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  1. Article ; Online: Human Coronary Plaque T Cells Are Clonal and Cross-React to Virus and Self.

    Chowdhury, Roshni Roy / D'Addabbo, Jessica / Huang, Xianxi / Veizades, Stefan / Sasagawa, Koki / Louis, David M / Cheng, Paul / Sokol, Jan / Jensen, Annie / Tso, Alexandria / Shankar, Vishnu / Wendel, Ben Shogo / Bakerman, Isaac / Liang, Grace / Koyano, Tiffany / Fong, Robyn / Nau, Allison N / Ahmad, Herra / Gopakumar, Jayakrishnan /
    Wirka, Robert / Lee, Andrew S / Boyd, Jack / Woo, Y Joseph / Quertermous, Thomas / Gulati, Gunsagar Singh / Jaiswal, Siddhartha / Chien, Yueh-Hsiu / Chan, Charles Kwok Fai / Davis, Mark M / Nguyen, Patricia K

    Circulation research

    2022  Volume 130, Issue 10, Page(s) 1510–1530

    Abstract: Background: Coronary artery disease is an incurable, life-threatening disease that was once considered primarily a disorder of lipid deposition. Coronary artery disease is now also characterized by chronic inflammation' notable for the buildup of ... ...

    Abstract Background: Coronary artery disease is an incurable, life-threatening disease that was once considered primarily a disorder of lipid deposition. Coronary artery disease is now also characterized by chronic inflammation' notable for the buildup of atherosclerotic plaques containing immune cells in various states of activation and differentiation. Understanding how these immune cells contribute to disease progression may lead to the development of novel therapeutic strategies.
    Methods: We used single-cell technology and in vitro assays to interrogate the immune microenvironment of human coronary atherosclerotic plaque at different stages of maturity.
    Results: In addition to macrophages, we found a high proportion of αβ T cells in the coronary plaques. Most of these T cells lack high expression of
    Conclusions: Taken together, these findings demonstrate that plaque T cells are clonally expanded potentially by antigen engagement, are potentially reactive to self-epitopes, and may interact with smooth muscle cells and macrophages in the plaque microenvironment.
    MeSH term(s) Antigens ; Clone Cells/immunology ; Coronary Artery Disease/immunology ; Endothelial Cells ; Epitopes ; HLA-DR alpha-Chains ; Humans ; Lymphocyte Activation ; Plaque, Atherosclerotic/immunology ; T-Lymphocytes/immunology
    Chemical Substances Antigens ; Epitopes ; HLA-DR alpha-Chains
    Language English
    Publishing date 2022-04-18
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 80100-8
    ISSN 1524-4571 ; 0009-7330 ; 0931-6876
    ISSN (online) 1524-4571
    ISSN 0009-7330 ; 0931-6876
    DOI 10.1161/CIRCRESAHA.121.320090
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Heme oxygenase-1 deficiency triggers exhaustion of hematopoietic stem cells.

    Szade, Krzysztof / Zukowska, Monika / Szade, Agata / Nowak, Witold / Skulimowska, Izabella / Ciesla, Maciej / Bukowska-Strakova, Karolina / Gulati, Gunsagar Singh / Kachamakova-Trojanowska, Neli / Kusienicka, Anna / Einwallner, Elisa / Kijowski, Jacek / Czauderna, Szymon / Esterbauer, Harald / Benes, Vladimir / L Weissman, Irving / Dulak, Jozef / Jozkowicz, Alicja

    EMBO reports

    2019  Volume 21, Issue 2, Page(s) e47895

    Abstract: While intrinsic changes in aging hematopoietic stem cells (HSCs) are well characterized, it remains unclear how extrinsic factors affect HSC aging. Here, we demonstrate that cells in the niche-endothelial cells (ECs) and CXCL12-abundant reticular cells ( ... ...

    Abstract While intrinsic changes in aging hematopoietic stem cells (HSCs) are well characterized, it remains unclear how extrinsic factors affect HSC aging. Here, we demonstrate that cells in the niche-endothelial cells (ECs) and CXCL12-abundant reticular cells (CARs)-highly express the heme-degrading enzyme, heme oxygenase 1 (HO-1), but then decrease its expression with age. HO-1-deficient animals (HO-1
    MeSH term(s) Animals ; Cell Differentiation ; Endothelial Cells ; Hematopoietic Stem Cells ; Heme Oxygenase-1/genetics ; Mesenchymal Stem Cells
    Chemical Substances Heme Oxygenase-1 (EC 1.14.14.18)
    Language English
    Publishing date 2019-12-29
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2020896-0
    ISSN 1469-3178 ; 1469-221X
    ISSN (online) 1469-3178
    ISSN 1469-221X
    DOI 10.15252/embr.201947895
    Database MEDical Literature Analysis and Retrieval System OnLINE

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