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  1. Article ; Online: Conditional deletion of CB2 cannabinoid receptors from peripheral sensory neurons eliminates CB2-mediated antinociceptive efficacy in a mouse model of carrageenan-induced inflammatory pain.

    Guenther, Kelsey G / Xu, Zhili / Romero, Julian / Hillard, Cecilia J / Mackie, Ken / Hohmann, Andrea G

    Neuropharmacology

    2023  Volume 237, Page(s) 109601

    Abstract: ... ...

    Abstract CB
    MeSH term(s) Animals ; Female ; Male ; Mice ; Analgesics/pharmacology ; Analgesics/therapeutic use ; Carrageenan/adverse effects ; Hyperalgesia/chemically induced ; Hyperalgesia/drug therapy ; Hyperalgesia/metabolism ; Pain/drug therapy ; Receptor, Cannabinoid, CB1 ; Receptor, Cannabinoid, CB2/genetics ; Receptors, Cannabinoid ; Sensory Receptor Cells
    Chemical Substances Analgesics ; Carrageenan (9000-07-1) ; Receptor, Cannabinoid, CB1 ; Receptor, Cannabinoid, CB2 ; Receptors, Cannabinoid ; Cnr2 protein, mouse
    Language English
    Publishing date 2023-06-05
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 218272-5
    ISSN 1873-7064 ; 0028-3908
    ISSN (online) 1873-7064
    ISSN 0028-3908
    DOI 10.1016/j.neuropharm.2023.109601
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Cannabinoid CB

    Guenther, Kelsey G / Lin, Xiaoyan / Xu, Zhili / Makriyannis, Alexandros / Romero, Julian / Hillard, Cecilia J / Mackie, Ken / Hohmann, Andrea G

    bioRxiv : the preprint server for biology

    2024  

    Abstract: Cannabinoid ... ...

    Abstract Cannabinoid CB
    Language English
    Publishing date 2024-03-10
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2024.03.05.583426
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Conditioned aversive responses produced by delayed, but not immediate, exposure to cocaine and morphine in male Sprague-Dawley rats.

    Guenther, Kelsey G / Wideman, Cassidy E / Rock, Erin M / Limebeer, Cheryl L / Parker, Linda A

    Psychopharmacology

    2018  Volume 235, Issue 11, Page(s) 3315–3327

    Abstract: Rationale: To determine the conditions under which tastes paired with delayed access to experimenter-delivered cocaine and morphine elicit a conditionally aversive affective state.: Objectives and methods: The potential of saccharin paired with ... ...

    Abstract Rationale: To determine the conditions under which tastes paired with delayed access to experimenter-delivered cocaine and morphine elicit a conditionally aversive affective state.
    Objectives and methods: The potential of saccharin paired with immediate access to cocaine (5, 10, 20 mg/kg, sc and ip) and delayed (30 and 10 min) access to cocaine (20 mg/kg, sc and ip) and morphine (10 mg/kg, sc) to elicit a pattern of aversive responding in the taste reactivity test (Grill and Norgren 1978a) was evaluated. Cocaine-induced aversions were compared with those produced by a moderate dose of LiCl (50 mg/kg). Finally, as an independent measure of cocaine withdrawal, the potential of exposure to saccharin paired with delayed access to cocaine to produce anxiogenic-like responding in the Light-Dark Emersion test was evaluated.
    Results: Immediate access to cocaine did not produce conditioned aversion at any dose. Delayed (30 or 10 min) access to sc cocaine (20 mg/kg) produced robust conditioned aversion and delayed access to ip cocaine (20 mg/kg; 30 min) and to sc morphine (10 mg/kg; 10 min) produced weaker conditioned aversion. Yawning emerged as a potential withdrawal response in rats conditioned with delayed (30 min) access to 20 mg/kg, sc, cocaine. Contextual cues did not produce conditioned aversion when paired with delayed access to sc cocaine (20 mg/kg). Finally, exposure to saccharin paired with delayed access to cocaine produced anxiogenic-like responding in the Light-Dark Emersion test.
    Conclusion: Our results support the contention that a conditioned aversive state develops when a taste cue comes to predict the delayed availability of drugs of abuse.
    MeSH term(s) Analgesics, Opioid/administration & dosage ; Anesthetics, Local/administration & dosage ; Animals ; Avoidance Learning/drug effects ; Avoidance Learning/physiology ; Cocaine/administration & dosage ; Conditioning, Classical/drug effects ; Conditioning, Classical/physiology ; Cues ; Male ; Morphine/administration & dosage ; Rats ; Rats, Sprague-Dawley ; Saccharin/administration & dosage ; Taste/drug effects ; Taste/physiology ; Time Factors
    Chemical Substances Analgesics, Opioid ; Anesthetics, Local ; Morphine (76I7G6D29C) ; Saccharin (FST467XS7D) ; Cocaine (I5Y540LHVR)
    Language English
    Publishing date 2018-09-24
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 130601-7
    ISSN 1432-2072 ; 0033-3158
    ISSN (online) 1432-2072
    ISSN 0033-3158
    DOI 10.1007/s00213-018-5038-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ui I Zs.240: Show issues Location:
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