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  1. Article ; Online: Effects of Qishen Yiqi dripping pills-containing serum on KATP channel opening and PI3K/AKT signaling pathway in hypoxic/ reoxygenated H9C2 cardiocytes

    Gui-Xin He

    Journal of Hainan Medical University, Vol 28, Iss 6, Pp 12-

    2022  Volume 18

    Abstract: Objective: To investigate the effects of Qishen Yiqi dropping pills serum on KATP channel opening and PI3K/AKT signaling pathway of hypoxic/reoxygenated H9C2 cardiocytes. Methods: H9C2 cardiocytes cultured in vitro were randomly divided into five groups, ...

    Abstract Objective: To investigate the effects of Qishen Yiqi dropping pills serum on KATP channel opening and PI3K/AKT signaling pathway of hypoxic/reoxygenated H9C2 cardiocytes. Methods: H9C2 cardiocytes cultured in vitro were randomly divided into five groups, A: H9C2 cell group B: H9C2 cells +H2O2 model group C:H9C2 cells +H2O2 model + Qishen Yiqi group D:H9C2 cells +H2O2 model + Qishen Yiqi +wort group E:H9C2 cells +H2O2 model + Qishenyiqi +5-HD group, the drug intervention is according to the corresponding conditions. CCK-8 method was used to detect the cell activity of each group; Western blot was used to detect the expression of AKT and P-Akt proteins in myocardial cells in each group. The current was recorded by the standard patch clamp whole cell recording method, and the current was collected and analyzed by Pclamp6.0 software. Results: CCK-8 test results showed that compared with group A, the activity of myocardial cells in group B was significantly decreased, and the difference was statistically significant (P<0.01); compared with group B, the difference in group C was statistically significant (P<0.01); compared with C, cardiomyocyte activity in D and E group were significantly decreased, and the difference was statistically significant (P<0.05); WB results showed that compared with A, p-Akt protein expression in B, C, D and E groups were significantly decreased, and the difference was statistically significant (P< 0.01); compared with group B, p-Akt protein expression in C, D and E group were significantly increased, and the difference was statistically significant (P< 0.01),but there was no significant difference in AKT expression among groups (P>0.05); The results of whole cell patch clamp experiment showed that the outward current of B was significantly increased compared with that of A, and the difference between groups was statistically significant (P<0.01); compared with group B, cardiomyocytes in group C further increased the outward current, and the difference between groups ...
    Keywords qishen yiqi dropping pills ; h9c2 ; hypoxia/reoxygenation ; p-akt ; mitokatp ; Medicine ; R
    Subject code 571
    Language English
    Publishing date 2022-03-01T00:00:00Z
    Publisher Editorial Board of Journal of Hainan Medical University
    Document type Article ; Online
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  2. Article ; Online: A theoretical study of miRNA155-DNA methylation mediated mitokATP regulating mitochondrial autophagy in the improvement of myocardial ischemia-reperfusion injury by Qishen Yiqi Dropping Pills

    Gui-Xin He

    Journal of Hainan Medical University, Vol 28, Iss 5, Pp 53-

    2022  Volume 58

    Abstract: In the state of acute myocardial ischemia, miRNA expression can regulate related genes and proteins, reduce myocardial cell damage, and thus play a protective role in the myocardium. However, the specific mechanism still needs to be further explored. ... ...

    Abstract In the state of acute myocardial ischemia, miRNA expression can regulate related genes and proteins, reduce myocardial cell damage, and thus play a protective role in the myocardium. However, the specific mechanism still needs to be further explored. Recent studies have found that the opening of the mitoKATP channel can regulate mitochondrial autophagy, and the initiation of miRNA-DNA methylation plays a regulatory role in inducing cell autophagy. The applicant research team previously found that Qishen Yiqi Dropping Pills could significantly improve myocardial ischemia by mediating MitokATP channels to regulate mitochondrial autophagy., and animal experiments have confirmed that miR-155 plays a significant role in the aspect of autophagy regulates, inflammatory reaction and Vascular smooth muscle cell migration. Therefore, the applicant innovatively proposed that Qishen Yiqi Dropping Pills can regulate miRNA155-DNA methylation to mediate the opening of mitoKATP, thereby regulating mitochondrial autophagy and improving myocardial ischemia. In this paper, the association between mitochondrial autophagy and oxidative stress injury after myocardial ischemia was described, and the possible mechanism of Qisen Yiqi dropping pills regulating mitochondrial autophagy by regulating miRNA155-DNA methylation to mediate MitokATP to improve myocardial ischemia reperfusion injury was discussed, so as to provide theoretical ideas for related research.
    Keywords qishen yiqi dropping pills ; myocardial ischemia ; mirna155-dna methylation ; mitochondrial autophagy ; mitokatp ; Medicine ; R
    Subject code 610
    Language English
    Publishing date 2022-03-01T00:00:00Z
    Publisher Editorial Board of Journal of Hainan Medical University
    Document type Article ; Online
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  3. Article ; Online: Experimental study of qishen yiqi drop pill combined with bone marrow mesenchymal stem cell transplantation on angiogenesis and cardiac function in mice with myocardial infarction

    Gui-Xin He

    Journal of Hainan Medical University, Vol 27, Iss 5, Pp 1-

    2021  Volume 6

    Abstract: Objective: To investigate the effects ofQishengyiqi drop pill combined with bone marrow mesenchymal stem cell transplantation on angiogenesis and cardiac function in mice after myocardial infarction through in vitro cell molecular biology experiments. ... ...

    Abstract Objective: To investigate the effects ofQishengyiqi drop pill combined with bone marrow mesenchymal stem cell transplantation on angiogenesis and cardiac function in mice after myocardial infarction through in vitro cell molecular biology experiments. Methods: The animals used in this experiment were male mice with eGFP +/-. Sixty mice were randomly divided into three groups (n = 20) : myocardial infarction group (MI + PBS), myocardial infarction + mesenchyme plasma stem cell transplantation group (MI + MSCs) and myocardial infarction + Qishenyiqi drip pill combined with mesenchymal stem cell transplantation group (MI + MSCs + QSYQ). Qishenyiqi dripping pills were prepared into a medicinal solution with a concentration of 3.9 mg / mL with distilled water. The MI + MSCs + QSYQ group was orally administered with 0.1 mL / kg / day, and the other two groups were orally administered with an equal amount of normal saline. Mice in each group were adaptively fed continuously for 2 weeks, and the myocardial infarction model was established by ligation of the anterior descending coronary artery by thoracic ligation. Twenty-four hours after the model was established, bone marrow mesenchymal stem cells were isolated from the tibia of the mice and injected intracardiacly Bone marrow-derived mesenchymal stem cells were transplanted, and multiple injections were made around the myocardial infarction area of mice. The control group was injected with the same amount of PBS. 0h, 3 days, 7 days, and 14 days after cell transplantation, observe the stem cell morphology under a microscope; on day 7 of cell transplantation, track the expression of eGFP-positive cells with a fluorescence microscope; before modeling, 14 and 21 days after cell transplantation, use Cardiac function was measured by echocardiography. After 21 days of modeling, the mice were sacrificed, and heart samples were taken. The angiogenesis of the mice was observed by immunohistochemical staining and microvascular density determination. Results: The morphological ...
    Keywords stem cells ; transplantation ; bone marrow mesenchymal stem cells ; qishenyiqi drop pills ; myocardial infarction ; angiogenesis ; cardiac function ; Medicine ; R
    Subject code 571
    Language English
    Publishing date 2021-03-01T00:00:00Z
    Publisher Editorial Board of Journal of Hainan Medical University
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Update on establishment of TCM animal model of myocardial ischemia and Chinese medicine treatment

    Yu-Fei Feng / Gui-Xin He

    Journal of Hainan Medical University, Vol 28, Iss 7, Pp 76-

    2022  Volume 76

    Abstract: The prevention and treatment of myocardial ischemia is a hot and difficult point in clinical research and animal experimental research in the cardiovascular field.The combined disease and syndrome animal model with the disease characteristics of Western ... ...

    Abstract The prevention and treatment of myocardial ischemia is a hot and difficult point in clinical research and animal experimental research in the cardiovascular field.The combined disease and syndrome animal model with the disease characteristics of Western medicine and guided by the theory of Chinese medicineto replicate the "syndrome" of Chinese medicine on the model animals by using experimental methods is an effective tool for the research of Chinese medicine. This article summarized the methoding methods and evaluation index of the animal model combined disease of coronary heart disease myocardial ischemia with cold blood stasis, phlegm and blood stasis, qi deficiency and blood stasis syndrome, kidney deficiency and blood stasis, and concluded the treatment of Traditional Chinese medicine. At the same time, it analyzed the main deficiencies of myocardial ischemia syndrome combined with anim
    Keywords myocardial ischemia ; animal model ; disease combination ; traditional chinese medicine ; Medicine ; R
    Subject code 630 ; 610
    Language English
    Publishing date 2022-04-01T00:00:00Z
    Publisher Editorial Board of Journal of Hainan Medical University
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Magnetic transitions in the 1D chain compounds NdPd

    Gui, Xin / Cava, Robert J

    Journal of physics. Condensed matter : an Institute of Physics journal

    2021  Volume 33, Issue 43

    Abstract: We present the structural and initial magnetic characterization of the previously unreported materials ... ...

    Abstract We present the structural and initial magnetic characterization of the previously unreported materials NdPd
    Language English
    Publishing date 2021-08-12
    Publishing country England
    Document type Journal Article
    ZDB-ID 1472968-4
    ISSN 1361-648X ; 0953-8984
    ISSN (online) 1361-648X
    ISSN 0953-8984
    DOI 10.1088/1361-648X/ac196a
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Selective α-oxidation of amides

    Liu, Shu-Hong / Dong, Zhi-Chao / Zang, Zhong-Lin / Zhou, Cheng-He / Cai, Gui-Xin

    Organic & biomolecular chemistry

    2024  Volume 22, Issue 6, Page(s) 1205–1212

    Abstract: Hydroxyl radicals (˙OH) as one of the highly reactive species can react unselectively with a wide range of chemicals. The ˙OH radicals are typically generated under harsh conditions. Herein, we report hydroxyl radical-induced ... ...

    Abstract Hydroxyl radicals (˙OH) as one of the highly reactive species can react unselectively with a wide range of chemicals. The ˙OH radicals are typically generated under harsh conditions. Herein, we report hydroxyl radical-induced selective
    Language English
    Publishing date 2024-02-07
    Publishing country England
    Document type Journal Article
    ZDB-ID 2097583-1
    ISSN 1477-0539 ; 1477-0520
    ISSN (online) 1477-0539
    ISSN 1477-0520
    DOI 10.1039/d3ob01984e
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Crystallographic Disorder and Strong Magnetic Anisotropy in Dy

    Paske, Terry / Guan, Yingdong / Wang, Chaoguo / Moore, Curtis / Mao, Zhiqiang / Gui, Xin

    Inorganic chemistry

    2024  Volume 63, Issue 8, Page(s) 3648–3655

    Abstract: We report the crystal growth and characterization of a rare-earth-containing material, ... ...

    Abstract We report the crystal growth and characterization of a rare-earth-containing material, Dy
    Language English
    Publishing date 2024-02-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1484438-2
    ISSN 1520-510X ; 0020-1669
    ISSN (online) 1520-510X
    ISSN 0020-1669
    DOI 10.1021/acs.inorgchem.3c01850
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  8. Article ; Online: Comparison between intramedullary nail and conventional plate for displaced intra-articular calcaneal fractures: A meta-analysis.

    Fu, Xin / Deng, Zhong-Bo / Wang, Gui-Xin / Wang, Chen-Guang / Li, Zhi-Jun

    Joint diseases and related surgery

    2024  Volume 35, Issue 2, Page(s) 276–284

    Abstract: Objectives: This study aimed to compare the efficacy and safety of the intramedullary nail and conventional plate for the treatment of displaced intra-articular calcaneal fractures from clinical comparative trials.: Materials and methods: A ... ...

    Abstract Objectives: This study aimed to compare the efficacy and safety of the intramedullary nail and conventional plate for the treatment of displaced intra-articular calcaneal fractures from clinical comparative trials.
    Materials and methods: A comprehensive search of English databases was carried out in the Springer, PubMed, ScienceDirect, Web of Science, and Cochrane Library databases until September 2023. Studies on calcaneal fractures treated by an intramedullary nail or a plate were considered for inclusion. Endpoints included duration of operation, length of hospital stay, the Visual Analog Scale (VAS) score, postoperative functional score, radiological parameters, and complications. The mean difference (MD) and risk difference (RD) as the combined variables, as well as the 95% confidence intervals, (CIs) were calculated.
    Results: Five retrospective controlled studies covering 473 feet at the one-year follow-up met the inclusion criteria. The meta-analysis demonstrated that there were significant differences in the duration of operation (MD: -10.81; 95% CI: -16.32, -5.31; p=0.0001), length of hospital stay (MD: -3.65; 95% CI: -4.35, -2.95; p<0.00001). No significant differences were found regarding postoperative American Orthopaedic Foot and Ankle Society (AOFAS) Ankle-Hindfoot Scale (MD: 0.36; 95% CI: -3.89, 4.61; p=0.87), VAS (MD: 1.95; 95% CI: -0.30, 4.21; p=0.09), or postoperative Böhler angle (MD: 0.94; 95% CI: -0.04, 1.92; p=0.06) between the two groups. The incidence of total complications (RD: -0.31; 95% CI: -0.46, -0.17; p<0.0001) and wound-healing complications (RD: -0.16; 95% CI: -0.30, -0.03; p=0.02) were lower in the intramedullary nail group. There were no significant differences in the incidences of revision surgery, implant removal, superficial wound infection, deep infection, and nonunion.
    Conclusion: Compared to conventional plates, the intramedullary nail showed a shorter duration of operation, reduced length of hospital stay, and fewer postoperative total complications and wound-healing complications in treating displaced intra-articular calcaneal fractures.
    MeSH term(s) Humans ; Calcaneus/injuries ; Calcaneus/surgery ; Bone Nails ; Fracture Fixation, Intramedullary/methods ; Fracture Fixation, Intramedullary/instrumentation ; Fracture Fixation, Intramedullary/adverse effects ; Bone Plates ; Intra-Articular Fractures/surgery ; Length of Stay ; Treatment Outcome ; Postoperative Complications/epidemiology ; Postoperative Complications/etiology
    Language English
    Publishing date 2024-04-26
    Publishing country Turkey
    Document type Journal Article ; Meta-Analysis ; Comparative Study ; Systematic Review
    ISSN 2687-4792
    ISSN (online) 2687-4792
    DOI 10.52312/jdrs.2024.1542
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Book ; Online: Metal-Insulator Transition and Anomalous Lattice Parameters Changes in Ru-doped VO2

    Gui, Xin / Cava, Robert J.

    2022  

    Abstract: VO2, of interest for decades due to both its phenomenology and its potential applications, has a monoclinic distortion of the rutile crystal structure at ambient temperature that is coupled to its metal-insulator transition (MIT). In contrast, RuO2 has ... ...

    Abstract VO2, of interest for decades due to both its phenomenology and its potential applications, has a monoclinic distortion of the rutile crystal structure at ambient temperature that is coupled to its metal-insulator transition (MIT). In contrast, RuO2 has three electrons more per formula unit, is a metallic conductor, and has an undistorted rutile structure. Here we report a systematic study of Ru-doped VO2 (V1-xRuxO2); generally characterizing its crystal structure, magnetic and electronic properties, and heat capacity. The composition-dependent Wilson ratio is determined. We find that an unusually high Ru doping value (x=0.8) is required to achieve a metallic state in V1-xRuxO2. No superconductivity was observed down to 0.1 K in the metallic materials. We propose a possible understanding for how the insulating state can exist in V1-xRuxO2 at high Ru contents.

    Comment: 23 pages, 10 figures
    Keywords Condensed Matter - Materials Science ; Condensed Matter - Strongly Correlated Electrons
    Subject code 530
    Publishing date 2022-03-26
    Publishing country us
    Document type Book ; Online
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  10. Article ; Online: Reaching strong absorption up to 700 nm with new benzo[

    Bruschi, Cecilia / Gui, Xin / Fuhr, Olaf / Klopper, Wim / Bizzarri, Claudia

    Dalton transactions (Cambridge, England : 2003)

    2023  Volume 52, Issue 23, Page(s) 7809–7818

    Abstract: Heteroleptic copper(I) complexes, with a diimine as a chromophoric unit and a bulky diphosphine as an ancillary ligand, have the advantage of a reduced pseudo Jahn-Teller effect in their excited state over the corresponding homoleptic bis(diimine) ... ...

    Abstract Heteroleptic copper(I) complexes, with a diimine as a chromophoric unit and a bulky diphosphine as an ancillary ligand, have the advantage of a reduced pseudo Jahn-Teller effect in their excited state over the corresponding homoleptic bis(diimine) complexes. Nevertheless, their lowest absorption lies generally between 350 to 500 nm. Aiming at a strong absorption in the visible by stable heteroleptic Cu(I) complexes, we designed a novel diimine based on 4-(benzo[
    Language English
    Publishing date 2023-06-13
    Publishing country England
    Document type Journal Article
    ZDB-ID 1472887-4
    ISSN 1477-9234 ; 1364-5447 ; 0300-9246 ; 1477-9226
    ISSN (online) 1477-9234 ; 1364-5447
    ISSN 0300-9246 ; 1477-9226
    DOI 10.1039/d3dt00902e
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