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  1. Article ; Online: Pulmonary cryptococcosis in a non-immunosuppressed patient

    Pasquier, Grégoire / Guemas, Emilie / Sobanska, Loïc / Demar, Magalie

    Annales de biologie clinique

    2022  Volume 80, Issue 5, Page(s) 495–496

    Title translation Cryptococcose pulmonaire chez un patient immunocompétent
    MeSH term(s) Humans ; Cryptococcosis/diagnosis ; Cryptococcosis/drug therapy
    Language French
    Publishing date 2022-08-12
    Publishing country France
    Document type Journal Article
    ZDB-ID 418098-7
    ISSN 1950-6112 ; 0003-3898
    ISSN (online) 1950-6112
    ISSN 0003-3898
    DOI 10.1684/abc.2022.1748
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    Ud II Zs.203: Show issues Location:
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  2. Article ; Online: Automatic patient-level recognition of four

    Guemas, Emilie / Routier, Baptiste / Ghelfenstein-Ferreira, Théo / Cordier, Camille / Hartuis, Sophie / Marion, Bénédicte / Bertout, Sébastien / Varlet-Marie, Emmanuelle / Costa, Damien / Pasquier, Grégoire

    Microbiology spectrum

    2024  Volume 12, Issue 2, Page(s) e0144023

    Abstract: Malaria remains a global health problem, with 247 million cases and 619,000 deaths in 2021. Diagnosis ... ...

    Abstract Malaria remains a global health problem, with 247 million cases and 619,000 deaths in 2021. Diagnosis of
    MeSH term(s) Humans ; Plasmodium ; Malaria ; Malaria, Falciparum ; Algorithms ; Plasmodium falciparum ; Piperazines
    Chemical Substances RHC 3281 (33353-30-9) ; Piperazines
    Language English
    Publishing date 2024-01-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2807133-5
    ISSN 2165-0497 ; 2165-0497
    ISSN (online) 2165-0497
    ISSN 2165-0497
    DOI 10.1128/spectrum.01440-23
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: A Clustered Case Series of Mucorales Detection in Respiratory Samples from COVID-19 Patients in Intensive Care, France, August to September 2021.

    Guemas, Emilie / Cassaing, Sophie / Malavaud, Sandra / Fillaux, Judith / Chauvin, Pamela / Lelièvre, Lucie / Ruiz, Stéphanie / Riu, Béatrice / Berry, Antoine / Iriart, Xavier

    Journal of fungi (Basel, Switzerland)

    2022  Volume 8, Issue 3

    Abstract: While COVID-19-associated pulmonary aspergillosis is now well described in developed countries, COVID-19-associated mucormycosis (CAM) has seemed to remain quite rare in Europe. A retrospective study was performed between March 2020 to September 2021 ... ...

    Abstract While COVID-19-associated pulmonary aspergillosis is now well described in developed countries, COVID-19-associated mucormycosis (CAM) has seemed to remain quite rare in Europe. A retrospective study was performed between March 2020 to September 2021 among COVID-19 adult patients in the intensive care unit (ICU) at Toulouse Hospital (Southern France). PCR screening on respiratory samples, which target
    Language English
    Publishing date 2022-03-03
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2784229-0
    ISSN 2309-608X ; 2309-608X
    ISSN (online) 2309-608X
    ISSN 2309-608X
    DOI 10.3390/jof8030258
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  4. Article ; Online: Diagnosis of Congenital Toxoplasmosis: Performance of Four IgG and IgM Automated Assays at Birth in a Tricentric Evaluation.

    Avignon, Marine / Lévêque, Maude F / Guemas, Emilie / Sasso, Milène / Albaba, Sahar / Lachaud, Laurence / Fillaux, Judith

    Journal of clinical microbiology

    2022  Volume 60, Issue 5, Page(s) e0011522

    Abstract: For postnatal diagnosis of congenital toxoplasmosis (CT), the gold standard for the detection of anti- ...

    Abstract For postnatal diagnosis of congenital toxoplasmosis (CT), the gold standard for the detection of anti-
    MeSH term(s) Antibodies, Protozoan ; Female ; Humans ; Immunoglobulin G ; Immunoglobulin M ; Infant, Newborn ; Pregnancy ; Pregnancy Complications, Parasitic/diagnosis ; Toxoplasma ; Toxoplasmosis/diagnosis ; Toxoplasmosis, Congenital/diagnosis
    Chemical Substances Antibodies, Protozoan ; Immunoglobulin G ; Immunoglobulin M
    Language English
    Publishing date 2022-05-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 390499-4
    ISSN 1098-660X ; 0095-1137
    ISSN (online) 1098-660X
    ISSN 0095-1137
    DOI 10.1128/jcm.00115-22
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    Zs.A 1188: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  5. Article: Evaluation of the Performance of the Novodiag

    Chauvin, Pamela / Barba, Florie / Guemas, Emilie / Charpentier, Eléna / Cottrel, Claire / Fillaux, Judith / Valentin, Alexis / Baklouti, Sarah / Cassaing, Sophie / Ménard, Sandie / Berry, Antoine / Iriart, Xavier

    Pathogens (Basel, Switzerland)

    2023  Volume 12, Issue 7

    Abstract: Objectives: We aimed to assess the performance of the Novodiag: Methods: A panel of 167 selected stool samples was retrospectively analysed with the NSP assay and compared to routine microscopy and qPCR methods for the detection of pathogenic ... ...

    Abstract Objectives: We aimed to assess the performance of the Novodiag
    Methods: A panel of 167 selected stool samples was retrospectively analysed with the NSP assay and compared to routine microscopy and qPCR methods for the detection of pathogenic protozoa and microsporidia.
    Results: Whereas specificity was high for all protozoa and microsporidia, NSP sensitivity was strongly dependent on the comparative method used as reference. When compared to microscopic methods, NSP sensitivity was high (96.7 to 100%) for
    Conclusions: The overall performance of the NSP assay in the diagnosis of gastrointestinal protozoa and microsporidia seems to be better than or equivalent to that observed with microscopic methods but inferior to that obtainable with classical targeted qPCR.
    Language English
    Publishing date 2023-06-29
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2695572-6
    ISSN 2076-0817
    ISSN 2076-0817
    DOI 10.3390/pathogens12070889
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  6. Article ; Online: Effect of sulfadoxine-pyrimethamine chemoprophylaxis in pregnant women on selection of the new P. falciparum dhps quintuple mutant carrying the I431V mutation.

    Cohen, Olivia / Guemas, Emilie / Menard, Sandie / Tsague Kenfack, Martial / Talom Ngassa, Carine / Iriart, Xavier / Bidzogo Lebobo, Marlise / Ondobo Ekae, Celestin / Eboumbou, Carole / Tiyou Kenmeni, Calvin / Berry, Antoine

    The Journal of antimicrobial chemotherapy

    2022  Volume 78, Issue 3, Page(s) 665–668

    Abstract: Background: A new mutation in the Plasmodium falciparum dihydropteroate synthetase gene (pfdhps), I431V, has been identified in several countries of Central and West Africa. This mutation is mostly found in association with four other SNPs on pfdhps ( ... ...

    Abstract Background: A new mutation in the Plasmodium falciparum dihydropteroate synthetase gene (pfdhps), I431V, has been identified in several countries of Central and West Africa. This mutation is mostly found in association with four other SNPs on pfdhps (S436A, A437G, A581G and A613S), forming a quintuple mutant (vagKgs) and almost always associated with the Plasmodium falciparum dihydrofolate reductase gene (pfdhfr) CirnI (C50R, N51I, S108N) triple mutant. To date, nothing is known about the impact of this new pfdhps genotype on sulfadoxine-pyrimethamine (SP) resistance.
    Objectives: We sought to assess the prevalence of this pfdhps vagKgs quintuple mutant in two groups of pregnant women with malaria, one that took intermittent preventive treatment with sulfadoxine-pyrimethamine (IPTp-SP) and one that did not.
    Methods: The pfdhfr and pfdhps genes from Plasmodium falciparum isolates collected in Yaoundé (Cameroon) from pregnant women with symptomatic malaria under IPTp-SP or not, were sequenced.
    Results: Of 159 patients evaluated, 70 had already taken SP during pregnancy and 89 had never taken SP. Only the vagKgs allele was significantly overrepresented in the SP+ group (21.4% versus 3.4%; P < 0.001), whereas the ISgKAA mutant, widely distributed in this area and known to be less susceptible to SP, tended to be less abundant in this group (48.6% versus 64.0%; P = 0.0503).
    Conclusions: We found a strong overrepresentation of the CirnI/vagKgs haplotype in the IPTp-SP pregnant group, suggesting a high level of resistance of this mutant to SP. This could compromise not only the effectiveness of IPTp-SP but also the seasonal malaria chemoprevention of young children, now widely implemented.
    MeSH term(s) Child ; Child, Preschool ; Female ; Humans ; Pregnancy ; Antimalarials/pharmacology ; Antimalarials/therapeutic use ; Cameroon ; Chemoprevention/methods ; Dihydropteroate Synthase/genetics ; Drug Combinations ; Drug Resistance/genetics ; Malaria, Falciparum/drug therapy ; Mutation ; Plasmodium falciparum/genetics ; Pregnant Women ; Pyrimethamine/pharmacology ; Pyrimethamine/therapeutic use ; Sulfadoxine/pharmacology ; Sulfadoxine/therapeutic use
    Chemical Substances Antimalarials ; Dihydropteroate Synthase (EC 2.5.1.15) ; Drug Combinations ; fanasil, pyrimethamine drug combination (37338-39-9) ; Pyrimethamine (Z3614QOX8W) ; Sulfadoxine (88463U4SM5)
    Language English
    Publishing date 2022-12-09
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 191709-2
    ISSN 1460-2091 ; 0305-7453
    ISSN (online) 1460-2091
    ISSN 0305-7453
    DOI 10.1093/jac/dkac432
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1197: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 124: Show issues

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  7. Article ; Online: Fatal mucormycosis and aspergillosis coinfection associated with haemophagocytic lymphohistiocytosis: A case report and literature review.

    Loubet, Dorian / Sarton, Benjamine / Lelièvre, Lucie / Grouteau, Gaspard / Iriart, Xavier / Chauvin, Pamela / Fillaux, Judith / Valentin, Alexis / Berry, Antoine / Silva, Stein / Bonneville, Fabrice / Cassaing, Sophie / Guemas, Emilie

    Journal de mycologie medicale

    2022  Volume 33, Issue 1, Page(s) 101325

    Abstract: Invasive mould infections are life-threatening and mainly occur in immunocompromised patients. Whereas aspergillosis is described during haemophagocytic lymphohistiocytosis (HLH), only a few cases of concomitant mucormycosis with HLH have been reported. ... ...

    Abstract Invasive mould infections are life-threatening and mainly occur in immunocompromised patients. Whereas aspergillosis is described during haemophagocytic lymphohistiocytosis (HLH), only a few cases of concomitant mucormycosis with HLH have been reported. Here, we present an uncommon coinfection of mucormycosis and aspergillosis associated with HLH probably due to a varicella zoster virus (VZV) viraemia which was unresponsive to triple antifungal therapy (liposomal amphotericin B combined with isavuconazole and caspofungin). A review of the cases of mucormycosis with HLH showed that this uncommon association was always lethal and underscored the relevance of screening for mould infections in patients with HLH.
    MeSH term(s) Humans ; Mucormycosis/complications ; Mucormycosis/diagnosis ; Mucormycosis/drug therapy ; Antifungal Agents/therapeutic use ; Coinfection/complications ; Coinfection/diagnosis ; Coinfection/drug therapy ; Lymphohistiocytosis, Hemophagocytic/complications ; Lymphohistiocytosis, Hemophagocytic/diagnosis ; Lymphohistiocytosis, Hemophagocytic/drug therapy ; Aspergillosis/complications ; Aspergillosis/diagnosis ; Aspergillosis/drug therapy ; Fungi
    Chemical Substances Antifungal Agents
    Language English
    Publishing date 2022-08-08
    Publishing country France
    Document type Review ; Case Reports
    ZDB-ID 1067006-3
    ISSN 1773-0449 ; 1156-5233
    ISSN (online) 1773-0449
    ISSN 1156-5233
    DOI 10.1016/j.mycmed.2022.101325
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    Zs.A 3148: Show issues Location:
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  8. Article ; Online: New Insights into Blood Circulating Lymphocytes in Human

    Charpentier, Eléna / Marques, Catherine / Ménard, Sandie / Chauvin, Pamela / Guemas, Emilie / Cottrel, Claire / Cassaing, Sophie / Fillaux, Judith / Valentin, Alexis / Blanchard, Nicolas / Berry, Antoine / Iriart, Xavier

    Journal of fungi (Basel, Switzerland)

    2021  Volume 7, Issue 8

    Abstract: The host lymphocyte response is decisive ... ...

    Abstract The host lymphocyte response is decisive in
    Language English
    Publishing date 2021-08-11
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2784229-0
    ISSN 2309-608X ; 2309-608X
    ISSN (online) 2309-608X
    ISSN 2309-608X
    DOI 10.3390/jof7080652
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  9. Article ; Online: Résumés du 4

    Brousseau, Julie / Bastide, Mathilda / Cadenet, Margaux / Caillault, Amandine / Ducastel, Morgane / Étienne, Marie-Liesse / Filser, Mathilde / François, Amandine / Guemas, Emilie / Guilbert, Zoé / Jatteau, Pierre / Lodin, Magalie / Ouaziz, Khadija / Rouabah, Lamia / Sakhi, Soraya / Schell, Bérénice / Puel, Mathilde / Roche, Mathilde

    Annales de biologie clinique

    2021  , Page(s) 265–275

    Title translation Abstracts of the 4th CoBioMe Congress.
    Language French
    Publishing date 2021-06-25
    Publishing country France
    Document type Journal Article
    ZDB-ID 418098-7
    ISSN 1950-6112 ; 0003-3898
    ISSN (online) 1950-6112
    ISSN 0003-3898
    DOI 10.1684/abc.2021.1649
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Evolution and spread of Plasmodium falciparum mutations associated with resistance to sulfadoxine-pyrimethamine in central Africa: a cross-sectional study.

    Guémas, Emilie / Coppée, Romain / Ménard, Sandie / du Manoir, Milena / Nsango, Sandrine / Makaba Mvumbi, Dieudonné / Nakoune, Emmanuel / Eboumbou Moukoko, Carole Else / Bouyou Akotet, Marielle Karine / Mirabeau, Tatfeng Youtchou / Manguin, Sylvie / Malekita Yobi, Doudou / Akiana, Jean / Kouna, Lady Charlène / Mawili Mboumba, Denise Patricia / Voumbo-Matoumona, Dominique Fatima / Otam, Alliance-Laure / Rubbo, Pierre-Alain / Lombart, Jean-Pierre /
    Kwanai, Elisabeth / Cohen, Olivia / Iriart, Xavier / Ayong, Lawrence / Lekana-Douki, Jean Bernard / Ariey, Frédéric / Berry, Antoine

    The Lancet. Microbe

    2023  Volume 4, Issue 12, Page(s) e983–e993

    Abstract: Background: Efficacy of sulfadoxine-pyrimethamine, the malaria chemoprophylaxis used in pregnant women, and in children when combined with amodiaquine, is threatened by the accumulation of mutations in the Plasmodium falciparum dihydropteroate synthase ( ...

    Abstract Background: Efficacy of sulfadoxine-pyrimethamine, the malaria chemoprophylaxis used in pregnant women, and in children when combined with amodiaquine, is threatened by the accumulation of mutations in the Plasmodium falciparum dihydropteroate synthase (pfdhps) and dihydrofolate reductase (pfdhfr) genes. Data on the prevalence of resistant alleles in central Africa and the new pfdhps I431V mutation, particularly associated with other mutations to form the pfdhps vagKgs allele, are scarce. We explored the frequency and geographical distribution of pfdhps and pfdhfr mutations in central Africa in 2014-18, and assessed the evolutionary origin of the vagKgs allele.
    Methods: Samples were collected at 18 health-care centres in seven countries (Angola, Cameroon, Central African Republic, Democratic Republic of the Congo, Gabon, Nigeria, and Republic of the Congo) from patients who showed possible symptoms of malaria between March 1, 2014, and Oct 31, 2018. Samples that were positive for P falciparum were transported to a laboratory in Toulouse, France, and genotyped. The frequency of pfdhfr and pfdhps mutations was studied in 1749 samples. Microsatellites in pfdhps flanking regions and whole-genome analysis compared with parasite genomes from the data-sharing network MalariaGEN were performed on samples carrying the vagKgs allele.
    Findings: Mapping of the prevalence of single nucleotide polymorphisms and corresponding alleles of pfdhfr and pfdhps showed a substantial spread of alleles associated with sulfadoxine-pyrimethamine resistance in central Africa during the 2014-18 period, especially an increase going west to east in pfdhps alleles carrying the K540E and A581G mutations. A high prevalence of the pfdhps I431V mutation was observed in Cameroon (exceeding 50% in the northern region) and Nigeria. Genomic analysis showed a recent African emergence and a clonal expansion of the most frequent pfdhps vagKgs allele.
    Interpretation: Reduced sulfadoxine-pyrimethamine efficacy due to increased resistance is a worrying situation, especially because the malaria transmission level is high in central Africa. Although the resistance phenotype remains to be confirmed, the emergence and spread of the vagKgs allele in west and central Africa could challenge the use of sulfadoxine-pyrimethamine.
    Funding: Toulouse Institute for Infectious and Inflammatory Diseases.
    MeSH term(s) Child ; Humans ; Female ; Pregnancy ; Plasmodium falciparum/genetics ; Cross-Sectional Studies ; Antimalarials/pharmacology ; Antimalarials/therapeutic use ; Drug Resistance/genetics ; Malaria, Falciparum/drug therapy ; Malaria, Falciparum/epidemiology ; Malaria, Falciparum/prevention & control ; Mutation ; Africa, Central/epidemiology ; Dihydropteroate Synthase/genetics
    Chemical Substances fanasil, pyrimethamine drug combination (37338-39-9) ; Antimalarials ; Dihydropteroate Synthase (EC 2.5.1.15)
    Language English
    Publishing date 2023-10-18
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2666-5247
    ISSN (online) 2666-5247
    DOI 10.1016/S2666-5247(23)00211-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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