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Book ; Online: Le Néolithique du nord-est de la France et des régions limitrophes

Guillaume, Christine

Actes du XIIIe colloque interrégional sur le Néolithique

(Documents d'archéologie française)

1993

Series title	Documents d'archéologie française
Keywords	Archaeology ; Néolithique ; habitat ; Alsace ; Allemagne ; Belgique ; faune ; céramique ; lithique ; Lorraine ; Rubané ; Bassin parisien
Language	fra
Size	1 electronic resource (184 pages)
Publisher	Éditions de la Maison des sciences de l'homme
Publishing place	Paris
Document type	Book ; Online
Note	French
HBZ-ID	HT030379172
ISBN	9782735104987 ; 2735104982
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article ; Online: Cytocompatibility of titanium and poly(etheretherketone) surfaces after O2 non-thermal plasma sterilization.

Maillet, Christina / Klein, Florence M / Le Bras, Florian / Velard, Frederic / Guillaume, Christine / Gangloff, Sophie C / Gelle, Marie-Paule

PloS one

2023 Volume 18, Issue 8, Page(s) e0290820

Abstract: The sterilization of medical devices is paramount to achieve an acceptable level of sterility assurance and to prevent hospital-acquired infections. However, some medical devices cannot be sterilized by usual processes such as autoclave (AC) and gamma- ... ...

Abstract	The sterilization of medical devices is paramount to achieve an acceptable level of sterility assurance and to prevent hospital-acquired infections. However, some medical devices cannot be sterilized by usual processes such as autoclave (AC) and gamma-ray irradiation (GI). A new non-thermal plasma (NTP) process using sealed bag that preserves the sterile state of the devices could be used as an alternative sterilization method. The aim of the study was to assess the cytocompatibility of titanium and poly(etheretherketone) (PEEK) surfaces after O2-NTP sterilization compared to GI and AC. MG-63 osteoblast-like cells were seeded on titanium (TA6V) and PEEK disks sterilized by AC, GI and O2-NTP. The cells' viability and proliferation, determined by WST-1 and DNA quantification respectively, were enhanced whatever the material types from 3 to 10 days. When seeded on titanium, MG-63 cells showed a higher viability and proliferation after GI and O2-NTP treatment compared to AC treatment. When cultured on PEEK, MG-63 cells showed a higher viability after O2-NTP treatment. No difference of proliferation was observed whatever the sterilization processes. The cell colonization of the materials' surface was confirmed by scanning electron microscopy. Lactate dehydrogenase (LDH) assay revealed no cytotoxicity. Thus, O2-NTP led to similar cell responses to AC and GI and could be a cost-effective alternative process to the usual sterilization methods for fragile medical devices.
MeSH term(s)	Humans ; Titanium/pharmacology ; Poly A ; Sterilization ; Benzophenones ; Infertility ; Plasma Gases/pharmacology
Chemical Substances	Titanium (D1JT611TNE) ; polyetheretherketone (31694-16-3) ; Poly A (24937-83-5) ; Benzophenones ; Plasma Gases
Language	English
Publishing date	2023-08-30
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0290820
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Article ; Online: Erratum to: Glomerular filtration rate estimated by Cockcroft-Gault formula better predicts anti-Xa levels than Modification of the diet in renal disease equation in older patients with prophylactic enoxaparin.

Dufour, B / Toussaint-Hacquard, M / Kearney-Schwartz, A / Manckoundia, M D P / Laurain, M-C / Joly, L / Deibener, J / Wahl, D / Lecompte, T / Benetos, A / Perret-Guillaume, Christine

The journal of nutrition, health & aging

2024 Volume 27, Issue 12, Page(s) 1289

Language	English
Publishing date	2024-01-04
Publishing country	France
Document type	Published Erratum
ZDB-ID	2081921-3
ISSN	1760-4788 ; 1279-7707
ISSN (online)	1760-4788
ISSN	1279-7707
DOI	10.1007/s12603-012-0380-x
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Article ; Online: An increase in Wharton's jelly membrane osteocompatibility by a genipin-cross-link.

Scomazzon, Loïc / Ledouble, Charlotte / Dubus, Marie / Braux, Julien / Guillaume, Christine / Bouland, Nicole / Baldit, Adrien / Boulmedais, Fouzia / Gribova, Varvara / Mauprivez, Cédric / Kerdjoudj, Halima

International journal of biological macromolecules

2023 Volume 255, Page(s) 127562

Abstract: Wharton's Jelly (WJ) has attracted significant interest in the field of tissue healing thanks to its biological properties, including antibacterial activity and immunomodulation. However, due to the fast degradation and poor mechanical behavior in ... ...

Abstract	Wharton's Jelly (WJ) has attracted significant interest in the field of tissue healing thanks to its biological properties, including antibacterial activity and immunomodulation. However, due to the fast degradation and poor mechanical behavior in biological environment, its application in bone regeneration is compromised. Here, we proposed to use genipin as an efficient cross-linking agent to significantly improve the elasticity and the enzymatical stability of the WJ matrix. The degree of cross-linking, linear elastic moduli, and collagenase resistance varied over a wide range depending on genipin concentration. Furthermore, our results highlighted that an increase in genipin concentration led to a decreased surface wettability, therefore impairing cell attachment and proliferation. The genipin cross-linking prevented rapid in vitro and in vivo degradation, but led to an adverse host reaction and calcification. When implanted in the parietal bone defect, a limited parietal bone regeneration to the dura was observed. We conclude that genipin-cross-linked WJ is a versatile medical device however, a careful selection is required with regards to the genipin concentration.
MeSH term(s)	Wharton Jelly/metabolism ; Mesenchymal Stem Cells ; Wound Healing ; Cell Differentiation ; Umbilical Cord ; Cell Proliferation
Chemical Substances	genipin (A3V2NE52YG)
Language	English
Publishing date	2023-10-20
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	282732-3
ISSN	1879-0003 ; 0141-8130
ISSN (online)	1879-0003
ISSN	0141-8130
DOI	10.1016/j.ijbiomac.2023.127562
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Article ; Online: Human Osteoblast-Conditioned Media Can Influence

Lamret, Fabien / Varin-Simon, Jennifer / Six, Mélodie / Thoraval, Léa / Chevrier, Julie / Adam, Cloé / Guillaume, Christine / Velard, Frédéric / Gangloff, Sophie C / Reffuveille, Fany

International journal of molecular sciences

2022 Volume 23, Issue 22

Abstract: Osteoblasts are bone-forming and highly active cells participating in bone homeostasis. In the case of osteomyelitis and more specifically prosthetic joint infections (PJI) for ... ...

Abstract	Osteoblasts are bone-forming and highly active cells participating in bone homeostasis. In the case of osteomyelitis and more specifically prosthetic joint infections (PJI) for which
MeSH term(s)	Humans ; Staphylococcus aureus ; Methicillin-Resistant Staphylococcus aureus ; Culture Media, Conditioned/pharmacology ; Tumor Necrosis Factor-alpha/pharmacology ; Anti-Bacterial Agents/pharmacology ; Staphylococcal Infections/microbiology ; Biofilms ; Osteoblasts
Chemical Substances	Culture Media, Conditioned ; Tumor Necrosis Factor-alpha ; Anti-Bacterial Agents
Language	English
Publishing date	2022-11-19
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms232214393
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Article ; Online: Inhibition of Recruitment and Activation of Neutrophils by Pyridazinone-Scaffold-Based Compounds.

Moniot, Aurélie / Braux, Julien / Siboni, Renaud / Guillaume, Christine / Audonnet, Sandra / Allart-Simon, Ingrid / Sapi, Janos / Tirouvanziam, Rabindra / Gérard, Stéphane / Gangloff, Sophie C / Velard, Frédéric

International journal of molecular sciences

2022 Volume 23, Issue 13

Abstract: In inflammatory diseases, polymorphonuclear neutrophils (PMNs) are known to produce elevated levels of pro-inflammatory cytokines and proteases. To limit ensuing exacerbated cell responses and tissue damage, novel therapeutic agents are sought. 4aa and ... ...

Abstract	In inflammatory diseases, polymorphonuclear neutrophils (PMNs) are known to produce elevated levels of pro-inflammatory cytokines and proteases. To limit ensuing exacerbated cell responses and tissue damage, novel therapeutic agents are sought. 4aa and 4ba, two pyridazinone-scaffold-based phosphodiesterase-IV inhibitors are compared in vitro to zardaverine for their ability to: (1) modulate production of pro-inflammatory mediators, reactive oxygen species (ROS), and phagocytosis; (2) modulate degranulation by PMNs after transepithelial lung migration. Compound 4ba and zardaverine were tested in vivo for their ability to limit tissue recruitment of PMNs in a murine air pouch model. In vitro treatment of lipopolysaccharide-stimulated PMNs with compounds 4aa and 4ba inhibited the release of interleukin-8, tumor necrosis factor-α, and matrix metalloproteinase-9. PMNs phagocytic ability, but not ROS production, was reduced following treatment. Using a lung inflammation model, we proved that PMNs transmigration led to reduced expression of the CD16 phagocytic receptor, which was significantly blunted after treatment with compound 4ba or zardaverine. Using the murine air pouch model, LPS-induced PMNs recruitment was significantly decreased upon addition of compound 4ba or zardaverine. Our data suggest that new pyridazinone derivatives have therapeutic potential in inflammatory diseases by limiting tissue recruitment and activation of PMNs.
MeSH term(s)	Animals ; Lipopolysaccharides/metabolism ; Lipopolysaccharides/pharmacology ; Mice ; Neutrophils/metabolism ; Phagocytosis ; Reactive Oxygen Species/metabolism ; Transendothelial and Transepithelial Migration
Chemical Substances	Lipopolysaccharides ; Reactive Oxygen Species
Language	English
Publishing date	2022-06-29
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms23137226
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Article ; Online: Osteoclastogenesis and sphingosine-1-phosphate secretion from human osteoclast precursor monocytes are modulated by the cystic fibrosis transmembrane conductance regulator.

Jourdain, Marie-Laure / Sergheraert, Johan / Braux, Julien / Guillaume, Christine / Gangloff, Sophie C / Hubert, Dominique / Velard, Frédéric / Jacquot, Jacky

Biochimica et biophysica acta. Molecular basis of disease

2020 Volume 1867, Issue 3, Page(s) 166010

Abstract: Osteopenia and increased fracture rates are well-recognized in patients with cystic fibrosis (CF) disease. In CF pathology, F508del is the most common CFTR mutation, with more than 85% of patients carrying it on at least one allele. The underlying ... ...

Abstract	Osteopenia and increased fracture rates are well-recognized in patients with cystic fibrosis (CF) disease. In CF pathology, F508del is the most common CFTR mutation, with more than 85% of patients carrying it on at least one allele. The underlying molecular defect in CFTR caused by the F508del-CFTR mutation in osteoclastogenesis, i.e., on the generation and bone-resorption activity of osteoclasts (OCs) from peripheral blood-derived monocytes (PBMCs) remained unexplored. We therefore investigated whether the F508del mutation could affect the osteoclastogenic capacity of PBMCs collected from 15 adult patients bearing the F508del-CFTR mutation, to modulate their bone-resorptive abilities and the level of sphingosine-1-phosphate (S1P) produced by OCs, a key factor in the bone mineral density and formation. In the present study, a severe, defective differentiation of CF-F508del PBMCs to CF-F508del OCs without any significant difference in nuclei number per OC was found compared to non-CF healthy PBMCs from 13 subjects after 7-14-days culture periods. We observed a reduced number of formed non-CF healthy OCs in the presence of a selective inhibitor of CFTR chloride conductance (CFTR-Inh
MeSH term(s)	Adult ; Cells, Cultured ; Cystic Fibrosis/genetics ; Cystic Fibrosis/metabolism ; Cystic Fibrosis/pathology ; Cystic Fibrosis Transmembrane Conductance Regulator/genetics ; Cystic Fibrosis Transmembrane Conductance Regulator/metabolism ; Humans ; Lysophospholipids/metabolism ; Middle Aged ; Monocytes/cytology ; Monocytes/metabolism ; Monocytes/pathology ; Osteoclasts/cytology ; Osteoclasts/metabolism ; Osteoclasts/pathology ; Osteogenesis ; Sequence Deletion ; Sphingosine/analogs & derivatives ; Sphingosine/metabolism
Chemical Substances	CFTR protein, human ; Lysophospholipids ; Cystic Fibrosis Transmembrane Conductance Regulator (126880-72-6) ; sphingosine 1-phosphate (26993-30-6) ; Sphingosine (NGZ37HRE42)
Language	English
Publishing date	2020-11-11
Publishing country	Netherlands
Document type	Clinical Trial ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	60-7
ISSN	1879-260X ; 1879-2596 ; 1872-8006 ; 1879-2642 ; 1879-2618 ; 1879-2650 ; 0006-3002 ; 0005-2728 ; 0005-2736 ; 0304-4165 ; 0167-4838 ; 1388-1981 ; 0167-4889 ; 0167-4781 ; 0304-419X ; 1570-9639 ; 0925-4439 ; 1874-9399
ISSN (online)	1879-260X ; 1879-2596 ; 1872-8006 ; 1879-2642 ; 1879-2618 ; 1879-2650
ISSN	0006-3002 ; 0005-2728 ; 0005-2736 ; 0304-4165 ; 0167-4838 ; 1388-1981 ; 0167-4889 ; 0167-4781 ; 0304-419X ; 1570-9639 ; 0925-4439 ; 1874-9399
DOI	10.1016/j.bbadis.2020.166010
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Article: Le Traitement médicamenteux du diabète de type 2.

Defer, Françoise / Tourneur, Marie-Laure / Guillaume, Christine

Revue de l'infirmiere

2014 , Issue 201, Page(s) 45–46

Title translation	Drug therapy for type 2 diabetes.
MeSH term(s)	Diabetes Mellitus, Type 2/drug therapy ; Humans ; Hypoglycemic Agents/therapeutic use
Chemical Substances	Hypoglycemic Agents
Language	French
Publishing date	2014-05
Publishing country	France
Document type	Journal Article
ZDB-ID	632538-5
ISSN	1293-8505 ; 0397-7900
ISSN	1293-8505 ; 0397-7900
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Article: Pyridazinone Derivatives Limit Osteosarcoma-Cells Growth In Vitro and In Vivo.

Moniot, Aurélie / Braux, Julien / Bour, Camille / Guillaume, Christine / Lamret, Fabien / Allart-Simon, Ingrid / Audonnet, Sandra / Renault, Sarah / Rédini, Francoise / Laronze-Cochard, Marie / Sapi, Janos / Gangloff, Sophie C / Gérard, Stéphane / Velard, Frédéric

Cancers

2021 Volume 13, Issue 23

Abstract: Osteosarcoma is a rare primary bone cancer that mostly affects children and young adults. Current therapeutic approaches consist of combining surgery and chemotherapy but remain unfortunately insufficient to avoid relapse and metastases. Progress in ... ...

Abstract	Osteosarcoma is a rare primary bone cancer that mostly affects children and young adults. Current therapeutic approaches consist of combining surgery and chemotherapy but remain unfortunately insufficient to avoid relapse and metastases. Progress in terms of patient survival has remained the same for 30 years. In this study, novel pyridazinone derivatives have been evaluated as potential anti-osteosarcoma therapeutics because of their anti-type 4 phosphodiesterase activity, which modulates the survival of several other cancer cells. By using five-four human and one murine osteosarcoma-cell lines, we demonstrated differential cytotoxic effects of four pyridazinone scaffold-based compounds (mitochondrial activity and DNA quantification). Proapoptotic (annexin V positive cells and caspase-3 activity), anti-proliferative (EdU integration) and anti-migratory effects (scratch test assay) were also observed. Owing to their cytotoxic activity in in vitro conditions and their ability to limit tumor growth in a murine orthotopic osteosarcoma model, our data suggest that these pyridazinone derivatives might be hit-candidates to develop new therapeutic strategies against osteosarcoma.
Language	English
Publishing date	2021-11-28
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers13235992
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Article ; Online: The Nexus Between Telomere Length and Lymphocyte Count in Seniors Hospitalized With COVID-19.

Benetos, Athanase / Lai, Tsung-Po / Toupance, Simon / Labat, Carlos / Verhulst, Simon / Gautier, Sylvie / Ungeheuer, Marie-Noelle / Perret-Guillaume, Christine / Levy, Daniel / Susser, Ezra / Aviv, Abraham

The journals of gerontology. Series A, Biological sciences and medical sciences

2021 Volume 76, Issue 8, Page(s) e97–e101

Abstract: Profound T-cell lymphopenia is the hallmark of severe coronavirus disease 2019 (COVID-19). T-cell proliferation is telomere length (TL) dependent and telomeres shorten with age. Older COVID-19 patients, we hypothesize, are, therefore, at a higher risk of ...

Abstract	Profound T-cell lymphopenia is the hallmark of severe coronavirus disease 2019 (COVID-19). T-cell proliferation is telomere length (TL) dependent and telomeres shorten with age. Older COVID-19 patients, we hypothesize, are, therefore, at a higher risk of having TL-dependent lymphopenia. We measured TL by the novel Telomere Shortest Length Assay (TeSLA), and by Southern blotting (SB) of the terminal restriction fragments in peripheral blood mononuclear cells of 17 COVID-19 and 21 non-COVID-19 patients, aged 87 ± 8 (mean ± SD) and 87 ± 9 years, respectively. TeSLA tallies and measures single telomeres, including short telomeres undetected by SB. Such telomeres are relevant to TL-mediated biological processes, including cell viability and senescence. TeSLA yields 2 key metrics: the proportions of telomeres with different lengths (expressed in %) and their mean (TeSLA mTL), (expressed in kb). Lymphocyte count (109/L) was 0.91 ± 0.42 in COVID-19 patients and 1.50 ± 0.50 in non-COVID-19 patients (p < .001). In COVID-19 patients, but not in non-COVID-19 patients, lymphocyte count was inversely correlated with the proportion of telomeres shorter than 2 kb (p = .005) and positively correlated with TeSLA mTL (p = .03). Lymphocyte count was not significantly correlated with SB mTL in either COVID-19 or non-COVID-19 patients. We propose that compromised TL-dependent T-cell proliferative response, driven by short telomere in the TL distribution, contributes to COVID-19 lymphopenia among old adults. We infer that infection with SARS-CoV-2 uncovers the limits of the TL reserves of older persons. Clinical Trials Registration Number: NCT04325646.
MeSH term(s)	Aged, 80 and over ; COVID-19/physiopathology ; Cellular Senescence ; Hospitalization ; Humans ; Lymphocyte Count ; Lymphopenia/etiology ; Lymphopenia/pathology ; SARS-CoV-2/pathogenicity ; T-Lymphocytes/immunology ; Telomere Shortening/physiology
Language	English
Publishing date	2021-02-02
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	1223643-3
ISSN	1758-535X ; 1079-5006
ISSN (online)	1758-535X
ISSN	1079-5006
DOI	10.1093/gerona/glab026
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