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  1. Article: [No title information]

    Guery, Benoît

    Revue medicale suisse

    2022  Volume 18, Issue 779, Page(s) 837–838

    Title translation Nouveaux antibiotiques ? Perspectives.
    MeSH term(s) Anti-Bacterial Agents/therapeutic use ; Humans
    Chemical Substances Anti-Bacterial Agents
    Language French
    Publishing date 2022-05-04
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2177010-4
    ISSN 1660-9379
    ISSN 1660-9379
    DOI 10.53738/REVMED.2022.18.779.837
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    Zs.A 5998: Show issues Location:
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  2. Article ; Online: Clostridium difficile infection trials: what is the primary endpoint?

    Guery, Benoit

    The Lancet. Infectious diseases

    2019  Volume 19, Issue 3, Page(s) 219–220

    MeSH term(s) Clostridium Infections ; Clostridium difficile ; Double-Blind Method ; Enterocolitis, Pseudomembranous ; Humans ; Oxazolidinones
    Chemical Substances Oxazolidinones ; cadazolid (2OEA2UN10Y)
    Language English
    Publishing date 2019-01-29
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2061641-7
    ISSN 1474-4457 ; 1473-3099
    ISSN (online) 1474-4457
    ISSN 1473-3099
    DOI 10.1016/S1473-3099(18)30626-1
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    Zs.A 5743: Show issues Location:
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  3. Article ; Online: Faecal microbiota transplantation for first and second episodes of Clostridioides difficile infection.

    Krutova, Marcela / Davis, Kerrie / Guery, Benoit / Barbut, Frédéric

    The lancet. Gastroenterology & hepatology

    2023  Volume 8, Issue 2, Page(s) 111–112

    MeSH term(s) Humans ; Fecal Microbiota Transplantation ; Clostridium Infections/therapy ; Clostridioides difficile
    Language English
    Publishing date 2023-01-05
    Publishing country Netherlands
    Document type Letter ; Comment
    ISSN 2468-1253
    ISSN (online) 2468-1253
    DOI 10.1016/S2468-1253(22)00388-0
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  4. Article ; Online: Infective endocarditis, is there a goal beyond antibiotics and surgery?

    Guery, Benoit / Papadimitriou-Olivgeris, Matthaios

    European journal of internal medicine

    2021  Volume 94, Page(s) 25–26

    MeSH term(s) Anti-Bacterial Agents/therapeutic use ; Endocarditis/drug therapy ; Endocarditis/surgery ; Endocarditis, Bacterial/drug therapy ; Goals ; Humans
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2021-11-12
    Publishing country Netherlands
    Document type Journal Article ; Comment
    ZDB-ID 1038679-8
    ISSN 1879-0828 ; 0953-6205
    ISSN (online) 1879-0828
    ISSN 0953-6205
    DOI 10.1016/j.ejim.2021.10.033
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  5. Article: Prevalence of Infective Endocarditis among Patients with

    Papadimitriou-Olivgeris, Matthaios / Guery, Benoit / Monney, Pierre / Senn, Laurence / Steinmetz, Sylvain / Boillat-Blanco, Noémie

    Microorganisms

    2024  Volume 12, Issue 2

    Abstract: We aimed to evaluate the occurrence of infective endocarditis (IE) among patients with bone and joint infections (BJIs) ... ...

    Abstract We aimed to evaluate the occurrence of infective endocarditis (IE) among patients with bone and joint infections (BJIs) and
    Language English
    Publishing date 2024-02-06
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2720891-6
    ISSN 2076-2607
    ISSN 2076-2607
    DOI 10.3390/microorganisms12020342
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  6. Article ; Online: Predictors of mortality of streptococcal bacteremia and the role of infectious diseases consultation; a retrospective cohort study.

    Fourre, Nicolas / Zimmermann, Virgile / Senn, Laurence / Aruanno, Marion / Guery, Benoit / Papadimitriou-Olivgeris, Matthaios

    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

    2024  

    Abstract: Background: Streptococcal bacteremia is associated with high mortality. The study aims to identify predictors of mortality among patients with streptococcal bacteremia.: Methods: This retrospective study was conducted at the Lausanne University ... ...

    Abstract Background: Streptococcal bacteremia is associated with high mortality. The study aims to identify predictors of mortality among patients with streptococcal bacteremia.
    Methods: This retrospective study was conducted at the Lausanne University Hospital, Switzerland and included episodes of streptococcal bacteremia among adult patients from 2015 to 2023.
    Results: During the study period, 861 episodes of streptococcal bacteremia were included. The majority of episodes were categorized in the Mitis group (348 episodes; 40%), followed by the Pyogenic group (215; 25%). Endocarditis was the most common source of bacteremia (164; 19%). The overall 14-day mortality rate was 8% (65 episodes). The results from the Cox multivariable regression model showed that a Charlson comorbidity index >4 (P 0.001; HR 2.87, CI 1.58-5.22), S. pyogenes (P 0.011; HR 2.54, CI 1.24-5.21), sepsis (P < 0.001; HR 7.48, CI 3.86-14.47), lower respiratory tract infection (P 0.002; HR 2.62, CI 1.42-4.81), and absence of source control interventions within 48 hours despite being warranted (P 0.002; HR 2.62, CI 1.43-4.80) were associated with 14-day mortality. Conversely, interventions performed within 48 hours of bacteremia onset, such as infectious diseases consultation (P < 0.001; HR 0.29, CI 0.17-0.48), and appropriate antimicrobial treatment (P < 0.001; HR 0.28, CI 0.14-0.57) were associated with improved outcome.
    Conclusions: Our findings underscore the pivotal role of infectious diseases consultation in guiding antimicrobial treatment and recommending source control interventions for patients with streptococcal bacteremia.
    Language English
    Publishing date 2024-03-25
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1099781-7
    ISSN 1537-6591 ; 1058-4838
    ISSN (online) 1537-6591
    ISSN 1058-4838
    DOI 10.1093/cid/ciae168
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    Zs.MO 480: Show issues

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  7. Article ; Online: Clinical significance of concomitant bacteriuria in patients with Staphylococcus aureus bacteraemia.

    Papadimitriou-Olivgeris, Matthaios / Jacot, Damien / Senn, Laurence / Guery, Benoit

    European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology

    2023  Volume 42, Issue 3, Page(s) 379–382

    Abstract: This retrospective study, conducted at Lausanne University Hospital (2015-2021), compared Staphylococcus aureus bacteraemia (SABA) patients with or without concomitant bacteriuria (SABU). Among 448 included bacteraemic patients, 62 (13.8%) had S. aureus ... ...

    Abstract This retrospective study, conducted at Lausanne University Hospital (2015-2021), compared Staphylococcus aureus bacteraemia (SABA) patients with or without concomitant bacteriuria (SABU). Among 448 included bacteraemic patients, 62 (13.8%) had S. aureus concurrently isolated from urine. In multivariate analysis, there was a significant difference in the odds of community-onset bacteraemia (P 0.030), malignancy (P 0.002), > 1 pair of positive blood cultures (P 0.037), and persistent bacteraemia for at least 48 h (P 0.045) in patients with concurrent SABU. No difference concerning mortality was found. On the other hand, SABU was associated with higher rates of SABA recurrence after antibiotic cessation.
    MeSH term(s) Humans ; Bacteriuria/complications ; Bacteriuria/microbiology ; Staphylococcus aureus ; Retrospective Studies ; Clinical Relevance ; Bacteremia/complications ; Bacteremia/microbiology ; Staphylococcal Infections/complications ; Staphylococcal Infections/microbiology
    Language English
    Publishing date 2023-02-02
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 603155-9
    ISSN 1435-4373 ; 0934-9723 ; 0722-2211
    ISSN (online) 1435-4373
    ISSN 0934-9723 ; 0722-2211
    DOI 10.1007/s10096-023-04559-z
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    Zs.A 1732: Show issues Location:
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  8. Article ; Online: Predictors of mortality of Staphylococcus aureus bacteremia among patients hospitalized in a Swiss University Hospital and the role of early source control; a retrospective cohort study.

    Papadimitriou-Olivgeris, Matthaios / Caruana, Giorgia / Senn, Laurence / Guery, Benoit

    European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology

    2023  Volume 42, Issue 3, Page(s) 347–357

    Abstract: S. aureus bacteremia is associated with high mortality. The aim was to identify predictors of mortality among patients with S. aureus bacteremia and evaluate the role of early source control. This retrospective study was conducted at the Lausanne ... ...

    Abstract S. aureus bacteremia is associated with high mortality. The aim was to identify predictors of mortality among patients with S. aureus bacteremia and evaluate the role of early source control. This retrospective study was conducted at the Lausanne University Hospital, Switzerland. All episodes of S. aureus bacteremia among adult patients from 2015 to 2021 were included. During the study period, 839 episodes of S. aureus bacteremia were included, of which 7.9% were due to methicillin-resistant isolates. Bacteremias were related to bone or joint infections (268; 31.9%), followed by bacteremia of unknown origin (158; 18.8%), proven endocarditis (118; 14.1%) and lower-respiratory tract infections (79; 9.4%). Overall 28-day mortality was 14.5%. Cox multivariate regression model showed that Charlson comorbidity index > 5 (P < 0.001), nosocomial bacteremia (P 0.019), time to blood culture positivity ≤ 13 h (P 0.004), persistent bacteremia for ≥ 48 h (P 0.004), sepsis (P < 0.001), bacteremia of unknown origin (P 0.036) and lower respiratory tract infection (P < 0.001) were associated with 28-day mortality, while infectious diseases consultation within 48 h from infection onset (P < 0.001) was associated with better survival. Source control was warranted in 575 episodes and performed in 345 episodes (60.0%) within 48 h from infection onset. Results from a second multivariate analysis confirmed that early source control (P < 0.001) was associated with better survival. Mortality among patients with S. aureus bacteremia was high and early source control was a key determinant of outcome. Infectious diseases consultation within 48 h played an important role in reducing mortality.
    MeSH term(s) Adult ; Humans ; Staphylococcus aureus ; Retrospective Studies ; Switzerland/epidemiology ; Staphylococcal Infections/microbiology ; Bacteremia/microbiology ; Hospitals, University ; Communicable Diseases ; Methicillin-Resistant Staphylococcus aureus
    Language English
    Publishing date 2023-02-02
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 603155-9
    ISSN 1435-4373 ; 0934-9723 ; 0722-2211
    ISSN (online) 1435-4373
    ISSN 0934-9723 ; 0722-2211
    DOI 10.1007/s10096-023-04557-1
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  9. Article ; Online: Re: 'The effect of antibiotic therapy for Clostridioides difficile infection on mortality and other patient-relevant outcomes' by Stabholz et al.

    van Prehn, Joffrey / Skinner, Andrew M / Krutova, Marcela / Guery, Benoit

    Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases

    2023  Volume 30, Issue 2, Page(s) 261–262

    MeSH term(s) Humans ; Anti-Bacterial Agents/therapeutic use ; Clostridium Infections/drug therapy ; Recurrence
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2023-10-20
    Publishing country England
    Document type Letter
    ZDB-ID 1328418-6
    ISSN 1469-0691 ; 1470-9465 ; 1198-743X
    ISSN (online) 1469-0691
    ISSN 1470-9465 ; 1198-743X
    DOI 10.1016/j.cmi.2023.10.015
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    Zs.MO 284: Show issues

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  10. Article: How to Manage Pseudomonas aeruginosa Infections.

    Papadimitriou-Olivgeris, Matthaios / Jacot, Damien / Guery, Benoit

    Advances in experimental medicine and biology

    2022  Volume 1386, Page(s) 425–445

    Abstract: Pseudomonas aeruginosa is a pathogen frequently encountered in healthcare-associated infections and immunocompromised patients. In bacteremia, this pathogen is associated with higher mortality than other Gram-negative pathogens. This increase in ... ...

    Abstract Pseudomonas aeruginosa is a pathogen frequently encountered in healthcare-associated infections and immunocompromised patients. In bacteremia, this pathogen is associated with higher mortality than other Gram-negative pathogens. This increase in mortality was also found globally for multi-resistant compared to susceptible strains. Several factors have been associated with the development of resistance: previous ICU stay, use of carbapenems, and comorbidities were identified in multivariate analysis. In the therapeutic choice, previous antibiotic treatment remains the strongest driver suggesting a potential resistant strain. These risk factors will decide whether multi-resistant strains must be considered in the empiric coverage. For susceptible strains, a single agent can be used, β-lactams are usually the first choice. Associations do not provide any advantage on mortality. Optimization of pharmacokinetic/pharmacodynamic parameters, such as prolonged infusion (for time-dependent antibiotics), increased dosage (for concentration-dependent antibiotics), and therapeutic drug monitoring, also influences the outcome. The increasing number of resistant strains led the clinician to use either recently approved new molecules but also associations. For multi-resistant strains, new molecules such as ceftolozane-tazobactam, ceftazidime-avibactam, and cefiderocol have shown an adequate activity against P. aeruginosa. Older molecules like colistin and fosfomycin are also used in this indication. The complexity of the resistance and consequences on a larger scale of antibiotic prescription will probably lead to more individualized prescriptions.
    MeSH term(s) Humans ; Pseudomonas Infections/drug therapy ; Pseudomonas Infections/chemically induced ; Colistin/therapeutic use ; Fosfomycin/therapeutic use ; Tazobactam/pharmacology ; Tazobactam/therapeutic use ; Anti-Bacterial Agents/pharmacology ; Pseudomonas aeruginosa ; Carbapenems/pharmacology ; Drug Combinations ; Microbial Sensitivity Tests ; Drug Resistance, Multiple, Bacterial
    Chemical Substances Colistin (Z67X93HJG1) ; Fosfomycin (2N81MY12TE) ; Tazobactam (SE10G96M8W) ; Anti-Bacterial Agents ; Carbapenems ; Drug Combinations
    Language English
    Publishing date 2022-10-18
    Publishing country United States
    Document type Journal Article
    ISSN 2214-8019 ; 0065-2598
    ISSN (online) 2214-8019
    ISSN 0065-2598
    DOI 10.1007/978-3-031-08491-1_16
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