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  1. Book ; Online: Cerebrovascular events and outcomes in hospitalized patients with COVID-19

    Siegler, James E. / Cardona, Pere / Arenillas, Juan F. / Talavera, Blanca / Guillen, Ana N. / Chavarrıa-Miranda, Alba / de Lera, Mercedes / Khandelwal, Priyank / Bach, Ivo / Hassan, Ameer E. / Preston, Laurie / Patterson, Mary S. / Bushnaq, Saif / Zaidat, Osama

    School of Medicine Publications and Presentations

    The SVIN COVID-19 Multinational Registry

    2020  

    Abstract: Background Severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) has been associated with a significant risk of thrombotic events in critically ill patients. Aim To summarize the findings of a multinational observational cohort of patients with ... ...

    Abstract Background Severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) has been associated with a significant risk of thrombotic events in critically ill patients. Aim To summarize the findings of a multinational observational cohort of patients with SARS-CoV-2 and cerebrovascular disease. Methods Retrospective observational cohort of consecutive adults evaluated in the emergency department and/or admitted with coronavirus disease 2019 (COVID-19) across 31 hospitals in four countries (1 February 2020–16 June 2020). The primary outcome was the incidence rate of cerebrovascular events, inclusive of acute ischemic stroke, intracranial hemorrhages (ICH), and cortical vein and/or sinus thrombosis (CVST). Results Of the 14,483 patients with laboratory-confirmed SARS-CoV-2, 172 were diagnosed with an acute cerebrovascular event (1.13% of cohort; 1130/100,000 patients, 95%CI 970–1320/100,000), 68/171 (40.5%) were female and 96/172 (55.8%) were between the ages 60 and 79 years. Of these, 156 had acute ischemic stroke (1.08%; 1080/100,000 95%CI 920–1260/100,000), 28 ICH (0.19%; 190/100,000 95%CI 130–280/100,000), and 3 with CVST (0.02%; 20/100,000, 95%CI 4–60/100,000). The in-hospital mortality rate for SARS-CoV-2-associated stroke was 38.1% and for ICH 58.3%. After adjusting for clustering by site and age, baseline stroke severity, and all predictors of in-hospital mortality found in univariate regression (p < 0.1: male sex, tobacco use, arrival by emergency medical services, lower platelet and lymphocyte counts, and intracranial occlusion), cryptogenic stroke mechanism (aOR 5.01, 95%CI 1.63–15.44, p < 0.01), older age (aOR 1.78, 95%CI 1.07–2.94, p = 0.03), and lower lymphocyte count on admission (aOR 0.58, 95%CI 0.34–0.98, p = 0.04) were the only independent predictors of mortality among patients with stroke and COVID-19. Conclusions COVID-19 is associated with a small but significant risk of clinically relevant cerebrovascular events, particularly ischemic stroke. The mortality rate is high for COVID-19-associated cerebrovascular complications; therefore, aggressive monitoring and early intervention should be pursued to mitigate poor outcomes.
    Keywords All cerebrovascular diseases/stroke ; intracranial hemorrhage ; cerebral venous thrombosis ; COVID-19 ; Medicine and Health Sciences ; covid19
    Subject code 610
    Publishing date 2020-09-30T07:00:00Z
    Publisher ScholarWorks @ UTRGV
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Cerebrovascular events and outcomes in hospitalized patients with COVID-19: The SVIN COVID-19 Multinational Registry.

    Siegler, James E / Cardona, Pere / Arenillas, Juan F / Talavera, Blanca / Guillen, Ana N / Chavarría-Miranda, Alba / de Lera, Mercedes / Khandelwal, Priyank / Bach, Ivo / Patel, Pratit / Singla, Amit / Requena, Manuel / Ribo, Marc / Jillella, Dinesh V / Rangaraju, Srikant / Nogueira, Raul G / Haussen, Diogo C / Vazquez, Alejandro R / Urra, Xabier /
    Chamorro, Ángel / Román, Luis S / Thon, Jesse M / Then, Ryna / Sanborn, Emma / de la Ossa, Natalia P / Millàn, Mònica / Ruiz, Isaac N / Mansour, Ossama Y / Megahed, Mohammed / Tiu, Cristina / Terecoasa, Elena O / Radu, Răzvan A / Nguyen, Thanh N / Curiale, Gioacchino / Kaliaev, Artem / Czap, Alexandra L / Sebaugh, Jacob / Zha, Alicia M / Liebeskind, David S / Ortega-Gutierrez, Santiago / Farooqui, Mudassir / Hassan, Ameer E / Preston, Laurie / Patterson, Mary S / Bushnaq, Saif / Zaidat, Osama / Jovin, Tudor G

    International journal of stroke : official journal of the International Stroke Society

    2020  Volume 16, Issue 4, Page(s) 437–447

    Abstract: Background: Severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) has been associated with a significant risk of thrombotic events in critically ill patients.: Aim: To summarize the findings of a multinational observational cohort of patients ... ...

    Abstract Background: Severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) has been associated with a significant risk of thrombotic events in critically ill patients.
    Aim: To summarize the findings of a multinational observational cohort of patients with SARS-CoV-2 and cerebrovascular disease.
    Methods: Retrospective observational cohort of consecutive adults evaluated in the emergency department and/or admitted with coronavirus disease 2019 (COVID-19) across 31 hospitals in four countries (1 February 2020-16 June 2020). The primary outcome was the incidence rate of cerebrovascular events, inclusive of acute ischemic stroke, intracranial hemorrhages (ICH), and cortical vein and/or sinus thrombosis (CVST).
    Results: Of the 14,483 patients with laboratory-confirmed SARS-CoV-2, 172 were diagnosed with an acute cerebrovascular event (1.13% of cohort; 1130/100,000 patients, 95%CI 970-1320/100,000), 68/171 (40.5%) were female and 96/172 (55.8%) were between the ages 60 and 79 years. Of these, 156 had acute ischemic stroke (1.08%; 1080/100,000 95%CI 920-1260/100,000), 28 ICH (0.19%; 190/100,000 95%CI 130-280/100,000), and 3 with CVST (0.02%; 20/100,000, 95%CI 4-60/100,000). The in-hospital mortality rate for SARS-CoV-2-associated stroke was 38.1% and for ICH 58.3%. After adjusting for clustering by site and age, baseline stroke severity, and all predictors of in-hospital mortality found in univariate regression (p < 0.1: male sex, tobacco use, arrival by emergency medical services, lower platelet and lymphocyte counts, and intracranial occlusion), cryptogenic stroke mechanism (aOR 5.01, 95%CI 1.63-15.44, p < 0.01), older age (aOR 1.78, 95%CI 1.07-2.94, p = 0.03), and lower lymphocyte count on admission (aOR 0.58, 95%CI 0.34-0.98, p = 0.04) were the only independent predictors of mortality among patients with stroke and COVID-19.
    Conclusions: COVID-19 is associated with a small but significant risk of clinically relevant cerebrovascular events, particularly ischemic stroke. The mortality rate is high for COVID-19-associated cerebrovascular complications; therefore, aggressive monitoring and early intervention should be pursued to mitigate poor outcomes.
    MeSH term(s) Adult ; Age Factors ; Aged ; Aged, 80 and over ; COVID-19/complications ; COVID-19/epidemiology ; COVID-19/therapy ; Cerebrovascular Disorders/epidemiology ; Cerebrovascular Disorders/etiology ; Cerebrovascular Disorders/therapy ; Cohort Studies ; Female ; Hospital Mortality ; Humans ; Intracranial Hemorrhages/epidemiology ; Ischemic Stroke/epidemiology ; Ischemic Stroke/etiology ; Ischemic Stroke/therapy ; Lymphocyte Count ; Male ; Middle Aged ; Prevalence ; Registries ; Retrospective Studies ; Risk Factors ; Sex Factors ; Thrombosis/etiology ; Tobacco Use ; Young Adult
    Keywords covid19
    Language English
    Publishing date 2020-09-30
    Publishing country United States
    Document type Journal Article ; Multicenter Study ; Observational Study
    ZDB-ID 2303728-3
    ISSN 1747-4949 ; 1747-4930
    ISSN (online) 1747-4949
    ISSN 1747-4930
    DOI 10.1177/1747493020959216
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Cerebrovascular events and outcomes in hospitalized patients with COVID-19: The SVIN COVID-19 Multinational Registry

    Siegler, James E / Cardona, Pere / Arenillas, Juan F / Talavera, Blanca / Guillen, Ana N / Chavarría-Miranda, Alba / de Lera, Mercedes / Khandelwal, Priyank / Bach, Ivo / Patel, Pratit / Singla, Amit / Requena, Manuel / Ribo, Marc / Jillella, Dinesh V / Rangaraju, Srikant / Nogueira, Raul G / Haussen, Diogo C / Vazquez, Alejandro R / Urra, Xabier /
    Chamorro, Ángel / Román, Luis S / Thon, Jesse M / Then, Ryna / Sanborn, Emma / de la Ossa, Natalia P / Millàn, Mònica / Ruiz, Isaac N / Mansour, Ossama Y / Megahed, Mohammed / Tiu, Cristina / Terecoasa, Elena O / Radu, Razvan A / Nguyen, Thanh N / Curiale, Gioacchino / Kaliaev, Artem / Czap, Alexandra L / Sebaugh, Jacob / Zha, Alicia M / Liebeskind, David S / Ortega-Gutierrez, Santiago / Farooqui, Mudassir / Hassan, Ameer E / Preston, Laurie / Patterson, Mary S / Bushnaq, Saif / Zaidat, Osama / Jovin, Tudor G

    Int J Stroke

    Abstract: BACKGROUND: Severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) has been associated with a significant risk of thrombotic events in critically ill patients. AIM: To summarize the findings of a multinational observational cohort of patients with ... ...

    Abstract BACKGROUND: Severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) has been associated with a significant risk of thrombotic events in critically ill patients. AIM: To summarize the findings of a multinational observational cohort of patients with SARS-CoV-2 and cerebrovascular disease. METHODS: Retrospective observational cohort of consecutive adults evaluated in the emergency department and/or admitted with coronavirus disease 2019 (COVID-19) across 31 hospitals in four countries (1 February 2020-16 June 2020). The primary outcome was the incidence rate of cerebrovascular events, inclusive of acute ischemic stroke, intracranial hemorrhages (ICH), and cortical vein and/or sinus thrombosis (CVST). RESULTS: Of the 14,483 patients with laboratory-confirmed SARS-CoV-2, 172 were diagnosed with an acute cerebrovascular event (1.13% of cohort; 1130/100,000 patients, 95%CI 970-1320/100,000), 68/171 (40.5%) were female and 96/172 (55.8%) were between the ages 60 and 79 years. Of these, 156 had acute ischemic stroke (1.08%; 1080/100,000 95%CI 920-1260/100,000), 28 ICH (0.19%; 190/100,000 95%CI 130-280/100,000), and 3 with CVST (0.02%; 20/100,000, 95%CI 4-60/100,000). The in-hospital mortality rate for SARS-CoV-2-associated stroke was 38.1% and for ICH 58.3%. After adjusting for clustering by site and age, baseline stroke severity, and all predictors of in-hospital mortality found in univariate regression (p < 0.1: male sex, tobacco use, arrival by emergency medical services, lower platelet and lymphocyte counts, and intracranial occlusion), cryptogenic stroke mechanism (aOR 5.01, 95%CI 1.63-15.44, p < 0.01), older age (aOR 1.78, 95%CI 1.07-2.94, p = 0.03), and lower lymphocyte count on admission (aOR 0.58, 95%CI 0.34-0.98, p = 0.04) were the only independent predictors of mortality among patients with stroke and COVID-19. CONCLUSIONS: COVID-19 is associated with a small but significant risk of clinically relevant cerebrovascular events, particularly ischemic stroke. The mortality rate is high for COVID-19-associated cerebrovascular complications; therefore, aggressive monitoring and early intervention should be pursued to mitigate poor outcomes.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #806135
    Database COVID19

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  4. Article ; Online: Cerebrovascular events and outcomes in hospitalized patients with COVID-19

    Siegler, James E / Cardona, Pere / Arenillas, Juan F / Talavera, Blanca / Guillen, Ana N / Chavarría-Miranda, Alba / de Lera, Mercedes / Khandelwal, Priyank / Bach, Ivo / Patel, Pratit / Singla, Amit / Requena, Manuel / Ribo, Marc / Jillella, Dinesh V / Rangaraju, Srikant / Nogueira, Raul G / Haussen, Diogo C / Vazquez, Alejandro R / Urra, Xabier /
    Chamorro, Ángel / Román, Luis S / Thon, Jesse M / Then, Ryna / Sanborn, Emma / de la Ossa, Natalia P / Millàn, Mònica / Ruiz, Isaac N / Mansour, Ossama Y / Megahed, Mohammed / Tiu, Cristina / Terecoasa, Elena O / Radu, Răzvan A / Nguyen, Thanh N / Curiale, Gioacchino / Kaliaev, Artem / Czap, Alexandra L / Sebaugh, Jacob / Zha, Alicia M / Liebeskind, David S / Ortega-Gutierrez, Santiago / Farooqui, Mudassir / Hassan, Ameer E / Preston, Laurie / Patterson, Mary S / Bushnaq, Saif / Zaidat, Osama / Jovin, Tudor G

    International Journal of Stroke

    The SVIN COVID-19 Multinational Registry

    2020  , Page(s) 174749302095921

    Abstract: Background Severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) has been associated with a significant risk of thrombotic events in critically ill patients. Aim To summarize the findings of a multinational observational cohort of patients with ... ...

    Abstract Background Severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) has been associated with a significant risk of thrombotic events in critically ill patients. Aim To summarize the findings of a multinational observational cohort of patients with SARS-CoV-2 and cerebrovascular disease. Methods Retrospective observational cohort of consecutive adults evaluated in the emergency department and/or admitted with coronavirus disease 2019 (COVID-19) across 31 hospitals in four countries (1 February 2020–16 June 2020). The primary outcome was the incidence rate of cerebrovascular events, inclusive of acute ischemic stroke, intracranial hemorrhages (ICH), and cortical vein and/or sinus thrombosis (CVST). Results Of the 14,483 patients with laboratory-confirmed SARS-CoV-2, 172 were diagnosed with an acute cerebrovascular event (1.13% of cohort; 1130/100,000 patients, 95%CI 970–1320/100,000), 68/171 (40.5%) were female and 96/172 (55.8%) were between the ages 60 and 79 years. Of these, 156 had acute ischemic stroke (1.08%; 1080/100,000 95%CI 920–1260/100,000), 28 ICH (0.19%; 190/100,000 95%CI 130–280/100,000), and 3 with CVST (0.02%; 20/100,000, 95%CI 4–60/100,000). The in-hospital mortality rate for SARS-CoV-2-associated stroke was 38.1% and for ICH 58.3%. After adjusting for clustering by site and age, baseline stroke severity, and all predictors of in-hospital mortality found in univariate regression (p < 0.1: male sex, tobacco use, arrival by emergency medical services, lower platelet and lymphocyte counts, and intracranial occlusion), cryptogenic stroke mechanism (aOR 5.01, 95%CI 1.63–15.44, p < 0.01), older age (aOR 1.78, 95%CI 1.07–2.94, p = 0.03), and lower lymphocyte count on admission (aOR 0.58, 95%CI 0.34–0.98, p = 0.04) were the only independent predictors of mortality among patients with stroke and COVID-19. Conclusions COVID-19 is associated with a small but significant risk of clinically relevant cerebrovascular events, particularly ischemic stroke. The mortality rate is high for COVID-19-associated cerebrovascular complications; therefore, aggressive monitoring and early intervention should be pursued to mitigate poor outcomes.
    Keywords Neurology ; covid19
    Language English
    Publisher SAGE Publications
    Publishing country us
    Document type Article ; Online
    ZDB-ID 2303728-3
    ISSN 1747-4930
    ISSN 1747-4930
    DOI 10.1177/1747493020959216
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6582: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

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