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  1. Article ; Online: Short-Term Biological Toxicity Prediction of [

    Dubois, Julien / Tosato, Guillaume / Garrigue, Philippe / Taieb, David / Guillet, Benjamin / Nail, Vincent

    Cancer biotherapy & radiopharmaceuticals

    2024  

    Abstract: Introduction: ...

    Abstract Introduction:
    Language English
    Publishing date 2024-04-24
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1315649-4
    ISSN 1557-8852 ; 1084-9785
    ISSN (online) 1557-8852
    ISSN 1084-9785
    DOI 10.1089/cbr.2023.0195
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    Zs.A 1896: Show issues Location:
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  2. Article ; Online: Correction to: Highlights of the 35th EANM Annual Congress 2022, onsite edition in Barcelona, Spain: "FROM BARCELONA WITH LOVE".

    Albert, Nathalie L / Garrigue, Philippe / Guillet, Benjamin / Burger, Irene A

    European journal of nuclear medicine and molecular imaging

    2023  Volume 50, Issue 13, Page(s) 4114

    Language English
    Publishing date 2023-09-29
    Publishing country Germany
    Document type Published Erratum
    ZDB-ID 8236-3
    ISSN 1619-7089 ; 0340-6997 ; 1619-7070
    ISSN (online) 1619-7089
    ISSN 0340-6997 ; 1619-7070
    DOI 10.1007/s00259-023-06419-6
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    Zs.A 1227: Show issues Location:
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  3. Article ; Online: Highlights of the 35th EANM Annual Congress 2022, onsite edition in Barcelona, Spain: "FROM BARCELONA WITH LOVE".

    Albert, Nathalie L / Garrigue, Philippe / Guillet, Benjamin / Burger, Irene A

    European journal of nuclear medicine and molecular imaging

    2023  Volume 50, Issue 11, Page(s) 3168–3176

    MeSH term(s) Humans ; Spain ; Nuclear Medicine ; Societies, Medical
    Language English
    Publishing date 2023-07-11
    Publishing country Germany
    Document type Editorial
    ZDB-ID 8236-3
    ISSN 1619-7089 ; 0340-6997 ; 1619-7070
    ISSN (online) 1619-7089
    ISSN 0340-6997 ; 1619-7070
    DOI 10.1007/s00259-023-06306-0
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    Zs.A 1227: Show issues Location:
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  4. Article ; Online: Kidney disease and stroke: epidemiology and potential mechanisms of susceptibility.

    Bobot, Mickaël / Suissa, Laurent / Hak, Jean-François / Burtey, Stéphane / Guillet, Benjamin / Hache, Guillaume

    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association

    2023  Volume 38, Issue 9, Page(s) 1940–1951

    Abstract: Patients with chronic kidney disease (CKD) have an increased risk of both ischaemic and haemorrhagic stroke compared with the general population. Both acute and chronic kidney impairment are independently associated with poor outcome after the onset of a ...

    Abstract Patients with chronic kidney disease (CKD) have an increased risk of both ischaemic and haemorrhagic stroke compared with the general population. Both acute and chronic kidney impairment are independently associated with poor outcome after the onset of a stroke, after adjustment for confounders. End-stage kidney disease (ESKD) is associated with a 7- and 9-fold increased incidence of both ischaemic and haemorrhagic strokes, respectively, poorer neurological outcome and a 3-fold higher mortality. Acute kidney injury (AKI) occurs in 12% of patients with stroke and is associated with a 4-fold increased mortality and unfavourable functional outcome. CKD patients seem to have less access to revascularisation techniques like thrombolysis and thrombectomy despite their poorer prognosis. Even if CKD patients could benefit from these specific treatments in acute ischaemic stroke, their prognosis remains poor. After thrombolysis, CKD is associated with a 40% increased risk of intracerebral haemorrhage (ICH), a 20% increase in mortality and poorer functional neurological outcomes. After thrombectomy, CKD is not associated with ICH but is still associated with increased mortality, and AKI with unfavourable outcome and mortality. The beneficial impact of gliflozins on the prevention of stroke is still uncertain. Non-traditional risk factors of stroke, like uraemic toxins, can lead to chronic cerebrovascular disease predisposing to stroke in CKD, notably through an increase in the blood-brain barrier permeability and impaired coagulation and thrombosis mechanisms. Preclinical and clinical studies are needed to specifically assess the impact of these non-traditional risk factors on stroke incidence and outcomes, aiming to optimize and identify potential therapeutic targets.
    MeSH term(s) Humans ; Stroke/etiology ; Stroke/complications ; Brain Ischemia ; Retrospective Studies ; Renal Insufficiency, Chronic/complications ; Renal Insufficiency, Chronic/epidemiology ; Risk Factors ; Acute Kidney Injury/epidemiology ; Acute Kidney Injury/etiology ; Ischemia
    Language English
    Publishing date 2023-01-26
    Publishing country England
    Document type Journal Article
    ZDB-ID 90594-x
    ISSN 1460-2385 ; 0931-0509
    ISSN (online) 1460-2385
    ISSN 0931-0509
    DOI 10.1093/ndt/gfad029
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    Zs.A 2198: Show issues Location:
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    Zs.MO 329: Show issues

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  5. Article ; Online: Rapid nanobody-based imaging of mesothelin expressing malignancies compatible with blocking therapeutic antibodies.

    Benloucif, Abdennour / Meyer, Damien / Balasse, Laure / Goubard, Armelle / Danner, Lucile / Bouhlel, Ahlem / Castellano, Rémy / Guillet, Benjamin / Chames, Patrick / Kerfelec, Brigitte

    Frontiers in immunology

    2023  Volume 14, Page(s) 1200652

    Abstract: Introduction: Mesothelin (MSLN) is overexpressed in a wide variety of cancers with few therapeutic options and has recently emerged as an attractive target for cancer therapy, with a large number of approaches currently under preclinical and clinical ... ...

    Abstract Introduction: Mesothelin (MSLN) is overexpressed in a wide variety of cancers with few therapeutic options and has recently emerged as an attractive target for cancer therapy, with a large number of approaches currently under preclinical and clinical investigation. In this respect, developing mesothelin specific tracers as molecular companion tools for predicting patient eligibility, monitoring then response to mesothelin-targeting therapies, and tracking the evolution of the disease or for real-time visualisation of tumours during surgery is of growing importance.
    Methods: We generated by phage display a nanobody (Nb S1) and used enzymatic approaches were used to site-directed conjugate Nb S1 with either ATTO 647N fluorochrome or NODAGA chelator for fluorescence and positron emission tomography imaging (PET) respectively.
    Results: We demonstrated that Nb S1 displays a high apparent affinity and specificity for human mesothelin and demonstrated that the binding, although located in the membrane distal domain of mesothelin, is not impeded by the presence of MUC16, the only known ligand of mesothelin, nor by the therapeutic antibody amatuximab.
    Conclusion: We demonstrated for the first time the use of an anti-MSLN nanobody as PET radiotracer for same day imaging of MSLN
    MeSH term(s) Humans ; Mesothelin ; Tissue Distribution ; Positron-Emission Tomography ; Neoplasms/diagnostic imaging ; Neoplasms/therapy ; Antibodies, Blocking
    Chemical Substances 1-(1,3-carboxypropyl)-4,7-carboxymethyl-1,4,7-triazacyclononane ; Mesothelin (J27WDC343N) ; Antibodies, Blocking
    Language English
    Publishing date 2023-06-14
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2023.1200652
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  6. Article ; Online: Probing the Cellular Size Distribution in Cell Samples Undergoing Cell Death.

    Franceschini, Emilie / Balasse, Laure / Roffino, Sandrine / Guillet, Benjamin

    Ultrasound in medicine & biology

    2019  Volume 45, Issue 7, Page(s) 1787–1798

    Abstract: A polydisperse scattering model adapted for concentrated medium, namely the polydisperse structure factor model, was examined to explain the backscatter coefficients (BSCs) measured from packed cell samples undergoing cell death. Cell samples were ... ...

    Abstract A polydisperse scattering model adapted for concentrated medium, namely the polydisperse structure factor model, was examined to explain the backscatter coefficients (BSCs) measured from packed cell samples undergoing cell death. Cell samples were scanned using high-frequency ultrasound in the 10-42 MHz bandwidth. A parameter estimation procedure was proposed to estimate the volume fraction and the relative impedance contrast that could explain the changes in BSC pattern by considering the actual change in cellular size distribution. Quantitative ultrasound parameters were estimated and related to the percentage of dead cells determined by flow cytometry. The standard deviation of scatterer size distribution extracted from the polydisperse structure factor model and the spectral intercept were found to be strongly correlated to the percentage of dead cells (r
    MeSH term(s) Adenocarcinoma/pathology ; Apoptosis/physiology ; Cell Culture Techniques ; Cell Death/physiology ; Colonic Neoplasms/pathology ; Flow Cytometry/methods ; Humans ; In Vitro Techniques ; Phantoms, Imaging ; Ultrasonography/methods
    Language English
    Publishing date 2019-04-22
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 186150-5
    ISSN 1879-291X ; 0301-5629
    ISSN (online) 1879-291X
    ISSN 0301-5629
    DOI 10.1016/j.ultrasmedbio.2019.01.006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 963: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Mortality, cardiac and cerebral damages reduction by IL-1 inhibition in a murine model of TTP.

    Muller, Romain / Cauchois, Raphael / Lagarde, Marie / Roffino, Sandrine / Genovesio, Cecile / Fernandez, Samantha / Hache, Guillaume / Guillet, Benjamin / Kara, Yeter / Marlinge, Marion / Lenting, Peter J / Poullin, Pascale / Dignat-George, Françoise / Tellier, Edwige / Kaplanski, Gilles

    Blood

    2024  

    Abstract: Thrombotic thrombocytopenic purpura (TTP), a rare but fatal disease if untreated, is due to alteration in Von Willebrand factor cleavage resulting in capillary microthrombi formation and ischemic organ damage. Interleukin-1 (IL-1), has been shown to ... ...

    Abstract Thrombotic thrombocytopenic purpura (TTP), a rare but fatal disease if untreated, is due to alteration in Von Willebrand factor cleavage resulting in capillary microthrombi formation and ischemic organ damage. Interleukin-1 (IL-1), has been shown to drive sterile inflammation following ischemia and could play an essential contribution to post-ischemic organ damage in TTP. Our objectives were to evaluate IL-1 involvement during TTP and to test the efficacy of the recombinant IL-1 receptor antagonist, anakinra, in a murine TTP model. We retrospectively measured plasmatic IL-1 concentrations in TTP patients and controls. TTP patients exhibited elevated plasma IL-1α and β concentrations, which correlated with disease course and survival. In a TTP mouse model, we administered anakinra (IL-1 inhibitor) or placebo for 5 days and evaluated the efficacy of this treatment. Anakinra significantly reduced mortality of mice (P<0.001). Anakinra significantly decreased TTP-induced cardiac damages as assessed by blood troponin concentrations, evaluation of left ventricular function by echocardiography, [18F]FDG PET of myocardial glucose metabolism, and cardiac histology. Anakinra also significantly reduced brain TTP-induced damages, evaluated through blood PS100b concentrations, nuclear imaging and histology. We finally showed that IL-1α and β trigger endothelial degranulation in vitro, leading to the release of Von Willebrand factor. In conclusion, Anakinra significantly reduced TTP mortality in a pre-clinical model of the disease by inhibiting both endothelial degranulation and post-ischemic inflammation, supporting further evaluations in humans.
    Language English
    Publishing date 2024-04-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80069-7
    ISSN 1528-0020 ; 0006-4971
    ISSN (online) 1528-0020
    ISSN 0006-4971
    DOI 10.1182/blood.2023021974
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    Uh III Zs.140: Show issues Location:
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    Zs.MO 364: Show issues

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  8. Article ; Online: Systemic Administration of G-CSF Accelerates Bone Regeneration and Modulates Mobilization of Progenitor Cells in a Rat Model of Distraction Osteogenesis.

    Roseren, Flavy / Pithioux, Martine / Robert, Stéphane / Balasse, Laure / Guillet, Benjamin / Lamy, Edouard / Roffino, Sandrine

    International journal of molecular sciences

    2021  Volume 22, Issue 7

    Abstract: Granulocyte colony-stimulating factor (G-CSF) was shown to promote bone regeneration and mobilization of vascular and osteogenic progenitor cells. In this study, we investigated the effects of a systemic low dose of G-CSF on both bone consolidation and ... ...

    Abstract Granulocyte colony-stimulating factor (G-CSF) was shown to promote bone regeneration and mobilization of vascular and osteogenic progenitor cells. In this study, we investigated the effects of a systemic low dose of G-CSF on both bone consolidation and mobilization of hematopoietic stem/progenitor cells (HSPCs), endothelial progenitor cells (EPCs) and mesenchymal stromal cells (MSCs) in a rat model of distraction osteogenesis (DO). Neovascularization and mineralization were longitudinally monitored using positron emission tomography and planar scintigraphy. Histological analysis was performed and the number of circulating HSPCs, EPCs and MSCs was studied by flow cytometry. Contrary to control group, in the early phase of consolidation, a bony bridge with lower osteoclast activity and a trend of an increase in osteoblast activity were observed in the distracted callus in the G-CSF group, whereas, at the late phase of consolidation, a significantly lower neovascularization was observed. While no difference was observed in the number of circulating EPCs between control and G-CSF groups, the number of MSCs was significantly lower at the end of the latency phase and that of HSPCs was significantly higher 4 days after the bone lengthening. Our results indicate that G-CSF accelerates bone regeneration and modulates mobilization of progenitor cells during DO.
    MeSH term(s) Animals ; Bone Regeneration/drug effects ; Disease Models, Animal ; Durapatite/chemistry ; Flow Cytometry ; Granulocyte Colony-Stimulating Factor/administration & dosage ; Hematopoietic Stem Cell Mobilization ; Kinetics ; Male ; Mesenchymal Stem Cells/cytology ; Neovascularization, Physiologic/drug effects ; Osteoblasts/metabolism ; Osteoclasts/drug effects ; Osteogenesis, Distraction ; Positron-Emission Tomography ; Rats ; Rats, Sprague-Dawley ; Single Photon Emission Computed Tomography Computed Tomography ; Stem Cells/cytology ; Stem Cells/metabolism
    Chemical Substances Granulocyte Colony-Stimulating Factor (143011-72-7) ; Durapatite (91D9GV0Z28)
    Language English
    Publishing date 2021-03-28
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms22073505
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  9. Article ; Online: Pharmaceutical interviews to overcome digestive artefacts on [

    Nail, Vincent / Moyon, Anaïs / Nachar, Oriane / Gabriel, Sophie / Guillet, Benjamin / Garrigue, Philippe

    Journal of clinical pharmacy and therapeutics

    2021  Volume 46, Issue 5, Page(s) 1480–1483

    Abstract: What is known and objectives: Poor image quality was randomly seen in [: Methods: Out of 40 patients planned for [: Results and discussion: P.I. led to identification of dipyridamole as the cause of the artefacts. The systematic ingestion of a ... ...

    Abstract What is known and objectives: Poor image quality was randomly seen in [
    Methods: Out of 40 patients planned for [
    Results and discussion: P.I. led to identification of dipyridamole as the cause of the artefacts. The systematic ingestion of a solid 25-gram high-fat snack bar and a glass of fresh water was introduced immediately after the injection of dipyridamole in 12 other patients undergoing [
    What is new and conclusion: P.I. identified the cause of poor scintigraphic images to allow improved diagnoses.
    MeSH term(s) Aged ; Aged, 80 and over ; Dipyridamole/pharmacology ; Female ; Humans ; Male ; Middle Aged ; Myocardial Perfusion Imaging/methods ; Organophosphorus Compounds/pharmacokinetics ; Organotechnetium Compounds/pharmacokinetics ; Radiopharmaceuticals/pharmacokinetics ; Tomography, Emission-Computed, Single-Photon ; Vasodilator Agents/pharmacology
    Chemical Substances Organophosphorus Compounds ; Organotechnetium Compounds ; Radiopharmaceuticals ; Vasodilator Agents ; technetium tc-99m tetrofosmin (42FOP1YX93) ; Dipyridamole (64ALC7F90C)
    Language English
    Publishing date 2021-03-22
    Publishing country England
    Document type Journal Article
    ZDB-ID 639006-7
    ISSN 1365-2710 ; 0269-4727
    ISSN (online) 1365-2710
    ISSN 0269-4727
    DOI 10.1111/jcpt.13418
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    Zs.A 1313: Show issues Location:
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  10. Article: Sublingual Atropine Administration as a Tool to Decrease Salivary Glands' PSMA-Ligand Uptake: A Preclinical Proof of Concept Study Using [

    Nail, Vincent / Louis, Béatrice / Moyon, Anaïs / Chabert, Adrien / Balasse, Laure / Fernandez, Samantha / Hache, Guillaume / Garrigue, Philippe / Taïeb, David / Guillet, Benjamin

    Pharmaceutics

    2022  Volume 14, Issue 6

    Abstract: Prostate Specific Membrane Antigen (PSMA)-directed radionuclide therapy has gained an important role in the management of advanced castration-resistant prostate cancer. Although extremely promising, the prolongation in survival and amelioration of ... ...

    Abstract Prostate Specific Membrane Antigen (PSMA)-directed radionuclide therapy has gained an important role in the management of advanced castration-resistant prostate cancer. Although extremely promising, the prolongation in survival and amelioration of disease-related symptoms must be balanced against the direct toxicities of the treatment. Xerostomia is amongst the most common and debilitating of these, particularly when using an alpha emitter. It is therefore of main importance to develop new preventive strategies. This preclinical study has evaluated the effect of α-adrenergic and anticholinergic drugs on [99mTc]TcO4− Single Photon Emission Computed Tomography/Computed Tomography (SPECT/CT) and [68Ga]Ga-PSMA-11 Positron Emission Tomography (PET/CT). Methods: The effects of phenylephrine, scopolamine, atropine, and ipratropium on salivary glands uptake were evaluated in non-tumor-bearing mice by [99mTc]TcO4− microSPECT/CT. The most efficient identified strategy was evaluated in non-tumor-bearing and xenografted mice by [68Ga]Ga-PSMA-11 PET/CT. Results: Scopolamine and atropine showed a significant decrease in the parotid glands’ uptake on SPECT/CT whereas phenylephrine and ipratropium failed. Atropine premedication (sublingual route), which was the most effective strategy, also showed a drastic decrease of [68Ga]Ga-PSMA-11 salivary glands’ uptake in both non-tumor-bearing mice (−51.6% for the parotids, p < 0.0001) and human prostate adenocarcinoma xenografted mice (−26.8% for the parotids, p < 0.0001). Conclusion: Premedication with a local administration of atropine could represent a simple, safe, and efficient approach for reducing salivary glands’ uptake.
    Language English
    Publishing date 2022-06-16
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527217-2
    ISSN 1999-4923
    ISSN 1999-4923
    DOI 10.3390/pharmaceutics14061276
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