Article ; Online: Knowledge-based multi-institution plan prediction of whole breast irradiation with tangential fields.
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology
2022 Volume 175, Page(s) 10–16
Abstract: Purpose: To quantify inter-institute variability of Knowledge-Based (KB) models for right breast cancer patients treated with tangential fields whole breast irradiation (WBI).: Materials and methods: Ten institutions set KB models by using RapidPlan ( ...
| Abstract | Purpose: To quantify inter-institute variability of Knowledge-Based (KB) models for right breast cancer patients treated with tangential fields whole breast irradiation (WBI). Materials and methods: Ten institutions set KB models by using RapidPlan (Varian Inc.), following previously shared methodologies. Models were tested on 20 new patients from the same institutes, exporting DVH predictions of heart, ipsilateral lung, contralateral lung, and contralateral breast. Inter-institute variability was quantified by the inter-institute SD Results: The overall inter-institute variability of DVH/Dmean ipsilateral lung dose prediction, was less than 2% (20%-80% dose range) and 0.55 Gy respectively (1SD) for a 40 Gy in 15 fraction schedule; it was < 0.2 Gy for other OARs. Institute 6 showed the lowest mean dose prediction value and no overlap between PTV and ipsilateral lung. Once excluded, the predicted ipsilateral lung Dmean was correlated with median PTV D99% (R Conclusions: Results show limited inter-institute variability of plan prediction models translating in high inter-institute interchangeability, except for one of ten institutes. These results encourage future investigations in generating benchmarks for plan prediction incorporating inter-institute variability. |
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| MeSH term(s) | Humans ; Female ; Radiotherapy Dosage ; Radiotherapy Planning, Computer-Assisted/methods ; Radiotherapy, Intensity-Modulated/methods ; Radiotherapy, Conformal/methods ; Breast/radiation effects ; Breast Neoplasms/radiotherapy ; Organs at Risk/radiation effects |
| Language | English |
| Publishing date | 2022-07-19 |
| Publishing country | Ireland |
| Document type | Journal Article ; Research Support, Non-U.S. Gov't |
| ZDB-ID | 605646-5 |
| ISSN | 1879-0887 ; 0167-8140 |
| ISSN (online) | 1879-0887 |
| ISSN | 0167-8140 |
| DOI | 10.1016/j.radonc.2022.07.012 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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