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  1. Article ; Online: Cellular Strategies for Separating GvHD from GvL in Haploidentical Transplantation.

    Di Ianni, Mauro / Liberatore, Carmine / Santoro, Nicole / Ranalli, Paola / Guardalupi, Francesco / Corradi, Giulia / Villanova, Ida / Di Francesco, Barbara / Lattanzio, Stefano / Passeri, Cecilia / Lanuti, Paola / Accorsi, Patrizia

    Cells

    2024  Volume 13, Issue 2

    Abstract: GvHD still remains, despite the continuous improvement of transplantation platforms, a fearful complication of transplantation from allogeneic donors. Being able to separate GvHD from GvL represents the greatest challenge in the allogeneic transplant ... ...

    Abstract GvHD still remains, despite the continuous improvement of transplantation platforms, a fearful complication of transplantation from allogeneic donors. Being able to separate GvHD from GvL represents the greatest challenge in the allogeneic transplant setting. This may be possible through continuous improvement of cell therapy techniques. In this review, current cell therapies are taken into consideration, which are based on the use of TCR alpha/beta depletion, CD45RA depletion, T regulatory cell enrichment, NK-cell-based immunotherapies, and suicide gene therapies in order to prevent GvHD and maximally amplify the GvL effect in the setting of haploidentical transplantation.
    MeSH term(s) Humans ; Transplantation, Haploidentical ; Cell- and Tissue-Based Therapy ; Fear ; Immunotherapy ; Killer Cells, Natural
    Language English
    Publishing date 2024-01-11
    Publishing country Switzerland
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells13020134
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Case Report: Invasive fungal infection after anti-CD19 CAR-T cell therapy. Implication for antifungal prophylaxis.

    Pennese, Elsa / Salutari, Prassede / Carriero, Luigi / Restuccia, Francesco / De Filippis, Antonio Fabio / De Luca, Giulia / Giancola, Raffaella / Guardalupi, Francesco / Corradi, Giulia / Fabi, Bianca / Baldoni, Stefano / Di Ianni, Mauro

    Frontiers in immunology

    2023  Volume 14, Page(s) 1272798

    Abstract: CAR-T therapy has revolutionized the treatment of relapsed/refractory B-cell malignancies. Patients who are receiving such therapy are susceptible to an increased incidence of infections due to post-treatment immunosuppression. The need for antifungal ... ...

    Abstract CAR-T therapy has revolutionized the treatment of relapsed/refractory B-cell malignancies. Patients who are receiving such therapy are susceptible to an increased incidence of infections due to post-treatment immunosuppression. The need for antifungal prophylaxis during the period of neutropenia remains to be determined. The clinical outcome of a 55-year-old patient with relapsed/refractory DLBCL who received axicabtagene ciloleucel is described here. The patient developed CRS grade II and ICANS grade IV requiring tocilizumab, prolonged use of steroids and anakinra. An invasive pulmonary aspergillosis arose after 1 month from CAR-T reinfusion, resolved with tracheal sleeve pneumonectomy. The patient is now in Complete Remission. This case suggests that antifungal prophylaxis should be considered. We have now included micafungin as a standard prophylaxis in our institution.
    MeSH term(s) Humans ; Middle Aged ; Receptors, Chimeric Antigen ; Antifungal Agents/therapeutic use ; Neoplasm Recurrence, Local/drug therapy ; Antigens, CD19/therapeutic use ; Invasive Fungal Infections/drug therapy ; Invasive Fungal Infections/etiology ; Invasive Fungal Infections/prevention & control ; Cell- and Tissue-Based Therapy
    Chemical Substances Receptors, Chimeric Antigen ; Antifungal Agents ; Antigens, CD19
    Language English
    Publishing date 2023-09-28
    Publishing country Switzerland
    Document type Case Reports ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2023.1272798
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: A pro-inflammatory environment in bone marrow of Treg transplanted patients matches with graft-versus-leukemia effect.

    Guardalupi, Francesco / Sorrentino, Carlo / Corradi, Giulia / Giancola, Raffaella / Baldoni, Stefano / Ulbar, Francesca / Fabi, Bianca / Andres Ejarque, Rosa / Timms, Jessica / Restuccia, Francesco / Santarone, Stella / Accorsi, Patrizia / Sportoletti, Paolo / De Falco, Filomena / Rosati, Emanuela / Carotti, Alessandra / Falzetti, Franca / Velardi, Andrea / Martelli, Massimo Fabrizio /
    Kordasti, Shahram / Pierini, Antonio / Ruggeri, Loredana / Di Ianni, Mauro

    Leukemia

    2023  Volume 37, Issue 7, Page(s) 1572–1575

    MeSH term(s) Humans ; Bone Marrow ; T-Lymphocytes, Regulatory ; Bone Marrow Transplantation ; Transplantation, Homologous ; Leukemia ; Graft vs Host Disease/etiology
    Language English
    Publishing date 2023-06-07
    Publishing country England
    Document type Research Support, Non-U.S. Gov't ; Letter
    ZDB-ID 807030-1
    ISSN 1476-5551 ; 0887-6924
    ISSN (online) 1476-5551
    ISSN 0887-6924
    DOI 10.1038/s41375-023-01932-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2295: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
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  4. Article ; Online: NOTCH1 inhibition prevents GvHD and maintains GvL effect in murine models.

    Baldoni, Stefano / Ruggeri, Loredana / Del Papa, Beatrice / Sorcini, Daniele / Guardalupi, Francesco / Ulbar, Francesca / Marra, Andrea / Dorillo, Erica / Stella, Arianna / Giancola, Raffaella / Fabi, Bianca / Sola, Rosaria / Ciardelli, Sara / De Falco, Filomena / Rompietti, Chiara / Adamo, Francesco Maria / Rosati, Emanuela / Pierini, Antonio / Sorrentino, Carlo /
    Sportoletti, Paolo / Di Ianni, Mauro

    Bone marrow transplantation

    2021  Volume 56, Issue 8, Page(s) 2019–2023

    MeSH term(s) Animals ; Bone Marrow Transplantation ; Disease Models, Animal ; Graft vs Host Disease/prevention & control ; Graft vs Leukemia Effect ; Humans ; Mice ; Mice, Inbred C57BL ; Receptor, Notch1/genetics
    Chemical Substances NOTCH1 protein, human ; Receptor, Notch1
    Language English
    Publishing date 2021-04-19
    Publishing country England
    Document type Letter ; Research Support, Non-U.S. Gov't
    ZDB-ID 632854-4
    ISSN 1476-5365 ; 0268-3369 ; 0951-3078
    ISSN (online) 1476-5365
    ISSN 0268-3369 ; 0951-3078
    DOI 10.1038/s41409-021-01297-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2168: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
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  5. Article: NOTCH1 Activation Negatively Impacts on Chronic Lymphocytic Leukemia Outcome and Is Not Correlated to the

    Baldoni, Stefano / Del Papa, Beatrice / De Falco, Filomena / Dorillo, Erica / Sorrentino, Carlo / Rompietti, Chiara / Adamo, Francesco Maria / Nogarotto, Manuel / Cecchini, Debora / Mondani, Elena / Silva Barcelos, Estevao Carlos / Moretti, Lorenzo / Mameli, Maria Grazia / Fabi, Bianca / Sorcini, Daniele / Stella, Arianna / Giancola, Raffaella / Guardalupi, Francesco / Ulbar, Francesca /
    Plebani, Sara / Guarente, Valerio / Rosati, Emanuela / Di Nicola, Marta / Marchioni, Michele / Di Ianni, Mauro / Sportoletti, Paolo

    Frontiers in oncology

    2021  Volume 11, Page(s) 668573

    Abstract: NOTCH1 mutations and deregulated signal have been commonly found in chronic lymphocytic leukemia (CLL) patients. Whereas the impact ... ...

    Abstract NOTCH1 mutations and deregulated signal have been commonly found in chronic lymphocytic leukemia (CLL) patients. Whereas the impact of
    Language English
    Publishing date 2021-05-26
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2021.668573
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Clinical-Grade Expanded Regulatory T Cells Are Enriched with Highly Suppressive Cells Producing IL-10, Granzyme B, and IL-35.

    Ulbar, Francesca / Villanova, Ida / Giancola, Raffaella / Baldoni, Stefano / Guardalupi, Francesco / Fabi, Bianca / Olioso, Paola / Capone, Anita / Sola, Rosaria / Ciardelli, Sara / Del Papa, Beatrice / Brattelli, Antonello / Ricciardi, Ilda / Taricani, Stefano / Sabbatinelli, Giulia / Iuliani, Ornella / Passeri, Cecilia / Sportoletti, Paolo / Santarone, Stella /
    Pierini, Antonio / Calabrese, Giuseppe / Falzetti, Franca / Bonfini, Tiziana / Accorsi, Patrizia / Ruggeri, Loredana / Martelli, Massimo Fabrizio / Velardi, Andrea / Di Ianni, Mauro

    Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation

    2020  Volume 26, Issue 12, Page(s) 2204–2210

    Abstract: In the setting of T cell-depleted, full-haplotype mismatched transplantation, adoptive immunotherapy with regulatory T cells (Tregs) and conventional T cells (Tcons) can prevent graft-versus-host disease (GVHD) and improve post-transplantation ... ...

    Abstract In the setting of T cell-depleted, full-haplotype mismatched transplantation, adoptive immunotherapy with regulatory T cells (Tregs) and conventional T cells (Tcons) can prevent graft-versus-host disease (GVHD) and improve post-transplantation immunologic reconstitution and is associated with a powerful graft-versus-leukemia effect. To improve the purity and the quantity of the infused Tregs, good manufacturing practices (GMP)-compatible expansion protocols are needed. Here we expanded Tregs using an automated, clinical-grade protocol. Cells were extensively characterized in vitro, and their efficiency was tested in vivo in a mouse model. Tregs were selected by CliniMacs (CD4
    MeSH term(s) Animals ; Forkhead Transcription Factors ; Graft vs Host Disease/prevention & control ; Granzymes ; Interleukin-10 ; Mice ; T-Lymphocytes, Regulatory
    Chemical Substances Forkhead Transcription Factors ; Interleukin-10 (130068-27-8) ; Granzymes (EC 3.4.21.-)
    Language English
    Publishing date 2020-09-19
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1474865-4
    ISSN 1523-6536 ; 1083-8791
    ISSN (online) 1523-6536
    ISSN 1083-8791
    DOI 10.1016/j.bbmt.2020.08.034
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5082: Show issues Location:
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    Zs.MO 462: Show issues

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