1.2 mL/kg, pH = 1.25). At 1 h after the model’s establishment, CEP dry powder inhalers (CEP DPIs) (30 mg/kg) were sprayed into the lungs of rats with ALI via the trachea. Compared with the model group, the treatment group exhibited a reduced pulmonary edema and hemorrhage, and significantly reduced content of inflammatory factors (TNF-α, IL-6 and total protein) in their lungs ( p < 0.01), indicating that the main mechanism of CEP underlying the treatment of ALI is anti-inflammation. Overall, the dry powder inhaler can deliver the drug directly to the site of the disease, increasing the intrapulmonary utilization of CEP and improving its efficacy, making it a promising inhalable formulation for the treatment of ALI.
    Keywords cepharanthine ; pulmonary drug delivery ; acute lung injury ; dry powder inhalers ; Organic chemistry ; QD241-441
    Subject code 610
    Language English
    Publishing date 2023-05-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  2. Article ; Online: A facile dual-template-directed successive assembly approach to hollow multi-shell mesoporous metal–organic framework particles

    Haidong Xu / Ji Han / Bin Zhao / Ruigang Sun / Guiyuan Zhong / Guangrui Chen / Yusuke Yamauchi / Buyuan Guan

    Nature Communications, Vol 14, Iss 1, Pp 1-

    2023  Volume 10

    Abstract: Abstract Hollow multi-shell mesoporous metal–organic framework (MOF) particles with accessible compartmentalization environments, plentiful heterogeneous interfaces, and abundant framework diversity are expected to hold great potential for catalysis, ... ...

    Abstract Abstract Hollow multi-shell mesoporous metal–organic framework (MOF) particles with accessible compartmentalization environments, plentiful heterogeneous interfaces, and abundant framework diversity are expected to hold great potential for catalysis, energy conversion, and biotechnology. However, their synthetic methodology has not yet been established. In this work, a facile dual-template-directed successive assembly approach has been developed for the preparation of monodisperse hollow multi-shell mesoporous MOF (UiO-66-NH2) particles through one-step selective etching of successively grown multi-layer MOFs with alternating two types of mesostructured layers. This strategy enables the preparation of hollow multi-shell mesoporous UiO-66-NH2 nanostructures with controllable shell numbers, accessible mesochannels, large pore volume, tunable shell thickness and chamber sizes. The methodology relies on creating multiple alternating layers of two different mesostructured MOFs via dual-template-directed successive assembly and their difference in framework stability upon chemical etching. Benefiting from the highly accessible Lewis acidic sites and the accumulation of reactants within the multi-compartment architecture, the resultant hollow multi-shell mesoporous UiO-66-NH2 particles exhibit enhanced catalytic activity for CO2 cycloaddition reaction. The dual-template-directed successive assembly strategy paves the way toward the rational construction of elaborate hierarchical MOF nanoarchitectures with specific physical and chemical features for different applications.
    Keywords Science ; Q
    Subject code 620
    Language English
    Publishing date 2023-12-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  3. Article ; Online: Bioavailability Enhancement of Cepharanthine via Pulmonary Administration in Rats and Its Therapeutic Potential for Pulmonary Fibrosis Associated with COVID-19 Infection

    Jian Li / Guangrui Chen / Zhiyun Meng / Zhuona Wu / Hui Gan / Xiaoxia Zhu / Peng Han / Taoyun Liu / Fanjun Wang / Ruolan Gu / Guifang Dou

    Molecules, Vol 27, Iss 2745, p

    2022  Volume 2745

    Abstract: Cepharanthine (CEP) has excellent anti-SARS-CoV-2 properties, indicating its favorable potential for COVID-19 treatment. However, its application is challenged by its poor dissolubility and oral bioavailability. The present study aimed to improve the ... ...

    Abstract Cepharanthine (CEP) has excellent anti-SARS-CoV-2 properties, indicating its favorable potential for COVID-19 treatment. However, its application is challenged by its poor dissolubility and oral bioavailability. The present study aimed to improve the bioavailability of CEP by optimizing its solubility and through a pulmonary delivery method, which improved its bioavailability by five times when compared to that through the oral delivery method (68.07% vs. 13.15%). An ultra-performance liquid chromatography tandem-mass spectrometry (UPLC-MS/MS) method for quantification of CEP in rat plasma was developed and validated to support the bioavailability and pharmacokinetic studies. In addition, pulmonary fibrosis was recognized as a sequela of COVID-19 infection, warranting further evaluation of the therapeutic potential of CEP on a rat lung fibrosis model. The antifibrotic effect was assessed by analysis of lung index and histopathological examination, detection of transforming growth factor (TGF)-β1, interleukin-6 (IL-6), α-smooth muscle actin (α-SMA), and hydroxyproline level in serum or lung tissues. Our data demonstrated that CEP could significantly alleviate bleomycin (BLM)-induced collagen accumulation and inflammation, thereby exerting protective effects against pulmonary fibrosis. Our results provide evidence supporting the hypothesis that pulmonary delivery CEP may be a promising therapy for pulmonary fibrosis associated with COVID-19 infection.
    Keywords cepharanthine ; COVID-19 ; pulmonary delivery ; anti-fibrosis ; UPLC-MS/MS ; bioavailability ; Organic chemistry ; QD241-441
    Subject code 610
    Language English
    Publishing date 2022-04-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  4. Article: Synthesis of anatase-free nano-sized hierarchical TS-1 zeolites and their excellent catalytic performance in alkene epoxidation

    Zhang, Tianjun / Xiaoxin Chen / Guangrui Chen / Mengyang Chen / Risheng Bai / Mingjun Jia / Jihong Yu

    Journal of materials chemistry. 2018 May 22, v. 6, no. 20

    2018  

    Abstract: Nano-sized hierarchical titanosilicate TS-1 without extra-framework anatase TiO₂ has been successfully synthesized by using Triton X-100 as a mesoporous template under rotational crystallization conditions. The resultant material contains a large ... ...

    Abstract Nano-sized hierarchical titanosilicate TS-1 without extra-framework anatase TiO₂ has been successfully synthesized by using Triton X-100 as a mesoporous template under rotational crystallization conditions. The resultant material contains a large external surface area and uniform mesopores (2–4 nm). Notably, the titanium ions are fully incorporated into the framework of TS-1 and no extra anatase TiO₂ exists. Triton X-100 and rotational crystallization conditions play an important role in eliminating anatase TiO₂. The addition of Triton X-100 slows down the crystallization rate of TS-1, while the rota-crystallization accelerates the incorporation rate of Ti, so that the insertion rate of titanium into the framework matches well with that of silicon. As such, the generation of extra-framework anatase TiO₂ can be inhibited. Furthermore, in comparison with nano-sized hierarchical TS-1 prepared under static conditions, nano-sized hierarchical TS-1 prepared under rotational conditions exhibits excellent catalytic activity and high stability in alkene epoxidation, especially in bulky alkene epoxidation. The facile synthetic strategy for nano-sized hierarchical TS-1 without extra-framework anatase TiO₂ may open new perspectives for its potential application in selective oxidation reactions involving large molecules.
    Keywords catalytic activity ; crystallization ; epoxidation reactions ; ions ; octoxynol ; oxidation ; porous media ; silicon ; surface area ; titanium ; titanium dioxide ; zeolites
    Language English
    Dates of publication 2018-0522
    Size p. 9473-9479.
    Publishing place The Royal Society of Chemistry
    Document type Article
    ZDB-ID 2702232-8
    ISSN 2050-7496 ; 2050-7488
    ISSN (online) 2050-7496
    ISSN 2050-7488
    DOI 10.1039/c8ta01439f
    Database NAL-Catalogue (AGRICOLA)

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  5. Article ; Online: Red Room-Temperature Phosphorescence of CDs@Zeolite Composites Triggered by Heteroatoms in Zeolite Frameworks

    Bolun Wang / Ying Mu / Hongyue Zhang / Huaizhong Shi / Guangrui Chen / Yue Yu / Ziqi Yang / Jiyang Li / Jihong Yu

    ACS Central Science, Vol 5, Iss 2, Pp 349-

    2019  Volume 356

    Keywords Chemistry ; QD1-999
    Language English
    Publishing date 2019-01-01T00:00:00Z
    Publisher American Chemical Society
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  6. Article: Synthesis of tiny carbon dots with high quantum yield using multi-walled carbon nanotubes as support for selective “turn-off-on” detection of rutin and Al3+

    Li, Huiyu / Guangrui Chen / Jie Ding / Lan Ding / Li Zhao / Mengyang Chen / Yi Li / Yuan Xu

    Carbon. 2019 Mar., v. 143

    2019  

    Abstract: The solid-phase pyrolysis method is widely used in the synthesis of fluorescent carbon dots (CDs) because of its large scale and solvent-saving advantages. However, CDs are inclined to agglomerate during the synthesis process, resulting in low quantum ... ...

    Abstract The solid-phase pyrolysis method is widely used in the synthesis of fluorescent carbon dots (CDs) because of its large scale and solvent-saving advantages. However, CDs are inclined to agglomerate during the synthesis process, resulting in low quantum yield (QY) and inhomogeneous distribution of particle sizes. Here, a simple and effective solid dispersion surface pyrolysis method was used for the synthesis of tiny-carbon dots (T-CDs) with a high QY. Multi-walled carbon nanotubes (MWCNTs) were used as a support and 2-(N-morpholino)ethanesulfonic acid (MES) as a precursor. MES was uniformly dispersed on the surface of MWCNTs by hydrogen bonding and π-π interactions. Due to the excellent thermal conductivity and rigidity of MWCNTs, the precursor is carbonized without agglomeration. Compared with the CDs obtained by the direct pyrolysis method without the use of a solid support, the particle size of the T-CDs is small (0.69 ± 0.14 nm) and the QY increased from 17.8 to 42.8%. It is anticipated that this method will lead to the improvement of the QY of CDs. Applications of the T-CDs included fluorescence detection of rutin in pharmaceuticals, human urine, and human serum samples, and determination of Al3+ in tap water samples.
    Keywords aluminum ; blood serum ; carbon nanotubes ; carbon quantum dots ; drugs ; fluorescence ; humans ; hydrogen bonding ; particle size ; pyrolysis ; rutin ; tap water ; thermal conductivity ; urine
    Language English
    Dates of publication 2019-03
    Size p. 391-401.
    Publishing place Elsevier Ltd
    Document type Article
    ISSN 0008-6223
    DOI 10.1016/j.carbon.2018.11.049
    Database NAL-Catalogue (AGRICOLA)

    Full text online

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

To top