Article ; Online: Weight Gain After 12 Months of Switching to Bictegravir/Emtricitabine/Tenofovir Alafenamide in Virologically Suppressed HIV Patients.
AIDS research and human retroviruses
2023 Volume 39, Issue 10, Page(s) 511–517
Abstract: Recent studies suggest that the introduction of antiretroviral agents such as integrase strand transfer inhibitors (INSTI) may lead to weight gain in people living with HIV (PLHIV). In this retrospective observational study, we report the weight changes ... ...
| Abstract | Recent studies suggest that the introduction of antiretroviral agents such as integrase strand transfer inhibitors (INSTI) may lead to weight gain in people living with HIV (PLHIV). In this retrospective observational study, we report the weight changes observed in virologically suppressed HIV patients after 12 months of switching to bictegravir/emtricitabine/tenofovir alafenamide (BIC/F/TAF) due to a national change in public policy in Mexico. Patients on prior regimens based on TDF/FTC or ABC/3TC plus non-nucleoside retrotranscriptase inhibitor, INSTI, or protease inhibitor were included. In the 399 patients analyzed, a significant weight increase was found, as well as an increase in body mass index (BMI), total cholesterol, low-density lipoprotein cholesterol (LDL-C), glucose, creatinine, and CD4 |
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| MeSH term(s) | Humans ; Adenine ; Anti-HIV Agents/adverse effects ; Cholesterol ; Drug Combinations ; Emtricitabine/adverse effects ; Heterocyclic Compounds, 3-Ring/adverse effects ; HIV Infections/drug therapy ; Weight Gain | |||||
| Chemical Substances | Adenine (JAC85A2161) ; Anti-HIV Agents ; bictegravir (8GB79LOJ07) ; Cholesterol (97C5T2UQ7J) ; Drug Combinations ; Emtricitabine (G70B4ETF4S) ; Heterocyclic Compounds, 3-Ring ; tenofovir alafenamide (EL9943AG5J) | |||||
| Language | English | |||||
| Publishing date | 2023-05-29 | |||||
| Publishing country | United States | |||||
| Document type | Observational Study ; Journal Article | |||||
| ZDB-ID | 639130-8 | |||||
| ISSN | 1931-8405 ; 0889-2229 | |||||
| ISSN (online) | 1931-8405 | |||||
| ISSN | 0889-2229 | |||||
| DOI | 10.1089/AID.2022.0130 | |||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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