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  1. Article ; Online: Insight into CMC-PVA-fHNTs Nanocomposite Hydrogel as an Advance Carrier for Cefadroxil Monohydrate: Fabrication and Characterization/Angiogenic Potential Analysis.

    Zia, Saba / Khan, Shahzad Maqsood / Butt, Muhammad Taqi Zahid / Gull, Nafisa

    Gels (Basel, Switzerland)

    2024  Volume 10, Issue 4

    Abstract: Controlled drug delivery is a key strategy aimed at reducing both the frequency of therapeutic dosages and potential systemic side effects, particularly in the case of high drug concentrations. The nanocomposite hydrogel systems presented in this study ... ...

    Abstract Controlled drug delivery is a key strategy aimed at reducing both the frequency of therapeutic dosages and potential systemic side effects, particularly in the case of high drug concentrations. The nanocomposite hydrogel systems presented in this study were synthesized by combining carboxymethyl cellulose, polyvinyl alcohol, and (3-aminopropyl)triethoxysilane-functionalized halloysite nanotubes (fHNTs). This hydrogel system is a potential candidate for the controlled release of cefadroxil monohydrate. These hydrogels are analyzed by Fourier transform infrared spectroscopy, scanning electron microscopy, thermogravimetric analysis, and rheological measurements. Additionally, swelling properties, porosity, hydrophilicity, drug release, and in vitro and in vivo analyses were also evaluated. The observed trends in swelling and drug release demonstrated that the outcomes are dependent on the presence of fHNTs in the hydrogel matrix. Notably, fHNTs-loaded hydrogels displayed sustained drug release patterns. This innovative approach eliminates the need for traditional encapsulation and presents promising and translatable strategies for achieving more effective drug release.
    Language English
    Publishing date 2024-03-29
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2813982-3
    ISSN 2310-2861 ; 2310-2861
    ISSN (online) 2310-2861
    ISSN 2310-2861
    DOI 10.3390/gels10040235
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  2. Article ; Online: Synergistic effect of GO/ZnO loading on the performance of cellulose acetate/chitosan blended reverse osmosis membranes for NOM rejection

    Shami, Rizwana / Sabir, Aneela / Iqbal, Sadia Sagar / Gull, Nafisa / Zohra, Rubab / Khan, Shahzad Maqsood

    Heliyon. 2023 Mar., v. 9, no. 3 p.e13736-

    2023  

    Abstract: Declining freshwater resources along with their pollution are threatening the life existence on earth. To meet the freshwater demand, one of the most appropriate and possible ways which has been adopted all over the world is to reuse wastewater by ... ...

    Abstract Declining freshwater resources along with their pollution are threatening the life existence on earth. To meet the freshwater demand, one of the most appropriate and possible ways which has been adopted all over the world is to reuse wastewater by removing its impurities. Among many water pollutants, natural organic matter (NOM) is found to be responsible as major precursor for the formation of other pollutants. Removal of NOM from wastewater is being done by using membrane filtration systems incorporated with certain nanofillers to increase membranes efficiency and permeability. In this study, novel nanocomposite reverse osmosis (RO) membranes were prepared using cellulose acetate and chitosan in N,N-Dimethyl formamide. Graphene oxide (GO) nanosheets and zinc oxide (ZnO) in different concentration were loaded to modify the membranes for tuning their RO performance. The confirmation of the functional groups is demonstrated by Fourier transform infrared spectroscopy which revealed the specific peaks indicating the formation of the nano-composite membranes. The surface morphology was studied by scanning electronic microscopy which shows a gradual transformation of the membrane surface from voids-free to macro-voids filled surface up to threshold concentration of GO and ZnO. The thermal properties of GO based membranes were analyzed using thermogravimetric analysis and differential scanning calorimetry. The uniform interaction of the GO and ZnO with polymers induced the remarkable thermal properties of the synthesized membranes. Permeate flux and contact angle measurements were considered to estimate their water content (96%) capacity and NOM rejection (96%) using 0.1 ppm humic acid solution. The permeate flux, NOM rejection and the water content changed directly with GO and inversely with ZnO wt% in the membranes up to GO5 (GO:0.14: ZnO:0.03) whereas the contact angle exhibited the inverse relationship with GO and ZnO concentration in casting solution of the synthesized membranes. Hence it can be concluded that prepared RO membranes are suitable for NOM rejection and recommended for water treatment.
    Keywords Fourier transform infrared spectroscopy ; calorimetry ; cellulose acetate ; chitosan ; contact angle ; electron microscopy ; freshwater ; graphene oxide ; humic acids ; microfiltration ; nanocomposites ; nanosheets ; permeability ; pollution ; reverse osmosis ; synergism ; thermogravimetry ; wastewater ; water content ; water treatment ; zinc oxide ; RO membranes
    Language English
    Dates of publication 2023-03
    Publishing place Elsevier Ltd
    Document type Article ; Online
    Note Use and reproduction
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2023.e13736
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  3. Article: Synergistic effect of GO/ZnO loading on the performance of cellulose acetate/chitosan blended reverse osmosis membranes for NOM rejection.

    Shami, Rizwana / Sabir, Aneela / Iqbal, Sadia Sagar / Gull, Nafisa / Zohra, Rubab / Khan, Shahzad Maqsood

    Heliyon

    2023  Volume 9, Issue 3, Page(s) e13736

    Abstract: Declining freshwater resources along with their pollution are threatening the life existence on earth. To meet the freshwater demand, one of the most appropriate and possible ways which has been adopted all over the world is to reuse wastewater by ... ...

    Abstract Declining freshwater resources along with their pollution are threatening the life existence on earth. To meet the freshwater demand, one of the most appropriate and possible ways which has been adopted all over the world is to reuse wastewater by removing its impurities. Among many water pollutants, natural organic matter (NOM) is found to be responsible as major precursor for the formation of other pollutants. Removal of NOM from wastewater is being done by using membrane filtration systems incorporated with certain nanofillers to increase membranes efficiency and permeability. In this study, novel nanocomposite reverse osmosis (RO) membranes were prepared using cellulose acetate and chitosan in
    Language English
    Publishing date 2023-02-15
    Publishing country England
    Document type Journal Article
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2023.e13736
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  4. Article ; Online: Development and evaluation of pH-sensitive biodegradable ternary blended hydrogel films (chitosan/guar gum/PVP) for drug delivery application.

    Ghauri, Zunaira Huma / Islam, Atif / Qadir, Muhammad Abdul / Gull, Nafisa / Haider, Bilal / Khan, Rafi Ullah / Riaz, Tabinda

    Scientific reports

    2021  Volume 11, Issue 1, Page(s) 21255

    Abstract: pH responsive hydrogels have gained much attraction in biomedical fields. We have formulated ternary hydrogel films as a new carrier of drug. Polyelectrolyte complex of chitosan/guar gum/polyvinyl pyrrolidone cross-linked via sodium tripolyphosphate was ... ...

    Abstract pH responsive hydrogels have gained much attraction in biomedical fields. We have formulated ternary hydrogel films as a new carrier of drug. Polyelectrolyte complex of chitosan/guar gum/polyvinyl pyrrolidone cross-linked via sodium tripolyphosphate was developed by solution casting method. Fourier transform infrared spectroscopy, scanning electron microscopy and thermogravimetric analysis were conducted to examine the interactions between the polymeric chains, surface morphology and thermal stability, respectively. The swelling tests resulted that the swelling was reduced with the increase in the concentration of crosslinker due to the more entangled arrangement and less availability of pores in hydrogels. Ciprofloxacin hydrochloride was used as a model drug and its release in simulated gastric fluid, simulated intestinal fluid and phosphate buffer saline solution was studied. pH responsive behaviour of the hydrogels have subjected these hydrogels for drug release applications.
    MeSH term(s) Biocompatible Materials/chemistry ; Chemical Phenomena ; Chitosan/chemistry ; Drug Carriers/chemistry ; Drug Delivery Systems ; Drug Liberation ; Galactans/chemistry ; Hydrogen-Ion Concentration ; Mannans/chemistry ; Methylgalactosides/chemistry ; Molecular Structure ; Plant Gums/chemistry ; Povidone/chemistry ; Spectrum Analysis ; Thermogravimetry
    Chemical Substances Biocompatible Materials ; Drug Carriers ; Galactans ; Mannans ; Methylgalactosides ; Plant Gums ; hydrogel film ; Chitosan (9012-76-4) ; guar gum (E89I1637KE) ; Povidone (FZ989GH94E)
    Language English
    Publishing date 2021-10-28
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-021-00452-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Novel Maleic Acid, Crosslinked, Nanofibrous Chitosan/Poly (Vinylpyrrolidone) Membranes for Reverse Osmosis Desalination.

    Ali, Israr / Raza, Muhammad Asim / Mehmood, Rashid / Islam, Atif / Sabir, Aneela / Gull, Nafisa / Haider, Bilal / Park, Sang Hyun / Khan, Rafi Ullah

    International journal of molecular sciences

    2020  Volume 21, Issue 19

    Abstract: Fresh and clean water is consistently depleting and becoming a serious problem with rapid increases in population, so seawater desalination technology has captured global attention. For an efficient desalination process, this work proposes a novel, ... ...

    Abstract Fresh and clean water is consistently depleting and becoming a serious problem with rapid increases in population, so seawater desalination technology has captured global attention. For an efficient desalination process, this work proposes a novel, nanofibrous, thin-film composite membrane (NF-TFC) based on the deposition of the nanofibrous active layer of a blend of chitosan (CS) and poly (vinylpyrrolidone) (PVP) crosslinked with maleic acid on a 3-triethoxysilylpropylamine functionalized cellulose acetate substrate. FTIR analysis demonstrated the development of chemical and physical interactions and confirmed the incorporation of functional groups present in the NF-TFC. Scanning electron microscopy (SEM) micrographs depict the fibrous structure of the active layers. The reverse osmosis (RO) desalination characteristics of NF-TFC membranes are elevated by increasing the concentration of the crosslinker in a CS/PVP blend. Cellulose acetate (CA)-S4 attained an optimal salt rejection of 98.3% and permeation flux of 42.9 L/m
    MeSH term(s) Chitosan/chemistry ; Filtration ; Humans ; Maleates/chemistry ; Nanofibers/chemistry ; Osmosis ; Seawater/chemistry ; Water/chemistry ; Water Purification
    Chemical Substances Maleates ; Water (059QF0KO0R) ; Chitosan (9012-76-4) ; maleic acid (91XW058U2C)
    Language English
    Publishing date 2020-10-04
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms21197338
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  6. Article: Designing of biocompatible and biodegradable chitosan based crosslinked hydrogel for in vitro release of encapsulated povidone-iodine: A clinical translation

    Gull, Nafisa / Khan, Shahzad Maqsood / Khalid, Syed / Zia, Saba / Islam, Atif / Sabir, Aneela / Sultan, Misbah / Hussain, Farieha / Khan, Rafi Ullah / Butt, Muhammad Taqi Zahid

    International journal of biological macromolecules. 2020 Dec. 01, v. 164

    2020  

    Abstract: Controlled drug delivery is a prime stratagem for minimizing both the frequency of therapeutic administration as well as systematic side effects with high drug content. One of the extensively studied approaches for controlling medicament delivery is the ... ...

    Abstract Controlled drug delivery is a prime stratagem for minimizing both the frequency of therapeutic administration as well as systematic side effects with high drug content. One of the extensively studied approaches for controlling medicament delivery is the encapsulation of drug within polymer chains which sluggish the release on the basis of its crosslinked network. Recent advances in biomedical field have led to the fabrication of chitosan (CS) based biocompatible and biodegradable hydrogels for controlled delivery of encapsulated drug. In this study, CS-PVP based hydrogels are fabricated by varying the concentration of 3-glycidyloxypropyl trimethoxysilane (GPTMS) via solution casting technique. Swelling indices of prepared hydrogel samples were determined in different media including distilled water, different pH and electrolyte solutions. FTIR, TGA and WAXRD are conducted to evaluate the structural, thermal and crystalline properties of prepared hydrogels, respectively. Porosity (71%), hydrophilicity (55°) and mechanical properties (97.56 MPa of UTS and 85.23% E%) were investigated for the fabricated samples. Extensively in vitro biodegradation, antimicrobial performance and cytotoxicity were evaluated for these hydrogels. The drug release analysis was carried out to examine the release response of encapsulated iodopovidone at physiological conditions. These results tender a strategy for the design of structural hydrogel with different crosslinking mechanism like physical and covalent interactions. These insights obviate the demand for encapsulation and offer promising and translatable strategies for more effective release of drugs.
    Keywords biodegradability ; biodegradation ; chitosan ; crosslinking ; cytotoxicity ; drug delivery systems ; drugs ; electrolytes ; encapsulation ; hydrogels ; hydrophilicity ; pH ; polymers ; porosity
    Language English
    Dates of publication 2020-1201
    Size p. 4370-4380.
    Publishing place Elsevier B.V.
    Document type Article
    Note NAL-AP-2-clean
    ZDB-ID 282732-3
    ISSN 1879-0003 ; 0141-8130
    ISSN (online) 1879-0003
    ISSN 0141-8130
    DOI 10.1016/j.ijbiomac.2020.09.031
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  7. Article: Synthesis and characterization of chitosan and guar gum based ternary blends with polyvinyl alcohol

    Iqbal, Dure Najaf / Tariq, Mehwish / Khan, Shahzad Maqsood / Gull, Nafisa / Sagar Iqbal, Sadia / Aziz, Abida / Nazir, Arif / Iqbal, Munawar

    International journal of biological macromolecules. 2020 Jan. 15, v. 143

    2020  

    Abstract: Biopolymers have paramount importance in pharmaceutical applications and blended biopolymers have shown promising properties versus individual counterparts. In view of excellent performance of blended biopolymers, a novel series of blended membranes ... ...

    Abstract Biopolymers have paramount importance in pharmaceutical applications and blended biopolymers have shown promising properties versus individual counterparts. In view of excellent performance of blended biopolymers, a novel series of blended membranes based on chitosan, guar gum and polyvinyl alcohol (CS/GG/PVA) were prepared by solution casting technique. The membranes were synthesized at different ratios of GG and CS, while keeping PVA constant. The surface morphology, structure, interaction of polymers and water absorbing capacity were determined with scanning electron microscope (SEM), Fourier-transform infrared spectroscopy (FTIR), X-ray diffraction (XRD) and swelling properties. FTIR exhibited intermolecular bonding between the biopolymers used for membranes preparation. SEM analysis revealed that the surface morphology depends upon the various ratios of polymers. The swelling pattern has shown that the prepared membranes were hydrophilic in nature. Results revealed that the chitosan and guar gum based ternary blends with polyvinyl alcohol have potential for controlled drug release.
    Keywords Fourier transform infrared spectroscopy ; X-ray diffraction ; biopolymers ; chitosan ; drug delivery systems ; guar gum ; hydrophilicity ; polyvinyl alcohol ; scanning electron microscopes ; scanning electron microscopy
    Language English
    Dates of publication 2020-0115
    Size p. 546-554.
    Publishing place Elsevier B.V.
    Document type Article
    ZDB-ID 282732-3
    ISSN 1879-0003 ; 0141-8130
    ISSN (online) 1879-0003
    ISSN 0141-8130
    DOI 10.1016/j.ijbiomac.2019.12.043
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  8. Article ; Online: Polymer-based biomaterials for chronic wound management: Promises and challenges.

    Maaz Arif, Muhammad / Khan, Shahzad Maqsood / Gull, Nafisa / Tabish, Tanveer A / Zia, Saba / Ullah Khan, Rafi / Awais, Sayed Muhammad / Arif Butt, Muhammad

    International journal of pharmaceutics

    2021  Volume 598, Page(s) 120270

    Abstract: Chronic non-healing wounds tender a great challenge to patients, physicians, and wound care professionals. In view of the increasing prevalence of chronic wounds due to ischemia, diabetic foot, venous, and pressure ulcers, their appropriate management ... ...

    Abstract Chronic non-healing wounds tender a great challenge to patients, physicians, and wound care professionals. In view of the increasing prevalence of chronic wounds due to ischemia, diabetic foot, venous, and pressure ulcers, their appropriate management requires significant attention. Along with the basic techniques of medical and surgical treatments; an ideal dressing is essential for a speedy recovery and rapid healing of such wounds. Mechanistic understanding of chronic wound pathology will not only help towards future directions for an ideal dressing model but also to resonant advance research related to specific dressings for various wound types. This review provides key insights into causes, pathophysiology, and critical issues pertaining to chronic wounds and their management. It also summarizes the challenges faced for chronic wound treatment and specified factors responsible for delayed healing. Moreover, this review delivers a detailed discussion on available polymeric materials (alginate, chitosan, hyaluronic acid, collagen, polyurethane, cellulose, dextran, gelatin, silk, and polyaniline), their functional characteristics, and usage as chronic wound healing agents for polymeric wound dressing development. Incorporation and comparison of the research studies for their thermal behavior, structural analysis, and microscopic studies by Fourier transform infrared spectroscopy, thermogravimetric analysis and scanning electron microscopy, respectively and swelling studies of different polymeric materials are discussed. Additionally, studies of anatomy cum physiology of wound healing, pathophysiology, tissue engineering and advance healing management approaches makes the content of this review a significant tool for future studies on chronic wounds healing by polymeric wound dressings. In this review, polymeric wound dressings have been explained in terms of their structures, function, chemistry, and key characteristics. These features are directly linked to the polymeric systems' potential in the management of chronic wounds. These polymeric systems have gained promising success in solving real word global health problems. More recently, innovative approaches to fabricate the polymer dressings have been introduced, but their commercial, sustainable, and high-scale production largely remains unexplored. This review also summarizes the promises of polymeric wound dressings and provides a future perspective on how the clinical and commercial landscape could potentially be propelled by utilizing polymers in wound care management.
    MeSH term(s) Bandages ; Biocompatible Materials ; Diabetic Foot/drug therapy ; Humans ; Polymers ; Wound Healing
    Chemical Substances Biocompatible Materials ; Polymers
    Language English
    Publishing date 2021-01-21
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 428962-6
    ISSN 1873-3476 ; 0378-5173
    ISSN (online) 1873-3476
    ISSN 0378-5173
    DOI 10.1016/j.ijpharm.2021.120270
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  9. Article ; Online: Development and characterization of chitosan and acrylic acid-based novel biodegradable polymeric films for soil conditioning.

    Sumayya / Gull, Nafisa / Islam, Atif / Ghaffar, Abdul / Jabeen, Sehrish / Iqbal, Sadia Sagar / Khan, Shahzad Maqsood / Khan, Rafi Ullah / Hussain, Nazim / Bilal, Muhammad

    International journal of biological macromolecules

    2021  Volume 182, Page(s) 950–958

    Abstract: In this study, biodegradable polymeric films (BPFs) based on chitosan and acrylic acid cross-linked with 3-aminopropyl triethoxysilane (APTES) were developed for water retention and soil-conditioning applications in areas sufferings from water scarcity. ... ...

    Abstract In this study, biodegradable polymeric films (BPFs) based on chitosan and acrylic acid cross-linked with 3-aminopropyl triethoxysilane (APTES) were developed for water retention and soil-conditioning applications in areas sufferings from water scarcity. A series of BPFs were prepared by varying the amount of silica nanoparticles (SiNPs) (0.67% to 2.6%) and a correlation of the optimum amount of SiNPs with thermal stability, morphology, swellability (at various pH), degradability, and anti-microbial activity were deduced. The obtained results showed that the NP 8 (containing 2.51% of SiNPs) exhibited the maximum absorption capacity (1815%) in distilled water, whereas NP6 (including 1.88% of SiNPs) expressed the maximum thermal stability (T
    MeSH term(s) Acrylates/chemistry ; Biodegradable Plastics/chemical synthesis ; Biodegradable Plastics/pharmacology ; Chitosan/analogs & derivatives ; Nanoparticles/chemistry ; Silicon Dioxide/chemistry ; Soil/chemistry ; Staphylococcus aureus/drug effects ; Wettability
    Chemical Substances Acrylates ; Biodegradable Plastics ; Soil ; Silicon Dioxide (7631-86-9) ; Chitosan (9012-76-4) ; acrylic acid (J94PBK7X8S)
    Language English
    Publishing date 2021-04-18
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 282732-3
    ISSN 1879-0003 ; 0141-8130
    ISSN (online) 1879-0003
    ISSN 0141-8130
    DOI 10.1016/j.ijbiomac.2021.04.098
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  10. Article ; Online: Synthesis and characterization of chitosan and guar gum based ternary blends with polyvinyl alcohol.

    Iqbal, Dure Najaf / Tariq, Mehwish / Khan, Shahzad Maqsood / Gull, Nafisa / Sagar Iqbal, Sadia / Aziz, Abida / Nazir, Arif / Iqbal, Munawar

    International journal of biological macromolecules

    2019  Volume 143, Page(s) 546–554

    Abstract: Biopolymers have paramount importance in pharmaceutical applications and blended biopolymers have shown promising properties versus individual counterparts. In view of excellent performance of blended biopolymers, a novel series of blended membranes ... ...

    Abstract Biopolymers have paramount importance in pharmaceutical applications and blended biopolymers have shown promising properties versus individual counterparts. In view of excellent performance of blended biopolymers, a novel series of blended membranes based on chitosan, guar gum and polyvinyl alcohol (CS/GG/PVA) were prepared by solution casting technique. The membranes were synthesized at different ratios of GG and CS, while keeping PVA constant. The surface morphology, structure, interaction of polymers and water absorbing capacity were determined with scanning electron microscope (SEM), Fourier-transform infrared spectroscopy (FTIR), X-ray diffraction (XRD) and swelling properties. FTIR exhibited intermolecular bonding between the biopolymers used for membranes preparation. SEM analysis revealed that the surface morphology depends upon the various ratios of polymers. The swelling pattern has shown that the prepared membranes were hydrophilic in nature. Results revealed that the chitosan and guar gum based ternary blends with polyvinyl alcohol have potential for controlled drug release.
    MeSH term(s) Calorimetry, Differential Scanning ; Chitosan/chemistry ; Delayed-Action Preparations/chemical synthesis ; Delayed-Action Preparations/chemistry ; Galactans/chemistry ; Mannans/chemistry ; Plant Gums/chemistry ; Polyvinyl Alcohol/chemistry ; Spectroscopy, Fourier Transform Infrared
    Chemical Substances Delayed-Action Preparations ; Galactans ; Mannans ; Plant Gums ; Polyvinyl Alcohol (9002-89-5) ; Chitosan (9012-76-4) ; guar gum (E89I1637KE)
    Language English
    Publishing date 2019-12-06
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 282732-3
    ISSN 1879-0003 ; 0141-8130
    ISSN (online) 1879-0003
    ISSN 0141-8130
    DOI 10.1016/j.ijbiomac.2019.12.043
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