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  1. Article ; Online: COVID-19 infection presented as severe dyskinesia in a patient with Parkinson's disease: a case with daily video recording.

    Gultekin, Murat / Tufekcioglu, Zeynep

    Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology

    2022  Volume 43, Issue 5, Page(s) 2961–2963

    MeSH term(s) Antiparkinson Agents ; COVID-19/complications ; Dyskinesias/diagnosis ; Dyskinesias/etiology ; Humans ; Levodopa ; Parkinson Disease/complications ; Parkinson Disease/drug therapy ; Video Recording
    Chemical Substances Antiparkinson Agents ; Levodopa (46627O600J)
    Language English
    Publishing date 2022-02-08
    Publishing country Italy
    Document type Letter
    ZDB-ID 2016546-8
    ISSN 1590-3478 ; 1590-1874
    ISSN (online) 1590-3478
    ISSN 1590-1874
    DOI 10.1007/s10072-022-05912-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Phenotypic Variants of Patients with Progressive Supranuclear Palsy.

    Gültekın, Murat

    Noro psikiyatri arsivi

    2017  Volume 57, Issue 1, Page(s) 61–64

    Abstract: Introduction: Progressive supranuclear palsy (PSP) is a commonly observed disease among Parkinson plus syndromes, and its early and accurate diagnosis is usually not possible. PSP is currently reported to have eight different subtypes. This study aims ... ...

    Abstract Introduction: Progressive supranuclear palsy (PSP) is a commonly observed disease among Parkinson plus syndromes, and its early and accurate diagnosis is usually not possible. PSP is currently reported to have eight different subtypes. This study aims to determine the phenotypic subtypes of PSP and reveal their accompanying characteristics.
    Methods: Eighteen patients who were diagnosed as having PSP according to the National Institute for Neurological Disorders and Society for PSP (NINDS-SPSP) criteria were included in the study. Initial symptoms of the patients, their initial diagnosis, course of the disease with time, cranial images, and predominant clinical features were assessed with regard to the subtypes of PSP.
    Results: The mean age of the patients was 65.83 years. According to the NINDS-SPSP criteria, all patients were diagnosed as having probable PSP. An evaluation of the patients with respect to the subtypes showed that five different subtypes had predominant characteristics. Richardson's syndrome was found to be the most common subtype.
    Conclusion: Classifying PSP with regard to its phenotypes may be useful for informing clinicians about the diverse clinical presentations of PSP, thereby possibly improving the diagnostic sensitivity of the disease.
    Language English
    Publishing date 2017-11-08
    Publishing country Turkey
    Document type Journal Article
    ZDB-ID 2565770-7
    ISSN 1300-0667
    ISSN 1300-0667
    DOI 10.5152/npa.2017.22771
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Foreign Accent Syndrome After COVID 19 Infection: A Case Report.

    Olguner Eker, Ozlem / Gultekin, Murat / Demirel Ozsoy, Saliha

    The Journal of nervous and mental disease

    2023  Volume 211, Issue 12, Page(s) 974–976

    Abstract: Abstract: Foreign accent syndrome (FAS) is an extremely rare disorder characterized by the appearance of speech changes that are perceived by the speaker and listeners as an acquired foreign accent. It still remains a poorly understood condition. Three ... ...

    Abstract Abstract: Foreign accent syndrome (FAS) is an extremely rare disorder characterized by the appearance of speech changes that are perceived by the speaker and listeners as an acquired foreign accent. It still remains a poorly understood condition. Three main types of FAS have been reported in the medical literature as neurogenic, psychogenic, and mixed type. Psychogenic FAS includes all cases of FAS in which an organic cause has not been identified and a clear psychological factor has been identified after careful clinical, neurological, and neuroradiological examination. Although the COVID-19 epidemic, which has been ongoing since February 2020, primarily manifests itself with upper respiratory tract infection findings, it is seen that it also causes a wide range of neurological and psychiatric signs and symptoms. In this study, a 42-year-old female patient who started to have speech disorder after COVID-19 infection is presented in the light of clinical history, diagnosis, and differential diagnosis literature findings.
    MeSH term(s) Female ; Humans ; Adult ; COVID-19/complications ; Diagnosis, Differential ; Speech
    Language English
    Publishing date 2023-10-17
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 3020-x
    ISSN 1539-736X ; 0022-3018
    ISSN (online) 1539-736X
    ISSN 0022-3018
    DOI 10.1097/NMD.0000000000001617
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Results of four million primary HPV-screenings in Turkey

    Gultekin, Murat

    Wiener medizinische Wochenschrift : Skriptum : Kongressjournal

    2019  Volume 16, Issue 4, Page(s) 12

    Language German
    Document type Article
    ZDB-ID 2142526-7
    ISSN 1613-3803 ; 0043-5341
    Database Current Contents Medicine

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  5. Article: Cervical proprioception in Parkinson's disease and its correlation with manual dexterity function.

    Menevşe, Özlem / Kepenek-Varol, Büşra / Gültekin, Murat / Bilgin, Sevil

    Journal of movement disorders

    2023  Volume 16, Issue 3, Page(s) 295–306

    Abstract: Objective: Cervical proprioception plays a crucial role in posture and movement control. This study aimed to determine the relationships of cervical proprioception, cervical muscle strength and endurance with manual dexterity and hand strength in ... ...

    Abstract Objective: Cervical proprioception plays a crucial role in posture and movement control. This study aimed to determine the relationships of cervical proprioception, cervical muscle strength and endurance with manual dexterity and hand strength in individuals with idiopathic Parkinson's disease (PD).
    Methods: Twenty individuals with PD (mean age: 63.9 years) and 20 healthy individuals as a control group (mean age: 61.9 years) were recruited. Cervical joint position error (JPE), static endurance of neck muscles, activation of deep cervical flexor muscles (Craniocervical Flexion Test, CCFT), manual dexterity (Purdue Pegboard Test, PPT), cognitive and motor tasks of the PPT, finger tapping test (FTT), pinch strength, and grip strength were assessed.
    Results: Cervical JPE was significantly higher in individuals with PD than in controls (p < 0.05). The strength and endurance of the cervical muscles were significantly decreased in individuals with PD (p < 0.05). Cervical JPE measurements were negatively correlated with PPT, cognitive and motor tasks of the PPT in individuals with PD (all p < 0.05). The endurance of cervical flexor muscles was negatively correlated with PPT and cognitive PPT scores in the PD group (p < 0.05). In addition, a significant positive correlation was found between cervical flexor endurance and hand strength in the PD group (p < 0.05).
    Conclusion: Cervical proprioception and the strength and endurance of cervical muscles decrease in individuals with PD compared to healthy individuals. Impairment of cervical proprioception appears to be associated with poorer upper extremity performance. Detailed evaluation of the cervical region in PD may help determine the factors affecting upper extremity function.
    Language English
    Publishing date 2023-07-03
    Publishing country Korea (South)
    Document type Journal Article
    ZDB-ID 3021788-X
    ISSN 2093-4939 ; 2005-940X
    ISSN (online) 2093-4939
    ISSN 2005-940X
    DOI 10.14802/jmd.23039
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Building research competency across low and middle resource settings: an ENGOT initiative and NOGGO mentorship program at the ESGO 2022 in Berlin.

    Nasser, Sara / Bilir, Esra / David, Atallah / Gultekin, Murat / Sehouli, Jalid

    International journal of gynecological cancer : official journal of the International Gynecological Cancer Society

    2023  

    Language English
    Publishing date 2023-11-28
    Publishing country England
    Document type Journal Article
    ZDB-ID 1070385-8
    ISSN 1525-1438 ; 1048-891X
    ISSN (online) 1525-1438
    ISSN 1048-891X
    DOI 10.1136/ijgc-2023-005019
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Review of the literature on combined oral contraceptives and cancer.

    Kamani, Mustafa / Akgor, Utku / Gültekin, Murat

    Ecancermedicalscience

    2022  Volume 16, Page(s) 1416

    Abstract: Millions of women have given preference to the use of combined oral contraceptives (COCs) since its introduction in the 1960s. Both oestrogens and progestogens can regulate proliferation and it is plausible these effects may contribute to carcinogenesis. ...

    Abstract Millions of women have given preference to the use of combined oral contraceptives (COCs) since its introduction in the 1960s. Both oestrogens and progestogens can regulate proliferation and it is plausible these effects may contribute to carcinogenesis. We aimed to review the accumulated knowledge to date to appreciate the modifying effects combined oral contraceptives may have on carcinogenesis. Our methodology involved a review of the current published literature, paying attention to studies published in the last 20 years. It has been noted that the overall cancer odds do not change with the use of COCs. Increased risk for breast cancer with COC use is not consistently backed in the literature; the results range from no increase in risk to a 20%-30% elevation in risk, and the risk seems to be temporary, limited to recent or current regular COC use. Also, diagnosed breast cancer cases seem to be clinically advanced in ever-users compared to never-users. Data show that the ongoing and prolonged use of COCs may provide diminished risk for endometrial, colorectal and ovarian cancers. Although studies do not clearly support increased risk with COC use in high-risk groups, such as women with family history of cancer or BRCA carriers, local and international guidelines are available for clinical decision-making. For cervical cancer, COCs seem to enhance the risk with more than 5 years of use, and in many studies, this enhanced risk diminishes after discontinuation and restores to those of never-users within 10 years. The relationship between COC use and liver malignancy risk assessments has provided conflicting findings. Some studies have suggested that hormonal contraceptives may increase the risk of not only hepatocellular carcinoma but also intrahepatic cholangiocarcinoma. Combined oral contraceptives are safe and effective and the effects are reversible. Patients who pursue family planning should be warned of possible carcinogenic outcomes, but it should also be explained that-in addition to sexual health advantages-preferring COCs may also decrease the risks of endometrial, colorectal and ovarian cancers.
    Language English
    Publishing date 2022-06-23
    Publishing country England
    Document type Journal Article ; Review
    ISSN 1754-6605
    ISSN 1754-6605
    DOI 10.3332/ecancer.2022.1416
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Novel frameshift

    Gultekin, Murat / Tufekcioglu, Zeynep / Baydemir, Recep

    Neurocase

    2022  Volume 28, Issue 1, Page(s) 107–109

    Abstract: Adult-onset neuronal ceroid lipofuscinoses (ANCLs, Kufs disease-KD) are rare, inherited, progressive, neurodegenerative, lysosomal storage diseases. Mutations in cathepsin F (CTSF) were linked to KD type B. Conversely, Frontotemporal dementia (FTD) is ... ...

    Abstract Adult-onset neuronal ceroid lipofuscinoses (ANCLs, Kufs disease-KD) are rare, inherited, progressive, neurodegenerative, lysosomal storage diseases. Mutations in cathepsin F (CTSF) were linked to KD type B. Conversely, Frontotemporal dementia (FTD) is the second most common type of presenile dementia and Parkinsonism is a mostly common accompanying feature. Due to pronounced behavioral, cognitive, and motor features in the patients with KD type B, mutations in CTSF may resemble FTD-parkinsonism. Here, we present a case of KD type B with a novel homozygous frameshift pathogenic variant (p.Gly439Alafs*36) in the Cathepsin F (CTSF) gene presenting behavioral changes, cognitive disturbances and parkinsonism with a family history mimicking FTD-parkinsonism.
    MeSH term(s) Adult ; Cathepsin F/genetics ; Frontotemporal Dementia/diagnosis ; Frontotemporal Dementia/genetics ; Frontotemporal Dementia/pathology ; Humans ; Mutation ; Neuronal Ceroid-Lipofuscinoses/genetics ; Neuronal Ceroid-Lipofuscinoses/pathology ; Parkinsonian Disorders/diagnosis ; Parkinsonian Disorders/genetics ; Pick Disease of the Brain
    Chemical Substances Cathepsin F (EC 3.4.22.41)
    Language English
    Publishing date 2022-02-09
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 1302651-3
    ISSN 1465-3656 ; 1355-4794
    ISSN (online) 1465-3656
    ISSN 1355-4794
    DOI 10.1080/13554794.2022.2038635
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: The evaluation of the nutritional status in Parkinson's disease: geriatric nutritional risk index comparison with mini nutritional assessment questionnaire.

    Yılmaz, Müge / Atuk Kahraman, Tutku / Kurtbeyoğlu, Emine / Konyalıgil Öztürk, Nurefşan / Gültekin, Murat

    Nutritional neuroscience

    2023  Volume 27, Issue 1, Page(s) 66–73

    Abstract: Objective: The symptoms associated with Parkinson's disease may lead to reduced food consumption and in turn, malnutrition. It is therefore important to apply a reliable nutrition screening tool to evaluate the nutritional status of individuals with ... ...

    Abstract Objective: The symptoms associated with Parkinson's disease may lead to reduced food consumption and in turn, malnutrition. It is therefore important to apply a reliable nutrition screening tool to evaluate the nutritional status of individuals with Parkinson's disease. This cross-sectional study aims to compare the Mini Nutritional Assessment (MNA) questionnaire and the Geriatric Nutrition Risk Index (GNRI) in the assessment of the nutritional status of individuals with Parkinson's disease, and to evaluate the usability of the GNRI in cases of Parkinson's disease.
    Methods: The study was conducted with 89 individuals over the age of 60 who were diagnosed with Parkinson's disease. Study data were collected using a questionnaire form administered through face-to-face interviews, the MNA-Long Form (MNA-LF), and the GNRI was calculated.
    Results: The mean GNRI scores were significantly lower in the participants with malnutrition (106.5 ± 19.4) than in the participants at risk of malnutrition (121.0 ± 10.3) and the participants with no malnutrition (125.3 ± 9.6) according to the MNA-LF (
    Conclusions: This is the first study to research the nutritional status of individuals with Parkinson's disease using the GNRI. The malnutrition rate detected by GNRI was found to be lower than MNA in Parkinson's patients receiving outpatient treatment. Similar studies are recommended to determine the usability of GNRI on inpatients.
    MeSH term(s) Humans ; Aged ; Nutritional Status ; Nutrition Assessment ; Parkinson Disease/complications ; Cross-Sectional Studies ; Malnutrition/diagnosis ; Malnutrition/epidemiology ; Malnutrition/etiology ; Surveys and Questionnaires
    Language English
    Publishing date 2023-01-03
    Publishing country England
    Document type Journal Article
    ZDB-ID 1447449-9
    ISSN 1476-8305 ; 1028-415X
    ISSN (online) 1476-8305
    ISSN 1028-415X
    DOI 10.1080/1028415X.2022.2161129
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Retinal dysfunction in Parkinson's disease-results of the extended protocol for photopic negative response (PHNR) full-field electroretinogram (ERG).

    Polat, Osman Ahmet / Gultekin, Murat / Sener, Hidayet / Ozer, Furkan / Arda, Hatice

    Documenta ophthalmologica. Advances in ophthalmology

    2023  Volume 147, Issue 2, Page(s) 89–98

    Abstract: Background: We investigated whether the photopic negative response (PhNR) in the electroretinogram (ERG) was affected in Parkinson's disease (PD) patients and whether it was associated with retinal changes on optical coherence tomography (OCT).: ... ...

    Abstract Background: We investigated whether the photopic negative response (PhNR) in the electroretinogram (ERG) was affected in Parkinson's disease (PD) patients and whether it was associated with retinal changes on optical coherence tomography (OCT).
    Methods: Thirty-two patients with PD and 31 age and sex-matched healthy controls from a single tertiary centre were included in the study. Hoehn and Yahr scale scores and the presence of REM sleep behaviour were recorded. PhNR, a-wave and b-wave responses in photopic ERG (red on blue background) and retinal layer thicknesses in OCT were obtained.
    Results: The mean age was 61 ± 10.4 in the PD group (female/male: 18/14) and 60.9 ± 7 in the control group (female/male: 18/13). The amplitudes of the PhNR, a- and b-waves in the ERG were significantly decreased in the PD group, but the implicit times were not significantly different. BCVA was significantly correlated with Hoehn and Yahr scores (p < 0.001, r = - 0.596). There was a significant correlation between BCVA and a-wave amplitude (p = 0.047, r = - 0.251). On OCT analysis, the thickness of the nasal INL was increased, and the temporal and inferior OPL and temporal peripapillary RNFL were decreased in the PD group compared to healthy controls (p = 0.032, p = 0.002, p = 0.016 and p = 0.012, respectively).
    Conclusion: This study demonstrated reduced a-wave, b-wave and PhNR-wave amplitudes on ERG measurements in PD patients. These findings suggest that the whole ERG response, not just the PhNR, is attenuated in patient with PD, suggesting a possible involvement of the visual system in the disease.
    MeSH term(s) Humans ; Male ; Female ; Middle Aged ; Aged ; Electroretinography/methods ; Retinal Ganglion Cells/physiology ; Parkinson Disease/complications ; Parkinson Disease/diagnosis ; Retina/physiology ; Color Vision ; Tomography, Optical Coherence
    Language English
    Publishing date 2023-07-29
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 212594-8
    ISSN 1573-2622 ; 0012-4486
    ISSN (online) 1573-2622
    ISSN 0012-4486
    DOI 10.1007/s10633-023-09945-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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