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  1. Article ; Online: Association of Endocrine Disrupting Chemicals With the Metabolic Syndrome Among Women in the Multiethnic Cohort Study.

    Ihenacho, Ugonna / Guillermo, Cherie / Wilkens, Lynne R / Franke, Adrian A / Tseng, Chiuchen / Li, Yuqing / Sangaramoorthy, Meera / Derouen, Mindy C / Haiman, Christopher A / Stram, Daniel O / Le Marchand, Loïc / Cheng, Iona / Wu, Anna H

    Journal of the Endocrine Society

    2023  Volume 7, Issue 12, Page(s) bvad136

    Abstract: Metabolic syndrome (MetS) is associated with a high risk of cardiovascular disease, a leading cause of death among women. MetS is a diagnosis of at least 3 of the following: high blood pressure, high fasting glucose, high triglycerides, high waist ... ...

    Abstract Metabolic syndrome (MetS) is associated with a high risk of cardiovascular disease, a leading cause of death among women. MetS is a diagnosis of at least 3 of the following: high blood pressure, high fasting glucose, high triglycerides, high waist circumference, and low high-density lipoprotein cholesterol. Epidemiological studies suggest that endocrine disrupting chemical (EDC) exposure is positively associated with individual components of MetS, but evidence of an association between EDCs and MetS remains inconsistent. In a cross-sectional analysis within the Multiethnic Cohort Study, we evaluated the association between 4 classes of urinary EDCs (bisphenol A [BPA], triclosan, parabens, and phthalates) and MetS among 1728 women. Multivariable logistic regression was used to estimate odds ratios and 95% CI for the association between tertiles of each EDC and MetS adjusting for age, body mass index (BMI), racial and ethnic group, and breast cancer status. Stratified analyses by race and ethnicity and BMI were conducted. MetS was identified in 519 (30.0%) women. We did not detect statistically significant associations of MetS with BPA, triclosan, or phthalate metabolite excretion. MetS was inversely associated with total parabens (
    Language English
    Publishing date 2023-11-17
    Publishing country United States
    Document type Journal Article
    ISSN 2472-1972
    ISSN (online) 2472-1972
    DOI 10.1210/jendso/bvad136
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: The association of a healthy lifestyle index and imaging-based body fat distribution with glycemic status and Type 2 diabetes in the Multi Ethnic Cohort: a cross-sectional analysis.

    Klapp, Rebecca / Nimptsch, Katharina / Pischon, Tobias / Wilkens, Lynne R / Lim, Unhee / Guillermo, Cherie / Setiawan, V Wendy / Shepherd, John A / Le Marchand, Loïc / Maskarinec, Gertraud

    European journal of clinical nutrition

    2023  Volume 78, Issue 3, Page(s) 236–242

    Abstract: Introduction: As several behaviors captured by the Lifestyle Risk Factor Index (LSRI) are protective against Type 2 diabetes (T2D) and may affect body fat distribution, we examined its relation with both outcomes.: Methods: In a subset of the ... ...

    Abstract Introduction: As several behaviors captured by the Lifestyle Risk Factor Index (LSRI) are protective against Type 2 diabetes (T2D) and may affect body fat distribution, we examined its relation with both outcomes.
    Methods: In a subset of the Multiethnic Cohort, participants from five ethnic groups (60-77 years) were assigned LSRI scores (one point each for consuming <1 (women)/<2 (men) alcoholic drinks/day, ≥1.5 physical activity hours/week, not smoking, and adhering to ≥3/7 dietary recommendations). All participants completed an extensive Quantitative Food Frequency Questionnaire to allow estimation of adherence to intake recommendations for fruits, vegetables, refined and whole grains, fish, processed and non-processed meat. Glycemic/T2D status was classified according to self-reports and fasting glucose. We estimated prevalence odds ratios (POR) of LSRI with glycemic/T2D status and DXA- and MRI-based body fat distribution using logistic regression.
    Results: Of 1713 participants, 43% had normoglycemia, 30% Pre-T2D, 9% Undiagnosed T2D, and 18% T2D. Overall, 39% scored 0-2, 49% 3, and 12% 4 LSRI points. T2D prevalence was 55% (POR 0.45; 95% confidence intervals 0.27, 0.76) lower for 4 vs. 0-2 LSRI points with weaker associations for abnormal glycemic status. Despite the low adherence to dietary recommendations (22%), this was the only component related to lower T2D prevalence. The inverse LSRI-T2D association was only observed among Latinos and Japanese Americans in ethnic-specific models. Visceral fat measures were higher in T2D patients and attenuated the LSRI-T2D association.
    Conclusion: These findings support the role of a healthy lifestyle, especially diet, in T2D prevention with differences across ethnicity.
    MeSH term(s) Male ; Animals ; Humans ; Female ; Diabetes Mellitus, Type 2/epidemiology ; Cross-Sectional Studies ; Diet ; Risk Factors ; Healthy Lifestyle
    Language English
    Publishing date 2023-12-14
    Publishing country England
    Document type Journal Article
    ZDB-ID 639358-5
    ISSN 1476-5640 ; 0954-3007
    ISSN (online) 1476-5640
    ISSN 0954-3007
    DOI 10.1038/s41430-023-01381-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1045: Show issues Location:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article: Diet Quality and Biomarker Profiles Related to Chronic Disease Prevention: The Multiethnic Cohort Study

    Guillermo, Cherie / Boushey, Carol J / Franke, Adrian A / Monroe, Kristine R / Lim, Unhee / Wilkens, Lynne R / Le Marchand, Loïc / Maskarinec, Gertraud

    Journal of the American College of Nutrition. 2020 Apr. 2, v. 39, no. 3

    2020  

    Abstract: Objective: To understand how diet quality affects chronic disease etiology, the associations of 4 a priori diet quality indices with blood levels of lipid-soluble micronutrients and biomarkers of inflammation, lipid, and glucose metabolism were examined ... ...

    Abstract Objective: To understand how diet quality affects chronic disease etiology, the associations of 4 a priori diet quality indices with blood levels of lipid-soluble micronutrients and biomarkers of inflammation, lipid, and glucose metabolism were examined in 5 ethnic groups. Methods: In a cross-sectional design, the Adiposity Phenotype Study, a subset of the Multiethnic Cohort in Hawaii and Los Angeles, recruited participants of white, African American, Native Hawaiian, Japanese American, and Latino ancestry. A total of 896 men and 910 women completed a validated quantitative food frequency questionnaire and anthropometric measurements and donated a fasting blood sample. Using general linear models, covariate-adjusted mean levels of lipid-soluble micronutrients (total carotenes, lycopene, total tocopherols, total lutein, cryptoxanthins), biomarkers of inflammation (C-reactive protein [CRP], tumor necrosis factor-), adipokines (adiponectin, leptin), lipids (total cholesterol, high-density lipoprotein cholesterol [HDL-C], triglycerides), and glucose metabolism (glucose, insulin, homeostatic model assessment of insulin resistance [HOMA-IR]) were computed across tertiles of 4 a priori dietary indices Healthy Eating Index (HEI)-2010, Alternative HEI (AHEI)-2010, alternate Mediterranean Diet (aMED), Dietary Approaches to Stop Hypertension (DASH); trends were evaluated in models with diet quality scores as continuous variables. Results: With better diet quality, levels of carotenes, lutein, cryptoxanthin, adiponectin, and HDL-C were significantly higher (pₜᵣₑₙd < 0.01), whereas levels of CRP, leptin, total cholesterol, triglycerides, glucose, insulin, and HOMA-IR were inversely associated (pₜᵣₑₙd < 0.05) with diet quality. With the exception of cryptoxanthins and triglycerides, the associations were consistent across ethnic groups. Conclusions: These findings confirm the association between diet quality and nutrition-related biomarkers and support the idea that a high-quality diet positively influences biologic pathways involved in chronic disease etiology across different ethnic groups.
    Keywords C-reactive protein ; Dietary Approaches to Stop Hypertension diet ; Latinos ; Mediterranean diet ; adiponectin ; adiposity ; ancestry ; anthropometric measurements ; biomarkers ; blood ; blood sampling ; chronic diseases ; cohort studies ; disease prevention ; etiology ; fasting ; food frequency questionnaires ; food quality ; glucose ; healthy eating habits ; high density lipoprotein cholesterol ; inflammation ; insulin ; insulin resistance ; leptin ; linear models ; lutein ; lycopene ; men ; metabolism ; neoplasms ; phenotype ; tocopherols ; triacylglycerols ; tumor necrosis factors ; women ; Hawaii
    Language English
    Dates of publication 2020-0402
    Size p. 216-223.
    Publishing place Taylor & Francis
    Document type Article
    ZDB-ID 603204-7
    ISSN 1541-1087 ; 0731-5724
    ISSN (online) 1541-1087
    ISSN 0731-5724
    DOI 10.1080/07315724.2019.1635921
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Bonn / Germany

    Z 3905: Show issues

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  4. Article ; Online: Diet Quality and Biomarker Profiles Related to Chronic Disease Prevention: The Multiethnic Cohort Study.

    Guillermo, Cherie / Boushey, Carol J / Franke, Adrian A / Monroe, Kristine R / Lim, Unhee / Wilkens, Lynne R / Le Marchand, Loïc / Maskarinec, Gertraud

    Journal of the American College of Nutrition

    2019  Volume 39, Issue 3, Page(s) 216–223

    Abstract: Objective: ...

    Abstract Objective:
    MeSH term(s) African Americans/statistics & numerical data ; Aged ; Asian Americans/statistics & numerical data ; Biomarkers/blood ; Carotenoids/administration & dosage ; Chronic Disease/prevention & control ; Cohort Studies ; Cross-Sectional Studies ; Diet, Healthy ; Ethnic Groups/statistics & numerical data ; European Continental Ancestry Group/statistics & numerical data ; Female ; Hawaii ; Hispanic Americans/statistics & numerical data ; Humans ; Los Angeles ; Male ; Micronutrients/blood ; Oceanic Ancestry Group/statistics & numerical data ; Tocopherols/administration & dosage
    Chemical Substances Biomarkers ; Micronutrients ; Carotenoids (36-88-4) ; Tocopherols (R0ZB2556P8)
    Language English
    Publishing date 2019-07-10
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 603204-7
    ISSN 1541-1087 ; 0731-5724
    ISSN (online) 1541-1087
    ISSN 0731-5724
    DOI 10.1080/07315724.2019.1635921
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1759: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
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  5. Article ; Online: Association between sleep duration and breast cancer incidence: The multiethnic cohort.

    Shigesato, Maryssa / Kawai, Yosuke / Guillermo, Cherie / Youkhana, Fadi / Shvetsov, Yurii B / Setiawan, Veronica W / Haiman, Christopher A / Le Marchand, Loïc / Maskarinec, Gertraud

    International journal of cancer

    2019  Volume 146, Issue 3, Page(s) 664–670

    Abstract: Breast cancer is the most common cancer and the second-leading cause of cancer-related death among women. Inconsistent findings for the relationship between melatonin levels, sleep duration and breast cancer have been reported. We investigated the ... ...

    Abstract Breast cancer is the most common cancer and the second-leading cause of cancer-related death among women. Inconsistent findings for the relationship between melatonin levels, sleep duration and breast cancer have been reported. We investigated the association of sleep duration at cohort entry and its interaction with body mass index (BMI) with risk of developing breast cancer in the large population-based Multiethnic Cohort study. Among the 74,481 at-risk participants, 5,790 breast cancer cases were identified during the study period. Although we detected no significant association between sleep duration and breast cancer incidence, higher risk estimates for short (HR = 1.03; 95% CI: 0.97-1.09) and long sleep (HR = 1.05; 95% CI: 0.95-1.15) compared to normal sleep (7-8 hr) were found. The patterns for models stratified by age, BMI, ethnicity and hormone receptor status were similar but did not indicate significant interaction effects. When examining the combined sleep duration and BMI interaction effect, in comparison to the normal BMI-normal sleep group, risk estimates for underweight, overweight and obesity were similar across categories of sleep duration (≤6, 7-8, and ≥9 hr). The underweight-normal sleep group had lower breast cancer incidence (HR = 0.66, 95% CI: 0.50-0.86), whereas the overweight-short sleep, overweight-normal sleep group and all obese women experienced elevated breast cancer incidence. The respective HRs for short, normal and long sleep among obese women were 1.35 (95% CI: 1.20-1.53), 1.27 (95% CI: 1.15-1.42) and 1.46 (95% CI: 1.21-1.76). Future perspectives need to examine the possibility that sleep quality, variations in circadian rhythm and melatonin are involved in breast cancer etiology.
    MeSH term(s) Aged ; Body Mass Index ; Breast Neoplasms/epidemiology ; Breast Neoplasms/etiology ; California/epidemiology ; Circadian Rhythm/physiology ; Female ; Follow-Up Studies ; Humans ; Incidence ; Middle Aged ; Overweight/complications ; Overweight/epidemiology ; Risk Assessment ; Risk Factors ; Sleep/physiology ; Thinness/complications ; Thinness/epidemiology ; Time Factors
    Language English
    Publishing date 2019-04-10
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 218257-9
    ISSN 1097-0215 ; 0020-7136
    ISSN (online) 1097-0215
    ISSN 0020-7136
    DOI 10.1002/ijc.32292
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 478: Show issues Location:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
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    Zs.MO 576: Show issues

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