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  1. Article ; Online: Management of Anterior Open Bite and Skeletal Class II Hyperdivergent Patient with Clear Aligner Therapy.

    Gudhimella, Sudha / Gandhi, Vaibhav / Schiro, Nichole Leigh / Janakiraman, Nandakumar

    Turkish journal of orthodontics

    2022  Volume 35, Issue 2, Page(s) 139–149

    Abstract: In orthodontics, patients with hyperdivergent facial types or problems in the vertical dimension are often challenging to treat with predictable treatment results. Conventionally along with fixed appliances, a headgear, posterior bite block, extraction, ... ...

    Abstract In orthodontics, patients with hyperdivergent facial types or problems in the vertical dimension are often challenging to treat with predictable treatment results. Conventionally along with fixed appliances, a headgear, posterior bite block, extraction, temporary anchorage devices, or orthognathic surgery are preferable approaches to treat such patients. This case report illustrates a non-extraction, non-surgical orthodontic treatment of 5 mm anterior open bite in a non-growing adult patient, utilizing clear aligner therapy.
    Language English
    Publishing date 2022-07-02
    Publishing country Turkey
    Document type Journal Article
    ISSN 2148-9505
    ISSN (online) 2148-9505
    DOI 10.5152/TurkJOrthod.2022.21053
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  2. Article ; Online: Variability associated with maxillary infrazygomatic crest and palatal bone width, height, and angulation in subjects with different vertical facial growth types: a retrospective cone-beam computed tomography study.

    Patel, Bhumika / De Rose, Jessica / Nash, Jansen / Sekula, Michael / Gioia, Carl / Deguchi, Toru / Gudhimella, Sudha / Gandhi, Vaibhav

    The Angle orthodontist

    2024  Volume 94, Issue 3, Page(s) 313–319

    Abstract: Objectives: To assess the infrazygomatic crest (IZC) and palatal bone width, height, and angulation in patients with different vertical facial growth types as potential miniscrew insertion sites.: Materials and methods: In this retrospective cone- ... ...

    Abstract Objectives: To assess the infrazygomatic crest (IZC) and palatal bone width, height, and angulation in patients with different vertical facial growth types as potential miniscrew insertion sites.
    Materials and methods: In this retrospective cone-beam computed tomography study, 162 subjects (81 males and 81 females, mean age 16.05 ± 0.65 years) were included. They were divided into three groups (hypodivergent, normodivergent, and hyperdivergent) based on the Frankfort mandibular plane angle. Ten buccal bone measurements were made at two different coronal sections: maxillary first molar mesiobuccal and distobuccal roots (bilaterally). Six palatal bone measurements were made on a sagittal section at the maxillary central incisors (bilaterally). A total of 32 measurements per subject were considered in the study.
    Results: No significant difference was observed for the IZC (width and angle) at the maxillary first molar mesiobuccal root. A comparison of normodivergent and hyperdivergent groups for buccal width at the distobuccal root of the first molar showed significant differences. Palatal bone thickness at the level of 2 mm distal to the apex of the central incisor was significantly higher for the hyperdivergent group (10.43 mm) compared with the normodivergent (7.58 mm) and hypodivergent groups (7.83 mm).
    Conclusions: Hyperdivergent subjects tend to present a longer and deeper IZC and increased palatal bone thickness compared with other groups. The recommended insertion angle for the IZC mini-implant at 3 mm from the alveolar crest should be between 75.5° and 77°.
    MeSH term(s) Male ; Female ; Humans ; Adolescent ; Retrospective Studies ; Maxilla/diagnostic imaging ; Palate/diagnostic imaging ; Cone-Beam Computed Tomography/methods ; Face
    Language English
    Publishing date 2024-02-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 390289-4
    ISSN 1945-7103 ; 0003-3219
    ISSN (online) 1945-7103
    ISSN 0003-3219
    DOI 10.2319/062023-430.1
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  3. Article: Comparison of anterior maxillary and mandibular alveolar parameters in African American and Caucasian women: A retrospective pilot study.

    Renaud, Lauren / Gandhi, Vaibhav / West, Cailynn / Gudhimella, Sudha / Janakiraman, Nandakumar

    Imaging science in dentistry

    2021  Volume 51, Issue 2, Page(s) 175–185

    Abstract: Purpose: The primary objective of this study was to analyze the thickness and height of alveolar bone around the maxillary and mandibular incisors. Additionally, this study aimed to compare bone parameters between Caucasian (CC) and African American (AA) ...

    Abstract Purpose: The primary objective of this study was to analyze the thickness and height of alveolar bone around the maxillary and mandibular incisors. Additionally, this study aimed to compare bone parameters between Caucasian (CC) and African American (AA) female patients.
    Materials and methods: In this retrospective pilot study, 50 female subjects (25 CC and 25 AA) were included. The inclusion criteria were AA or CC women between the ages of 18 and 50 with a normo-divergent facial pattern and Angle's class I, end-on class II, or mild class III malocclusion. The distance from the cementoenamel junction (CEJ) to the buccal and lingual alveolar crest; the alveolar ridge thickness at the mid-root and apex; and the buccal and lingual bone thickness at 3, 6, and 9 mm from the CEJ were measured.
    Results: No significant difference was found (
    Conclusion: There were no differences in maxillomandibular anterior alveolar bone measurements between normo-divergent adult AA and CC women, except for a few parameters at varying locations. However, future studies can be planned based the current pilot study data, which may provide valuable information.
    Language English
    Publishing date 2021-03-11
    Publishing country Korea (South)
    Document type Journal Article
    ZDB-ID 2631801-5
    ISSN 2233-7830 ; 2233-7822
    ISSN (online) 2233-7830
    ISSN 2233-7822
    DOI 10.5624/isd.20200323
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  4. Article ; Online: Racial and gender differences of cervical vertebral maturation staging between African Americans versus Caucasian patients of various age groups: A retrospective study.

    Gudhimella, Sudha / Gandhi, Vaibhav / Glatt, Brian / Wong, Ariel / Wood, Clara / Janakiraman, Nandakumar / Spiller, Robert / Chandiramani, Sunita

    International orthodontics

    2022  Volume 20, Issue 1, Page(s) 100606

    Abstract: Background and objective: The primary purpose of this study was to compare CVM staging between African American (AA) and Caucasian (CC) subjects, grouped based on gender. The secondary objectives were to conduct a CVM comparison of (1) male vs. female ... ...

    Abstract Background and objective: The primary purpose of this study was to compare CVM staging between African American (AA) and Caucasian (CC) subjects, grouped based on gender. The secondary objectives were to conduct a CVM comparison of (1) male vs. female subjects, grouped based on their race, and (2) AA vs. CC subjects, categorized based on their age group.
    Materials and methods: All patients between 8-18 years of age (University of XXX), meeting the criteria, were included between the period of the year 2007 to 2020. Three blinded independent evaluators analysed the lateral cephalograms for a 6-stage CVM system (CS1 to CS6) as described by McNamara and Franchi. Samples were divided based on race, gender, and age to conduct the statistical analysis for racial and gender comparisons.
    Results: Out of the initial 1,300 lateral cephalograms, 1,276 with the mean age: 12.7 years SD 2.5 years, and median CVM: 4 (IQR: 25% percentile- 2 and 75% percentile- 4) were included. Gender-specific racial age comparison showed no significant differences for male subjects for most of the CVM stages (P>0.05). Overall and race-specific gender comparison of age showed significant differences for almost all CVM stages (P<0.05). No significant difference of CVM was found on racial comparison for overall, females (P=0.6131) or males (P=0.0825) subjects. On age-specific racial comparison, AA girls (8-10 years) were skeletally more mature than CC girls (P=0.0143); over 14-year-old CC girls (P<0.0001) and over 16-year-old CC boys (P=0.0008), being skeletally more mature than AA boys of the same age.
    Conclusions: There was no significant difference between AA and CC subjects on gender-specific comparisons for most of the CVM stages. A significant difference of age was observed for most of the CVM stage between male and female subjects on race-specific comparisons. Female patients were ahead in skeletal maturity as compared to males for each CVM stage. The CVM for 8-12-year-old AA females was significantly higher than that of the CC females, whereas the CVM for>14-year-old CC females was significantly higher than AA females.
    MeSH term(s) Adolescent ; African Americans ; Age Determination by Skeleton ; Cephalometry ; Cervical Vertebrae/diagnostic imaging ; Child ; Female ; Humans ; Male ; Retrospective Studies ; Sex Factors
    Language English
    Publishing date 2022-01-03
    Publishing country France
    Document type Journal Article
    ISSN 1879-680X
    ISSN (online) 1879-680X
    DOI 10.1016/j.ortho.2021.100606
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  5. Article ; Online: A rodent model using skeletal anchorage and low forces for orthodontic tooth movement.

    Gudhimella, Sudha / Ibrahim, Abdelhamed Y / Karanth, Divakar / Kluemper, Alex M / Westgate, Philip M / Puleo, David A / Huja, Sarandeep S

    American journal of orthodontics and dentofacial orthopedics : official publication of the American Association of Orthodontists, its constituent societies, and the American Board of Orthodontics

    2019  Volume 155, Issue 2, Page(s) 254–263

    Abstract: Introduction: Nonhuman animal models have been used extensively to study orthodontic tooth movement (OTM). However, rodent models have disadvantages, including a reported reduction in bone volume during OTM. The purpose of this study was to determine ... ...

    Abstract Introduction: Nonhuman animal models have been used extensively to study orthodontic tooth movement (OTM). However, rodent models have disadvantages, including a reported reduction in bone volume during OTM. The purpose of this study was to determine the viability of a skeletal anchorage and the effect of low force (∼3 cN) on interradicular bone volume during OTM.
    Methods: Ninety Sprague-Dawley rats were divided into 5 time points. A miniscrew and a nickel titanium coil spring placed a load of 3 cN (experimental) or 0 cN (sham) on the maxillary first molar in a split-mouth design. Displacement of the first molar and bone volume/total volume (BV/TV) in the interradicular region were quantified.
    Results: The success rate of the miniscrew was 98.9% (89 out of 90). Linear and angular tooth movement increased steadily (mean 0.1 mm/wk, 0.48 mm at 40 days). BV/TV was significantly reduced between the tooth movement and non-tooth movement sides in the 3 cN group: by 13%, 23%, 15%, 23%, and 16% at 3, 7, 14, 28, and 40 days, respectively.
    Conclusions: Our model resulted in efficient OTM without skeletal anchorage failure. BV/TV reduction was lower than in previous reports. This novel validated model is likely to be the basis for future studies.
    MeSH term(s) Animals ; Male ; Maxilla/anatomy & histology ; Models, Animal ; Organ Size ; Orthodontic Anchorage Procedures ; Rats ; Rats, Sprague-Dawley ; Tooth Movement Techniques/methods
    Language English
    Publishing date 2019-02-04
    Publishing country United States
    Document type Journal Article
    ZDB-ID 356699-7
    ISSN 1097-6752 ; 0889-5406 ; 0002-9416
    ISSN (online) 1097-6752
    ISSN 0889-5406 ; 0002-9416
    DOI 10.1016/j.ajodo.2018.03.022
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    In stock of ZB MED Cologne/Königswinter

    Ul III Zs.73: Show issues Location:
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  6. Article ; Online: Bone biology-related gingival transcriptome in ageing and periodontitis in non-human primates.

    Pandruvada, Subramanya N / Gonzalez, Octavio A / Kirakodu, Sreenatha / Gudhimella, Sudha / Stromberg, Arnold J / Ebersole, Jeffrey L / Orraca, Luis / Gonzalez-Martinez, Janis / Novak, Michael J / Huja, Sarandeep S

    Journal of clinical periodontology

    2016  Volume 43, Issue 5, Page(s) 408–417

    Abstract: Aim: Cellular and molecular immunoinflammatory changes in gingival tissues drive alveolar bone loss in periodontitis. Since ageing is a risk factor for periodontitis, we sought to identify age-related gingival transcriptome changes associated with bone ... ...

    Abstract Aim: Cellular and molecular immunoinflammatory changes in gingival tissues drive alveolar bone loss in periodontitis. Since ageing is a risk factor for periodontitis, we sought to identify age-related gingival transcriptome changes associated with bone metabolism in both healthy and in naturally occurring periodontitis.
    Materials and methods: Adult (12-16 years) and aged (18-23 years) non-human primates (M. mulatta) (n = 24) were grouped into healthy and periodontitis. Gingival tissue samples were obtained and subjected to microarray analysis using the Gene Chip Macaque Genome Array. Gene expression profiles involved in osteoclast/osteoblast proliferation, adhesion and function were evaluated and compared across and between the age groups. QPCR was also performed on selected genes to validate microarray data.
    Results: Healthy aged tissues showed a gene profile expression that suggest enhancement of osteoclastic adhesion, proliferation/survival and function (SPP1, TLR4, MMP8 and TFEC) and impaired osteoblastic activity (SMEK3P and SMAD5). The gingival transcriptome in both adult and aged animals with naturally occurring periodontitis (FOS, IL6, TLR4, MMP9, MMP10 and SPP1 genes) was consistent with a local inflammatory response driving towards bone/connective tissue destruction.
    Conclusion: A pro-osteoclastogenic gingival transcriptome is associated with periodontitis irrespective of age; however; a greater bone-destructive molecular environment is associated with ageing in healthy tissues.
    MeSH term(s) Adolescent ; Aging ; Alveolar Bone Loss ; Animals ; Gingiva ; Humans ; Macaca mulatta ; Periodontitis ; Transcriptome ; Young Adult
    Language English
    Publishing date 2016-04-06
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 188647-2
    ISSN 1600-051X ; 0303-6979
    ISSN (online) 1600-051X
    ISSN 0303-6979
    DOI 10.1111/jcpe.12528
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