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  1. Article: Radiosynthesis automation, non-human primate biodistribution and dosimetry of K

    Zhou, Yu-Peng / Wilks, Moses Q / Dhaynaut, Maeva / Guehl, Nicolas J / Moon, Sung-Hyun / Fakhri, Georges El / Normandin, Marc D / Brugarolas, Pedro

    bioRxiv : the preprint server for biology

    2023  

    Abstract: Purpose: 4-Aminopyridine (4AP) is a medication for the symptomatic treatment of multiple sclerosis. Several 4AP-based PET tracers have been developed for imaging demyelination. In preclinical studies, [ : Methods: Automated radiosynthesis was carried ...

    Abstract Purpose: 4-Aminopyridine (4AP) is a medication for the symptomatic treatment of multiple sclerosis. Several 4AP-based PET tracers have been developed for imaging demyelination. In preclinical studies, [
    Methods: Automated radiosynthesis was carried out using a GE TRACERlab FX-C Pro synthesis module. One male and one female adult rhesus macaques were used in the study. A high-resolution CT from cranial vertex to knee was acquired. PET data were collected using a dynamic acquisition protocol with 4 bed positions and 13 passes over a total scan time of ∼150 minutes. Based on the CT and PET images, volumes of interest (VOIs) were manually drawn for selected organs. Non-decay corrected time-activity curves (TACs) were extracted for each VOI. Radiation dosimetry and effective dose were calculated from the integrated TACs using OLINDA software.
    Results: Fully automated radiosynthesis of [
    Conclusion: The cGMP compliant automated radiosynthesis of [
    Language English
    Publishing date 2023-03-28
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.03.28.534386
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: PET imaging of M4 muscarinic acetylcholine receptors in rhesus macaques using [

    Belov, Vasily / Guehl, Nicolas J / Duvvuri, Sridhar / Iredale, Philip / Moon, Sung-Hyun / Dhaynaut, Maeva / Chakilam, Srinivas / MacDonagh, Alexander C / Rice, Peter A / Yokell, Daniel L / Renger, John J / El Fakhri, Georges / Normandin, Marc D

    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism

    2024  , Page(s) 271678X241238820

    Abstract: Stimulation of the ... ...

    Abstract Stimulation of the M
    Language English
    Publishing date 2024-03-13
    Publishing country United States
    Document type Journal Article
    ZDB-ID 604628-9
    ISSN 1559-7016 ; 0271-678X
    ISSN (online) 1559-7016
    ISSN 0271-678X
    DOI 10.1177/0271678X241238820
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    Zs.A 1663: Show issues Location:
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  3. Article: Radiosynthesis automation, non-human primate biodistribution and dosimetry of K

    Zhou, Yu-Peng / Wilks, Moses Q / Dhaynaut, Maeva / Guehl, Nicolas J / Vesper, Danielle R / Moon, Sung-Hyun / Rice, Peter A / El Fakhri, Georges / Normandin, Marc D / Brugarolas, Pedro

    EJNMMI research

    2024  Volume 14, Issue 1, Page(s) 43

    Abstract: Background: 4-Aminopyridine (4AP) is a medication for the symptomatic treatment of multiple sclerosis. Several 4AP-based PET tracers have been developed for imaging demyelination. In preclinical studies, [: Methods: Automated radiosynthesis was ... ...

    Abstract Background: 4-Aminopyridine (4AP) is a medication for the symptomatic treatment of multiple sclerosis. Several 4AP-based PET tracers have been developed for imaging demyelination. In preclinical studies, [
    Methods: Automated radiosynthesis was carried out using a GE TRACERlab FX-C Pro synthesis module. One male and one female adult rhesus macaques were used in the study. A high-resolution CT from cranial vertex to knee was acquired. PET data were collected using a dynamic acquisition protocol with four bed positions and 13 passes over a total scan time of ~ 150 min. Based on the CT and PET images, volumes of interest (VOIs) were manually drawn for selected organs. Non-decay corrected time-activity curves (TACs) were extracted for each VOI. Radiation dosimetry and effective dose were calculated from the integrated TACs using OLINDA software.
    Results: Fully automated radiosynthesis of [
    Conclusion: A cGMP-compatible automated radiosynthesis of [
    Language English
    Publishing date 2024-04-29
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2619892-7
    ISSN 2191-219X
    ISSN 2191-219X
    DOI 10.1186/s13550-024-01092-8
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  4. Article ; Online: Reply to: Fitting of late dynamic [

    Guehl, Nicolas J / Wooten, Dustin W / El Fakhri, Georges / Normandin, Marc D

    European journal of nuclear medicine and molecular imaging

    2020  Volume 47, Issue 13, Page(s) 2947–2949

    MeSH term(s) Humans ; Positron-Emission Tomography ; tau Proteins
    Chemical Substances tau Proteins
    Language English
    Publishing date 2020-06-18
    Publishing country Germany
    Document type Letter ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 8236-3
    ISSN 1619-7089 ; 0340-6997 ; 1619-7070
    ISSN (online) 1619-7089
    ISSN 0340-6997 ; 1619-7070
    DOI 10.1007/s00259-020-04927-3
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    Zs.A 1227: Show issues Location:
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  5. Article: Evaluation of

    Zhou, Yu-Peng / Normandin, Marc D / Belov, Vasily / Macdonald-Soccorso, Marina T / Moon, Sung-Hyun / Sun, Yang / Fakhri, Georges El / Guehl, Nicolas J / Brugarolas, Pedro

    bioRxiv : the preprint server for biology

    2023  

    Abstract: Gabapentin, a selective ligand for the α2δ subunit of voltage-dependent calcium channels, is an anticonvulsant medication used in the treatment of neuropathic pain, epilepsy and other neurological conditions. We recently described two radiofluorinated ... ...

    Abstract Gabapentin, a selective ligand for the α2δ subunit of voltage-dependent calcium channels, is an anticonvulsant medication used in the treatment of neuropathic pain, epilepsy and other neurological conditions. We recently described two radiofluorinated derivatives of gabapentin (
    Language English
    Publishing date 2023-10-18
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.09.01.555353
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Evaluation of

    Zhou, Yu-Peng / Normandin, Marc D / Belov, Vasily / Macdonald-Soccorso, Marina T / Moon, Sung-Hyun / Sun, Yang / El Fakhri, Georges / Guehl, Nicolas J / Brugarolas, Pedro

    ACS chemical neuroscience

    2023  Volume 14, Issue 23, Page(s) 4208–4215

    Abstract: Gabapentin, a selective ligand for the α2δ subunit of voltage-dependent calcium channels, is an anticonvulsant medication used in the treatment of neuropathic pain, epilepsy, and other neurological conditions. We recently described two radiofluorinated ... ...

    Abstract Gabapentin, a selective ligand for the α2δ subunit of voltage-dependent calcium channels, is an anticonvulsant medication used in the treatment of neuropathic pain, epilepsy, and other neurological conditions. We recently described two radiofluorinated derivatives of gabapentin (
    MeSH term(s) Animals ; Gabapentin/pharmacology ; Gabapentin/metabolism ; Macaca mulatta ; Positron-Emission Tomography/methods ; Brain/diagnostic imaging ; Brain/metabolism ; Neuralgia/metabolism
    Chemical Substances Gabapentin (6CW7F3G59X)
    Language English
    Publishing date 2023-11-10
    Publishing country United States
    Document type Journal Article
    ISSN 1948-7193
    ISSN (online) 1948-7193
    DOI 10.1021/acschemneuro.3c00593
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  7. Article ; Online: Correction to: Evaluation of pharmacokinetic modeling strategies for in-vivo quantification of tau with the radiotracer [

    Guehl, Nicolas J / Wooten, Dustin W / Yokell, Daniel L / Moon, Sung-Hyun / Dhaynaut, Maeva / Katz, Samantha / Moody, Kirsten A / Gharagouzloo, Codi / Kas, Aurélie / Johnson, Keith A / Fakhri, Georges El / Normandin, Marc D

    European journal of nuclear medicine and molecular imaging

    2023  Volume 50, Issue 4, Page(s) 1273

    Language English
    Publishing date 2023-01-05
    Publishing country Germany
    Document type Published Erratum
    ZDB-ID 8236-3
    ISSN 1619-7089 ; 0340-6997 ; 1619-7070
    ISSN (online) 1619-7089
    ISSN 0340-6997 ; 1619-7070
    DOI 10.1007/s00259-022-06102-2
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1227: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  8. Article ; Online: Injectable ice slurry for reducing pericardial adipose tissue.

    Shuhaiber, Jeffrey / Moradi Tuchayi, Sara / Bijari, Felicitas J / Guehl, Nicolas J / Wang, Ying / Farinelli, William A / Arkun, Knarik / El Fakhri, Georges / Anderson, Richard R / Garibyan, Lilit

    Lasers in surgery and medicine

    2023  Volume 55, Issue 7, Page(s) 674–679

    Abstract: Objectives: Excess pericardial adipose tissue (PAT) is associated with a higher risk of cardiovascular diseases. Currently, available methods for reducing PAT volume include weight loss through diet and exercise, weight loss with medications, and ... ...

    Abstract Objectives: Excess pericardial adipose tissue (PAT) is associated with a higher risk of cardiovascular diseases. Currently, available methods for reducing PAT volume include weight loss through diet and exercise, weight loss with medications, and bariatric surgery. However, these methods are all limited by low patient compliance to maintain the results. We have developed an injectable ice slurry that could selectively target and reduce subcutaneous adipose tissue volume. The aim of this study was to investigate the feasibility and safety of using injectable slurry to selectively reduce PAT volume in a preclinical large animal model.
    Methods: PAT in Yucatan swine was injected with slurry or room temperature control solution. All animals were imaged with baseline chest computed tomography (CT) before slurry injection and at 2 months after injection to quantify PAT volume. Specimens from injected and noninjected PAT were harvested for histology.
    Results: Slurry treatment of PAT was well tolerated in all animals. Slurry-induced selective cryolipolysis in treated PAT. CT imaging showed decrease in PAT volume in treated area at 8 weeks posttreatment compared to baseline, that was significantly different from control solution treated group (median [range]: -29.66 [-35.07 to -27.92]% vs. -1.50 [-11.69 to 8.69]% in control animals respectively, p < 0.05).
    Conclusions: This study demonstrated that slurry injection into PAT is feasible in a large animal model. Slurry injection was safe and effective in inducing selective cryolipolysis in PAT and reducing PAT volume. Slurry reduction of PAT could potentially serve as a novel treatment for cardiovascular diseases.
    MeSH term(s) Swine ; Animals ; Ice ; Cardiovascular Diseases ; Adipose Tissue/pathology ; Subcutaneous Fat ; Weight Loss
    Chemical Substances Ice
    Language English
    Publishing date 2023-07-18
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 604493-1
    ISSN 1096-9101 ; 0196-8092
    ISSN (online) 1096-9101
    ISSN 0196-8092
    DOI 10.1002/lsm.23709
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    Zs.A 1603: Show issues Location:
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  9. Article ; Online: Measurement of Cerebral Perfusion Indices from the Early Phase of [

    Guehl, Nicolas J / Dhaynaut, Maeva / Hanseeuw, Bernard J / Moon, Sung-Hyun / Lois, Cristina / Thibault, Emma / Fu, Jessie Fanglu / Price, Julie C / Johnson, Keith A / El Fakhri, Georges / Normandin, Marc D

    Journal of nuclear medicine : official publication, Society of Nuclear Medicine

    2023  Volume 64, Issue 6, Page(s) 968–975

    Abstract: 6-(fluoro- ...

    Abstract 6-(fluoro-
    MeSH term(s) Humans ; Alzheimer Disease/diagnostic imaging ; Brain/diagnostic imaging ; Positron-Emission Tomography/methods ; Cognitive Dysfunction/diagnostic imaging ; Aniline Compounds ; Cerebrovascular Circulation
    Chemical Substances Aniline Compounds
    Language English
    Publishing date 2023-03-30
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 80272-4
    ISSN 1535-5667 ; 0097-9058 ; 0161-5505 ; 0022-3123
    ISSN (online) 1535-5667
    ISSN 0097-9058 ; 0161-5505 ; 0022-3123
    DOI 10.2967/jnumed.122.265072
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    Zs.A 114: Show issues Location:
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    Zs.MO 328: Show issues

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  10. Article ; Online: Radiochemical Synthesis and Evaluation in Non-Human Primates of 3-[

    Guehl, Nicolas J / Neelamegam, Ramesh / Zhou, Yu-Peng / Moon, Sung-Hyun / Dhaynaut, Maeva / El Fakhri, Georges / Normandin, Marc D / Brugarolas, Pedro

    ACS chemical neuroscience

    2021  Volume 12, Issue 4, Page(s) 756–765

    Abstract: Demyelination, the loss of the protecting sheath of neurons, contributes to disability in many neurological diseases. In order to fully understand its role in different diseases and to monitor treatments aiming at reversing this process, it would be ... ...

    Abstract Demyelination, the loss of the protecting sheath of neurons, contributes to disability in many neurological diseases. In order to fully understand its role in different diseases and to monitor treatments aiming at reversing this process, it would be valuable to have PET radiotracers that can detect and quantify molecular changes involved in demyelination such as the uncovering and upregulation of the axonal potassium channels K
    MeSH term(s) 4-Aminopyridine ; Animals ; Brain/diagnostic imaging ; Haplorhini ; Positron-Emission Tomography ; Potassium Channels ; Radiochemistry
    Chemical Substances Potassium Channels ; 4-Aminopyridine (BH3B64OKL9)
    Language English
    Publishing date 2021-02-04
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ISSN 1948-7193
    ISSN (online) 1948-7193
    DOI 10.1021/acschemneuro.0c00791
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