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Book ; Online: Machine learning approaches for parameter reweighting in MC samples of top quark production in CMS

Guglielmi, Valentina

2023

Abstract: In particle physics, Monte Carlo (MC) event generators are needed to compare theory to the measured data. Many MC samples have to be generated to account for theoretical systematic uncertainties, at a significant computational cost. Therefore, the MC ... ...

Abstract	In particle physics, Monte Carlo (MC) event generators are needed to compare theory to the measured data. Many MC samples have to be generated to account for theoretical systematic uncertainties, at a significant computational cost. Therefore, the MC statistic becomes a limiting factor for most measurements and the significant computational cost of these programs a bottleneck in most physics analyses. In this contribution, the Deep neural network using Classification for Tuning and Reweighting (DCTR) approach is evaluated for the reweighting of two systematic uncertainties in MC simulations of top quark pair production within the CMS experiment. DCTR is a method, based on a Deep Neural Network (DNN) technique, to reweight simulations to different model parameters by using the full kinematic information in the event. This methodology avoids the need for simulating the detector response multiple times by incorporating the relevant variations in a single sample. Comment: To appear in the Proceedings of the European Physical Society conference, EPS2023, 20-25 August 2023 , Hamburg (Germany)
Keywords	High Energy Physics - Experiment
Subject code	621
Publishing date	2023-12-01
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Sporadic Inclusion Body Myositis at the Crossroads between Muscle Degeneration, Inflammation, and Aging.

Guglielmi, Valeria / Cheli, Marta / Tonin, Paola / Vattemi, Gaetano

International journal of molecular sciences

2024 Volume 25, Issue 5

Abstract: Sporadic inclusion body myositis (sIBM) is the most common muscle disease of older people and is clinically characterized by slowly progressive asymmetrical muscle weakness, predominantly affecting the quadriceps, deep finger flexors, and foot extensors. ...

Abstract	Sporadic inclusion body myositis (sIBM) is the most common muscle disease of older people and is clinically characterized by slowly progressive asymmetrical muscle weakness, predominantly affecting the quadriceps, deep finger flexors, and foot extensors. At present, there are no enduring treatments for this relentless disease that eventually leads to severe disability and wheelchair dependency. Although sIBM is considered a rare muscle disorder, its prevalence is certainly higher as the disease is often undiagnosed or misdiagnosed. The histopathological phenotype of sIBM muscle biopsy includes muscle fiber degeneration and endomysial lymphocytic infiltrates that mainly consist of cytotoxic CD8
MeSH term(s)	Humans ; Aged ; Myositis, Inclusion Body/genetics ; CD8-Positive T-Lymphocytes/metabolism ; Inflammation/complications ; Aging ; Proteins ; Myocardium/metabolism
Chemical Substances	Proteins
Language	English
Publishing date	2024-02-27
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms25052742
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Ketogenic Diet for Preoperative Weight Reduction in Bariatric Surgery: A Narrative Review.

Colangeli, Luca / Gentileschi, Paolo / Sbraccia, Paolo / Guglielmi, Valeria

Nutrients

2022 Volume 14, Issue 17

Abstract: Bariatric surgery (BS) is the most effective treatment in reducing weight and the burden of comorbidities in patients with severe obesity. Despite the overall low mortality rate, intra- and post-operative complications remains quite common. Weight loss ... ...

Abstract	Bariatric surgery (BS) is the most effective treatment in reducing weight and the burden of comorbidities in patients with severe obesity. Despite the overall low mortality rate, intra- and post-operative complications remains quite common. Weight loss before BS reduces surgical risk, but studies are inconclusive regarding which is the best approach to apply. In this review, we summarize the current evidence on the effect of a ketogenic diet (KD) before BS. All studies agree that KD leads to considerable weight loss and important improvements in terms of surgical risk, but populations, interventions and outcomes are very heterogeneous. KD appears to be a safe and effective approach to induce weight loss before BS. However, randomized controlled trials with better-defined dietary protocols and homogeneous outcomes are necessary in order to draw firm conclusions.
MeSH term(s)	Bariatric Surgery ; Diet, Ketogenic/methods ; Humans ; Obesity, Morbid/surgery ; Treatment Outcome ; Weight Loss
Language	English
Publishing date	2022-08-31
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2518386-2
ISSN	2072-6643 ; 2072-6643
ISSN (online)	2072-6643
ISSN	2072-6643
DOI	10.3390/nu14173610
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Article: Determination of Saffron Quality through a Multi-Analytical Approach.

Bergomi, Andrea / Comite, Valeria / Santagostini, Laura / Guglielmi, Vittoria / Fermo, Paola

Foods (Basel, Switzerland)

2022 Volume 11, Issue 20

Abstract: Currently, the specifications for the assessment of saffron quality are contained in the ISO 3632 technical standard. This norm evaluates saffron quality through a UV-Vis spectrophotometric method and grades the spice into three commercial categories. ... ...

Abstract	Currently, the specifications for the assessment of saffron quality are contained in the ISO 3632 technical standard. This norm evaluates saffron quality through a UV-Vis spectrophotometric method and grades the spice into three commercial categories. However, numerous studies have highlighted several weaknesses and limitations of the ISO method. For this reason, a new multi-analytical approach for the determination of saffron quality is proposed in this work. Different techniques were employed to assess saffron quality: UV-visible spectroscopy (UV-Vis), attenuated total reflectance Fourier transform infrared spectroscopy (ATR-FTIR), scanning electron microscopy coupled with energy dispersive X-ray spectroscopy (SEM-EDX) and inductively coupled plasma-optical emission spectroscopy (ICP-OES). The results show that the commercial grading based on the ISO 3632 methodology is not always in line with the observations made with the other techniques. Moreover, the use of two new techniques in the field of saffron quality determination, i.e., SEM-EDX and ICP-OES, proved to be effective for the determination of elemental composition and metal content, which are two important parameters to take into consideration when assessing the quality of the spice.
Language	English
Publishing date	2022-10-15
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2704223-6
ISSN	2304-8158
ISSN	2304-8158
DOI	10.3390/foods11203227
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Article: Editorial: Covid-19 and obesity.

Guglielmi, Valeria / El Ghoch, Marwan / Bettini, Silvia / Holly, Jeff M P

Frontiers in endocrinology

2022 Volume 13, Page(s) 1122274

MeSH term(s)	Humans ; COVID-19 ; SARS-CoV-2 ; Obesity/complications ; Obesity/epidemiology
Language	English
Publishing date	2022-12-23
Publishing country	Switzerland
Document type	Editorial
ZDB-ID	2592084-4
ISSN	1664-2392
ISSN	1664-2392
DOI	10.3389/fendo.2022.1122274
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Article: Gli infortuni a rischio biologico in una realtà ospedaliera pugliese: studio osservazionale in una coorte di infermieri e studenti infermieri.

Vitale, Elsa / Guglielmi, Vittorio / Iosca, Mirko / Celani, Fabrizio

Giornale italiano di medicina del lavoro ed ergonomia

2021 Volume 43, Issue 2, Page(s) 111–117

Abstract: Summary: Introduction. An injury caused by a biological agent is an event that causes damage to the health of the operator. Nursing is one of the most affected professions. Objectives. This study aims to analyze and quantify the injuries caused by ... ...

Title translation	Biological injuries in a hospital in Puglia: an observational study between nurses and nursing students.
Abstract	Summary: Introduction. An injury caused by a biological agent is an event that causes damage to the health of the operator. Nursing is one of the most affected professions. Objectives. This study aims to analyze and quantify the injuries caused by exposure to biological agents among working nurses and students of the degree course in Nursing at the "F. Miulli" Regional General Ecclesiastical Body, located in Acquaviva delle Fonti, province of Bari, Italy. Methods. The retrospective study was carried out by collecting data from May 2019 to July 2019. The data were collected from the archive of biological accidents for the five-year period 2014-2018. The data collected was divided according to the professional category of the subject: whether it is a nurse-worker, or a nurse-student, enrolled in the Nursing course of the University of Bari Aldo Moro. Results. 249 injuries caused by biological agents were recorded, of which 69.1% were female and 30.9% were male. The operating units most involved are the medical branch departments (55.4%). The anatomical sites most affected are the upper limbs with 205 cases. Discussion. It is necessary to invest in training and refresher campaigns for nursing staff and nursing students in order to ensure the standards of effectiveness of the services provided and safety in providing them.
MeSH term(s)	Female ; Hospitals ; Humans ; Italy/epidemiology ; Male ; Nurses ; Retrospective Studies ; Students, Nursing
Language	Italian
Publishing date	2021-08-09
Publishing country	Italy
Document type	Journal Article ; Observational Study
ZDB-ID	603103-1
ISSN	1592-7830 ; 0391-9889
ISSN	1592-7830 ; 0391-9889
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Article ; Online: Is type 2 diabetes an adiposity-based metabolic disease? From the origin of insulin resistance to the concept of dysfunctional adipose tissue.

Sbraccia, Paolo / D'Adamo, Monica / Guglielmi, Valeria

Eating and weight disorders : EWD

2021 Volume 26, Issue 8, Page(s) 2429–2441

Abstract: In the last decades of the past century, a remarkable amount of research efforts, money and hopes was generated to unveil the basis of insulin resistance that was believed to be the primary etiological factor in the development of type 2 diabetes. From ... ...

Abstract	In the last decades of the past century, a remarkable amount of research efforts, money and hopes was generated to unveil the basis of insulin resistance that was believed to be the primary etiological factor in the development of type 2 diabetes. From the Reaven's insulin resistance syndrome to the DeFronzo's triumvirate (skeletal muscle, liver and beta-cell) and to Kahn's discovery (among many others) of insulin receptor downregulation and autophosphorylation, an enthusiastic age of metabolic in vivo and in vitro research took place, making the promise of a resolutory ending. However, from many published data (those of insulin receptoropathies and lipodystrophies, the genome-wide association studies results, the data on reversibility of type 2 diabetes after bariatric surgery or very-low-calorie diets, and many others) it appears that insulin resistance is not a primary defect but it develops secondarily to increased fat mass. In particular, it develops from a mismatch between the surplus caloric intake and the storage capacity of adipose tissue. On this basis, we propose to change the today's definition of type 2 diabetes in adiposity-based diabetes.Level of Evidence as a narrative review a vast array of studies have been included in the analysis, ranging from properly designed randomized controlled trials to case studies; however, the overall conclusion may be regarded as level IV.
MeSH term(s)	Adipose Tissue ; Adiposity ; Diabetes Mellitus, Type 2 ; Genome-Wide Association Study ; Humans ; Insulin Resistance
Language	English
Publishing date	2021-02-08
Publishing country	Germany
Document type	Journal Article ; Review
ZDB-ID	2038625-4
ISSN	1590-1262 ; 1124-4909
ISSN (online)	1590-1262
ISSN	1124-4909
DOI	10.1007/s40519-021-01109-4
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Article: Staphylococcal scalded skin syndrome in adults with obesity and type 2 diabetes: A case series.

Vitale, Carolina / Spinozzi, Valentina / Colangeli, Luca / Sbraccia, Paolo / Guglielmi, Valeria

Clinical case reports

2022 Volume 10, Issue 11, Page(s) e6471

Abstract: Staphylococcal scalded skin syndrome (SSSS) primarily affects children and rarely adults with immunodepression. We describe two cases of adults diagnosed with SSSS with no additional cause of immunological compromise other than obesity and uncontrolled ... ...

Abstract	Staphylococcal scalded skin syndrome (SSSS) primarily affects children and rarely adults with immunodepression. We describe two cases of adults diagnosed with SSSS with no additional cause of immunological compromise other than obesity and uncontrolled diabetes. An increased risk of infection should be considered in cases of obesity and diabetes.
Language	English
Publishing date	2022-11-16
Publishing country	England
Document type	Case Reports
ZDB-ID	2740234-4
ISSN	2050-0904
ISSN	2050-0904
DOI	10.1002/ccr3.6471
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Article ; Online: Letter to the Editor. Classic radiological appearance of a carotid web.

Guglielmi, Valeria / Mandell, Daniel M

Journal of neurosurgery

2019 , Page(s) 1–2

Language	English
Publishing date	2019-04-05
Publishing country	United States
Document type	Journal Article ; Letter
ZDB-ID	3089-2
ISSN	1933-0693 ; 0022-3085
ISSN (online)	1933-0693
ISSN	0022-3085
DOI	10.3171/2018.12.JNS183522
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Article ; Online: Protein Expression of Canine and Feline Muscular Dystrophies.

Salvadori, C / Vattemi, G / Guglielmi, V / Marini, M / Tomelleri, G / Cantile, C

Topics in companion animal medicine

2020 Volume 42, Page(s) 100500

Abstract: Muscular dystrophies in dogs and cats represent a heterogeneous group of inherited, sometimes congenital, but infrequently diagnosed, progressive neuromuscular disorders. A correct identification and characterization of canine and feline muscular ... ...

Abstract	Muscular dystrophies in dogs and cats represent a heterogeneous group of inherited, sometimes congenital, but infrequently diagnosed, progressive neuromuscular disorders. A correct identification and characterization of canine and feline muscular dystrophies could increase diagnostic and treatment strategies for veterinary neurologists and could identify useful animal models for the study of human dystrophies. However, in dogs and cats, diagnosis of muscular dystrophies is challenging due to a nonspecific clinical phenotype and pathological lesions, thus is most likely underestimated. We performed immunofluorescence and Western blot techniques using a wide panel of antibodies against proteins involved in human dystrophies (dystrophin mid-rod and carboxyterminal domain, α, β, γ, and δ-sarcoglycan, α-dystroglycan, caveolin-3, emerin, merosin, dysferlin, calpain-3, spectrin epitopes), on 9 canine and 3 feline muscle biopsies characterized by myopathic changes. Dystrophin deficiency was detected in 3 dogs and 2 novel canine muscular dystrophies have been identified, characterized by deficiency of caveolin-3 and calpain-3, respectively. In 2 cats, deficiency of β-SG and carboxyterminal domain of dystrophin in all muscle fibers has been detected. Performing immunofluorescence and Western blot analyses with a wider panel of antibodies allowed a correct identification of muscular dystrophies in dogs and cats and provides a direction for subsequent targeted genetic testing.
MeSH term(s)	Animals ; Cat Diseases ; Cats ; Dog Diseases ; Dogs ; Dystrophin/metabolism ; Immunohistochemistry/veterinary ; Muscle, Skeletal ; Muscular Dystrophies/genetics ; Muscular Dystrophies/metabolism ; Muscular Dystrophies/pathology ; Sarcoglycans/analysis ; Sarcoglycans/deficiency ; Sarcoglycans/genetics
Chemical Substances	Dystrophin ; Sarcoglycans
Language	English
Publishing date	2020-11-26
Publishing country	United States
Document type	Journal Article
ISSN	1946-9837
ISSN (online)	1946-9837
DOI	10.1016/j.tcam.2020.100500
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