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  1. AU="Gudymo, Andrei S"
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  1. Article: Immunogenic and Protective Properties of Recombinant Hemagglutinin of Influenza A (H5N8) Virus.

    Rudometova, Nadezhda B / Fando, Anastasia A / Kisakova, Lyubov A / Kisakov, Denis N / Borgoyakova, Mariya B / Litvinova, Victoria R / Yakovlev, Vladimir A / Tigeeva, Elena V / Vahitov, Danil I / Sharabrin, Sergey V / Shcherbakov, Dmitriy N / Evseenko, Veronika I / Ivanova, Ksenia I / Gudymo, Andrei S / Ilyicheva, Tatiana N / Marchenko, Vasiliy Yu / Ilyichev, Alexander A / Rudometov, Andrey P / Karpenko, Larisa I

    Vaccines

    2024  Volume 12, Issue 2

    Abstract: In this study, we characterized recombinant hemagglutinin (HA) of influenza A (H5N8) virus produced in Chinese hamster ovary cells (CHO-K1s). Immunochemical analysis showed that the recombinant hemagglutinin was recognized by the serum of ferrets ... ...

    Abstract In this study, we characterized recombinant hemagglutinin (HA) of influenza A (H5N8) virus produced in Chinese hamster ovary cells (CHO-K1s). Immunochemical analysis showed that the recombinant hemagglutinin was recognized by the serum of ferrets infected with influenza A (H5N8) virus, indicating that its antigenic properties were retained. Two groups of Balb/c mice were immunized with intramuscular injection of recombinant hemagglutinin or propiolactone inactivated A/Astrakhan/3212/2020 (H5N8) influenza virus. The results demonstrated that both immunogens induced a specific antibody response as determined by ELISA. Virus neutralization assay revealed that sera of immunized animals were able to neutralize A/turkey/Stavropol/320-01/2020 (H5N8) influenza virus-the average neutralizing titer was 2560. Immunization with both recombinant HA/H5 hemagglutinin and inactivated virus gave 100% protection against lethal H5N8 virus challenge. This study shows that recombinant HA (H5N8) protein may be a useful antigen candidate for developing subunit vaccines against influenza A (H5N8) virus with suitable immunogenicity and protective efficacy.
    Language English
    Publishing date 2024-01-29
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2703319-3
    ISSN 2076-393X
    ISSN 2076-393X
    DOI 10.3390/vaccines12020143
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Human Adenovirus and Influenza A Virus Exacerbate SARS-CoV-2 Infection in Animal Models.

    Svyatchenko, Victor A / Ternovoi, Vladimir A / Lutkovskiy, Roman Y / Protopopova, Elena V / Gudymo, Andrei S / Danilchenko, Nataliya V / Susloparov, Ivan M / Kolosova, Nataliya P / Ryzhikov, Alexander B / Taranov, Oleg S / Omigov, Vladimir V / Gavrilova, Elena V / Agafonov, Alexander P / Maksyutov, Rinat A / Loktev, Valery B

    Microorganisms

    2023  Volume 11, Issue 1

    Abstract: In this study, we investigated the features of the infectious process by simulating co-infection with SARS-CoV-2 and human adenovirus type 5 (HAdV-5) or influenza A virus (IAV) in vitro and in vivo. The determination of infectious activity of viruses and ...

    Abstract In this study, we investigated the features of the infectious process by simulating co-infection with SARS-CoV-2 and human adenovirus type 5 (HAdV-5) or influenza A virus (IAV) in vitro and in vivo. The determination of infectious activity of viruses and digital PCR demonstrated that during simultaneous and sequential HAdV-5 followed by SARS-CoV-2 infection in vitro and in vivo, the HAdV-5 infection does not interfere with replication of SARS-CoV-2. The hamsters co-infected and mono-infected with SARS-CoV-2 exhibited nearly identical viral titers and viral loads of SARS-CoV-2 in the lungs. The hamsters and ferrets co-infected by SARS-CoV-2- and IAV demonstrated more pronounced clinical manifestations than mono-infected animals. Additionally, the lung histological data illustrate that HAdV-5 or IAV and SARS-CoV-2 co-infection induces more severe pathological changes in the lungs than mono-infection. The expression of several genes specific to interferon and cytokine signaling pathways in the lungs of co-infected hamsters was more upregulated compared to single infected with SARS-CoV-2 animals. Thus, co-infection with HAdV-5 or IAV and SARS-CoV-2 leads to more severe pulmonary disease in animals.
    Language English
    Publishing date 2023-01-11
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2720891-6
    ISSN 2076-2607
    ISSN 2076-2607
    DOI 10.3390/microorganisms11010180
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Severe cases of seasonal influenza and detection of seasonal A(H1N2) in Russia in 2018-2019.

    Kolosova, Natalia P / Ilyicheva, Tatyana N / Danilenko, Alexey V / Svyatchenko, Svetlana V / Goncharova, Natalia I / Bulanovich, Julia A / Torzhkova, Polina Yu / Durymanov, Alexander G / Gudymo, Andrei S / Shvalov, Alexander N / Susloparov, Ivan M / Tregubchak, Tatyana V / Gavrilova, Elena V / Maksyutov, Rinat A / Ryzhikov, Alexander B

    Archives of virology

    2020  Volume 165, Issue 9, Page(s) 2045–2051

    Abstract: Data obtained from monitoring cases of severe influenza, cases of vaccinated individuals, and unique cases were used to describe influenza viruses that circulated in Russia in the 2018-2019 epidemic season. A high proportion of the mutations D222G/N in A( ...

    Abstract Data obtained from monitoring cases of severe influenza, cases of vaccinated individuals, and unique cases were used to describe influenza viruses that circulated in Russia in the 2018-2019 epidemic season. A high proportion of the mutations D222G/N in A(H1N1)pdm09 HA was detected in fatal cases. Viruses of the B/Victoria lineage with deletions in HA were detected in Russia, and a reassortant seasonal influenza A(H1N2) virus was identified. A C-terminal truncation in the NS1 protein was detected in a substantial proportion of A(H3N2) viruses.
    MeSH term(s) Genome, Viral ; Hemagglutinin Glycoproteins, Influenza Virus/genetics ; Humans ; Influenza A Virus, H1N2 Subtype/classification ; Influenza A Virus, H1N2 Subtype/genetics ; Influenza A Virus, H1N2 Subtype/isolation & purification ; Influenza A Virus, H3N2 Subtype/genetics ; Influenza A Virus, H3N2 Subtype/isolation & purification ; Influenza, Human/virology ; Phylogeny ; Reassortant Viruses/classification ; Reassortant Viruses/genetics ; Reassortant Viruses/isolation & purification ; Russia ; Seasons
    Chemical Substances Hemagglutinin Glycoproteins, Influenza Virus
    Language English
    Publishing date 2020-06-10
    Publishing country Austria
    Document type Journal Article
    ZDB-ID 7491-3
    ISSN 1432-8798 ; 0304-8608
    ISSN (online) 1432-8798
    ISSN 0304-8608
    DOI 10.1007/s00705-020-04699-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ud II Zs.110: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  4. Article: Severe cases of seasonal influenza and detection of seasonal A(H1N2) in Russia in 2018–2019

    Kolosova, Natalia P / Ilyicheva, Tatyana N / Danilenko, Alexey V / Svyatchenko, Svetlana V / Goncharova, Natalia I / Bulanovich, Julia A / Torzhkova, Polina Yu / Durymanov, Alexander G / Gudymo, Andrei S / Shvalov, Alexander N / Susloparov, Ivan M / Tregubchak, Tatyana V / Gavrilova, Elena V / Maksyutov, Rinat A / Ryzhikov, Alexander B

    Archives of virology. 2020 Sept., v. 165, no. 9

    2020  

    Abstract: Data obtained from monitoring cases of severe influenza, cases of vaccinated individuals, and unique cases were used to describe influenza viruses that circulated in Russia in the 2018–2019 epidemic season. A high proportion of the mutations D222G/N in A( ...

    Abstract Data obtained from monitoring cases of severe influenza, cases of vaccinated individuals, and unique cases were used to describe influenza viruses that circulated in Russia in the 2018–2019 epidemic season. A high proportion of the mutations D222G/N in A(H1N1)pdm09 HA was detected in fatal cases. Viruses of the B/Victoria lineage with deletions in HA were detected in Russia, and a reassortant seasonal influenza A(H1N2) virus was identified. A C-terminal truncation in the NS1 protein was detected in a substantial proportion of A(H3N2) viruses.
    Keywords Russia ; influenza ; virology ; viruses
    Language English
    Dates of publication 2020-09
    Size p. 2045-2051.
    Publishing place Springer Vienna
    Document type Article
    Note NAL-AP-2-clean
    ZDB-ID 7491-3
    ISSN 1432-8798 ; 0304-8608
    ISSN (online) 1432-8798
    ISSN 0304-8608
    DOI 10.1007/s00705-020-04699-z
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Bonn / Germany

    Z 70/128: Show issues

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  5. Article ; Online: Severe cases of seasonal influenza in Russia in 2017-2018.

    Kolosova, Natalia P / Ilyicheva, Tatyana N / Danilenko, Alexey V / Bulanovich, Julia A / Svyatchenko, Svetlana V / Durymanov, Alexander G / Goncharova, Natalia I / Gudymo, Andrei S / Shvalov, Alexander N / Susloparov, Ivan M / Marchenko, Vasiliy Y / Tregubchak, Tatyana V / Gavrilova, Elena V / Maksyutov, Rinat A / Ryzhikov, Alexander B

    PloS one

    2019  Volume 14, Issue 7, Page(s) e0220401

    Abstract: The 2017-2018 influenza epidemic season in Russia was characterized by a relatively low morbidity and mortality. We evaluated herd immunity prior to the 2017-2018 influenza season in hemagglutination inhibition assay, and performed characterization of ... ...

    Abstract The 2017-2018 influenza epidemic season in Russia was characterized by a relatively low morbidity and mortality. We evaluated herd immunity prior to the 2017-2018 influenza season in hemagglutination inhibition assay, and performed characterization of influenza viruses isolated from severe or fatal influenza cases and from influenza cases in people vaccinated in the fall of 2017. During the 2017-2018 epidemic season, 87 influenza A and B viruses were isolated and viruses of the 75 influenza cases, including selected viral isolates and viruses analyzed directly from the original clinical material, were genetically characterized. The analyzed A(H1N1)pdm09 viruses belonged to clade 6B.1, B/Yamagata-like viruses belonged to clade 3, and B/Victoria-like viruses belonged to clade 1A and they were antigenically similar to the corresponding vaccine strains. A(H3N2) viruses belonged to clade 3C.2a and were difficult to characterize antigenically and the analysis indicated antigenic differences from the corresponding egg-grown vaccine strain. The next generation sequencing revealed the presence of D222/G/N polymorphism in the hemagglutinin gene in 32% of the analyzed A(H1N1)pdm09 lethal cases. This study demonstrated the importance of monitoring D222G/N polymorphism, including detection of minor viral variants with the mutations, in the hemagglutinin gene of A(H1N1)pdm09 for epidemiological surveillance. One strain of influenza virus A(H1N1)pdm09 was resistant to oseltamivir and had the H275Y amino acid substitution in the NA protein. All other isolates were susceptible to NA inhibitors. Prior to the 2017-2018 epidemic season, 67.4 million people were vaccinated, which accounted for 46.6% of the country's population. Just before the epidemic season 33-47% and 24-30% of blood sera samples collected within the territory of Russia showed the presence of protective antibody titers against vaccine strains of influenza A and influenza B/Victoria-like, respectively. Mass vaccination of the population had evidently reduced the severity of the flu epidemic during the 2017-2018 influenza epidemic season in Russia.
    MeSH term(s) Adolescent ; Adult ; Child ; Child, Preschool ; Drug Resistance, Viral ; Epidemics ; Epidemiological Monitoring ; Female ; Hemagglutination Inhibition Tests ; Hemagglutinin Glycoproteins, Influenza Virus/genetics ; Humans ; Infant ; Infant, Newborn ; Influenza B virus/classification ; Influenza B virus/genetics ; Influenza B virus/immunology ; Influenza, Human/epidemiology ; Influenza, Human/virology ; Alphainfluenzavirus/classification ; Alphainfluenzavirus/genetics ; Alphainfluenzavirus/immunology ; Male ; Middle Aged ; Phylogeny ; Polymorphism, Genetic ; RNA, Viral/genetics ; Russia/epidemiology ; Young Adult
    Chemical Substances Hemagglutinin Glycoproteins, Influenza Virus ; RNA, Viral
    Language English
    Publishing date 2019-07-29
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0220401
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Correction: Severe cases of seasonal influenza in Russia in 2017-2018.

    Kolosova, Natalia P / Ilyicheva, Tatyana N / Danilenko, Alexey V / Bulanovich, Julia A / Svyatchenko, Svetlana V / Durymanov, Alexander G / Goncharova, Natalia I / Gudymo, Andrei S / Shvalov, Alexander N / Susloparov, Ivan M / Marchenko, Vasiliy Y / Tregubchak, Tatyana V / Gavrilova, Elena V / Maksyutov, Rinat A / Ryzhikov, Alexander B

    PloS one

    2019  Volume 14, Issue 12, Page(s) e0227382

    Abstract: This corrects the article DOI: 10.1371/journal.pone.0220401.]. ...

    Abstract [This corrects the article DOI: 10.1371/journal.pone.0220401.].
    Language English
    Publishing date 2019-12-27
    Publishing country United States
    Document type Published Erratum
    ISSN 1932-6203
    ISSN (online) 1932-6203
    DOI 10.1371/journal.pone.0227382
    Database MEDical Literature Analysis and Retrieval System OnLINE

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