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  1. Article: Inhibition of collagenase and metalloproteinases by aloins and aloe gel.

    Barrantes, Esther / Guinea, María

    Life sciences

    2003  Volume 72, Issue 7, Page(s) 843–850

    Abstract: The effects of Aloe barbadensis gel and aloe gel constituents on the activity of microbial and human metalloproteinases have been investigated. Clostridium histolyticum collagenase (ChC) results dose-dependently inhibited by aloe gel and the activity- ... ...

    Abstract The effects of Aloe barbadensis gel and aloe gel constituents on the activity of microbial and human metalloproteinases have been investigated. Clostridium histolyticum collagenase (ChC) results dose-dependently inhibited by aloe gel and the activity-guided fractionation led to an active fraction enriched in phenolics and aloins. Aloins have been shown to be able to bind and to inhibit ChC reversibly and non-competitively. Aloe gel and aloins are also effective inhibitors of stimulated granulocyte matrix metalloproteinases (MMPs). The remarkable structural resemblances between aloins and the pharmacophore structure of inhibitory tetracyclines, suggest that the inhibitory effects of aloins are via an interaction between the carbonyl group at C(9) and an adjacent hydroxyl group of anthrone (C(1) or C(8)) at the secondary binding site of enzyme, destabilizing the structure of granulocyte MMPs.
    MeSH term(s) Aloe ; Aminopeptidases/antagonists & inhibitors ; Clostridium ; Dose-Response Relationship, Drug ; Emodin/analogs & derivatives ; Emodin/pharmacology ; Enzyme Inhibitors/pharmacology ; Gels/pharmacology ; Granulocytes/drug effects ; Granulocytes/enzymology ; Humans ; Matrix Metalloproteinase Inhibitors
    Chemical Substances Enzyme Inhibitors ; Gels ; Matrix Metalloproteinase Inhibitors ; Aminopeptidases (EC 3.4.11.-) ; clostridial aminopeptidase (EC 3.4.11.13) ; Emodin (KA46RNI6HN) ; alloin (W41H6S09F4)
    Language English
    Publishing date 2003-01-03
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 3378-9
    ISSN 1879-0631 ; 0024-3205
    ISSN (online) 1879-0631
    ISSN 0024-3205
    DOI 10.1016/s0024-3205(02)02308-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uc I Zs.368: Show issues Location:
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  2. Article: In vivo UVB-photoprotective activity of extracts from commercial marine macroalgae

    Guinea, María / Franco, Virginia / Araujo-Bazán, Lidia / Rodríguez-Martín, Iván / González, Salvador

    Food and chemical toxicology. 2012 , v. 50, no. 3-4

    2012  

    Abstract: The photoprotective potential against UVB radiation of extracts obtained from 21 commercial macroalgae from the Phyla Ochrophyta and Rhodophyta, was evaluated in vivo, using the zebrafish embryo as a whole model organism. Our results showed that the ... ...

    Abstract The photoprotective potential against UVB radiation of extracts obtained from 21 commercial macroalgae from the Phyla Ochrophyta and Rhodophyta, was evaluated in vivo, using the zebrafish embryo as a whole model organism. Our results showed that the phenolic extracts from Macrocystis pyrifera and Porphyra columbina exhibited the highest photoprotective activity, close to complete photoprotection (100%), similar to that obtained for the carrageenophytes Sarcothalia radula and Gigartina skottsbergii. Under the assayed conditions, the extracts were safe and non-toxic to the embryos at a concentration of 0.04mg/ml PGE.
    Keywords Danio rerio ; Gigartina ; Macrocystis pyrifera ; Porphyra ; macroalgae ; photostability ; toxicology
    Language English
    Dates of publication 2012-03
    Size p. 1109-1117.
    Publishing place Elsevier Ltd
    Document type Article
    ZDB-ID 782617-5
    ISSN 1873-6351 ; 0278-6915
    ISSN (online) 1873-6351
    ISSN 0278-6915
    DOI 10.1016/j.fct.2012.01.004
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Bonn / Germany

    Z 4035: Show issues

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  3. Article ; Online: In vivo UVB-photoprotective activity of extracts from commercial marine macroalgae.

    Guinea, María / Franco, Virginia / Araujo-Bazán, Lidia / Rodríguez-Martín, Iván / González, Salvador

    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association

    2012  Volume 50, Issue 3-4, Page(s) 1109–1117

    Abstract: The photoprotective potential against UVB radiation of extracts obtained from 21 commercial macroalgae from the Phyla Ochrophyta and Rhodophyta, was evaluated in vivo, using the zebrafish embryo as a whole model organism. Our results showed that the ... ...

    Abstract The photoprotective potential against UVB radiation of extracts obtained from 21 commercial macroalgae from the Phyla Ochrophyta and Rhodophyta, was evaluated in vivo, using the zebrafish embryo as a whole model organism. Our results showed that the phenolic extracts from Macrocystis pyrifera and Porphyra columbina exhibited the highest photoprotective activity, close to complete photoprotection (100%), similar to that obtained for the carrageenophytes Sarcothalia radula and Gigartina skottsbergii. Under the assayed conditions, the extracts were safe and non-toxic to the embryos at a concentration of 0.04 mg/ml PGE.
    MeSH term(s) Animals ; Marine Biology ; Microalgae/chemistry ; Plant Extracts/pharmacology ; Polyphenols/isolation & purification ; Radiation-Protective Agents/pharmacology ; Ultraviolet Rays ; Zebrafish/embryology
    Chemical Substances Plant Extracts ; Polyphenols ; Radiation-Protective Agents
    Language English
    Publishing date 2012-03
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 782617-5
    ISSN 1873-6351 ; 0278-6915
    ISSN (online) 1873-6351
    ISSN 0278-6915
    DOI 10.1016/j.fct.2012.01.004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 529: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  4. Article ; Online: Endothelial function of von Hippel-Lindau tumor suppressor gene: control of fibroblast growth factor receptor signaling.

    Champion, Kristen J / Guinea, Maria / Dammai, Vincent / Hsu, Tien

    Cancer research

    2008  Volume 68, Issue 12, Page(s) 4649–4657

    Abstract: von Hippel-Lindau (VHL) disease results from germline and somatic mutations in the VHL tumor suppressor gene and is characterized by highly vascularized tumors. VHL mutations lead to stabilization of hypoxia-inducible factor (HIF), which up-regulates ... ...

    Abstract von Hippel-Lindau (VHL) disease results from germline and somatic mutations in the VHL tumor suppressor gene and is characterized by highly vascularized tumors. VHL mutations lead to stabilization of hypoxia-inducible factor (HIF), which up-regulates proangiogenic factors such as vascular endothelial growth factor (VEGF). This pathway is therefore believed to underlie the hypervascular phenotypes of the VHL tumors. However, recent studies have identified novel VHL functions that are independent of the HIF-VEGF pathway. In addition, a potential role of VHL in the tumor microenvironment, which carries heterozygous VHL mutations in VHL patients, has been overlooked. Here, we report a novel HIF-independent VHL function in the endothelium. VHL knockdown in primary human microvascular endothelial cells caused defective turnover of surface fibroblast growth factor (FGF) receptor, increased extracellular signal-regulated kinase signaling, and ETS1 activation, leading to increased cell motility in response to FGF and three-dimensional cord formation in vitro. HIF-alpha knockdown in VHL loss-of-function endothelial cells does not impede their elevated in vitro angiogenic activity. Importantly, the elevated angiogenic response to FGF is recapitulated in Vhl-heterozygous mice. Thus, partial loss of function of VHL in endothelium may be a contributing factor in tumor angiogenesis through a HIF-VEGF-independent mechanism.
    MeSH term(s) Animals ; Biotinylation ; Blotting, Western ; Cell Movement ; Cells, Cultured ; Endocytosis/physiology ; Endothelium, Vascular/cytology ; Endothelium, Vascular/metabolism ; Fibroblasts/cytology ; Fibroblasts/metabolism ; Gene Expression Regulation, Neoplastic ; Humans ; Hypoxia-Inducible Factor 1, alpha Subunit/metabolism ; Immunoenzyme Techniques ; Infant, Newborn ; Kidney/cytology ; Kidney/metabolism ; Mice ; Mice, Knockout ; Mitogen-Activated Protein Kinase 1/metabolism ; Mitogen-Activated Protein Kinase 3/metabolism ; Neovascularization, Physiologic ; Proto-Oncogene Protein c-ets-1/metabolism ; RNA Interference ; Receptor, Fibroblast Growth Factor, Type 2/metabolism ; Receptors, Fibroblast Growth Factor/genetics ; Receptors, Fibroblast Growth Factor/metabolism ; Recombinant Proteins/genetics ; Recombinant Proteins/metabolism ; Signal Transduction ; Skin/cytology ; Skin/metabolism ; Transfection ; Vascular Endothelial Growth Factor A/physiology ; Von Hippel-Lindau Tumor Suppressor Protein/antagonists & inhibitors ; Von Hippel-Lindau Tumor Suppressor Protein/physiology
    Chemical Substances ETS1 protein, human ; HIF1A protein, human ; Hypoxia-Inducible Factor 1, alpha Subunit ; Proto-Oncogene Protein c-ets-1 ; Receptors, Fibroblast Growth Factor ; Recombinant Proteins ; Vascular Endothelial Growth Factor A ; vascular endothelial growth factor A, mouse ; Von Hippel-Lindau Tumor Suppressor Protein (EC 2.3.2.27) ; Fgfr2 protein, mouse (EC 2.7.10.1) ; Receptor, Fibroblast Growth Factor, Type 2 (EC 2.7.10.1) ; Mitogen-Activated Protein Kinase 1 (EC 2.7.11.24) ; Mitogen-Activated Protein Kinase 3 (EC 2.7.11.24) ; VHL protein, human (EC 6.3.2.-) ; VHL protein, mouse (EC 6.3.2.-)
    Language English
    Publishing date 2008-06-16
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 1432-1
    ISSN 1538-7445 ; 0008-5472
    ISSN (online) 1538-7445
    ISSN 0008-5472
    DOI 10.1158/0008-5472.CAN-07-6003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uh III Zs.135/5: Show issues Location:
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  5. Article ; Online: Drosophila von Hippel-Lindau tumor suppressor gene function in epithelial tubule morphogenesis.

    Hsouna, Anita / Nallamothu, Gouthami / Kose, Nurgun / Guinea, Maria / Dammai, Vincent / Hsu, Tien

    Molecular and cellular biology

    2010  Volume 30, Issue 15, Page(s) 3779–3794

    Abstract: Mutations in the human von Hippel-Lindau (VHL) gene are the cause of VHL disease that displays multiple benign and malignant tumors. The VHL gene has been shown to regulate angiogenic potential and glycolic metabolism via its E3 ubiquitin ligase function ...

    Abstract Mutations in the human von Hippel-Lindau (VHL) gene are the cause of VHL disease that displays multiple benign and malignant tumors. The VHL gene has been shown to regulate angiogenic potential and glycolic metabolism via its E3 ubiquitin ligase function against the alpha subunit of hypoxia-inducible factor (HIF-alpha). However, many HIF-independent functions of VHL have been identified. Recent evidence also indicates that the canonical function cannot fully explain the VHL mutant cell phenotypes, although it is still unclear how many of these noncanonical functions relate to the pathophysiological processes because of a lack of tractable genetic systems. Here, we report the first genomic mutant phenotype of Drosophila melanogaster VHL (dVHL) in the epithelial tubule network, the trachea, and show that dVHL regulates branch migration and lumen formation via its endocytic function. The endocytic function regulates the surface level of the chemotactic signaling receptor Breathless and promotes clearing of the lumen matrix during maturation of the tracheal tubes. Importantly, the regulatory function in tubular morphogenesis is conserved in the mammalian system, as conditional knockout of Vhl in mouse kidney also resulted in similar cell motility and lumen phenotypes.
    MeSH term(s) Animals ; Animals, Genetically Modified ; Cell Movement/genetics ; Drosophila/genetics ; Drosophila/metabolism ; Embryo, Mammalian ; Embryo, Nonmammalian ; Genes ; Humans ; Kidney/metabolism ; Mice ; Morphogenesis/genetics ; Mutation ; Phenotype ; Ubiquitin-Protein Ligases/genetics ; Ubiquitin-Protein Ligases/metabolism ; Von Hippel-Lindau Tumor Suppressor Protein ; von Hippel-Lindau Disease/genetics ; von Hippel-Lindau Disease/metabolism
    Chemical Substances Ubiquitin-Protein Ligases (EC 2.3.2.27) ; Von Hippel-Lindau Tumor Suppressor Protein (EC 2.3.2.27) ; VHL protein, human (EC 6.3.2.-)
    Language English
    Publishing date 2010-06-01
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 779397-2
    ISSN 1098-5549 ; 0270-7306
    ISSN (online) 1098-5549
    ISSN 0270-7306
    DOI 10.1128/MCB.01578-09
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1666: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  6. Article ; Online: CD147-dependent heterogeneity in malignant and chemoresistant properties of cancer cells.

    Dai, Lu / Guinea, Maria C / Slomiany, Mark G / Bratoeva, Momka / Grass, G Daniel / Tolliver, Lauren B / Maria, Bernard L / Toole, Bryan P

    The American journal of pathology

    2012  Volume 182, Issue 2, Page(s) 577–585

    Abstract: CD147 (alias emmprin or basigin), an integral plasma membrane glycoprotein and a member of the Ig superfamily, is widespread in normal tissues, but highly up-regulated in many types of malignant cancer cells. CD147 is multifunctional, with numerous ... ...

    Abstract CD147 (alias emmprin or basigin), an integral plasma membrane glycoprotein and a member of the Ig superfamily, is widespread in normal tissues, but highly up-regulated in many types of malignant cancer cells. CD147 is multifunctional, with numerous binding partners. Recent studies suggest that complexes of CD147 with the hyaluronan receptor CD44 and associated transporters and receptor tyrosine kinases are enriched in the plasma membrane of cancer stem-like cells. Here, we show that subpopulations of tumor cell lines constitutively expressing high levels of cell-surface CD147 exhibit cancer stem-like cell properties; that is, they exhibit much greater invasiveness, anchorage-independent growth, spheroid formation, and drug resistance in vitro and higher tumorigenicity in vivo than those constitutively expressing low levels of cell-surface CD147. Primary CD147-rich cell subpopulations derived from mouse mammary adenocarcinomas also exhibit high levels of invasiveness and spheroid-forming capacity, whereas CD147-low cells do not. Moreover, localization at the plasma membrane of CD44, the EGF receptor, the ABCB1 and ABCG2 drug transporters, and the MCT4 monocarboxylate transporter is elevated in cells constitutively expressing high levels of cell-surface CD147. These results show that CD147 is associated with assembly of numerous pro-oncogenic proteins in the plasma membrane and may play a fundamental role in properties characteristic of cancer stem-like cells.
    MeSH term(s) Animals ; Basigin/metabolism ; Cell Adhesion ; Cell Line, Tumor ; Cell Membrane/metabolism ; Cell Proliferation ; Cell Transformation, Neoplastic/pathology ; Drug Resistance, Neoplasm ; ErbB Receptors/metabolism ; Female ; Flow Cytometry ; Genetic Heterogeneity ; Humans ; Hyaluronan Receptors/metabolism ; Mammary Neoplasms, Animal ; Mammary Tumor Virus, Mouse ; Mice ; Neoplasm Invasiveness ; Neoplasms/metabolism ; Neoplasms/pathology ; Spheroids, Cellular/metabolism ; Spheroids, Cellular/pathology
    Chemical Substances Hyaluronan Receptors ; Basigin (136894-56-9) ; ErbB Receptors (EC 2.7.10.1)
    Language English
    Publishing date 2012-11-22
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 2943-9
    ISSN 1525-2191 ; 0002-9440
    ISSN (online) 1525-2191
    ISSN 0002-9440
    DOI 10.1016/j.ajpath.2012.10.011
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ud II Zs.76: Show issues Location:
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  7. Book ; Thesis: Estudio sobre la sociedad soriana en el siglo XVIII

    Pérez de Guinea, María del C

    los censos y distribución de la población

    1982  

    Author's details María del Carmen Pérez de Guinea
    Language Undetermined
    Size 296 S
    Publisher Consejo General de Castilla y León
    Publishing place Valladolid
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Zugl.: Zaragoza, Univ., Diss. : 1973
    Database Former special subject collection: coastal and deep sea fishing

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  8. Article: In vivo UVB-photoprotective activity of extracts from commercial marine macroalgae

    Guinea, María / Franco, Virginia / Araujo-Bazán, Lidia / Rodríguez-Martín, Iván / González, Salvador

    Food and chemical toxicology

    Volume v. 50,, Issue no. 3

    Abstract: The photoprotective potential against UVB radiation of extracts obtained from 21 commercial macroalgae from the Phyla Ochrophyta and Rhodophyta, was evaluated in vivo, using the zebrafish embryo as a whole model organism. Our results showed that the ... ...

    Abstract The photoprotective potential against UVB radiation of extracts obtained from 21 commercial macroalgae from the Phyla Ochrophyta and Rhodophyta, was evaluated in vivo, using the zebrafish embryo as a whole model organism. Our results showed that the phenolic extracts from Macrocystis pyrifera and Porphyra columbina exhibited the highest photoprotective activity, close to complete photoprotection (100%), similar to that obtained for the carrageenophytes Sarcothalia radula and Gigartina skottsbergii. Under the assayed conditions, the extracts were safe and non-toxic to the embryos at a concentration of 0.04mg/ml PGE.
    Keywords Danio rerio ; photostability ; Macrocystis pyrifera ; toxicology ; Gigartina ; Porphyra ; macroalgae
    Language English
    Document type Article
    ISSN 0278-6915
    Database AGRIS - International Information System for the Agricultural Sciences and Technology

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