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Article: Reduced corneal endothelial cell density after toxic anterior segment syndrome (TASS) caused by inadvertent intraocular ointment migration: A case report.

Mohamed-Noriega, Karim / Guerra-Lorenzo, Fernando / Mohamed-Noriega, Jibran / Villarreal-Mendez, Gerardo / Morales-Wong, Fernando / Mohamed-Hamsho, Jesús

International journal of surgery case reports

2022 Volume 94, Page(s) 107029

Abstract: Introduction and importance: Toxic anterior segment syndrome (TASS) is an acute sterile inflammation of the anterior segment which may occur after surgery. This case presents endothelial cell density (ECD) loss due to months of TASS caused by ... ...

Abstract	Introduction and importance: Toxic anterior segment syndrome (TASS) is an acute sterile inflammation of the anterior segment which may occur after surgery. This case presents endothelial cell density (ECD) loss due to months of TASS caused by intraocular migration of ocular ointment. The chronicity of this case and the clinical consequences are rare in the literature. Case presentation: A Colombian 71-year-old man developed TASS secondary to intraocular ointment migration after uneventful cataract surgery with phacoemulsification and intraocular lens placement in the capsular bag. The main complaint for the patient was a chronic red eye, no pain or visual disturbance were reported, rheumatologic diseases were discarded. It was documented the presence of intraocular ointment in the anterior chamber, over the iris and in the anterior chamber angle. The ECD was reduced secondary to TASS and the long-term presence of ointment moving in the anterior chamber, so it had to be removed. Clinical discussion: It is important to avoid using ocular ointment after intraocular surgeries to avoid the risk of ointment migration into the anterior chamber. Intraocular ointments should be removed promptly to reduce ECD loss as documented in the present case report in which after ointment elimination ECD remains stable for 7 years. Conclusion: Topical ointments should not be used after routine cataract surgery because of the risk of intraocular ointment migration and subsequent risk of developing TASS and reduced ECD.
Language	English
Publishing date	2022-04-03
Publishing country	Netherlands
Document type	Journal Article
ISSN	2210-2612
ISSN	2210-2612
DOI	10.1016/j.ijscr.2022.107029
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Article ; Online: Crestal bone changes around early vs. conventionally loaded implants with a multi-phosphonate coated surface: A randomized pilot clinical trial.

Galindo-Moreno, Pablo / Gutierrez-Garrido, Lourdes / Lopez-Chaichio, Lucia / Guerra-Lorenzo, Claudia / Rodriguez-Alvarez, Roque / Padial-Molina, Miguel

Clinical oral implants research

2020 Volume 32, Issue 1, Page(s) 75–87

Abstract: Objectives: To compare the marginal bone level around implants with a thin multi-phosphonate coated surface after either an early or conventional loading protocol.: Material and methods: A randomized pilot clinical trial was conducted. Dental ... ...

Abstract	Objectives: To compare the marginal bone level around implants with a thin multi-phosphonate coated surface after either an early or conventional loading protocol. Material and methods: A randomized pilot clinical trial was conducted. Dental impressions were obtained after either 4 (test) or 8 weeks (control) and single crowns screwed-in 2 weeks later. Several variables were evaluated including radiographical marginal bone level (MBL), patient's level variables, and those related to the restoration and surrounding tissues. These data were obtained at several time points up to a 1-year follow-up. Results: Thirty-four patients were included in the study, 18 assigned to the test group. No differences at implant placement were detected for tissue thickness, keratinized mucosa, nor any other clinical or radiological variable. At the time of impressions, tissue was thinner in the test group (2.30 (0.46) versus 2.78 (0.66) mm, test versus control, respectively; p = .012) so shorter abutments were used in this group. Regardless, no significant changes in marginal bone level were detected neither within group along time nor between groups. The average MBL at the 1-year follow-up was -0.15 (0.32) versus -0.22 (0.37) (p = .443) (test versus control, respectively). None of the clinical or radiological variables evaluated had a determinant influence on the MBL at any visit nor group. Conclusion: The use of implants with a multi-phosphonate coated surface for early loading offers successful radiographical outcomes 1 year after loading. MBL over time was not affected by taking the impressions 4 or 8 weeks after implant placement and loading them 2 weeks later.
MeSH term(s)	Alveolar Bone Loss/diagnostic imaging ; Crowns ; Dental Implantation, Endosseous ; Dental Implants ; Dental Prosthesis, Implant-Supported ; Humans ; Immediate Dental Implant Loading ; Organophosphonates ; Pilot Projects
Chemical Substances	Dental Implants ; Organophosphonates
Language	English
Publishing date	2020-12-18
Publishing country	Denmark
Document type	Journal Article ; Randomized Controlled Trial
ZDB-ID	1067626-0
ISSN	1600-0501 ; 0905-7161
ISSN (online)	1600-0501
ISSN	0905-7161
DOI	10.1111/clr.13681
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Article ; Online: Small-molecule drugs for cystic fibrosis: Where are we now?

Laselva, Onofrio / Guerra, Lorenzo / Castellani, Stefano / Favia, Maria / Di Gioia, Sante / Conese, Massimo

Pulmonary pharmacology & therapeutics

2021 Volume 72, Page(s) 102098

Abstract: The cystic fibrosis (CF) lung disease is due to the lack/dysfunction of the CF Transmembrane Conductance Regulator (CFTR), a chloride channel expressed by epithelial cells as the main regulator of ion and fluid homeostasis. More than 2000 genetic ... ...

Abstract	The cystic fibrosis (CF) lung disease is due to the lack/dysfunction of the CF Transmembrane Conductance Regulator (CFTR), a chloride channel expressed by epithelial cells as the main regulator of ion and fluid homeostasis. More than 2000 genetic variation in the CFTR gene are known, among which those with identified pathomechanism have been divided into six mutation classes. A major advancement in the pharmacotherapy of CF has been the development of small-molecule drugs hitting the root of the disease, i.e. the altered ion and fluid transport through the airway epithelium. These drugs, called CFTR modulators, have been advanced to the clinics to treat nearly 90% of CF patients, including the CFTR potentiator ivacaftor, approved for residual function mutations (Classes III and IV), and combinations of correctors (lumacaftor, tezacaftor, elexacaftor) and ivacaftor for patients bearing at least one the F508del mutation, the most frequent mutation belonging to class II. To cover the 10% of CF patients without etiological therapies, other novel small-molecule CFTR modulators are in evaluation of their effectiveness in all the CFTR mutation classes: read-through agents for Class I, correctors, potentiators and amplifiers from different companies for Class II-V, stabilizers for Class VI. In alternative, other solute carriers, such as SLC26A9 and SLC6A14, are the focus of intensive investigation. Finally, other molecular targets are being evaluated for patients with no approved CFTR modulator therapy or as means of enhancing CFTR modulatory therapy, including small molecules forming ion channels, inhibitors of the ENaC sodium channel and potentiators of the calcium-activated chloride channel TMEM16A. This paper aims to give an up-to-date overview of old and novel CFTR modulators as well as of novel strategies based on small-molecule drugs. Further investigations in in-vivo and cell-based models as well as carrying out large prospective studies will be required to determine if novel CFTR modulators, stabilizers, amplifiers, and the ENaC inhibitors or TMEM16A potentiators will further improve the clinical outcomes in CF management.
MeSH term(s)	Aminophenols/adverse effects ; Chloride Channels/genetics ; Cystic Fibrosis/drug therapy ; Cystic Fibrosis/genetics ; Cystic Fibrosis Transmembrane Conductance Regulator/genetics ; Cystic Fibrosis Transmembrane Conductance Regulator/therapeutic use ; Humans ; Mutation ; Prospective Studies
Chemical Substances	Aminophenols ; Chloride Channels ; Cystic Fibrosis Transmembrane Conductance Regulator (126880-72-6)
Language	English
Publishing date	2021-11-15
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	1399707-5
ISSN	1522-9629 ; 1094-5539
ISSN (online)	1522-9629
ISSN	1094-5539
DOI	10.1016/j.pupt.2021.102098
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Article ; Online: Dopamine- and Grape-Seed-Extract-Loaded Solid Lipid Nanoparticles: Interaction Studies between Particles and Differentiated SH-SY5Y Neuronal Cell Model of Parkinson's Disease.

Mallamaci, Rosanna / Musarò, Debora / Greco, Marco / Caponio, Antonello / Castellani, Stefano / Munir, Anas / Guerra, Lorenzo / Damato, Marina / Fracchiolla, Giuseppe / Coppola, Chiara / Cardone, Rosa Angela / Rashidi, Mehdi / Tardugno, Roberta / Sergio, Sara / Trapani, Adriana / Maffia, Michele

Molecules (Basel, Switzerland)

2024 Volume 29, Issue 8

Abstract: Parkinson's disease (PD) is a prevalent neurodegenerative disorder, primarily associated with dopaminergic neuron depletion in the Substantia Nigra. Current treatment focuses on compensating for dopamine (DA) deficiency, but the blood-brain barrier (BBB) ...

Abstract	Parkinson's disease (PD) is a prevalent neurodegenerative disorder, primarily associated with dopaminergic neuron depletion in the Substantia Nigra. Current treatment focuses on compensating for dopamine (DA) deficiency, but the blood-brain barrier (BBB) poses challenges for effective drug delivery. Using differentiated SH-SY5Y cells, we investigated the co-administration of DA and the antioxidant Grape Seed Extract (GSE) to study the cytobiocompability, the cytoprotection against the neurotoxin Rotenone, and their antioxidant effects. For this purpose, two solid lipid nanoparticle (SLN) formulations, DA-co-GSE-SLNs and GSE-ads-DA-SLNs, were synthesized. Such SLNs showed mean particle sizes in the range of 187-297 nm, zeta potential values in the range of -4.1--9.7 mV, and DA association efficiencies ranging from 35 to 82%, according to the formulation examined. The results showed that DA/GSE-SLNs did not alter cell viability and had a cytoprotective effect against Rotenone-induced toxicity and oxidative stress. In addition, this study also focused on the evaluation of Alpha-synuclein (aS) levels; SLNs showed the potential to modulate the Rotenone-mediated increase in aS levels. In conclusion, our study investigated the potential of SLNs as a delivery system for addressing PD, also representing a promising approach for enhanced delivery of pharmaceutical and antioxidant molecules across the BBB.
MeSH term(s)	Humans ; Parkinson Disease/drug therapy ; Parkinson Disease/metabolism ; Dopamine/chemistry ; Dopamine/metabolism ; Nanoparticles/chemistry ; Grape Seed Extract/chemistry ; Grape Seed Extract/pharmacology ; Rotenone/pharmacology ; Cell Line, Tumor ; alpha-Synuclein/metabolism ; Cell Survival/drug effects ; Antioxidants/pharmacology ; Antioxidants/chemistry ; Oxidative Stress/drug effects ; Cell Differentiation/drug effects ; Particle Size ; Liposomes/chemistry ; Dopaminergic Neurons/drug effects ; Dopaminergic Neurons/metabolism ; Neurons/drug effects ; Neurons/metabolism
Chemical Substances	Dopamine (VTD58H1Z2X) ; Grape Seed Extract ; Rotenone (03L9OT429T) ; alpha-Synuclein ; Antioxidants ; Lipid Nanoparticles ; Liposomes
Language	English
Publishing date	2024-04-13
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules29081774
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Article ; Online: Solid Lipid Nanoparticles Containing Dopamine and Grape Seed Extract: Freeze-Drying with Cryoprotection as a Formulation Strategy to Achieve Nasal Powders.

De Giglio, Elvira / Bakowsky, Udo / Engelhardt, Konrad / Caponio, Antonello / La Pietra, Matteo / Cometa, Stefania / Castellani, Stefano / Guerra, Lorenzo / Fracchiolla, Giuseppe / Poeta, Maria Luana / Mallamaci, Rosanna / Cardone, Rosa Angela / Bellucci, Stefano / Trapani, Adriana

Molecules (Basel, Switzerland)

2023 Volume 28, Issue 23

Abstract: 1) Background: DA- ... ...

Abstract	(1) Background: DA-Gelucire
MeSH term(s)	Humans ; Grape Seed Extract/pharmacology ; Dopamine ; Powders ; Nanoparticles/chemistry ; Cryoprotective Agents ; Freeze Drying/methods ; Sucrose/chemistry ; Particle Size
Chemical Substances	Lipid Nanoparticles ; Grape Seed Extract ; Dopamine (VTD58H1Z2X) ; Powders ; Cryoprotective Agents ; Sucrose (57-50-1)
Language	English
Publishing date	2023-11-22
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules28237706
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Article: Combined Dopamine and Grape Seed Extract-Loaded Solid Lipid Nanoparticles: Nasal Mucosa Permeation, and Uptake by Olfactory Ensheathing Cells and Neuronal SH-SY5Y Cells.

Trapani, Adriana / Castellani, Stefano / Guerra, Lorenzo / De Giglio, Elvira / Fracchiolla, Giuseppe / Corbo, Filomena / Cioffi, Nicola / Passantino, Giuseppe / Poeta, Maria Luana / Montemurro, Pasqualina / Mallamaci, Rosanna / Cardone, Rosa Angela / Conese, Massimo

Pharmaceutics

2023 Volume 15, Issue 3

Abstract: We have already formulated solid lipid nanoparticles (SLNs) in which the combination of the neurotransmitter dopamine (DA) and the antioxidant grape-seed-derived proanthocyanidins (grape seed extract, GSE) was supposed to be favorable for Parkinson's ... ...

Abstract	We have already formulated solid lipid nanoparticles (SLNs) in which the combination of the neurotransmitter dopamine (DA) and the antioxidant grape-seed-derived proanthocyanidins (grape seed extract, GSE) was supposed to be favorable for Parkinson's disease (PD) treatment. In fact, GSE supply would reduce the PD-related oxidative stress in a synergic effect with DA. Herein, two different methods of DA/GSE loading were studied, namely, coadministration in the aqueous phase of DA and GSE, and the other approach consisting of a physical adsorption of GSE onto preformed DA containing SLNs. Mean diameter of DA coencapsulating GSE SLNs was 187 ± 4 nm vs. 287 ± 15 nm of GSE adsorbing DA-SLNs. TEM microphotographs evidenced low-contrast spheroidal particles, irrespective of the SLN type. Moreover, Franz diffusion cell experiments confirmed the permeation of DA from both SLNs through the porcine nasal mucosa. Furthermore, fluorescent SLNs also underwent cell-uptake studies by using flow cytometry in olfactory ensheathing cells and neuronal SH-SY5Y cells, evidencing higher uptake when GSE was coencapsulated rather than adsorbed onto the particles.
Language	English
Publishing date	2023-03-08
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527217-2
ISSN	1999-4923
ISSN	1999-4923
DOI	10.3390/pharmaceutics15030881
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Article ; Online: Deconstructing SARS-CoV-2 neutralization: A modular molecular framework for computational design and comparison of antibodies and nanobodies targeting the spike RBD.

Tragni, Vincenzo / Mercurio, Ivan / Paoletti, Diletta Pia / Onofrio, Angelo / Laera, Luna / Cafferati Beltrame, Lucas / Sgobba, Maria Noemi / Guerra, Lorenzo / Volpicella, Mariateresa / De Grassi, Anna / Elia, Gabriella / Pierri, Ciro Leonardo

Journal of medical virology

2023 Volume 95, Issue 6, Page(s) e28875

Abstract: Since 2020 the COVID-19 pandemic has led scientists to search for strategies to predict the transmissibility and virulence of new severe acute respiratory syndrome coronavirus 2 variants based on the estimation of the affinity of the spike receptor ... ...

Abstract	Since 2020 the COVID-19 pandemic has led scientists to search for strategies to predict the transmissibility and virulence of new severe acute respiratory syndrome coronavirus 2 variants based on the estimation of the affinity of the spike receptor binding domain (RBD) for the human angiotensin-converting enzyme 2 (ACE2) receptor and/or neutralizing antibodies. In this context, our lab developed a computational pipeline to quickly quantify the free energy of interaction at the spike RBD/ACE2 protein-protein interface, reflecting the incidence trend observed in the transmissibility/virulence of the investigated variants. In this new study, we used our pipeline to estimate the free energy of interaction between the RBD from 10 variants, and 14 antibodies (ab), or 5 nanobodies (nb), highlighting the RBD regions preferentially targeted by the investigated ab/nb. Our structural comparative analysis and interaction energy calculations allowed us to propose the most promising RBD regions to be targeted by future ab/nb to be designed by site-directed mutagenesis of existing high-affinity ab/nb, to increase their affinity for the target RBD region, for preventing spike-RBD/ACE2 interactions and virus entry in host cells. Furthermore, we evaluated the ability of the investigated ab/nb to simultaneously interact with the three RBD located on the surface of the trimeric spike protein, which can alternatively be in up- or down- (all-3-up-, all-3-down-, 1-up-/2-down-, 2-up-/1-down-) conformations.
MeSH term(s)	Humans ; SARS-CoV-2/genetics ; Angiotensin-Converting Enzyme 2 ; Single-Domain Antibodies/genetics ; COVID-19 ; Pandemics ; Antibodies, Neutralizing ; Spike Glycoprotein, Coronavirus/genetics ; Protein Binding
Chemical Substances	Angiotensin-Converting Enzyme 2 (EC 3.4.17.23) ; Single-Domain Antibodies ; Antibodies, Neutralizing ; Spike Glycoprotein, Coronavirus ; spike protein, SARS-CoV-2
Language	English
Publishing date	2023-06-19
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	752392-0
ISSN	1096-9071 ; 0146-6615
ISSN (online)	1096-9071
ISSN	0146-6615
DOI	10.1002/jmv.28875
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Zs.A 1320: Show issues

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Article ; Online: The hyperchromatic supranuclear stria corresponds to the Golgi apparatus in nasal ciliated cells.

Gelardi, Matteo / Guerra, Lorenzo / Giangregorio, Nicola / Cassano, Michele / Favia, Maria / Ciprandi, Giorgio

Acta bio-medica : Atenei Parmensis

2020 Volume 91, Issue 2, Page(s) 373–375

Abstract: ...

Abstract	.
MeSH term(s)	Golgi Apparatus
Language	English
Publishing date	2020-05-11
Publishing country	Italy
Document type	Letter ; Comment
ZDB-ID	2114240-3
ISSN	2531-6745 ; 0392-4203
ISSN (online)	2531-6745
ISSN	0392-4203
DOI	10.23750/abm.v91i2.9265
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Article ; Online: Camel (

Iglesias Pastrana, Carlos / Delgado Bermejo, Juan Vicente / Sgobba, Maria Noemi / Navas González, Francisco Javier / Guerra, Lorenzo / Pinto, Diana C G A / Gil, Ana M / Duarte, Iola F / Lentini, Giovanni / Ciani, Elena

International journal of molecular sciences

2022 Volume 23, Issue 23

Abstract: Up to the present day, studies on the therapeutic properties of camel ( ...

Abstract	Up to the present day, studies on the therapeutic properties of camel (
Language	English
Publishing date	2022-11-30
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms232315024
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Article ; Online: The Non-Gastric H

Favia, Maria / Gerbino, Andrea / Notario, Elisabetta / Tragni, Vincenzo / Sgobba, Maria Noemi / Dell'Aquila, Maria Elena / Pierri, Ciro Leonardo / Guerra, Lorenzo / Ciani, Elena

International journal of molecular sciences

2022 Volume 23, Issue 3

Abstract: ... ...

Abstract	H
MeSH term(s)	Animals ; Buffaloes/metabolism ; Cattle ; H(+)-K(+)-Exchanging ATPase/metabolism ; Ion Transport ; Male ; Sodium-Potassium-Exchanging ATPase/metabolism ; Spermatozoa/metabolism
Chemical Substances	H(+)-K(+)-Exchanging ATPase (EC 3.6.3.10) ; Sodium-Potassium-Exchanging ATPase (EC 7.2.2.13)
Language	English
Publishing date	2022-01-19
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms23031048
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