Article ; Online: Opportunistic pneumonia caused by E. cuniculi in mice immunosuppressed with cyclophosphamide.
2022 Volume 227, Issue 3, Page(s) 152194
Abstract: Opportunistic fungal pneumonia is a cause of concern in immunocompromised patients due to its high morbidity and mortality rates. One such opportunistic agent affecting immunocompromised patients is the microsporidia called Encephalitozoon cuniculi. This ...
| Abstract | Opportunistic fungal pneumonia is a cause of concern in immunocompromised patients due to its high morbidity and mortality rates. One such opportunistic agent affecting immunocompromised patients is the microsporidia called Encephalitozoon cuniculi. This study aimed to evaluate pneumonia caused by E. cuniculi in mice treated with the immunosuppressive agent cyclophosphamide (Cy). This study also aimed to describe the immune cells associated with the microsporidial pneumonia. C57BL/6 mice were infected intravenously with E. cuniculi spores and treated with Cy (75 mg/kg/week, intraperitoneally). Thirty days post-infection, the fungal burden (qPCR), histopathological lesions, cytokine production, and the phenotype of the immune cells in the lung parenchyma were evaluated. Histologically, interstitial pneumonia with lymphocytic infiltrate was observed in the infected animals. The infiltrate mainly consisted of CD8 |
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| MeSH term(s) | Animals ; Cuniculidae ; Cyclophosphamide/adverse effects ; Encephalitozoonosis ; Humans ; Immunocompromised Host ; Mice ; Mice, Inbred C57BL ; Pneumonia/drug therapy | |||||
| Chemical Substances | Cyclophosphamide (8N3DW7272P) | |||||
| Language | English | |||||
| Publishing date | 2022-03-06 | |||||
| Publishing country | Netherlands | |||||
| Document type | Journal Article ; Research Support, Non-U.S. Gov't | |||||
| ZDB-ID | 563292-4 | |||||
| ISSN | 1878-3279 ; 0171-2985 | |||||
| ISSN (online) | 1878-3279 | |||||
| ISSN | 0171-2985 | |||||
| DOI | 10.1016/j.imbio.2022.152194 | |||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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