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Article ; Online: Skin score correlates with global DNA methylation and GSTO1 A140D polymorphism in arsenic-affected population of Eastern India.

Majumder, Moumita / Dasgupta, Uma B / Guha Mazumder, D N / Das, Nilansu

2017 Volume 27, Issue 6, Page(s) 467–475

Abstract: Arsenic is a potent environmental toxicant causing serious public health concerns in India, Bangladesh and other parts of the world. Gene- and promoter-specific hypermethylation has been reported in different arsenic-exposed cell lines, whereas whole ... ...

Abstract	Arsenic is a potent environmental toxicant causing serious public health concerns in India, Bangladesh and other parts of the world. Gene- and promoter-specific hypermethylation has been reported in different arsenic-exposed cell lines, whereas whole genome DNA methylation study suggested genomic hypo- and hypermethylation after arsenic exposure in in vitro and in vivo studies. Along with other characteristic biomarkers, arsenic toxicity leads to typical skin lesions. The present study demonstrates significant correlation between severities of skin manifestations with their whole genome DNA methylation status as well as with a particular polymorphism (Ala 140 Asp) status in arsenic metabolizing enzyme Glutathione S-transferase Omega-1 (GSTO1) in arsenic-exposed population of the district of Nadia, West Bengal, India.
Language	English
Publishing date	2017-07
Publishing country	England
Document type	Journal Article
ZDB-ID	2081252-8
ISSN	1537-6524 ; 1537-6516 ; 1051-7235
ISSN (online)	1537-6524
ISSN	1537-6516 ; 1051-7235
DOI	10.1080/15376516.2017.1323255
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Article: Chronic arsenic toxicity & human health.

Guha Mazumder, D N

The Indian journal of medical research

2008 Volume 128, Issue 4, Page(s) 436–447

Abstract: Chronic arsenic toxicity (arsenicosis) due to drinking of arsenic contaminated ground water is a major environmental health hazard throughout the world including India. A lot of new information is emerging from extensive research on health effects of ... ...

Abstract	Chronic arsenic toxicity (arsenicosis) due to drinking of arsenic contaminated ground water is a major environmental health hazard throughout the world including India. A lot of new information is emerging from extensive research on health effects of chronic arsenic toxicity (CAT) in humans during the last two decades. Available literature has been reviewed to highlight the problem including its malignancies. Pigmentation and keratosis are the specific skin lesions characteristics of CAT. CAT also produces various systemic manifestations over and above skin lesions, important ones being chronic lung disease like chronic bronchitis, chronic obstructive pulmonary disease and bronchiectasis, liver disease like non-cirrhotic portal fibrosis and other diseases like polyneuropathy, peripheral vascular disease, hypertension and ischeamic heart disease, diabetes mellitus, non-pitting oedema of feet/hands, weakness and anaemia. Cancer of skin, lung and urinary bladder are important cancers associated with chronic arsenic toxicity. Stoppage of drinking of arsenic contaminated water is the main stay in the management of arsenicosis as specific chelation therapy has limited value. Early skin cancer, detectable by regular active surveillance, is curable. In addition to dermatological features, CAT produces protean clinical manifestations. Treatment of arsenicosis is unsatisfactory and is mostly symtomatic.
MeSH term(s)	Arsenic/toxicity ; Environmental Exposure ; Humans ; Water Pollutants, Chemical/toxicity ; Water Supply
Chemical Substances	Water Pollutants, Chemical ; Arsenic (N712M78A8G)
Language	English
Publishing date	2008-10
Publishing country	India
Document type	Journal Article ; Review
ZDB-ID	390883-5
ISSN	0971-5916 ; 0019-5340
ISSN	0971-5916 ; 0019-5340
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Article: Arsenic and non-malignant lung disease.

Guha Mazumder, D N

Journal of environmental science and health. Part A, Toxic/hazardous substances & environmental engineering

2007 Volume 42, Issue 12, Page(s) 1859–1867

Abstract: Many aquifers in various parts of the world have been found to be contaminated with arsenic at concentration above 0.05 mg/L. However reports of large number of affected people in India and Bangladesh are unprecedented. Characteristic skin lesions ( ... ...

Abstract	Many aquifers in various parts of the world have been found to be contaminated with arsenic at concentration above 0.05 mg/L. However reports of large number of affected people in India and Bangladesh are unprecedented. Characteristic skin lesions (pigmentation, depigmentation and keratosis) are the hallmark signs of chronic arsenic toxicity. Emerging evidences show that ingestion of arsenic through drinking water may also lead to non-malignant respiratory effects. Early report of non-malignant pulmonary effect of chronic ingestion of arsenic was available from studies in children in Chile as early as 1970. However on the basis of case studies, respiratory effect of chronic arsenic toxicity in adults following drinking of arsenic contaminated water in West Bengal was first reported in 1997. Epidemiological studies carried out in West Bengal on a population of 7683 showed that the prevalence odds ratio (POR) estimates were markedly increased for participants with arsenic induced skin lesions who also had high levels of arsenic in their current drinking water source (> or = 0.5 mg/L) compared with individuals who had normal skin and were exposed to low levels of arsenic (< 0.05 mg/L). In participants with skin lesions, age-adjusted POR estimates for chronic cough were 7.8 for females (95% CI:3.1-19.5) and 5.0 for males (95% CI:2.6-9.9). In Bangladesh, similar study carried out on a population of 218 showed that the crude prevalence ratio for chronic bronchitis was found to be 10.3 (95% CI:2.4-43.1) for females and 1.6 (95% CI:0.8-3.1) for males. Reports of lung function tests were available from both hospital and population based studies. Results show evidences of restrictive, obstructive and combined obstructive and restrictive lung disease in different people having chronic lung disease associated with chronic arsenic toxicity. On the basis of clinical study, chest X-ray and HRCT done in Arsenicosis patients with features of chronic lung disease, the abnormalities observed were varied. Evidences of obstructive pulmonary disease (COPD), interstitial lung disease (ILD) and bronchiectasis were found in some of the cases. Results of studies carried out on people showing features of Arsenicosis due to drinking arsenic contaminated water provide evidence that arsenic is a potent respiratory toxicant, even following ingestion.
MeSH term(s)	Adult ; Arsenic/analysis ; Arsenic Poisoning/epidemiology ; Arsenic Poisoning/etiology ; Arsenic Poisoning/pathology ; Bangladesh/epidemiology ; Bronchiectasis/chemically induced ; Bronchiectasis/epidemiology ; Bronchiectasis/pathology ; Bronchitis, Chronic/chemically induced ; Bronchitis, Chronic/epidemiology ; Bronchitis, Chronic/pathology ; Environmental Exposure/adverse effects ; Environmental Exposure/analysis ; Female ; Humans ; India/epidemiology ; Lung Diseases/chemically induced ; Lung Diseases/epidemiology ; Lung Diseases/pathology ; Lung Diseases, Interstitial/chemically induced ; Lung Diseases, Interstitial/epidemiology ; Lung Diseases, Interstitial/pathology ; Male ; Middle Aged ; Odds Ratio ; Prevalence ; Pulmonary Disease, Chronic Obstructive/chemically induced ; Pulmonary Disease, Chronic Obstructive/epidemiology ; Pulmonary Disease, Chronic Obstructive/pathology ; Skin Diseases/chemically induced ; Skin Diseases/epidemiology ; Skin Diseases/pathology ; Water Pollutants, Chemical/analysis ; Water Pollutants, Chemical/poisoning ; Water Supply/analysis
Chemical Substances	Water Pollutants, Chemical ; Arsenic (N712M78A8G)
Language	English
Publishing date	2007-10
Publishing country	England
Document type	Journal Article
ZDB-ID	196584-0
ISSN	1532-4117 ; 1093-4529 ; 0360-1226 ; 1077-1204
ISSN (online)	1532-4117
ISSN	1093-4529 ; 0360-1226 ; 1077-1204
DOI	10.1080/10934520701566926
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Article: Hepatology in Kolkata.

Guha Mazumder, D N

Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology

2007 Volume 26 Suppl 1, Page(s) S18–23

MeSH term(s)	Animals ; Gastroenterology/history ; Gastroenterology/trends ; History, 20th Century ; Humans ; India ; Liver Diseases/history
Language	English
Publishing date	2007-07-17
Publishing country	India
Document type	Historical Article ; Journal Article
ZDB-ID	632595-6
ISSN	0254-8860
ISSN	0254-8860
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Article: Effect of drinking arsenic-contaminated water in children.

Majumdar, Kunal K / Guha Mazumder, D N

Indian journal of public health

2012 Volume 56, Issue 3, Page(s) 223–226

Abstract: Chronic arsenic toxicity due to drinking of arsenic-contaminated water has been a major environmental health hazard throughout the world including India. Although a lot of information is available on health effects due to chronic arsenic toxicity in ... ...

Abstract	Chronic arsenic toxicity due to drinking of arsenic-contaminated water has been a major environmental health hazard throughout the world including India. Although a lot of information is available on health effects due to chronic arsenic toxicity in adults, knowledge of such effect on children is scanty. A review of the available literature has been made to highlight the problem in children. Scientific publications on health effects of chronic arsenic toxicity in children with special reference to psychological issues are reviewed. The prevalence of skin abnormalities such as pigmentation change and keratosis, the diagnostic signs of chronic arsenic toxicity, vary in various arsenic-exposed children population in different regions of the world. The occurrence of chronic lung disease including pulmonary interstitial fibrosis has been described in arsenic-exposed children in Chile. Affection of intellectual function has also been reported to occur in arsenic-exposed children studied in Thailand, Bangladesh, and India. Methylation patterns of arsenic in children aggregate in families and are correlated in siblings, providing evidence of a genetic basis for the variation in arsenic methylation. Chronic arsenic toxicity due to drinking of arsenic-contaminated water causes significant morbidity in children resulting in skin lesions, lung disease, and defect in intellectual function.
MeSH term(s)	Arsenic/toxicity ; Arsenic Poisoning/epidemiology ; Child ; Drinking Water/chemistry ; Environmental Exposure/adverse effects ; Female ; Humans ; Male ; Prevalence ; Water Pollutants, Chemical/toxicity
Chemical Substances	Drinking Water ; Water Pollutants, Chemical ; Arsenic (N712M78A8G)
Language	English
Publishing date	2012-07
Publishing country	India
Document type	Journal Article ; Review
ZDB-ID	800737-8
ISSN	2229-7693 ; 0019-557X
ISSN (online)	2229-7693
ISSN	0019-557X
DOI	10.4103/0019-557X.104250
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Article: Chronic arsenic toxicity: clinical features, epidemiology, and treatment: experience in West Bengal.

Guha Mazumder, D N

Journal of environmental science and health. Part A, Toxic/hazardous substances & environmental engineering

2003 Volume 38, Issue 1, Page(s) 141–163

Abstract: Chronic arsenic toxicity due to drinking arsenic-contaminated water has been one of the worst environmental health hazards affecting eight districts of West Bengal since the early eighties. Detailed clinical examination and investigation of 248 such ... ...

Abstract	Chronic arsenic toxicity due to drinking arsenic-contaminated water has been one of the worst environmental health hazards affecting eight districts of West Bengal since the early eighties. Detailed clinical examination and investigation of 248 such patients revealed protean clinical manifestations of such toxicity. Over and above hyperpigmentation and keratosis, weakness, anaemia, burning sensation of eyes, solid swelling of legs, liver fibrosis, chronic lung disease, gangrene of toes, neuropathy, and skin cancer are some of the other manifestations. A cross-sectional survey involving 7683 participants of all ages was conducted in an arsenic-affected region between April 1995 and March 1996. Out of a population of 7683 surveyed, 3467 and 4216 people consumed water containing As below and above 0.05 mg/L, respectively. Except pain abdomen the prevalence of all other clinical manifestations tested (e.g., pigmentation, keratosis, hepatomegaly, weakness, nausea, lung disease and neuropathy) were found to be significantly higher in As exposed people (water As > 0.05 mg/L) compared to control population (water As level < 0.05 mg/L). The prevalence of pigmentation and keratosis, hepatomegaly, chronic respiratory disease and weakness rose significantly with increasing arsenic concentrations in drinking water. The respiratory effects were most pronounced in individuals with high arsenic water concentrations who also had skin lesion. Therapy with chelating agent DMSA was not found to be superior to placebo effect. However, therapy with DMPS caused significant improvement of clinical condition of chronic arsenicosis patients as evidenced by significant reduction of total clinical scores from 8.90 +/- 2.84 to 3.27 +/- 1.73; p < 0.0001. Efficacy of specific chelation therapy for patients suffering from chronic As toxicity has further need to be fully substantiated. However, supportive treatment could help in reducing many symptoms of the patients. Treatment in hospital with good nutritious diet has been found to reduce symptom score in a subset of placebo treated patients in West Bengal during the course of DMSA and DMPS trial. People should be advised to stop drinking As contaminated water or exposure to As from any other source. The various clinical manifestations should be treated symptomatically.
MeSH term(s)	Abdominal Pain/etiology ; Adult ; Arsenic Poisoning/epidemiology ; Arsenic Poisoning/physiopathology ; Arsenic Poisoning/therapy ; Chelating Agents/therapeutic use ; Chemical and Drug Induced Liver Injury ; Cross-Sectional Studies ; Female ; Humans ; India ; Male ; Middle Aged ; Nausea/chemically induced ; Nervous System Diseases/chemically induced ; Nutritional Support ; Pulmonary Fibrosis/chemically induced ; Skin Diseases/chemically induced ; Succimer/therapeutic use ; Water Supply
Chemical Substances	Chelating Agents ; Succimer (DX1U2629QE)
Language	English
Publishing date	2003-11-03
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, U.S. Gov't, P.H.S.
ZDB-ID	196584-0
ISSN	1532-4117 ; 1093-4529 ; 0360-1226 ; 1077-1204
ISSN (online)	1532-4117
ISSN	1093-4529 ; 0360-1226 ; 1077-1204
DOI	10.1081/ese-120016886
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Article: Arsenic exposure and health effects.

Guha Mazumder, D N

Journal of toxicology. Clinical toxicology

2002 Volume 40, Issue 4, Page(s) 527–8; author reply 529–30

MeSH term(s)	Arsenic Poisoning/complications ; Humans ; Laryngitis/chemically induced ; Muscular Diseases/chemically induced
Language	English
Publishing date	2002
Publishing country	United States
Document type	Comment ; Letter
ZDB-ID	204476-6
ISSN	1556-9519 ; 0731-3810 ; 0009-9309 ; 1556-3650
ISSN (online)	1556-9519
ISSN	0731-3810 ; 0009-9309 ; 1556-3650
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Article: Arsenic and liver disease.

Guha Mazumder, D N

Journal of the Indian Medical Association

2001 Volume 99, Issue 6, Page(s) 311, 314–5, 318–20

Abstract: The hepatotoxic action of arsenic, when used as a therapeutic agent, has long been recognised. Data on liver involvement following chronic exposure to arsenic-contaminated water are scanty. The nature and degree of liver involvement are reported on the ... ...

Abstract	The hepatotoxic action of arsenic, when used as a therapeutic agent, has long been recognised. Data on liver involvement following chronic exposure to arsenic-contaminated water are scanty. The nature and degree of liver involvement are reported on the basis of hospital based studies in patients who consumed arsenic contaminated drinking water for one to 15 years. Two hundred forty-eight patients with evidence of chronic arsenic toxicity underwent clinical and laboratory examination including liver function tests and hepatitis B surface antigen (HBsAg) status. Liver biopsy was done in 69 cases; in 29 patients, liver arsenic content was estimated by neutron activation analysis. Hepatomegaly was present in 190 of 248 patients (76.6%). Non-cirrhotic portal fibrosis was the predominant lesion (91.3%) in liver histology. The maximum arsenic content in liver was 6 mg/kg (mean 1.46 [0.42], control value 0.16 [0.04]; p <0.001); it was undetected in 6 of 29 samples studied. The largest number of patients with liver disease due to chronic arsenicosis from drinking arsenic contaminated water are reported. Non-cirrhotic portal fibrosis is the predominant lesion in this population. Hepatic fibrosis has also been demonstrated due to long term arsenic toxicity in an animal model. Initial biochemical evidence of hepatic membrane damage, probably due to reduction of glutathione and antioxidant enzymes, may be seen by 6 months. Continued arsenic feeding resulted in fatty liver with serum aminotransferases elevated at 12 months and hepatic fibrosis at 15 months.
MeSH term(s)	Adult ; Animals ; Arsenic/analysis ; Arsenic Poisoning/etiology ; Arsenic Poisoning/pathology ; Chemical and Drug Induced Liver Injury ; Chronic Disease ; Female ; Glutathione/metabolism ; Humans ; Liver/enzymology ; Liver/pathology ; Liver Diseases/pathology ; Male ; Mice ; Mice, Inbred BALB C ; Organ Size/drug effects ; Sodium-Potassium-Exchanging ATPase/metabolism ; Water Pollution, Chemical
Chemical Substances	Sodium-Potassium-Exchanging ATPase (EC 3.6.3.9) ; Glutathione (GAN16C9B8O) ; Arsenic (N712M78A8G)
Language	English
Publishing date	2001-06
Publishing country	India
Document type	Journal Article
ZDB-ID	390814-8
ISSN	0019-5847
ISSN	0019-5847
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Ua VI Zs.415: Show issues

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Article ; Online: Safe limit of arsenic in soil in relation to dietary exposure of arsenicosis patients from Malda district, West Bengal- A case study.

Golui, Debasis / Guha Mazumder, D N / Sanyal, S K / Datta, S P / Ray, P / Patra, P K / Sarkar, S / Bhattacharya, K

Ecotoxicology and environmental safety

2017 Volume 144, Page(s) 227–235

Abstract: Safe limit of arsenic in soil in relation to dietary exposure of arsenicosis patients was established in Malda district of West Bengal. Out of 182 participants examined, 80 (43.9%) participants showed clinical features of arsenicosis, characterized by ... ...

Abstract	Safe limit of arsenic in soil in relation to dietary exposure of arsenicosis patients was established in Malda district of West Bengal. Out of 182 participants examined, 80 (43.9%) participants showed clinical features of arsenicosis, characterized by arsenical skin lesion (pigmentation and keratosis), while 102 participants did not have any such lesion (control). Experimental results of the twenty eight soils (own field) of the participants showed the mean Olsen extractable and total arsenic concentration of 0.206 and 6.70mgkg
MeSH term(s)	Arsenic/analysis ; Arsenic Poisoning/epidemiology ; Arsenic Poisoning/prevention & control ; Eating ; Edible Grain/chemistry ; Food Safety ; Humans ; India ; Models, Theoretical ; Oryza/chemistry ; Risk Assessment ; Soil/chemistry ; Soil/standards ; Soil Pollutants/analysis ; Water Pollutants, Chemical/analysis
Chemical Substances	Soil ; Soil Pollutants ; Water Pollutants, Chemical ; Arsenic (N712M78A8G)
Language	English
Publishing date	2017-10
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	436536-7
ISSN	1090-2414 ; 0147-6513
ISSN (online)	1090-2414
ISSN	0147-6513
DOI	10.1016/j.ecoenv.2017.06.027
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Article: Baseline characteristics of HIV & hepatitis B virus (HIV/HBV) co-infected patients from Kolkata, India.

Sarkar, Jayeeta / Saha, Debraj / Bandyopadhyay, Bhaswati / Saha, Bibhuti / Kedia, Deepika / Guha Mazumder, D N / Chakravarty, Runu / Guha, Subhasish Kamal

The Indian journal of medical research

2016 Volume 143, Issue 5, Page(s) 636–642

Abstract: Background & objectives: Hepatitis B virus (HBV) and HIV co-infection has variable prevalence worldwide. In comparison to HBV mono-infection, the course of chronic HBV infection is accelerated in HIV/HBV co-infected patients. the present study was ... ...

Abstract	Background & objectives: Hepatitis B virus (HBV) and HIV co-infection has variable prevalence worldwide. In comparison to HBV mono-infection, the course of chronic HBV infection is accelerated in HIV/HBV co-infected patients. the present study was carried out to analyse the baseline characteristics (clinical, biochemical, serological and virological) of treatment naïve HIV/HBV co-infected and HIV mono-infected patients. Methods: Between July 2011 and January 2013, a total number of 1331 HIV-seropositive treatment naïve individuals, enrolled in the ART Centre of Calcutta School of Tropical Medicine, Kolkata, India, were screened for hepatitis B surface antigen (HBsAg). A total of 1253 HIV mono-infected and 78 HIV/HBV co-infected patients were characterized. The co-infected patients were evaluated for HBeAg and anti-HBe antibody by ELISA. HIV RNA was quantified for all co-infected patients. HBV DNA was detected and quantified by real time-PCR amplification followed by HBV genotype determination. Results: HIV/HBV co-infected patients had proportionately more advanced HIV disease (WHO clinical stage 3 and 4) than HIV mono-infected individuals (37.1 vs. 19.9%). The co-infected patients had significantly higher serum bilirubin, alanine aminotransferase (ALT), alkaline phosphatase and ALT/platelet ratio index (APRI). CD4 count was non-significantly lower in co-infected patients. Majority (61.5%) were HBeAg positive with higher HIV RNA (P<0.05), HBV DNA (p<0.001) and APRI (p<0.05) compared to those who were HBeAg negative. HBV/D was the predominant genotype (73.2%) and D2 (43.7%) was the commonest subgenotype. Interpretation & conclusions: HIV/HBV co-infected patients had significantly higher serum bilirubin, ALT, alkaline phosphatase and lower platelet count. HBeAg positive co-infected patients had higher HIV RNA and HBV DNA compared to HBeAg negative co-infected patients. Prior to initiation of antiretroviral treatment (ART) all patients should be screened for HBsAg to initiate appropriate ART regimen.
MeSH term(s)	Adolescent ; Adult ; Aged ; Coinfection/physiopathology ; Female ; HIV/pathogenicity ; HIV Infections/blood ; HIV Infections/physiopathology ; HIV Infections/virology ; Hepatitis B/blood ; Hepatitis B/physiopathology ; Hepatitis B/virology ; Hepatitis B Surface Antigens/blood ; Hepatitis B virus/isolation & purification ; Hepatitis B virus/pathogenicity ; Humans ; Male ; Middle Aged
Chemical Substances	Hepatitis B Surface Antigens
Language	English
Publishing date	2016-05
Publishing country	India
Document type	Journal Article
ZDB-ID	390883-5
ISSN	0971-5916 ; 0019-5340
ISSN	0971-5916 ; 0019-5340
DOI	10.4103/0971-5916.187113
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