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  1. Article ; Online: Balloon Angioplasty of the Radial Artery to Solve a Challenging Radial Sheath Insertion.

    Talanas, Giuseppe / Guarino, Simona / Canonico, Mario Enrico / Parodi, Guido

    The Journal of invasive cardiology

    2020  Volume 33, Issue 1, Page(s) E69

    Abstract: The inability to advance the dedicated wire of the transradial sheath in a radial artery with a good pulsatile blood flow is a very rare event. In this case, the advancement of a high-performance 0.014 inch coronary wire is the only option to gain the ... ...

    Abstract The inability to advance the dedicated wire of the transradial sheath in a radial artery with a good pulsatile blood flow is a very rare event. In this case, the advancement of a high-performance 0.014 inch coronary wire is the only option to gain the vessel. Then, if the transradial sheath is stuck in the proximal radial artery wall, balloon angioplasty of the radial artery may allow successful reinsertion of the transradial sheath. This technique allows the preservation of radial artery access, avoiding a shift to an alternative arterial approach.
    MeSH term(s) Angioplasty, Balloon ; Angioplasty, Balloon, Coronary ; Coronary Angiography ; Humans ; Radial Artery/surgery
    Language English
    Publishing date 2020-12-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1154372-3
    ISSN 1557-2501 ; 1042-3931
    ISSN (online) 1557-2501
    ISSN 1042-3931
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 3701: Show issues Location:
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  2. Article ; Online: Platelet inhibition with orodispersible ticagrelor in acute coronary syndromes according to morphine use: the TASTER study final results.

    Parodi, Guido / Dossi, Filippo / Raccis, Mario / Talanas, Giuseppe / Mura, Enrico / Siciliano, Roberta / Guarino, Simona / Marini, Alessandro / Franca, Paolo / Saba, Pier Sergio / Sanna, Giuseppe D / Canonico, Mario E

    European heart journal. Cardiovascular pharmacotherapy

    2023  Volume 9, Issue 8, Page(s) 692–700

    Abstract: Aim: To date, it is still unknown whether orodispersible tablet (ODT) ticagrelor might represent a suitable way to reach a proper antiaggregation in acute coronary syndrome (ACS) patients receiving morphine. Aim of the present study was to evaluate ... ...

    Abstract Aim: To date, it is still unknown whether orodispersible tablet (ODT) ticagrelor might represent a suitable way to reach a proper antiaggregation in acute coronary syndrome (ACS) patients receiving morphine. Aim of the present study was to evaluate platelet inhibition with 180 mg ticagrelor loading dose (LD) administered as ODT compared with standard coated tablet ticagrelor formulation in ACS patients undergoing percutaneous coronary intervention (PCI) according to morphine use.
    Methods and results: One-hundred and 30 patients presenting with STEMI or very high-risk NSTE-ACS were randomly assigned to receive ODT or standard ticagrelor LD. Potential morphine-ticagrelor interaction was assessed by stratified randomization according to morphine use. Platelet reactivity was evaluated by Platelet Reactivity Units (PRU) VerifyNow™ 1, 2, 4, and 6 h after ticagrelor LD. The primary endpoint was residual platelet reactivity 1 h after LD across the two ticagrelor formulation and according to morphine use. Safety endpoints were major bleedings and other in-hospital ticagrelor administration-related adverse events. One hour after LD, PRU median value was higher in morphine-treated patients (N = 32) as compared with patients not receiving morphine (N = 98; PRU = 187 [70-217]) vs. 73 [7-187]; P = 0.012). In patients with morphine, 1-h PRU values were similar between study groups (192 [114-236] vs. 173 [16-215] in ODT and standard tablet ticagrelor, respectively). Similarly, in patients without morphine, 1-h PRU values were not significantly different between study groups (69 [8-152] vs. 110 [6-193] in ODT and standard tablet ticagrelor, respectively). Platelet reactivity appeared similar in the 2 study arms at 2, 4, and 6 h after LD. No significant difference was observed among patients with or without morphine regarding in-hospital adverse events or drug side-effects, even if a reinfarction due to acute stent thrombosis was observed in a patient treated with morphine.
    Conclusions: There was no difference between ODT and standard ticagrelor tablets in terms of post-LD residual platelet reactivity, percentage of platelet inhibition or safety regardless to morphine use.
    MeSH term(s) Humans ; Ticagrelor/adverse effects ; Acute Coronary Syndrome/diagnosis ; Acute Coronary Syndrome/drug therapy ; Platelet Aggregation Inhibitors/adverse effects ; Percutaneous Coronary Intervention/adverse effects ; Percutaneous Coronary Intervention/methods ; Adenosine/adverse effects ; Tablets ; Morphine Derivatives
    Chemical Substances Ticagrelor (GLH0314RVC) ; Platelet Aggregation Inhibitors ; Adenosine (K72T3FS567) ; Tablets ; Morphine Derivatives
    Language English
    Publishing date 2023-08-15
    Publishing country England
    Document type Randomized Controlled Trial ; Journal Article
    ZDB-ID 2808613-2
    ISSN 2055-6845 ; 2055-6837
    ISSN (online) 2055-6845
    ISSN 2055-6837
    DOI 10.1093/ehjcvp/pvad061
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Impact of glucose-6-phosphate dehydrogenase deficiency on the severity of coronary atherosclerosis in patients with acute coronary syndromes.

    Sanna, Giuseppe D / Canonico, Mario E / Siciliano, Roberta / Guarino, Simona / Montereggi, Francesco / Ponti, Enrico / Corda, Giulia / Talanas, Giuseppe / Parodi, Guido

    Journal of cardiovascular medicine (Hagerstown, Md.)

    2021  Volume 22, Issue 11, Page(s) 813–817

    Abstract: Aims: The impact of glucose-6-phosphate dehydrogenase (G6PD) deficiency on coronary atherosclerosis has not been clearly investigated so far. We aimed to assess the effects of G6PD deficiency on the extent and complexity of coronary atherosclerosis in a ...

    Abstract Aims: The impact of glucose-6-phosphate dehydrogenase (G6PD) deficiency on coronary atherosclerosis has not been clearly investigated so far. We aimed to assess the effects of G6PD deficiency on the extent and complexity of coronary atherosclerosis in a large unselected cohort of consecutive patients with acute coronary syndromes (ACS).
    Methods: We studied 623 consecutive patients presenting with ACS and undergoing coronary angiography and percutaneous coronary intervention (PCI). G6PD activity was quantitatively measured in all individuals using a biochemical assay based on the G6PD/6GPD ratio in erythrocytes. Individuals were defined as deficient when the ratio was less than 0.80. The severity and complexity of coronary atherosclerosis were assessed by SYNTAX score at baseline angiography.
    Results: Fifty-six patients (9%) showed G6PD deficiency. Severe (i.e. enzymatic activity < 0.10) G6PD deficiency was detected in 33 (5.3%) individuals, mainly of male sex (n = 32). Overall, the cardiovascular risk profile was similar between patients with G6PD deficiency and controls. Patients with G6PD deficiency showed similar severity and complexity of coronary atherosclerosis as compared to control patients; accordingly, the SYNTAX score (15 vs. 14.5, P = 0.90, respectively, in G6PD-deficent patients and controls), and all its components were similar between deficient individuals and controls. The only independent predictor of a SYNTAX score of more than 22 was patients' age (odds ratio 1.035, 95% confidence interval 1.018-1.051; P < 0.001).
    Conclusion: G6PD deficiency does not impact on the extent and complexity of coronary atherosclerosis assessed by coronary angiography in patents presenting with ACS.
    MeSH term(s) Acute Coronary Syndrome/complications ; Acute Coronary Syndrome/physiopathology ; Acute Coronary Syndrome/therapy ; Aged ; Cohort Studies ; Coronary Angiography ; Coronary Artery Disease/complications ; Coronary Artery Disease/physiopathology ; Cross-Sectional Studies ; Female ; Glucosephosphate Dehydrogenase/blood ; Glucosephosphate Dehydrogenase Deficiency/complications ; Glucosephosphate Dehydrogenase Deficiency/epidemiology ; Humans ; Logistic Models ; Male ; Middle Aged ; Percutaneous Coronary Intervention ; Severity of Illness Index
    Chemical Substances Glucosephosphate Dehydrogenase (EC 1.1.1.49)
    Language English
    Publishing date 2021-07-07
    Publishing country United States
    Document type Journal Article ; Observational Study
    ZDB-ID 2223461-5
    ISSN 1558-2035 ; 1558-2027
    ISSN (online) 1558-2035
    ISSN 1558-2027
    DOI 10.2459/JCM.0000000000001227
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5210: Show issues Location:
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    Zs.MO 559: Show issues

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  4. Article ; Online: Not-high before-treatment platelet reactivity in patients with STEMI: prevalence, clinical characteristics, response to therapy and outcomes.

    Canonico, Mario E / Sanna, Giuseppe D / Siciliano, Roberta / Guarino, Simona / Bellandi, Benedetta / Scudiero, Fernando / Saba, Pier Sergio / Esposito, Giovanni / Alexopoulos, Dimitrios / Parodi, Guido

    Platelets

    2021  Volume 33, Issue 3, Page(s) 390–397

    Abstract: Platelet reactivity (PR) has been indicated as a pathophysiological key element for ST-Elevation Myocardial Infarction (STEMI) development. Patients with not-high before-treatment platelet reactivity (NHPR) have been poorly studied so far. The aim of ... ...

    Abstract Platelet reactivity (PR) has been indicated as a pathophysiological key element for ST-Elevation Myocardial Infarction (STEMI) development. Patients with not-high before-treatment platelet reactivity (NHPR) have been poorly studied so far. The aim of this study is to investigate the prevalence, clinical characteristics, response to therapy and outcomes of baseline prior to treatment NHPR among patients with STEMI undergoing primary PCI.We analyzed the data from 358 STEMI patients with assessment of PR by VerifyNow before P2Y
    MeSH term(s) Blood Platelets/metabolism ; Female ; Humans ; Male ; Middle Aged ; Precision Medicine/methods ; Prevalence ; ST Elevation Myocardial Infarction/blood ; ST Elevation Myocardial Infarction/physiopathology ; Treatment Outcome
    Language English
    Publishing date 2021-04-15
    Publishing country England
    Document type Journal Article
    ZDB-ID 1034283-7
    ISSN 1369-1635 ; 0953-7104
    ISSN (online) 1369-1635
    ISSN 0953-7104
    DOI 10.1080/09537104.2021.1915973
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Orodispersible Ticagrelor in Acute Coronary Syndromes: The TASTER Study.

    Parodi, Guido / Talanas, Giuseppe / Mura, Enrico / Canonico, Mario E / Siciliano, Roberta / Guarino, Simona / Marini, Alessandro / Dossi, Filippo / Franca, Paolo / Raccis, Mario / Saba, Pier Sergio / Sanna, Giuseppe D

    Journal of the American College of Cardiology

    2021  Volume 78, Issue 3, Page(s) 292–294

    MeSH term(s) Acute Coronary Syndrome/drug therapy ; Administration, Oral ; Aged ; Dose-Response Relationship, Drug ; Drug Compounding/methods ; Humans ; Male ; Middle Aged ; Platelet Aggregation Inhibitors ; Ticagrelor/administration & dosage ; Ticagrelor/therapeutic use
    Chemical Substances Platelet Aggregation Inhibitors ; Ticagrelor (GLH0314RVC)
    Language English
    Publishing date 2021-07-15
    Publishing country United States
    Document type Letter ; Research Support, Non-U.S. Gov't
    ZDB-ID 605507-2
    ISSN 1558-3597 ; 0735-1097
    ISSN (online) 1558-3597
    ISSN 0735-1097
    DOI 10.1016/j.jacc.2021.05.015
    Database MEDical Literature Analysis and Retrieval System OnLINE

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