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Article ; Online: Thermoring basis for the TRPV3 bio-thermometer

Guangyu Wang

Scientific Reports, Vol 13, Iss 1, Pp 1-

2023 Volume 14

Abstract: Abstract The thermosensitive transient receptor potential (TRP) channels are well-known as bio-thermometers with specific temperature thresholds and sensitivity. However, their precise structural origins are still mysterious. Here, graph theory was used ... ...

Abstract	Abstract The thermosensitive transient receptor potential (TRP) channels are well-known as bio-thermometers with specific temperature thresholds and sensitivity. However, their precise structural origins are still mysterious. Here, graph theory was used to test how the temperature-dependent non-covalent interactions as identified in the 3D structures of thermo-gated TRPV3 could form a systematic fluidic grid-like mesh network with the constrained thermo-rings from the biggest grids to the smallest ones as necessary structural motifs for the variable temperature thresholds and sensitivity. The results showed that the heat-evoked melting of the biggest grids may control the specific temperature thresholds to initiate channel gating while the smaller grids may be required to secure heat efficacy. Together, all the grids along the lipid-dependent minimal gating pathway may be necessary to change with molar heat capacity for the specific temperature sensitivity. Therefore, this graph theory-based grid thermodynamic model may provide an extensive structural basis for the thermo-gated TRP channels.
Keywords	Medicine ; R ; Science ; Q
Subject code	541
Language	English
Publishing date	2023-12-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Lipid-dependent sequential allosteric activation of heat-sensing TRPV1 channels by anchor-stereoselective “hot” vanilloid compounds and analogs

Guangyu Wang

Biochemistry and Biophysics Reports, Vol 28, Iss , Pp 101109- (2021)

2021

Abstract: Both a silent resident phosphatidylinositol lipid and a “hot” vanilloid agonist capsaicin or resiniferatoxin have been shown to share the same inter-subunit binding pocket between a voltage sensor like domain and a pore domain in TRPV1. However, how the ... ...

Abstract	Both a silent resident phosphatidylinositol lipid and a “hot” vanilloid agonist capsaicin or resiniferatoxin have been shown to share the same inter-subunit binding pocket between a voltage sensor like domain and a pore domain in TRPV1. However, how the vanilloid competes off the resident lipid for allosteric TRPV1 activation is unknown. Here, the in silico research suggested that anchor-stereoselective sequential cooperativity between an initial recessive transient silent weak ligand binding site and a subsequent dominant steady-state strong ligand binding site in the vanilloid pocket may facilitate the lipid release for allosteric activation of TRPV1 by vanilloids or analogs upon non-covalent interactions. Thus, the resident lipid may play a critical role in allosteric activation of TRPV1 by vanilloid compounds and analogs.
Keywords	Sequential cooperativity ; Active site stereoselectivity ; Dominant steady-state ligand binding ; Recessive transient ligand binding ; Lipid-ligand interaction ; Hydrogen bonding network ; Biology (General) ; QH301-705.5 ; Biochemistry ; QD415-436
Language	English
Publishing date	2021-12-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Design of a Semantic Understanding System for Optical Staff Symbols

Fengbin Lou / Yaling Lu / Guangyu Wang

Applied Sciences, Vol 13, Iss 23, p

2023 Volume 12627

Abstract: Symbolic semantic understanding of staff images is an important technological support to achieve “intelligent score flipping”. Due to the complex composition of staff symbols and the strong semantic correlation between symbol spaces, it is difficult to ... ...

Abstract	Symbolic semantic understanding of staff images is an important technological support to achieve “intelligent score flipping”. Due to the complex composition of staff symbols and the strong semantic correlation between symbol spaces, it is difficult to understand the pitch and duration of each note when the staff is performed. In this paper, we design a semantic understanding system for optical staff symbols. The system uses the YOLOv5 to implement the optical staff’s low-level semantic understanding stage, which understands the pitch and duration in natural scales and other symbols that affect the pitch and duration. The proposed note encoding reconstruction algorithm is used to implement the high-level semantic understanding stage. Such an algorithm understands the logical, spatial, and temporal relationships between natural scales and other symbols based on music theory and outputs digital codes for the pitch and duration of the main notes during performances. The model is trained with a self-constructed SUSN dataset. Experimental results with YOLOv5 show that the precision is 0.989 and that the recall is 0.972. The system’s error rate is 0.031, and the omission rate is 0.021. The paper concludes by analyzing the causes of semantic understanding errors and offers recommendations for further research. The results of this paper provide a method for multimodal music artificial intelligence applications such as notation recognition through listening, intelligent score flipping, and automatic performance.
Keywords	semantic understanding ; neural networks ; optical music recognition ; YOLOv5 ; digital code ; Technology ; T ; Engineering (General). Civil engineering (General) ; TA1-2040 ; Biology (General) ; QH301-705.5 ; Physics ; QC1-999 ; Chemistry ; QD1-999
Subject code	780
Language	English
Publishing date	2023-11-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: The effect of node features on GCN-based brain network classification

Guangyu Wang / Limei Zhang / Lishan Qiao

PeerJ, Vol 11, p e

an empirical study

2023 Volume 14835

Abstract: Brain functional network (BFN) analysis has become a popular technique for identifying neurological/mental diseases. Due to the fact that BFN is a graph, a graph convolutional network (GCN) can be naturally used in the classification of BFN. Different ... ...

Abstract	Brain functional network (BFN) analysis has become a popular technique for identifying neurological/mental diseases. Due to the fact that BFN is a graph, a graph convolutional network (GCN) can be naturally used in the classification of BFN. Different from traditional methods that directly use the adjacency matrices of BFNs to train a classifier, GCN requires an additional input-node features. To our best knowledge, however, there is no systematic study to analyze their influence on the performance of GCN-based brain disorder classification. Therefore, in this study, we conduct an empirical study on various node feature measures, including (1) original fMRI signals, (2) one-hot encoding, (3) node statistics, (4) node correlation, and (5) their combination. Experimental results on two benchmark databases show that different node feature inputs to GCN significantly affect the brain disease classification performance, and node correlation usually contributes higher accuracy compared to original signals and manually extracted statistical features.
Keywords	Graph convolutional network ; Node features ; Empirical study ; Mild cognitive impairment ; Autism spectrum disorder ; Medicine ; R ; Biology (General) ; QH301-705.5
Subject code	006
Language	English
Publishing date	2023-03-01T00:00:00Z
Publisher	PeerJ Inc.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Fire regime and management in Canada's protected areas

Weiwei Wang / Wanli Wu / Futao Guo / Guangyu Wang

International Journal of Geoheritage and Parks, Vol 10, Iss 2, Pp 240-

2022 Volume 251

Abstract: Wildland fires are a vital ecological process in Canada's protected areas (PAs), resulting in both ecological benefits and detrimental disturbances. In the face of rapid global changes, maximizing fire's ecological benefits while minimizing its negative ... ...

Abstract	Wildland fires are a vital ecological process in Canada's protected areas (PAs), resulting in both ecological benefits and detrimental disturbances. In the face of rapid global changes, maximizing fire's ecological benefits while minimizing its negative impacts is particularly difficult but essential for PA fire management. To facilitate fire management in Canada's PAs, we conducted a comprehensive review of fire regimes and management strategies in PAs using several scholarly sources and national databases. We found that a high proportion of protected areas are in the remote boreal forest region or the Montane Cordillera. Fire regimes varied from the high-intensity fires in the boreal forest region to the more complex mixed-severity fires in the Montane Cordillera ecozone. Numerous fire tools and science-based management plans have been developed to address the varied and complex fire regimes. However, many challenges are still presented under longer fire seasons with increasingly severe burning across the country. To cope with these challenges, we proposed a protection-conservation integrated fire management framework. It is expected to improve the capability of the existing tools in guiding both fire protection and ecological fire use in Canada's PAs.
Keywords	fire regime ; fire management ; fire model ; prescribed fire ; protected areas ; Environmental sciences ; GE1-350 ; Geography (General) ; G1-922
Subject code	690
Language	English
Publishing date	2022-06-01T00:00:00Z
Publisher	KeAi Communications Co., Ltd.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Digital Economy, R&D Investment, and Regional Green Innovation—Analysis Based on Provincial Panel Data in China

Debao Dai / Yaodong Fan / Guangyu Wang / Jiaping Xie

Sustainability, Vol 14, Iss 6508, p

2022 Volume 6508

Abstract: The digital economy plays an important role in promoting regional green innovation. Based on the panel data of 30 provincial administrative regions in mainland China (except Tibet) from 2011 to 2018, this paper constructs a comprehensive development ... ...

Abstract	The digital economy plays an important role in promoting regional green innovation. Based on the panel data of 30 provincial administrative regions in mainland China (except Tibet) from 2011 to 2018, this paper constructs a comprehensive development index of the digital economy and explores the potential path of the digital economy affecting regional green innovation through factor analysis and regression analysis. The results show the following: Firstly, the digital economy can effectively promote regional green innovation capability. The causal relationship is mainly realized through scientific research funds and human resources. Secondly, in terms of regional heterogeneity, the role of the digital economy in promoting green innovation and R&D investment in eastern China is stronger than that in central and western China. Thirdly, further analysis showed that the digital economy has a significant nonlinear influence on regional green innovation capability. This feature is mainly reflected in the influence of R&D personnel on regional green innovation. Therefore, the rational allocation of R&D resources is conducive to the development of regional green innovation. Finally, it is suggested to improve the two mechanisms of R&D funds and personnel investment to actuate regional green innovation development.
Keywords	digital economy ; R&D funds ; R&D personnel ; green innovation ; Environmental effects of industries and plants ; TD194-195 ; Renewable energy sources ; TJ807-830 ; Environmental sciences ; GE1-350
Subject code	650 ; 339
Language	English
Publishing date	2022-05-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Editorial

Hui Zhang / Guangyu Wang / Wenxing Long

Frontiers in Ecology and Evolution, Vol

Trait-Based Plant Community Assembly, Ecological Restoration, and the Biocontrol of Invasive Exotic Plant Species

2022 Volume 10

Keywords	ecological restoration ; functional trait ; community assembly ; ecosystem functioning ; biocontrol ; trait-based restoration ; Evolution ; QH359-425 ; Ecology ; QH540-549.5
Language	English
Publishing date	2022-02-01T00:00:00Z
Publisher	Frontiers Media S.A.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Synthesis and Insecticidal Activity of Fire Ant Venom Alkaloid-Based 2-Methyl-6-alkyl-Δ 1,6 -piperideines

Xiaoqing Wu / Guangyu Wang / Guangxin Xu / Li Chen

Molecules, Vol 27, Iss 1107, p

2022 Volume 1107

Abstract: 2,6-dialkylpiperideines found in the venom of Solenopsis (Hymenoptera, Formicidae) fire ants are a range of compounds possessing various biological activities. A series of racemic 2-methyl-6-alkyl-Δ 1,6 -piperideines were synthesized for chemical ... ...

Abstract	2,6-dialkylpiperideines found in the venom of Solenopsis (Hymenoptera, Formicidae) fire ants are a range of compounds possessing various biological activities. A series of racemic 2-methyl-6-alkyl-Δ 1,6 -piperideines were synthesized for chemical confirmation of the natural products found in fire ant venom, and the evaluation of their biological activity. Synthetic Δ 1,6 -piperideines and the natural compounds in the cis -alkaloid fraction of Solenopsis invicta had identical mass spectra and retention times. Their insecticidal activities against the third-instar larvae of cotton bollworm ( Helicoverpa armigera ) were evaluated by using injection and topical application methods. All three compounds exhibited no lethal effect at concentrations of 0.05–0.4 mol/L by topical treatment, but moderate lethal effect at 0.4 mol/L through injection treatment. Compound 6a showed significantly higher activity than the natural insecticide nicotine. The differences in activity among compounds 6b , 6c and nicotine were not significant. The elongation of the carbon chain at the 6-position of the piperideine ring appears to decrease insecticidal activity.
Keywords	piperideine ; venom ; Solenopsis invicta ; biological activity ; contact toxicity ; injection toxicity ; Organic chemistry ; QD241-441
Language	English
Publishing date	2022-02-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Preparation and Characterization of Thermally Stable Collagens from the Scales of Lizardfish ( Synodus macrops )

Junde Chen / Guangyu Wang / Yushuang Li

Marine Drugs, Vol 19, Iss 597, p

2021 Volume 597

Abstract: Marine collagen is gaining vast interest because of its high biocompatibility and lack of religious and social restrictions compared with collagen from terrestrial sources. In this study, lizardfish ( Synodus macrops ) scales were used to isolate acid- ... ...

Abstract	Marine collagen is gaining vast interest because of its high biocompatibility and lack of religious and social restrictions compared with collagen from terrestrial sources. In this study, lizardfish ( Synodus macrops ) scales were used to isolate acid-soluble collagen (ASC) and pepsin-soluble collagen (PSC). Both ASC and PSC were identified as type I collagen with intact triple-helix structures by sodium dodecyl sulfate-polyacrylamide gel electrophoresis and spectroscopy. The ASC and PSC had high amino acids of 237 residues/1000 residues and 236 residues/1000 residues, respectively. Thus, the maximum transition temperature (T max ) of ASC (43.2 °C) was higher than that of PSC (42.5 °C). Interestingly, the T max of both ASC and PSC was higher than that of rat tail collagen (39.4 °C) and calf skin collagen (35.0 °C), the terrestrial collagen. Solubility tests showed that both ASC and PSC exhibited high solubility in the acidic pH ranges. ASC was less susceptible to the “salting out” effect compared with PSC. Both collagen types were nontoxic to HaCaT and MC3T3-E1 cells, and ASC was associated with a higher cell viability than PSC. These results indicated that ASC from lizardfish scales could be an alternative to terrestrial sources of collagen, with potential for biomedical applications.
Keywords	lizardfish scale ; marine collagen ; thermal stability ; cell viability ; Biology (General) ; QH301-705.5
Subject code	610
Language	English
Publishing date	2021-10-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Evaluation of PTV margins with daily iterative online adaptive radiotherapy for postoperative treatment of endometrial and cervical cancer

Guangyu Wang / Zhiqun Wang / Yuping Guo / Yu Zhang / Jie Qiu / Ke Hu / Jing Li / JunFang Yan / Fuquan Zhang

Radiation Oncology, Vol 19, Iss 1, Pp 1-

a prospective single-arm phase 2 study

2024 Volume 9

Abstract: Abstract Background To determine the optimal planning target volume (PTV) margins for adequate coverage by daily iterative cone-beam computed tomography (iCBCT)-guided online adaptive radiotherapy (oART) in postoperative treatment of endometrial and ... ...

Abstract	Abstract Background To determine the optimal planning target volume (PTV) margins for adequate coverage by daily iterative cone-beam computed tomography (iCBCT)-guided online adaptive radiotherapy (oART) in postoperative treatment of endometrial and cervical cancer and the benefit of reducing PTV margins. Methods Fifteen postoperative endometrial and cervical cancer patients treated with daily iCBCT-guided oART were enrolled in this prospective phase 2 study. Pre- and posttreatment iCBCT images of 125 fractions from 5 patients were obtained as a training cohort, and clinical target volumes (CTV) were contoured separately. Uniform three-dimensional expansions were applied to the PTVpre to assess the minimum margin required to encompass the CTVpost. The dosimetric advantages of the proposed online adaptive margins were compared with conventional margin plans (7–15 mm) using an oART emulator in another cohort of 125 iCBCT scans. A CTV-to-PTV expansion was verified on a validation cohort of 253 fractions from 10 patients, and further margin reduction and acute toxicity were studied. Results The average time from pretreatment iCBCT to posttreatment iCBCT was 22 min. A uniform PTV margin of 5 mm could encompass nodal CTVpost in 100% of the fractions (175/175) and vaginal CTVpost in 98% of the fractions (172/175). The margin of 5 mm was verified in our validation cohort, and the nodal PTV margin could be further reduced to 4 mm if ≥ 95% CTV coverage was predicted to be achieved. The adapted plan with a 5 mm margin significantly improved pelvic organ-at-risk dosimetry compared with the conventional margin plan. Grade 3 toxicities were observed in only one patient with leukopenia, and no patients experienced acute urinary toxicity. Conclusion In the postoperative treatment of endometrial and cervical cancer, oART could reduce PTV margins to 5 mm, which significantly decrease the dose to critical organs at risk and potentially lead to a lower incidence of acute toxicity.
Keywords	Cone-beam computed tomography ; Online adaptive radiotherapy ; Margins ; Acute toxicity ; Endometrial cancer ; Cervical cancer ; Medical physics. Medical radiology. Nuclear medicine ; R895-920 ; Neoplasms. Tumors. Oncology. Including cancer and carcinogens ; RC254-282
Subject code	610 ; 616
Language	English
Publishing date	2024-01-01T00:00:00Z
Publisher	BMC
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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