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  1. Article: Redox Homeostasis in Cardiovascular Disease: The Role of Mitochondrial Sirtuins.

    Zullo, Alberto / Guida, Rosa / Sciarrillo, Rosaria / Mancini, Francesco P

    Frontiers in endocrinology

    2022  Volume 13, Page(s) 858330

    Abstract: Cardiovascular disease (CVD) is still the leading cause of death worldwide. Despite successful advances in both pharmacological and lifestyle strategies to fight well-established risk factors, the burden of CVD is still increasing. Therefore, it is ... ...

    Abstract Cardiovascular disease (CVD) is still the leading cause of death worldwide. Despite successful advances in both pharmacological and lifestyle strategies to fight well-established risk factors, the burden of CVD is still increasing. Therefore, it is necessary to further deepen our knowledge of the pathogenesis of the disease for developing novel therapies to limit even more its related morbidity and mortality. Oxidative stress has been identified as a common trait of several manifestations of CVD and could be a promising target for innovative treatments. Mitochondria are a major source of oxidative stress and sirtuins are a family of enzymes that generate different post-translational protein modifications, thus regulating important cellular processes, including cell cycle, autophagy, gene expression, and others. In particular, three sirtuins, SIRT3, SIRT4, and SIRT5 are located within the mitochondrial matrix where they regulate energy production and antioxidant pathways. Therefore, these sirtuins are strongly involved in the balance between oxidant and antioxidant mechanisms. In this review, we summarize the activities of these sirtuins with a special focus on their role in the control of oxidative stress, in relation to energy metabolism, atherosclerosis, and CVD.
    MeSH term(s) Cardiovascular Diseases/metabolism ; Homeostasis ; Humans ; Mitochondria/metabolism ; Oxidation-Reduction ; Sirtuins/physiology
    Chemical Substances Sirtuins (EC 3.5.1.-)
    Language English
    Publishing date 2022-03-18
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2592084-4
    ISSN 1664-2392
    ISSN 1664-2392
    DOI 10.3389/fendo.2022.858330
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  2. Article ; Online: Novel Weight-Based Approach for Soil Moisture Content Estimation via Synthetic Aperture Radar, Multispectral and Thermal Infrared Data Fusion.

    Yahia, Oualid / Guida, Raffaella / Iervolino, Pasquale

    Sensors (Basel, Switzerland)

    2021  Volume 21, Issue 10

    Abstract: Though current remote sensing technologies, especially synthetic aperture radars (SARs), exhibit huge potential for soil moisture content (SMC) retrievals, such technologies also present several performance disadvantages. This study explored the merits ... ...

    Abstract Though current remote sensing technologies, especially synthetic aperture radars (SARs), exhibit huge potential for soil moisture content (SMC) retrievals, such technologies also present several performance disadvantages. This study explored the merits of proposing a novel data fusion methodology (partly decision level and partly feature level) for SMC estimation. Initially, individual estimations were derived from three distinct methods: the inversion of an Empirically Adapted Integral Equation Model (EA-IEM) applied to SAR data, the Perpendicular Drought Index (PDI), and the Temperature Vegetation Dryness Index (TVDI) determined from Landsat-8 data. Subsequently, three feature level fusions were performed to produce three different novel salient feature combinations where said features were extracted from each of the previously mentioned methods to be the input of an artificial neural network (ANN). The latter underwent a modification of its performance function, more specifically from absolute error to root mean square error (RMSE). Eventually, all SMC estimations, including the feature level fusion estimation, were fused at the decision level through a novel weight-based estimation. The performance of the proposed system was analysed and validated by measurements collected from three study areas, an agricultural field in Blackwell farms, Guildford, United Kingdom, and two different agricultural fields in Sidi Rached, Tipasa, Algeria. Those measurements contained SMC levels and surface roughness profiles. The proposed SMC estimation system yielded stronger correlations and lower RMSE values than any of the considered SMC estimation methods in the order of 0.38%, 1.4%, and 1.09% for the Blackwell farms, Sidi Rached 1, and Sidi Rached 2 datasets, respectively.
    Language English
    Publishing date 2021-05-15
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2052857-7
    ISSN 1424-8220 ; 1424-8220
    ISSN (online) 1424-8220
    ISSN 1424-8220
    DOI 10.3390/s21103457
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  3. Article ; Online: O-specific polysaccharide structure isolated from the LPS of the Antarctic bacterium Pseudomonas ANT_J38B.

    Di Guida, Rossella / Casillo, Angela / Corsaro, Maria Michela

    Carbohydrate research

    2020  Volume 497, Page(s) 108125

    Abstract: Pseudomonas ANT_J38B is a Gram-negative bacterium isolated from an Antarctic island. LPS was extracted using the phenol/chloroform/petroleum ether method. A mild acid hydrolysis followed by a gel filtration purification afforded the O-chain. The ... ...

    Abstract Pseudomonas ANT_J38B is a Gram-negative bacterium isolated from an Antarctic island. LPS was extracted using the phenol/chloroform/petroleum ether method. A mild acid hydrolysis followed by a gel filtration purification afforded the O-chain. The polysaccharide was characterized by means of chemical analyses and NMR spectroscopy. The O-chain displays a disaccharide repeating unit with the following backbone: →4)-α-l-GulpNAc3OAcAN-(1 →3)-β-d-QuipNAc-(1→ .
    Language English
    Publishing date 2020-08-17
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1435-7
    ISSN 1873-426X ; 0008-6215
    ISSN (online) 1873-426X
    ISSN 0008-6215
    DOI 10.1016/j.carres.2020.108125
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  4. Article ; Online: Complete Characterization of the O-Antigen from the LPS of

    Di Guida, Rossella / Casillo, Angela / Tomás, Juan M / Merino, Susana / Corsaro, Maria Michela

    International journal of molecular sciences

    2022  Volume 23, Issue 3

    Abstract: ... ...

    Abstract Aeromonas
    MeSH term(s) Aeromonas/metabolism ; Carbohydrate Sequence ; Hydrolysis ; Lipid A/chemistry ; Lipopolysaccharides/chemistry ; Lipopolysaccharides/metabolism ; O Antigens/chemistry ; Polymers/chemistry
    Chemical Substances Lipid A ; Lipopolysaccharides ; O Antigens ; Polymers
    Language English
    Publishing date 2022-01-21
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms23031204
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  5. Book ; Online: SeizNet

    Saeizadeh, Ali / Schonholtz, Douglas / Uvaydov, Daniel / Guida, Raffaele / Demirors, Emrecan / Johari, Pedram / Jimenez, Jorge M. / Neimat, Joseph S. / Melodia, Tommaso

    An AI-enabled Implantable Sensor Network System for Seizure Prediction

    2024  

    Abstract: In this paper, we introduce SeizNet, a closed-loop system for predicting epileptic seizures through the use of Deep Learning (DL) method and implantable sensor networks. While pharmacological treatment is effective for some epilepsy patients (with ~65M ... ...

    Abstract In this paper, we introduce SeizNet, a closed-loop system for predicting epileptic seizures through the use of Deep Learning (DL) method and implantable sensor networks. While pharmacological treatment is effective for some epilepsy patients (with ~65M people affected worldwide), one out of three suffer from drug-resistant epilepsy. To alleviate the impact of seizure, predictive systems have been developed that can notify such patients of an impending seizure, allowing them to take precautionary measures. SeizNet leverages DL techniques and combines data from multiple recordings, specifically intracranial electroencephalogram (iEEG) and electrocardiogram (ECG) sensors, that can significantly improve the specificity of seizure prediction while preserving very high levels of sensitivity. SeizNet DL algorithms are designed for efficient real-time execution at the edge, minimizing data privacy concerns, data transmission overhead, and power inefficiencies associated with cloud-based solutions. Our results indicate that SeizNet outperforms traditional single-modality and non-personalized prediction systems in all metrics, achieving up to 99% accuracy in predicting seizure, offering a promising new avenue in refractory epilepsy treatment.

    Comment: 4 pages, 4 figures, 1 table
    Keywords Computer Science - Machine Learning ; Electrical Engineering and Systems Science - Signal Processing
    Subject code 006
    Publishing date 2024-01-12
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article: Relationship lending and firms’ leverage

    Guida, Roberto / Sabato, Valentina

    European financial management : the journal of the European Financial Management Association Vol. 23, No. 4 , p. 807-835

    empirical evidence in Europe

    2017  Volume 23, Issue 4, Page(s) 807–835

    Author's details Roberto Guida, Valentina Sabato
    Keywords relations hip lending ; soft informat ion ; capital structure ; leverage ; financial systems
    Language English
    Publisher Wiley-Blackwell
    Publishing place Oxford
    Document type Article
    ZDB-ID 1235378-4 ; 1480712-9
    ISSN 1468-036X ; 1354-7798
    ISSN (online) 1468-036X
    ISSN 1354-7798
    Database ECONomics Information System

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  7. Article: The data project: a shared approach between stakeholders of the healthcare system in definition of a therapeutic algorithm for inflammatory arthritis.

    Pantano, I / Mauro, D / Simone, D / Costa, L / Capocotta, D / Raimondo, M / Birra, D / Cuomo, G / D'Errico, T / Ferrucci, M / Comentale, F / Italiano, G / Moscato, P / Pappone, N / Russo, R / Scarpato, S / Tirri, R / Buono, P / Postiglione, A /
    Guida, R / Scarpa, R / Trama, U / Tirri, E / Ciccia, F

    Reumatismo

    2023  Volume 74, Issue 4

    Abstract: Rheumatic musculoskeletal diseases or RMD [rheumatoid arthritis (RA) and spondyloarthritis (SpA)] are systemic inflammatory diseases for which there are no biomarkers capable of predicting treatments with a higher likelihood of response in naive patients. ...

    Abstract Rheumatic musculoskeletal diseases or RMD [rheumatoid arthritis (RA) and spondyloarthritis (SpA)] are systemic inflammatory diseases for which there are no biomarkers capable of predicting treatments with a higher likelihood of response in naive patients. In addition, the expiration of the anti-TNF blocking drugs' patents has resulted in the availability of anti-TNF biosimilar drugs with the same efficacy and safety than originators but at significantly reduced prices. To guarantee a personalized therapeutic approach to RMD treatment, a board of rheumatologists and stakeholders from the Campania region, Italy, developed a clinically applicable arthritis therapeutic algorithm to guide rheumatologists (DATA project). The general methodology relied on a Delphi technique forecast to produce a set of statements that summarized the experts' consensus. Selected clinical scenarios were discussed in light of the available evidence, and there were two rounds of voting on the therapeutic approaches. Separate discussions were held regarding rheumatoid arthritis, psoriatic arthritis, and ankylosing spondylitis. The decision-making factors for each disease were clinical presentation, demographics, and comorbidities. In this paper, we describe a virtuous process between rheumatologists and healthcare system stakeholders that resulted in the development of a shared therapeutic algorithm for RMD patients naive to bDMARDs.
    MeSH term(s) Humans ; Tumor Necrosis Factor Inhibitors/therapeutic use ; Spondylitis, Ankylosing/drug therapy ; Spondylarthritis ; Arthritis, Rheumatoid/drug therapy ; Arthritis, Psoriatic/diagnosis ; Arthritis, Psoriatic/drug therapy ; Delivery of Health Care ; Algorithms ; Antirheumatic Agents/therapeutic use
    Chemical Substances Tumor Necrosis Factor Inhibitors ; Antirheumatic Agents
    Language English
    Publishing date 2023-03-21
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 414816-2
    ISSN 2240-2683 ; 0048-7449
    ISSN (online) 2240-2683
    ISSN 0048-7449
    DOI 10.4081/reumatismo.2022.1528
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    In stock of ZB MED Cologne/Königswinter

    Zs.B 392: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 654: Show issues

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  8. Article: O-specific polysaccharide structure isolated from the LPS of the Antarctic bacterium Pseudomonas ANT_J38B

    Di Guida, Rossella / Casillo, Angela / Corsaro, Maria Michela

    Carbohydrate research. 2020 Nov., v. 497

    2020  

    Abstract: Pseudomonas ANT_J38B is a Gram-negative bacterium isolated from an Antarctic island. LPS was extracted using the phenol/chloroform/petroleum ether method. A mild acid hydrolysis followed by a gel filtration purification afforded the O-chain. The ... ...

    Abstract Pseudomonas ANT_J38B is a Gram-negative bacterium isolated from an Antarctic island. LPS was extracted using the phenol/chloroform/petroleum ether method. A mild acid hydrolysis followed by a gel filtration purification afforded the O-chain. The polysaccharide was characterized by means of chemical analyses and NMR spectroscopy. The O-chain displays a disaccharide repeating unit with the following backbone: →4)-α-l-GulpNAc3OAcAN-(1 →3)-β-d-QuipNAc-(1→ .
    Keywords Gram-negative bacteria ; O-antigens ; Pseudomonas ; acid hydrolysis ; carbohydrate structure ; chloroform ; gel chromatography ; nuclear magnetic resonance spectroscopy ; petroleum ; phenol ; research ; Antarctic region
    Language English
    Dates of publication 2020-11
    Publishing place Elsevier Ltd
    Document type Article
    Note NAL-AP-2-clean
    ZDB-ID 1435-7
    ISSN 1873-426X ; 0008-6215
    ISSN (online) 1873-426X
    ISSN 0008-6215
    DOI 10.1016/j.carres.2020.108125
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  9. Article: Capsular polysaccharide from a fish-gut bacterium induces/promotes apoptosis of colon cancer cells in vitro through Caspases' pathway activation

    Di Guida, Rossella / Casillo, Angela / Stellavato, Antonietta / Kawai, Soichiro / Ogawa, Takuya / Di Meo, Celeste / Kawamoto, Jun / Kurihara, Tatsuo / Schiraldi, Chiara / Corsaro, Maria Michela

    Carbohydrate polymers. 2022 Feb. 15, v. 278

    2022  

    Abstract: Among the widespread malignancies colorectal cancer is the most lethal. Treatments of this malignant tumor include surgery for lesions and metastases, radiotherapy, immunotherapy, and chemotherapy. Nevertheless, novel therapies to reduce morbidity and ... ...

    Abstract Among the widespread malignancies colorectal cancer is the most lethal. Treatments of this malignant tumor include surgery for lesions and metastases, radiotherapy, immunotherapy, and chemotherapy. Nevertheless, novel therapies to reduce morbidity and mortality are demanding. Natural products, such as polysaccharides, can be a valuable alternative to sometimes very toxic chemotherapeutical agents, also because they are biocompatible and biodegradable biomaterials. Microbial polysaccharides have been demonstrated to fulfill this requirement.In this paper, the results about the structure and the activity of a capsular polysaccharide isolated from the psychrotroph Pseudoalteromonas nigrifaciens Sq02-Rifʳ, newly isolated from the fish intestine, have been described. The characterization has been obtained by spectroscopic and chemical methods, and it is supported by the bioinformatic analysis. The polymer activates Caspases 3 and 9 on colon cancer cells CaCo-2 and HCT-116, indicating a promising antitumor effect, and suggesting a potential capacity of CPS to induce apoptosis.
    Keywords Pseudoalteromonas nigrifaciens ; antineoplastic activity ; apoptosis ; biocompatible materials ; biodegradability ; bioinformatics ; caspases ; colorectal neoplasms ; drug therapy ; fish ; immunotherapy ; intestines ; morbidity ; mortality ; polymers ; polysaccharides ; psychrotrophic bacteria ; radiotherapy ; spectroscopy ; surgery ; toxicity
    Language English
    Dates of publication 2022-0215
    Publishing place Elsevier Ltd
    Document type Article
    ZDB-ID 1501516-6
    ISSN 1879-1344 ; 0144-8617
    ISSN (online) 1879-1344
    ISSN 0144-8617
    DOI 10.1016/j.carbpol.2021.118908
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  10. Article ; Online: The Lives Saved Tool (LiST) as a Model for Prevention of Anemia in Women of Reproductive Age.

    Heidkamp, Rebecca / Guida, Renee / Phillips, Erica / Clermont, Adrienne

    The Journal of nutrition

    2017  Volume 147, Issue 11, Page(s) 2156S–2162S

    Abstract: Background: ...

    Abstract Background:
    MeSH term(s) Adolescent ; Adult ; Anemia, Iron-Deficiency/epidemiology ; Anemia, Iron-Deficiency/prevention & control ; Dietary Supplements ; Female ; Food, Fortified ; Humans ; Micronutrients/administration & dosage ; Micronutrients/blood ; Micronutrients/deficiency ; Middle Aged ; Models, Theoretical ; Pregnancy ; Pregnancy Complications, Hematologic/epidemiology ; Pregnancy Complications, Hematologic/prevention & control ; Prevalence ; Randomized Controlled Trials as Topic ; Young Adult
    Chemical Substances Micronutrients
    Language English
    Publishing date 2017-09-13
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 218373-0
    ISSN 1541-6100 ; 0022-3166
    ISSN (online) 1541-6100
    ISSN 0022-3166
    DOI 10.3945/jn.117.252429
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