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  1. Article ; Online: DEW: A wavelet approach of rare sound event detection.

    Gul, Sania / Khan, Muhammad Salman / Ur-Rehman, Ata

    PloS one

    2024  Volume 19, Issue 3, Page(s) e0300444

    Abstract: This paper presents a novel sound event detection (SED) system for rare events occurring in an open environment. Wavelet multiresolution analysis (MRA) is used to decompose the input audio clip of 30 seconds into five levels. Wavelet denoising is then ... ...

    Abstract This paper presents a novel sound event detection (SED) system for rare events occurring in an open environment. Wavelet multiresolution analysis (MRA) is used to decompose the input audio clip of 30 seconds into five levels. Wavelet denoising is then applied on the third and fifth levels of MRA to filter out the background. Significant transitions, which may represent the onset of a rare event, are then estimated in these two levels by combining the peak-finding algorithm with the K-medoids clustering algorithm. The small portions of one-second duration, called 'chunks' are cropped from the input audio signal corresponding to the estimated locations of the significant transitions. Features from these chunks are extracted by the wavelet scattering network (WSN) and are given as input to a support vector machine (SVM) classifier, which classifies them. The proposed SED framework produces an error rate comparable to the SED systems based on convolutional neural network (CNN) architecture. Also, the proposed algorithm is computationally efficient and lightweight as compared to deep learning models, as it has no learnable parameter. It requires only a single epoch of training, which is 5, 10, 200, and 600 times lesser than the models based on CNNs and deep neural networks (DNNs), CNN with long short-term memory (LSTM) network, convolutional recurrent neural network (CRNN), and CNN respectively. The proposed model neither requires concatenation with previous frames for anomaly detection nor any additional training data creation needed for other comparative deep learning models. It needs to check almost 360 times fewer chunks for the presence of rare events than the other baseline systems used for comparison in this paper. All these characteristics make the proposed system suitable for real-time applications on resource-limited devices.
    MeSH term(s) Neural Networks, Computer ; Algorithms ; Wavelet Analysis ; Memory ; Support Vector Machine
    Language English
    Publishing date 2024-03-28
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0300444
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Solid Self-Nanoemulsifying Drug Delivery Systems of Furosemide: In Vivo Proof of Concept for Enhanced Predictable Therapeutic Response.

    Gul, Sania / Sridhar, Sathvik Belagodu / Jalil, Aamir / Akhlaq, Muhammad / Arshad, Muhammad Sohail / Sarwar, Hafiz Shoaib / Usman, Faisal / Shareef, Javedh / Thomas, Sabin

    Pharmaceuticals (Basel, Switzerland)

    2024  Volume 17, Issue 4

    Abstract: Liquid self-nano emulsifying drug delivery systems (SNEDDS) of furosemide (FSM) have been explored as a potential solution for enhancing solubility and permeability but are associated with rapid emulsification, spontaneous drug release, and poor in vivo ... ...

    Abstract Liquid self-nano emulsifying drug delivery systems (SNEDDS) of furosemide (FSM) have been explored as a potential solution for enhancing solubility and permeability but are associated with rapid emulsification, spontaneous drug release, and poor in vivo correlation. To overcome the shortcoming, this study aimed to develop liquid and solid self-emulsifying drug delivery systems for FSM, compare formulation dynamics, continue in vivo therapeutic efficacy, and investigate the advantages of solidification. For this purpose, liquid SNEDDS (L-SEDDS-FSM) were formed using oleic acid as an oil, chremophore EL, Tween 80, Tween 20 as a surfactant, and PEG 400 as a co-surfactant containing 53 mg/mL FSM. At the same time, solid SNEDDS (S-SEDDS-FSM) was developed by adsorbing liquid SNEDDS onto microcrystalline cellulose in a 1:1 ratio. Both formulations were evaluated for size, zeta potential, lipase degradation, and drug release. Moreover, in vivo diuretic studies regarding urine volume were carried out in mice to investigate the therapeutic responses of liquid and solid SNEDDS formulations. After dilution, L-SEDDS-FSM showed a mean droplet size of 115 ± 4.5 nm, while S-SEDDS-FSM depicted 116 ± 2.6 nm and zeta potentials of -5.4 ± 0.55 and -6.22 ± 1.2, respectively. S-SEDDS-FSM showed 1.8-fold reduced degradation by lipase enzymes in comparison to L-SEDDS-FSM. S-SEDDS-FSM demonstrated a sustained drug release pattern, releasing 63% of the drug over 180 min, in contrast to L-SEDDS-FSM, exhibiting 90% spontaneous drug release within 30 min. L-SEDDS-FSM exhibited a rapid upsurge in urine output (1550 ± 56 μL) compared to S-SEDDS-FSM, showing gradual urine output (969 ± 29 μL) till the 4th h of the study, providing sustained urine output yet a predictable therapeutic response. The solidification of SNEDDS effectively addresses challenges associated with spontaneous drug release and precipitation observed in liquid SNEDDS, highlighting the potential benefits of solid SNEDDS in improving the therapeutic response of furosemide.
    Language English
    Publishing date 2024-04-14
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2193542-7
    ISSN 1424-8247
    ISSN 1424-8247
    DOI 10.3390/ph17040500
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Book ; Online: Preserving the beamforming effect for spatial cue-based pseudo-binaural dereverberation of a single source

    Gul, Sania / Khan, Muhammad Salman / Shah, Syed Waqar

    2022  

    Abstract: Reverberations are unavoidable in enclosures, resulting in reduced intelligibility for hearing impaired and non native listeners and even for the normal hearing listeners in noisy circumstances. It also degrades the performance of machine listening ... ...

    Abstract Reverberations are unavoidable in enclosures, resulting in reduced intelligibility for hearing impaired and non native listeners and even for the normal hearing listeners in noisy circumstances. It also degrades the performance of machine listening applications. In this paper, we propose a novel approach of binaural dereverberation of a single speech source, using the differences in the interaural cues of the direct path signal and the reverberations. Two beamformers, spaced at an interaural distance, are used to extract the reverberations from the reverberant speech. The interaural cues generated by these reverberations and those generated by the direct path signal act as a two class dataset, used for the training of U-Net (a deep convolutional neural network). After its training, the beamformers are removed and the trained U-Net along with the maximum likelihood estimation (MLE) algorithm is used to discriminate between the direct path cues from the reverberation cues, when the system is exposed to the interaural spectrogram of the reverberant speech signal. Our proposed model has outperformed the classical signal processing dereverberation model weighted prediction error in terms of cepstral distance (CEP), frequency weighted segmental signal to noise ratio (FWSEGSNR) and signal to reverberation modulation energy ratio (SRMR) by 1.4 points, 8 dB and 0.6dB. It has achieved better performance than the deep learning based dereverberation model by gaining 1.3 points improvement in CEP with comparable FWSEGSNR, using training dataset which is almost 8 times smaller than required for that model. The proposed model also sustained its performance under relatively similar unseen acoustic conditions and at positions in the vicinity of its training position.

    Comment: 25 pages, 7 figures
    Keywords Electrical Engineering and Systems Science - Audio and Speech Processing ; Computer Science - Sound
    Subject code 621
    Publishing date 2022-08-10
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Book ; Online: Integration of deep learning with expectation maximization for spatial cue based speech separation in reverberant conditions

    Gul, Sania / Khan, Muhammad Salman / Shah, Syed Waqar

    2021  

    Abstract: In this paper, we formulate a blind source separation (BSS) framework, which allows integrating U-Net based deep learning source separation network with probabilistic spatial machine learning expectation maximization (EM) algorithm for separating speech ... ...

    Abstract In this paper, we formulate a blind source separation (BSS) framework, which allows integrating U-Net based deep learning source separation network with probabilistic spatial machine learning expectation maximization (EM) algorithm for separating speech in reverberant conditions. Our proposed model uses a pre-trained deep learning convolutional neural network, U-Net, for clustering the interaural level difference (ILD) cues and machine learning expectation maximization (EM) algorithm for clustering the interaural phase difference (IPD) cues. The integrated model exploits the complementary strengths of the two approaches to BSS: the strong modeling power of supervised neural networks and the ease of unsupervised machine learning algorithms, whose few parameters can be estimated on as little as a single segment of an audio mixture. The results show an average improvement of 4.3 dB in signal to distortion ratio (SDR) and 4.3% in short time speech intelligibility (STOI) over the EM based source separation algorithm MESSL-GS (model-based expectation-maximization source separation and localization with garbage source) and 4.5 dB in SDR and 8% in STOI over deep learning convolutional neural network (U-Net) based speech separation algorithm SONET under the reverberant conditions ranging from anechoic to those mostly encountered in the real world.
    Keywords Electrical Engineering and Systems Science - Audio and Speech Processing
    Subject code 006
    Publishing date 2021-02-26
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Book ; Online: Recycling an anechoic pre-trained speech separation deep neural network for binaural dereverberation of a single source

    Gul, Sania / Khan, Muhammad Salman / Shah, Syed Waqar / Ur-Rehman, Ata

    2022  

    Abstract: Reverberation results in reduced intelligibility for both normal and hearing-impaired listeners. This paper presents a novel psychoacoustic approach of dereverberation of a single speech source by recycling a pre-trained binaural anechoic speech ... ...

    Abstract Reverberation results in reduced intelligibility for both normal and hearing-impaired listeners. This paper presents a novel psychoacoustic approach of dereverberation of a single speech source by recycling a pre-trained binaural anechoic speech separation neural network. As training the deep neural network (DNN) is a lengthy and computationally expensive process, the advantage of using a pre-trained separation network for dereverberation is that the network does not need to be retrained, saving both time and computational resources. The interaural cues of a reverberant source are given to this pretrained neural network to discriminate between the direct path signal and the reverberant speech. The results show an average improvement of 1.3% in signal intelligibility, 0.83 dB in SRMR (signal to reverberation energy ratio) and 0.16 points in perceptual evaluation of speech quality (PESQ) over other state-of-the-art signal processing dereverberation algorithms and 14% in intelligibility and 0.35 points in quality over orthogonal matching pursuit with spectral subtraction (OSS), a machine learning based dereverberation algorithm.

    Comment: 15 pages, 4 figures
    Keywords Electrical Engineering and Systems Science - Audio and Speech Processing ; Computer Science - Sound
    Subject code 006
    Publishing date 2022-08-09
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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